R Sheldon

Summary

Affiliation: University of Calgary
Country: Canada

Publications

  1. doi request reprint Norepinephrine transport inhibition for treatment of vasovagal syncope
    Robert S Sheldon
    Libin Cardiovascular Institute of Calgary, Calgary, Alberta, Canada
    J Cardiovasc Electrophysiol 24:799-803. 2013
  2. doi request reprint Syncope diagnostic scores
    Robert Sheldon
    Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada
    Prog Cardiovasc Dis 55:390-5. 2013
  3. doi request reprint Syncope 2020: five grand challenges
    Robert Sheldon
    Libin Cardiovascular Institute of Alberta, University of Calgary, 3280 Hospital Drive Northwest, Calgary, Alberta T2N 4N1, Canada
    Cardiol Clin 31:143-4. 2013
  4. doi request reprint Tilt table testing and implantable loop recorders for syncope
    Robert Sheldon
    Libin Cardiovascular Institute of Alberta, University of Calgary, 3280 Hospital Drive Northwest, Calgary, Alberta T2N 4N1, Canada
    Cardiol Clin 31:67-74. 2013
  5. ncbi request reprint Management of vasovagal syncope: 2004
    Robert Sheldon
    University of Calgary, Libin Cardiovascular Institute of Alberta, Faculty of Medicine, 3330 Hospital Drive NW Calgary, Alberta, T2N 4N1, Canada
    Expert Rev Cardiovasc Ther 2:915-23. 2004
  6. ncbi request reprint Tilt testing for syncope: a reappraisal
    Robert Sheldon
    Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada
    Curr Opin Cardiol 20:38-41. 2005
  7. doi request reprint Syncope and structural heart disease: historical criteria for vasovagal syncope and ventricular tachycardia
    Robert Sheldon
    Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada
    J Cardiovasc Electrophysiol 21:1358-64. 2010
  8. ncbi request reprint Diagnostic criteria for vasovagal syncope based on a quantitative history
    Robert Sheldon
    Cardiovascular Research Group, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N2, Canada
    Eur Heart J 27:344-50. 2006
  9. ncbi request reprint Age of first faint in patients with vasovagal syncope
    Robert S Sheldon
    Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada
    J Cardiovasc Electrophysiol 17:49-54. 2006
  10. ncbi request reprint Prevention of Syncope Trial (POST): a randomized, placebo-controlled study of metoprolol in the prevention of vasovagal syncope
    Robert Sheldon
    University of Calgary, Calgary, Alberta T2N 4N1, Canada
    Circulation 113:1164-70. 2006

Collaborators

Detail Information

Publications50

  1. doi request reprint Norepinephrine transport inhibition for treatment of vasovagal syncope
    Robert S Sheldon
    Libin Cardiovascular Institute of Calgary, Calgary, Alberta, Canada
    J Cardiovasc Electrophysiol 24:799-803. 2013
    ..As a test of concept we assessed whether sibutramine prevents fainting in highly symptomatic VVS patients...
  2. doi request reprint Syncope diagnostic scores
    Robert Sheldon
    Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada
    Prog Cardiovasc Dis 55:390-5. 2013
    ..Work from several centres indicates that scores will distinguish among competing causes of syncope in select populations, such as those with bifascicular heart block, Brugada syndrome, and Long QT syndrome...
  3. doi request reprint Syncope 2020: five grand challenges
    Robert Sheldon
    Libin Cardiovascular Institute of Alberta, University of Calgary, 3280 Hospital Drive Northwest, Calgary, Alberta T2N 4N1, Canada
    Cardiol Clin 31:143-4. 2013
    ..However, 5 important challenges remain, including syncope etiology, treatment, health services delivery, and an individualized approach to syncope...
  4. doi request reprint Tilt table testing and implantable loop recorders for syncope
    Robert Sheldon
    Libin Cardiovascular Institute of Alberta, University of Calgary, 3280 Hospital Drive Northwest, Calgary, Alberta T2N 4N1, Canada
    Cardiol Clin 31:67-74. 2013
    ..They have identified 2 populations of older patients with syncope who may benefit from permanent pacing. Randomized studies have established the safety and efficacy of their early application in the diagnosis of syncope...
  5. ncbi request reprint Management of vasovagal syncope: 2004
    Robert Sheldon
    University of Calgary, Libin Cardiovascular Institute of Alberta, Faculty of Medicine, 3330 Hospital Drive NW Calgary, Alberta, T2N 4N1, Canada
    Expert Rev Cardiovasc Ther 2:915-23. 2004
    ..This review highlights the most important of these advances and suggests strategies for managing this often difficult problem...
  6. ncbi request reprint Tilt testing for syncope: a reappraisal
    Robert Sheldon
    Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada
    Curr Opin Cardiol 20:38-41. 2005
    ..The purpose of this review is to summarize the major contributions of tilt tests and provide a critical assessment of the true validity and usefulness of this diagnostic test...
  7. doi request reprint Syncope and structural heart disease: historical criteria for vasovagal syncope and ventricular tachycardia
    Robert Sheldon
    Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada
    J Cardiovasc Electrophysiol 21:1358-64. 2010
    ..to develop evidence-based criteria that distinguish syncope due to ventricular tachycardia (VT) from vasovagal syncope (VVS) in patients with structural heart disease (SHD)...
  8. ncbi request reprint Diagnostic criteria for vasovagal syncope based on a quantitative history
    Robert Sheldon
    Cardiovascular Research Group, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N2, Canada
    Eur Heart J 27:344-50. 2006
    ..Our goal was to develop historical criteria for the diagnosis of vasovagal syncope...
  9. ncbi request reprint Age of first faint in patients with vasovagal syncope
    Robert S Sheldon
    Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada
    J Cardiovasc Electrophysiol 17:49-54. 2006
    ..Accordingly, we determined the age of the first syncopal spell in adult patients who sought care for syncope...
  10. ncbi request reprint Prevention of Syncope Trial (POST): a randomized, placebo-controlled study of metoprolol in the prevention of vasovagal syncope
    Robert Sheldon
    University of Calgary, Calgary, Alberta T2N 4N1, Canada
    Circulation 113:1164-70. 2006
    ..Previous studies that assessed the effects of beta-blockers in preventing vasovagal syncope provided mixed results. Our goal was to determine whether treatment with metoprolol reduces the risk of syncope in patients with vasovagal syncope...
  11. pmc Mechanism of hypotensive transients associated with abrupt bradycardias in conscious rabbits
    Robert S Sheldon
    Cardiovascular Research Group, University of Calgary, Alberta
    Can J Cardiol 23:721-6. 2007
    ..Transient bradycardic hypotensive events occur in resting rabbits. If the hypotension is due to vasodepression, these events may be a model for vasovagal syncope...
  12. ncbi request reprint Worsening of symptoms before presentation with vasovagal syncope
    Robert S Sheldon
    Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Canada
    J Cardiovasc Electrophysiol 18:954-9. 2007
    ..Much of the natural history of vasovagal syncope is unknown. We determined whether patients presenting for care have had a recently worsened syncope frequency...
  13. doi request reprint Design and use of a quantitative scale for measuring presyncope
    Robert S Sheldon
    Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada
    J Cardiovasc Electrophysiol 20:888-93. 2009
    ..One important symptom is presyncope, but there are no clinimetric measures of this. We developed the Calgary Presyncope Form (CPF) and used it to test whether metoprolol reduces presyncope in a randomized trial...
  14. doi request reprint Effect of metoprolol on quality of life in the Prevention of Syncope Trial
    Robert S Sheldon
    University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
    J Cardiovasc Electrophysiol 20:1083-8. 2009
    ..No therapies have proven useful to improve quality of life in adequately designed randomized clinical trials. Beta-blockers have mixed evidence for effectiveness in preventing syncope...
  15. doi request reprint Standardized approaches to the investigation of syncope: Canadian Cardiovascular Society position paper
    Robert S Sheldon
    University of Calgary, Calgary, Alberta, Canada
    Can J Cardiol 27:246-53. 2011
    ....
  16. ncbi request reprint Second Vasovagal Pacemaker Study (VPS II): rationale, design, results, and implications for practice and future clinical trials
    Robert Sheldon
    Cardiovascular Research Group, University of Calgary, Calgary, Alberta, Canada
    Card Electrophysiol Rev 7:411-5. 2003
    ..14). The AHA/ACC guidelines about pacing and vasovagal syncope should be reassessed. Future clinical trials of therapies for vasovagal syncope should be randomized and placebo-controlled...
  17. ncbi request reprint Effect of clinical risk stratification on cost-effectiveness of the implantable cardioverter-defibrillator: the Canadian implantable defibrillator study
    R Sheldon
    Cardiovascular Research Group, University of Calgary, Alberta, Canada
    Circulation 104:1622-6. 2001
    ..We estimated the extent to which selecting patients for ICD therapy based on these risk factors makes ICD therapy more economically attractive...
  18. ncbi request reprint Components of clinical trials for vasovagal syncope
    R Sheldon
    Cardiovascular Research Group, University of Calgary, Alberta, Canada
    Europace 3:233-40. 2001
    ..Data for power calculations are presented for the primary outcome, the time to the first syncope recurrence. Strengths and weakness of the four main types of outcomes for clinical trials are compared...
  19. ncbi request reprint Historical criteria that distinguish syncope from seizures
    Robert Sheldon
    Cardiovascular Research Group, University of Calgary, Calgary, Alberta, Canada
    J Am Coll Cardiol 40:142-8. 2002
    ..We prospectively sought evidence-based criteria that distinguished between seizures and syncope...
  20. ncbi request reprint Syncope: investigation and treatment
    Satish R Raj
    Faculty of Medicine, University of Calgary, Health Sciences Centre, 3330 Hospital Drive, NW, Calgary, Alberta, T2N 4N1, Canada
    Curr Cardiol Rep 4:363-70. 2002
    ....
  21. ncbi request reprint Prevention of Syncope Trial (POST): a randomized clinical trial of beta blockers in the prevention of vasovagal syncope; rationale and study design
    R Sheldon
    Cardiovascular Research Group, University of Calgary, Calgary, Alberta, Canada
    Europace 5:71-5. 2003
    ..Few therapies for vasovagal syncope have been proven effective. A large, placebo-controlled clinical trial of beta-blockers is needed...
  22. ncbi request reprint Usefulness of clinical factors in predicting outcomes of passive tilt tests in patients with syncope
    R Sheldon
    Cardiovascular Research Group, University of Calgary, Alberta, Canada
    Am J Cardiol 85:360-4. 2000
    ..Measures of symptom burden do not predict test outcome, and younger patients are more likely to faint during passive tilt testing...
  23. ncbi request reprint Identification of patients most likely to benefit from implantable cardioverter-defibrillator therapy: the Canadian Implantable Defibrillator Study
    R Sheldon
    Cardiovascular Research Group, University of Calgary, Calgary, Alberta
    Circulation 101:1660-4. 2000
    ..We hypothesized that the patients who benefit most from an ICD are those at greatest risk of death...
  24. ncbi request reprint Pacing to prevent vasovagal syncope
    R Sheldon
    Cardiovascular Research Group, University of Calgary, Alberta, Canada
    Cardiol Clin 18:81-93. 2000
    ..At this point, we do not know the role of placebo, and specific pacing modes in this improvement are not known. Ongoing trials will clarify how to select patients and how best to pace them...
  25. ncbi request reprint A randomized study of tilt test angle in patients with undiagnosed syncope
    R Sheldon
    University of Calgary, Calgary, Canada
    Can J Cardiol 17:1051-7. 2001
    ..Little is known about the effects of passive tilt angle and duration, duration of isoproterenol infusion or hemodynamic diagnostic criteria...
  26. ncbi request reprint Origins of heart rate variability: autonomic blockade of large magnitude, transient bradycardia in conscious rabbits
    D Roach
    Cardiovascular Research Group, University of Calgary, Calgary, Alberta, Canada
    Can J Cardiol 17:185-91. 2001
    ..The presence of LMTBs may indicate ongoing, subtle changes in the laboratory environment...
  27. ncbi request reprint Outcome of patients with dual-chamber pacemakers implanted for the prevention of neurally mediated syncope
    Satish R Raj
    Cardiovascular Research Group, University of Calgary, Alberta, Canada
    Am J Cardiol 91:565-9. 2003
    ..Some, but not all, patients respond to permanent PI for NMS. The long-term benefit of permanent PI can be predicted by timing of the first recurrence of syncope, but not by preimplantation factors...
  28. ncbi request reprint Paced QT dispersion and QT morphology after radiofrequency atrioventricular junction ablation: impact of left ventricular function
    Satish R Raj
    Division of Cardiology, Foothills Medical Center and the Cardiovascular Disease Research Group, University of Calgary, Calgary, Alberta, Canada
    Pacing Clin Electrophysiol 26:662-8. 2003
    ..02) function groups. Following AVJ ablation, QTdisp increased during a sudden rate drop in patients with reduced LV function, but not in patients with normal LV function...
  29. ncbi request reprint Noninvasive risk assessment early after a myocardial infarction the REFINE study
    Derek V Exner
    Libin Cardiovascular Institute of Alberta, Calgary, Canada Department of Community Health Sciences, University of Calgary, Calgary, Canada
    J Am Coll Cardiol 50:2275-84. 2007
    ....
  30. ncbi request reprint Precordial QT dispersion does not predict inducibility of ventricular tachyarrhythmias at post-revascularization electrophysiologic study
    Satish R Raj
    Division of Cardiology, Foothills Medical Centre and the Cardiovascular Disease Research Group, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada, T2N 4N1
    J Interv Card Electrophysiol 6:25-33. 2002
    ..We tested the hypothesis that revascularization would decrease QT interval dispersion and that QT interval dispersion would predict the outcome of the electrophysiologic study following revascularization...
  31. doi request reprint Beneficial effects of statin therapy for prevention of atrial fibrillation following DDDR pacemaker implantation
    Anne M Gillis
    Department of Cardiac Sciences, Libin Cardiovascular Institute of Alberta, University of Calgary and Calgary Health Region, Calgary, AB, Canada
    Eur Heart J 29:1873-80. 2008
    ..The clinical predictors of at/af recurrence following dual-chamber pacemaker insertion were examined in 185 consecutive patients with paroxysmal AF...
  32. doi request reprint Impact of atrial antitachycardia pacing and atrial pace prevention therapies on atrial fibrillation burden over long-term follow-up
    Anne M Gillis
    Health Sciences Centre, Department of Cardiac Sciences, University of Calgary, Calgary Health Region, Rm 1634, 3330 Hospital Dr NW, Calgary, Alberta, Canada
    Europace 11:1041-7. 2009
    ..Accordingly, we compared atrial antitachycardia pacing (ATP) therapy and combined atrial ATP and atrial pace prevention (ATP + Prevention) algorithms to conventional DDD/R pacing for prevention of AT/AF over long-term follow-up...
  33. doi request reprint Recent history of vasovagal syncope in a young, referral-based population is a stronger predictor of recurrent syncope than lifetime syncope burden
    Glen L Sumner
    Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada
    J Cardiovasc Electrophysiol 21:1375-80. 2010
    ..We aimed to test the hypothesis that recent history of vasovagal syncope compared to distant history better predicts subsequent recurrence of syncope...
  34. ncbi request reprint Randomized controlled trial of fixed rate versus rate responsive pacing after radiofrequency atrioventricular junction ablation: quality of life, ventricular refractoriness, and paced QT dispersion
    Henry J Duff
    Cardiovascular Disease Research Group, University of Calgary Health Sciences Centre, HSC 1632, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1
    J Cardiovasc Electrophysiol 14:1163-70. 2003
    ..The aim of this study was to provide information about the balance between measures of quality of life versus measures of electrical remodeling achieved by pacing with different rate modalities in a randomized pilot clinical trial...
  35. ncbi request reprint Clinical and electrophysiologic predictors of ventricular tachyarrhythmia recurrence in patients with implantable cardioverter defibrillators
    Anne M Gillis
    Division of Cardiology, Foothills Hospital and Cardiovascular Research Group, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    J Cardiovasc Electrophysiol 14:492-8. 2003
    ..We evaluated the clinical and electrophysiologic predictors of ventricular tachycardia (VT) and ventricular fibrillation (VF) recurrence following ICD implantation...
  36. ncbi request reprint Current concepts in the evaluation and management of syncope
    Vikas Kuriachan
    Cardiovascular Research Group, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
    Curr Cardiol Rep 10:384-90. 2008
    ..Recent randomized trials have highlighted the roles of physical counterpressure maneuvers and midodrine and the limitations of treatment with beta blockers and permanent cardiac pacing...
  37. ncbi request reprint Permanent cardiac pacing to prevent vasovagal syncope
    Satish R Raj
    Cardiovascular Research Group, University of Calgary, Calgary, Alberta, Canada
    Curr Opin Cardiol 17:90-5. 2002
    ..The second Vasovagal Pacemaker Study will quantify the true benefits of pacing for vasovagal syncope and assess the role of rate-drop response algorithms...
  38. ncbi request reprint Measuring transient systemic conductance and capacitance responses using a modified Brooksby-Donald technique in anesthetized, autonomically intact rabbits
    Christopher I Wright
    Department of Medicine, University of Calgary, Alberta
    Can J Cardiol 20:1127-34. 2004
    ..The Brooksby-Donald approach uses two flow probes to measure the inflow and outflow from an organ or vascular bed; the difference in flow can be time-integrated to assess changes in venous capacitance...
  39. ncbi request reprint Learning needs of patients with vasovagal syncope
    William D White
    Cardiovascular Research Group, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
    Can J Cardiovasc Nurs 13:26-30. 2003
    ..Patients with vasovagal syncope share a number of well-defined categories of subjectively identified learning needs. These categories should guide attempts to provide patients with relevant counselling, reassurance, and education...
  40. ncbi request reprint Activity-responsive pacing produces long-term heart rate variability
    Satish R Raj
    Cardiovascular Research Group, University of Calgary, Calgary, Alberta, Canada
    J Cardiovasc Electrophysiol 15:179-83. 2004
    ..We tested the hypothesis that long-term HRV arises from physical activity in a randomized cross-over study in patients with rate-responsive pacemakers...
  41. pmc Selective knockout of mouse ERG1 B potassium channel eliminates I(Kr) in adult ventricular myocytes and elicits episodes of abrupt sinus bradycardia
    James P Lees-Miller
    Department of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N1
    Mol Cell Biol 23:1856-62. 2003
    ..This phenomenon was never observed in +/+ mice (0 out of 16). We conclude that ERG1 B is necessary for I(Kr) expression in the surface membrane of adult myocytes. Knockout of ERG1 B predisposes mice to episodic sinus bradycardia...
  42. ncbi request reprint Role of pacemakers in treating neurocardiogenic syncope
    Satish R Raj
    Cardiovascular Research Group, University of Calgary, Calgary, Alberta, Canada
    Curr Opin Cardiol 18:47-52. 2003
    ..The second Vasovagal Pacemaker Study will quantify the true benefits of pacing for vasovagal syncope and assess the role of rate-drop response algorithms...
  43. doi request reprint Effects of ovarian hormones and aging on respiratory sinus arrhythmia and breathing patterns in women
    Marlen Lüthi
    Department of Physiology and Biophysics, Faculty of Medicine, Heritage Medical Research Building, Room 212, University of Calgary, 3330 Hospital Drive NW, T2N 4N1 Calgary, AB, Canada
    Clin Auton Res 18:134-44. 2008
    ..Third, RSA did not change with age. Fourth, RSA did not change with IH and EH-induced changes in breathing patterns. Finally, high individual variability of average RR-interval change per breath was found...
  44. ncbi request reprint Vasovagal syncope in medical students and their first-degree relatives
    Anna Serletis
    Libin Cardiovascular Institute of Alberta, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta, Canada T2N 4N2
    Eur Heart J 27:1965-70. 2006
    ..To determine the effect of family history on the likelihood of vasovagal syncope...
  45. ncbi request reprint Vasovagal syncope: state or trait?
    Anna Serletis Bizios
    Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada
    Curr Opin Cardiol 24:68-73. 2009
    ..There are several features of this trait that suggest a genetic origin. The purposes of this review are to present a rationale for considering a genetic origin and critically summarize recent findings...
  46. doi request reprint Evidence-based treatment for vasovagal syncope
    Vikas Kuriachan
    Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada
    Heart Rhythm 5:1609-14. 2008
    ..The routine use of beta-blockers, serotonin-specific reuptake inhibitors, fludrocortisone, and pacemakers is discouraged. Whether loop recorders can be used to target treatment is under investigation, as is fludrocortisone...
  47. ncbi request reprint The Second Prevention of Syncope Trial (POST II)--a randomized clinical trial of fludrocortisone for the prevention of neurally mediated syncope: rationale and study design
    Satish R Raj
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University, Nashville, TN, USA
    Am Heart J 151:1186.e11-7. 2006
    ..05...
  48. ncbi request reprint Letter regarding article by Adamson et al, "Continuous autonomic assessment in patients with symptomatic heart failure: prognostic value of heart rate variability measured by an implanted cardiac resynchronization device"
    Satish R Raj
    Circulation 112:e37-8; author reply e37-8. 2005
  49. ncbi request reprint Standard Deviation of Sequential Five-Minute R-R Interval Means (SDANN) is a prognostic marker, but not necessarily an autonomic marker
    Satish R Raj
    J Am Coll Cardiol 48:1285-6; author reply 1286. 2006
  50. ncbi request reprint Role of hypotension in heart rate turbulence physiology
    Satish R Raj
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, USA
    Heart Rhythm 2:820-7. 2005
    ..Heart rate turbulence is a recently described cardiac prognostic marker that may be mediated by arterial baroreceptor sensitivity, suggesting it is induced by a brief initial hypotension...