Andrew William Sheel

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. doi request reprint Ventilation and respiratory mechanics
    Andrew William Sheel
    the School of Kinesiology, The University of British Columbia, Vancouver, Canada
    Compr Physiol 2:1093-142. 2012
  2. pmc Clinical review: Guyton--the role of mean circulatory filling pressure and right atrial pressure in controlling cardiac output
    William R Henderson
    Critical Care Medicine, Vancouver General Hospital, ICU, JPPN, 2nd Floor, Room 2438, 899 West 12th Avenue, Vancouver, BC, V5Z 1M9, Canada
    Crit Care 14:243. 2010
  3. ncbi request reprint Physiological responses to indoor rock-climbing and their relationship to maximal cycle ergometry
    A William Sheel
    School of Human Kinetics, The University of British Columbia, Vancouver, BC, Canada
    Med Sci Sports Exerc 35:1225-31. 2003
  4. ncbi request reprint Effects of physical activity on exercise capacity in twins with alpha-1 antitrypsin deficiency
    A William Sheel
    Health and Integrative Physiology Laboratory, School of Human Kinetics, University of British Columbia, Vancouver, British Columbia, Canada
    Clin J Sport Med 15:183-5. 2005
  5. ncbi request reprint Autonomic dysreflexia during sperm retrieval in spinal cord injury: influence of lesion level and sildenafil citrate
    A William Sheel
    International Collaboration on Repair Discoveries, and School of Human Kinetics, The Univ of British Columbia, 210 6081 Univ Blvd, Vancouver, BC, Canada V6T 1Z1
    J Appl Physiol 99:53-8. 2005
  6. doi request reprint Hypoxia and exercise: different models for different questions
    A William Sheel
    Health and Integrative Physiology Laboratory, School of Human Kinetics, University of British Columbia, Vancouver, BC V6T1Z3, Canada
    Appl Physiol Nutr Metab 33:571-2. 2008
  7. doi request reprint Control of ventilation in humans following intermittent hypoxia
    Andrew William Sheel
    Health and Integrative Physiology Laboratory, School of Human Kinetics, University of British Columbia, Vancouver, BC V6T1Z3, Canada
    Appl Physiol Nutr Metab 33:573-81. 2008
  8. doi request reprint Mechanics of breathing during exercise in men and women: sex versus body size differences?
    A William Sheel
    School of Human Kinetics, The University of British Columbia, Vancouver, British Columbia, Canada
    Exerc Sport Sci Rev 36:128-34. 2008
  9. ncbi request reprint Sex differences in respiratory exercise physiology
    A William Sheel
    Health and Integrative Physiology Laboratory, School of Human Kinetics, The University of British Columbia, Vancouver, British Columbia, Canada
    Sports Med 34:567-79. 2004
  10. pmc Physiology of sport rock climbing
    A W Sheel
    University of British Columbia, School of Human Kinetics, Vancouver, Canada
    Br J Sports Med 38:355-9. 2004

Collaborators

Detail Information

Publications51

  1. doi request reprint Ventilation and respiratory mechanics
    Andrew William Sheel
    the School of Kinesiology, The University of British Columbia, Vancouver, Canada
    Compr Physiol 2:1093-142. 2012
    ..We review recent evidence concerning how exercise hyperpnea influences sympathetic vasoconstrictor outflow and the effect this might have on the ability to perform muscular work. We also review sex-based differences in lung mechanics...
  2. pmc Clinical review: Guyton--the role of mean circulatory filling pressure and right atrial pressure in controlling cardiac output
    William R Henderson
    Critical Care Medicine, Vancouver General Hospital, ICU, JPPN, 2nd Floor, Room 2438, 899 West 12th Avenue, Vancouver, BC, V5Z 1M9, Canada
    Crit Care 14:243. 2010
    ..Further concerns have been raised in regard to the artificial experimental preparations that Guyton used. Recently reported measurements in humans support Guyton's theoretical and animal work...
  3. ncbi request reprint Physiological responses to indoor rock-climbing and their relationship to maximal cycle ergometry
    A William Sheel
    School of Human Kinetics, The University of British Columbia, Vancouver, BC, Canada
    Med Sci Sports Exerc 35:1225-31. 2003
    ..It was hypothesized that as climbing difficulty increased, oxygen consumption ([V02] and heart rate would increase, and that climbing would require utilization of a significant fraction of maximal cycling values...
  4. ncbi request reprint Effects of physical activity on exercise capacity in twins with alpha-1 antitrypsin deficiency
    A William Sheel
    Health and Integrative Physiology Laboratory, School of Human Kinetics, University of British Columbia, Vancouver, British Columbia, Canada
    Clin J Sport Med 15:183-5. 2005
  5. ncbi request reprint Autonomic dysreflexia during sperm retrieval in spinal cord injury: influence of lesion level and sildenafil citrate
    A William Sheel
    International Collaboration on Repair Discoveries, and School of Human Kinetics, The Univ of British Columbia, 210 6081 Univ Blvd, Vancouver, BC, Canada V6T 1Z1
    J Appl Physiol 99:53-8. 2005
    ..Administration of sildenafil citrate had no effect on heart rate or blood pressure during penile vibratory stimulation in men with spinal cord injury...
  6. doi request reprint Hypoxia and exercise: different models for different questions
    A William Sheel
    Health and Integrative Physiology Laboratory, School of Human Kinetics, University of British Columbia, Vancouver, BC V6T1Z3, Canada
    Appl Physiol Nutr Metab 33:571-2. 2008
    ..e., generations spanning millennia). Lastly, the third paper uses acute hypoxia to better understand cardio-pulmonary interactions during exercise. Collectively, these reviews are intended to stimulate additional study and debate...
  7. doi request reprint Control of ventilation in humans following intermittent hypoxia
    Andrew William Sheel
    Health and Integrative Physiology Laboratory, School of Human Kinetics, University of British Columbia, Vancouver, BC V6T1Z3, Canada
    Appl Physiol Nutr Metab 33:573-81. 2008
    ..We also suggest future directions for this relatively young field, including potential clinical applications of IH research...
  8. doi request reprint Mechanics of breathing during exercise in men and women: sex versus body size differences?
    A William Sheel
    School of Human Kinetics, The University of British Columbia, Vancouver, British Columbia, Canada
    Exerc Sport Sci Rev 36:128-34. 2008
    ..Women use a greater fraction of their ventilatory reserve and have a higher metabolic cost of breathing...
  9. ncbi request reprint Sex differences in respiratory exercise physiology
    A William Sheel
    Health and Integrative Physiology Laboratory, School of Human Kinetics, The University of British Columbia, Vancouver, British Columbia, Canada
    Sports Med 34:567-79. 2004
    ..However, detailed sex comparisons are difficult because the number of subjects studied to date has been woefully small...
  10. pmc Physiology of sport rock climbing
    A W Sheel
    University of British Columbia, School of Human Kinetics, Vancouver, Canada
    Br J Sports Med 38:355-9. 2004
    ..The determinants of climbing performance are not clear but may be attributed to trainable variables rather than specific anthropometric characteristics...
  11. pmc Evidence for dysanapsis using computed tomographic imaging of the airways in older ex-smokers
    A William Sheel
    School of Human Kinetics, University of British Columbia, BC, Canada
    J Appl Physiol 107:1622-8. 2009
    ..In males and females matched for lung size women had significantly smaller airway luminal areas. The larger conducting airways in females are significantly smaller than those of males even after controlling for lung size...
  12. pmc Fatiguing inspiratory muscle work causes reflex reduction in resting leg blood flow in humans
    A W Sheel
    Department of Population Health Sciences, John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin Madison, Madison, WI, USA
    J Physiol 537:277-89. 2001
    ..Q(L) and increases in LVR. We attribute these changes to a metaboreflex originating in the diaphragm. Diaphragm and forearm muscle fatigue showed very similar time-dependent effects on LVR and .Q(L)...
  13. ncbi request reprint Human ventilatory responsiveness to hypoxia is unrelated to maximal aerobic capacity
    A William Sheel
    School of Human Kinetics, The University of British Columbia, 210 6081 Univ Blvd, Vancouver, BC, Canada V6T 1Z1
    J Appl Physiol 100:1204-9. 2006
    ..We interpret these observations to mean that other factors are more important in determining hypoxic ventilatory control than physical conditioning per se...
  14. ncbi request reprint Threshold effects of respiratory muscle work on limb vascular resistance
    A William Sheel
    University of Wisconsin Madison, Department of Population Health Sciences, John Rankin Laboratory of Pulmonary Medicine, Madison, Wisconsin 53705, USA
    Am J Physiol Heart Circ Physiol 282:H1732-8. 2002
    ..We attribute the limb vasoconstriction to a metaboreflex originating in the diaphragm, which reaches its threshold for activation during fatiguing contractions...
  15. doi request reprint Exercise and its impact on dyspnea
    A William Sheel
    School of Human Kinetics, University of British Columbia, Vancouver, British Columbia, Canada
    Curr Opin Pharmacol 11:195-203. 2011
    ..Lastly, we review the effects of healthy aging and recent evidence for a male-female difference with respect to exertional-related dyspnea...
  16. pmc Effects of exercise training and inspiratory muscle training in spinal cord injury: a systematic review
    A William Sheel
    School of Human Kinetics, University of British Columbia, Vancouver, British Columbia, USA
    J Spinal Cord Med 31:500-8. 2008
    ..To provide a systematic review of the studies assessing exercise training and inspiratory muscle training (IMT) in individuals for the improved respiratory function of patients with spinal cord injury (SCI)...
  17. doi request reprint The pulmonary system during exercise in hypoxia and the cold
    A William Sheel
    University of British Columbia, 6108 Thunderbird Boulevard, Vancouver, BC, Canada
    Exp Physiol 95:422-30. 2010
    ..We also highlight new findings and controversial questions that would benefit from additional study...
  18. doi request reprint Effects of 10 days of modest intermittent hypoxia on circulating measures of inflammation in healthy humans
    Jordan S Querido
    School of Human Kinetics, Osborne Centre, Unit II, University of British Columbia, Vancouver, BC, Canada
    Sleep Breath 16:657-62. 2012
    ..The purpose of this study was to test the hypothesis that IH would increase systemic inflammatory markers in healthy human males...
  19. pmc Cardiovascular responses to vibrostimulation for sperm retrieval in men with spinal cord injury
    Victoria Elizabeth Claydon
    International Collaboration on Repair Discoveries, University of British Columbia, Canada
    J Spinal Cord Med 29:207-16. 2006
    ..The study aimed to examine cardiovascular control in men with SCI undergoing this procedure...
  20. ncbi request reprint Physiological consequences of a high work of breathing during heavy exercise in humans
    J A Guenette
    School of Human Kinetics, The University of British Columbia, Vancouver, BC, Canada
    J Sci Med Sport 10:341-50. 2007
    ..This brief review summarizes the literature as it pertains to the work of breathing, expiratory flow limitation, and exercise-induced diaphragmatic fatigue in healthy humans...
  21. ncbi request reprint Exhaled nitric oxide during exercise
    A W Sheel
    Allan McGavin Sports Medicine Center, The University of British Columbia, Vancouver, Canada
    Sports Med 28:83-90. 1999
    ..Scientific debate surrounds the site of NO production and the stimuli for production. Resolution of these controversial issues will explain the significance of exhaled NO during exercise...
  22. ncbi request reprint The human diving response, its function, and its control
    G E Foster
    Health and Integrative Physiology Laboratory, School of Human Kinetics, University of British Columbia, Vancouver, BC, Canada
    Scand J Med Sci Sports 15:3-12. 2005
    ..We suggest that future research should be focused towards understanding the role of altered ventilatory responses in human breath-hold athletes as well as in patients suffering from sleep-disordered breathing...
  23. ncbi request reprint Comments on Point-Counterpoint "The muscle metaboreflex does/does not restore blood flow to contracting muscles"
    A William Sheel
    J Appl Physiol 100:371. 2006
  24. ncbi request reprint Dose response of inhaled salbutamol on exercise performance and urine concentrations
    Benjamin C Sporer
    School of Human Kinetics, University of British Columbia, Vancouver, Canada
    Med Sci Sports Exerc 40:149-57. 2008
    ..This study determined the dose-response effects of inhaled salbutamol (SAL) on time-trial performance and urine concentrations of SAL (cSAL)...
  25. doi request reprint Muscle deoxygenation of upper-limb muscles during progressive arm-cranking exercise
    Sarah Jane C Lusina
    School of Human Kinetics, The University of British Columbia, Vancouver, BC, Canada
    Appl Physiol Nutr Metab 33:231-8. 2008
    ....
  26. doi request reprint Post-exercise hypotension and cardiovascular responses to moderate orthostatic stress in endurance-trained males
    Jessica M Scott
    Cardiovascular Physiology and Rehabilitation Laboratory, University of British Columbia, Vancouver, BC, Canada
    Appl Physiol Nutr Metab 33:246-53. 2008
    ....
  27. ncbi request reprint Repeated measurement of hypoxic ventilatory response as an intermittent hypoxic stimulus
    Michael S Koehle
    Department of Family Medicine, Allan McGavin Sport Medicine Centre, University of British Columbia, Vancouver, BC, Canada V6T 1Z1
    Respir Physiol Neurobiol 145:33-9. 2005
    ..There is no evidence that the short exposure to hypoxia as part of HVR measurement is a co-intervention when measured repeatedly over 5 days in physiological studies...
  28. ncbi request reprint Acute hypoxic ventilatory response and exercise-induced arterial hypoxemia in men and women
    Jordan A Guenette
    Health and Integrative Physiology Laboratory, School of Human Kinetics, The University of British Columbia, Vancouver, BC, Canada V6T 1Z1
    Respir Physiol Neurobiol 143:37-48. 2004
    ..53) (P < 0.05) but AHVR was unrelated to Sa(O(2)) for any groups (P > 0.05). We conclude that resting AHVR does not have a significant role in maintaining Sa(O(2)) during sea-level maximal cycle exercise in men or women...
  29. ncbi request reprint Entrainment of breathing in cyclists and non-cyclists during arm and leg exercise
    Ben C Sporer
    School of Human Kinetics, University of British Columbia, Vancouver, BC, Canada
    Respir Physiol Neurobiol 155:64-70. 2007
    ..These results suggest that during cycling exercise at intensities of 75% VO2max or less, regular training may result in higher %ENT and that ENT is not transferable to an unfamiliar mode of exercise using different muscle groups...
  30. ncbi request reprint Effects of upper extremity exercise training on peak aerobic and anaerobic fitness in patients after transplantation
    Darren E R Warburton
    School of Human Kinetics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Cardiol 93:939-43. 2004
    ..It also appears that patients with cardiac and noncardiac transplants have an increased reliance on anaerobic energy systems during exercise conditions compared with healthy control subjects...
  31. ncbi request reprint [The John Sutton Lecture: CSEP, 2002]. Pulmonary system limitations to exercise in health
    Jerome A Dempsey
    Dept of Population Health Sciences, John Rankin Laboratory of Pulmonary Medicine, University of Wisconsin Madison, Madison, WI 53705, USA
    Can J Appl Physiol 28:S2-24. 2003
    ..In this brief review, we describe the characteristics and causes of each of these proposed pulmonary limitations and their consequences to maximal O2 uptake and exercise performance...
  32. ncbi request reprint Respiratory influences on sympathetic vasomotor outflow in humans
    Jerome A Dempsey
    John Rankin Laboratory of Pulmonary Medicine, Department of Population Health Sciences, University of Wisconsin, 504 N Walnut Street, Madison, WI 53706, USA
    Respir Physiol Neurobiol 130:3-20. 2002
    ..Recent evidence suggests that these respiratory influences contribute significantly to sympathetic vasomotor outflow and to the distribution of systemic vascular conductances and blood flow in the exercising human...
  33. ncbi request reprint Respiratory muscle training in healthy individuals: physiological rationale and implications for exercise performance
    A William Sheel
    School of Human Kinetics, University of British Columbia, Vancouver, British Columbia, Canada bill sheel ubc ca
    Sports Med 32:567-81. 2002
    ..This review summarises the current literature on the physiology of RM training in healthy individuals and critically evaluates the possible implications for exercise performance...
  34. ncbi request reprint Effects of expiratory muscle work on muscle sympathetic nerve activity
    P Alexander Derchak
    John Rankin Laboratory of Pulmonary Medicine, Department of Population Health Sciences, University of Wisconsin, Madison, Wisconsin 53705, USA
    J Appl Physiol 92:1539-52. 2002
    ..The evidence suggests that these effects are mediated primarily via a muscle metaboreflex with a minor, variable contribution from augmented central expiratory motor output...
  35. ncbi request reprint Exercise-induced arterial hypoxaemia in active young women
    Jordan A Guenette
    Health and Integrative Physiology Laboratory, School of Human Kinetics, The University of British Columbia, 6108 Thunderbird Blvd, Vancouver, BC V6T 1Z3
    Appl Physiol Nutr Metab 32:1263-73. 2007
    ..Furthermore, we discuss unresolved questions dealing with pulmonary system limitations during exercise in women...
  36. ncbi request reprint Two patterns of daily hypoxic exposure and their effects on measures of chemosensitivity in humans
    Michael S Koehle
    Allan McGavin Sport Medicine Centre, Vancouver, BC, Canada
    J Appl Physiol 103:1973-8. 2007
    ..These results also suggest that the two methods of measuring CO(2) response are not completely concordant and that the changes in CO(2) control do not correlate with the increase in the HVR...
  37. pmc Inspiratory muscle training attenuates the human respiratory muscle metaboreflex
    Jonathan D Witt
    School of Human Kinetics, University of British Columbia, Vancouver, BC, Canada
    J Physiol 584:1019-28. 2007
    ..We attribute our findings to a reduced activity of chemosensitive afferents within the inspiratory muscles and may provide a mechanism for some of the whole-body exercise endurance improvements associated with IMT...
  38. ncbi request reprint Effects of enhanced human chemosensitivity on ventilatory responses to exercise
    Glen E Foster
    School of Human Kinetics, The University of British Columbia, Vancouver, BC, Canada
    Exp Physiol 91:221-8. 2006
    ..30) and day 12 (r = 0.47; P > 0.05). Our findings point to a lack of functional significance of increasing HVR via intermittent hypoxia on ventilatory responses to exercise at sea level...
  39. ncbi request reprint Measurement of exercise ventilation by a portable respiratory inductive plethysmograph
    Jonathan D Witt
    School of Human Kinetics, Health and Integrative Physiology Laboratory, The University of British Columbia, 210 6081 University Blvd, Vancouver, BC, Canada V6T 1Z1
    Respir Physiol Neurobiol 154:389-95. 2006
    ..9652, respectively) and the mean bias values were low (-0.102+/-2.91, 0.033+/-0.207 and -0.715+/-8.362, respectively). These data suggest that the ambulatory RIP provides reasonable estimates of ventilation during rest and exercise...
  40. ncbi request reprint Comment on point: counterpoint "in health and in a normoxic environment, VO2 max is/is not limited primarily by cardiac output and locomotor muscle blood flow". Vol 100: 744-8, 2006. This exchange does little to resolve the question
    A William Sheel
    J Appl Physiol 100:1086. 2006
  41. ncbi request reprint A comparison of inspiratory muscle fatigue following maximal exercise in moderately trained males and females
    Atila Ozkaplan
    School of Human Kinetics, University of British Columbia, UBC War Memorial Gym 210, 6081 University Blvd, Vancouver, BC, V6T 1Z1, Canada
    Eur J Appl Physiol 95:52-6. 2005
    ..05). The findings in this study conclude that IMF, observed immediately following maximal exercise, demonstrated the same pattern of recovery for both genders...
  42. ncbi request reprint Variable effects of respiratory muscle training on cycle exercise performance in men and women
    Jordan A Guenette
    School of Human Kinetics, University of British Columbia, Vancouver, BC, Canada
    Appl Physiol Nutr Metab 31:159-66. 2006
    ..01), but not when compared with days 4 or 5 (P > 0.05). RMT increases MIP and may improve exercise performance; however, improvements are variable with no differences between men and women...
  43. pmc Long-term intermittent hypoxia increases sympathetic activity and chemosensitivity during acute hypoxia in humans
    Sarah Jane C Lusina
    Health and Integrative Physiology Laboratory, School of Human Kinetics, The University of British Columbia, 6108 Thunderbird Blvd, Vancouver, B C, Canada
    J Physiol 575:961-70. 2006
    ..82) during the post-IH trial. Following IH the rise in MSNA burst frequency was strongly related to the change in HVR (r = 0.79, P < 0.05) suggesting that these sympathetic and ventilatory responses may have common central control...
  44. doi request reprint Intermittent hypoxia reduces cerebrovascular sensitivity to isocapnic hypoxia in humans
    Jordan S Querido
    School of Human Kinetics, The University of British Columbia, Vancouver, British Columbia, Canada
    Respir Physiol Neurobiol 161:1-9. 2008
    ..Thus, it appears that intermittent hypoxia has direct cerebrovascular effects that can occur in the absence of changes to the ventilatory and neurovascular control systems...
  45. pmc Effects of two protocols of intermittent hypoxia on human ventilatory, cardiovascular and cerebral responses to hypoxia
    Glen E Foster
    School of Human Kinetics, University of British Columbia, Vancouver, BC, Canada
    J Physiol 567:689-99. 2005
    ..Our findings indicate that the vascular processes required to control blood flow and oxygen supply to cerebral tissue in a healthy human are hindered following exposure to 12 days of isocapnic intermittent hypoxia...
  46. pmc Respiratory mechanics during exercise in endurance-trained men and women
    Jordan A Guenette
    School of Human Kinetics and Faculty of Medicine, Health and Integrative Physiology Laboratory, University of British Columbia, 6108 Thunderbird Blvd, Vancouver, BC, Canada V6T 1Z3
    J Physiol 581:1309-22. 2007
    ..Collectively, these findings suggest that women utilize a greater majority of their ventilatory reserve compared to men and this is associated with a higher cost of breathing...
  47. ncbi request reprint Human lung density is not altered following normoxic and hypoxic moderate-intensity exercise: implications for transient edema
    Alastair N H Hodges
    Allan McGavin Sports Medicine Centre, University of British Columbia, Vancouver, British Columbia, Canada
    J Appl Physiol 103:111-8. 2007
    ..Transient interstitial pulmonary edema did not occur following sustained steady-state cycling exercise in N or H, indicating that transient edema does not result from pulmonary capillary leakage during sustained submaximal exercise...
  48. ncbi request reprint Enhancement of the human inspiratory pressure-flow relationship via the stretch-shortening cycle
    A William Sheel
    Acta Physiol Scand 185:169. 2005
  49. ncbi request reprint Lung density is not altered following intense normobaric hypoxic interval training in competitive female cyclists
    Jordan A Guenette
    Health and Integrative Physiology Laboratory, University of British Columbia, 6108 Thunderbird Blvd, Vancouver, BC, Canada V6T 1Z3
    J Appl Physiol 103:875-82. 2007
    ..Mean lung density did not change from pre (0.138 +/- 0.014 g/ml)- to postexercise (0.137 +/- 0.011 g/ml). These findings suggest that pulmonary edema does not occur in highly trained females following intense normobaric hypoxic exercise...
  50. ncbi request reprint Regulation of cerebral blood flow during exercise
    Jordan S Querido
    Health and Integrative Physiology Laboratory, School of Human Kinetics, The University of British Columbia, Vancouver, British Columbia, Canada
    Sports Med 37:765-82. 2007
    ....
  51. ncbi request reprint Prevalence of exercise-induced arterial hypoxemia in healthy women
    Jennifer C Richards
    School of Human Kinetics, The University of British Columbia, Vancouver, Canada
    Med Sci Sports Exerc 36:1514-21. 2004
    ..It was hypothesized that EIAH would occur with a greater prevalence and at relatively lower predicted VO2max than that previously reported in males...