James A Sharpe

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint Recovery of peripheral versus central nerves identified by saccadic velocity after abducens neuropathy
    James A Sharpe
    Division of Neurology and Department of Opthalmology and Vision Sciences, University Health Network WW5 440TWH, 399 Bathurst Street, Toronto, Ontario, Canada M5T 2S8
    Ann N Y Acad Sci 1039:417-29. 2005
  2. ncbi request reprint Adaptations and deficits in the vestibulo-ocular reflex after peripheral ocular motor palsies
    James A Sharpe
    Division of Neurology, and Department of Ophthalmology, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Ann N Y Acad Sci 1004:111-21. 2003
  3. doi request reprint Neurophysiology and neuroanatomy of smooth pursuit: lesion studies
    James A Sharpe
    Division of Neurology, University Health Network WW5 440 TWH, University of Toronto, 399 Bathurst Street, Toronto, ON, Canada M5T 2S8
    Brain Cogn 68:241-54. 2008
  4. ncbi request reprint Midbrain disorders of vertical gaze: a quantitative re-evaluation
    James A Sharpe
    Division of Neurology, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Ann N Y Acad Sci 956:143-54. 2002
  5. ncbi request reprint Saccadic adaptation in children
    Michael S Salman
    Division of Neurology, The Hospital for Sick Children, Toronto, ON, Canada
    J Child Neurol 21:1025-31. 2006
  6. ncbi request reprint The vestibulo-ocular reflex in fourth nerve palsy: deficits and adaptation
    Agnes M F Wong
    Division of Neurology, University of Toronto, University Health Network, Toronto Western Hospital, 5 440 WW, 399 Bathurst Street, Ont, M5T 2S8, Toronto, Canada
    Vision Res 42:2205-218. 2002
  7. ncbi request reprint Saccade dynamics in peripheral vs central sixth nerve palsies
    Agnes M F Wong
    Department of Ophthalmology and Vision Sciences, University Health Network, University of Toronto, Ontario, Canada
    Neurology 66:1390-8. 2006
  8. ncbi request reprint Saccadic adaptation in Chiari type II malformation
    Michael S Salman
    Division of Neurology, The Hospital for Sick Children, Toronto, ON
    Can J Neurol Sci 33:372-8. 2006
  9. doi request reprint Ocular motor nerve palsies: implications for diagnosis and mechanisms of repair
    James A Sharpe
    Division of Neurology and Department of Ophthalmology and Vision Sciences, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Prog Brain Res 171:59-66. 2008
  10. doi request reprint Adaptive neural mechanism for Listing's law revealed in patients with skew deviation caused by brainstem or cerebellar lesion
    Maryam Fesharaki
    Department of Physiology, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Invest Ophthalmol Vis Sci 49:204-14. 2008

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Recovery of peripheral versus central nerves identified by saccadic velocity after abducens neuropathy
    James A Sharpe
    Division of Neurology and Department of Opthalmology and Vision Sciences, University Health Network WW5 440TWH, 399 Bathurst Street, Toronto, Ontario, Canada M5T 2S8
    Ann N Y Acad Sci 1039:417-29. 2005
    ....
  2. ncbi request reprint Adaptations and deficits in the vestibulo-ocular reflex after peripheral ocular motor palsies
    James A Sharpe
    Division of Neurology, and Department of Ophthalmology, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Ann N Y Acad Sci 1004:111-21. 2003
    ..Motions of the eyes after nerve palsies indicate monocular VOR adaptation in three dimensions...
  3. doi request reprint Neurophysiology and neuroanatomy of smooth pursuit: lesion studies
    James A Sharpe
    Division of Neurology, University Health Network WW5 440 TWH, University of Toronto, 399 Bathurst Street, Toronto, ON, Canada M5T 2S8
    Brain Cogn 68:241-54. 2008
    ..The anatomical and physiological bases of defective smooth pursuit are discussed here in the context of the effects of lesion in the human brain...
  4. ncbi request reprint Midbrain disorders of vertical gaze: a quantitative re-evaluation
    James A Sharpe
    Division of Neurology, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Ann N Y Acad Sci 956:143-54. 2002
    ..These associations and dissociations of impaired vertical eye motion signify discrete structural and functional effects of supranuclear midbrain damage that are undetected by examination of saccades...
  5. ncbi request reprint Saccadic adaptation in children
    Michael S Salman
    Division of Neurology, The Hospital for Sick Children, Toronto, ON, Canada
    J Child Neurol 21:1025-31. 2006
    ..05). Saccadic adaptation was not influenced by age. We conclude that children as young as 8 years old have established functions of the neural circuits responsible for the motor learning required for saccadic adaptation...
  6. ncbi request reprint The vestibulo-ocular reflex in fourth nerve palsy: deficits and adaptation
    Agnes M F Wong
    Division of Neurology, University of Toronto, University Health Network, Toronto Western Hospital, 5 440 WW, 399 Bathurst Street, Ont, M5T 2S8, Toronto, Canada
    Vision Res 42:2205-218. 2002
    ..Motions of the eyes after fourth nerve palsy exemplify monocular adaptation of the VOR, in response to peripheral neuromuscular deficits...
  7. ncbi request reprint Saccade dynamics in peripheral vs central sixth nerve palsies
    Agnes M F Wong
    Department of Ophthalmology and Vision Sciences, University Health Network, University of Toronto, Ontario, Canada
    Neurology 66:1390-8. 2006
    ..To investigate differences between peripheral idiopathic and central sixth nerve palsies from brainstem damage by comparing peak velocities and durations of horizontal saccades...
  8. ncbi request reprint Saccadic adaptation in Chiari type II malformation
    Michael S Salman
    Division of Neurology, The Hospital for Sick Children, Toronto, ON
    Can J Neurol Sci 33:372-8. 2006
    ..Chiari type II malformation (CII) is a developmental deformity of the cerebellum and brainstem that is associated with spina bifida. We investigated the effects of CII on saccadic adaptation...
  9. doi request reprint Ocular motor nerve palsies: implications for diagnosis and mechanisms of repair
    James A Sharpe
    Division of Neurology and Department of Ophthalmology and Vision Sciences, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Prog Brain Res 171:59-66. 2008
    ..Adaptive repair of the VOR after ocular motor nerve palsies reduces asymmetric retinal image slip and binocular disparity, and repair of saccadic velocity drives both eyes rapidly and simultaneously into the paretic field of motion...
  10. doi request reprint Adaptive neural mechanism for Listing's law revealed in patients with skew deviation caused by brainstem or cerebellar lesion
    Maryam Fesharaki
    Department of Physiology, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Invest Ophthalmol Vis Sci 49:204-14. 2008
    ....
  11. ncbi request reprint Adaptive neural mechanism for Listing's law revealed in patients with sixth nerve palsy
    Agnes M F Wong
    Division of Neurology, The University of Toronto, and University Health Network, Toronto Western Hospital, Toronto, Ontario, Canada
    Invest Ophthalmol Vis Sci 43:112-9. 2002
    ..To study the mechanisms that implement Listing's law, the authors measured whether the law was violated in peripheral and central unilateral sixth nerve palsy...
  12. ncbi request reprint Adaptations and deficits in the vestibulo-ocular reflex after sixth nerve palsy
    Agnes M F Wong
    Division of Neurology, The University of Toronto, and University Health Network Toronto Western Hospital, Toronto, Ontario, Canada
    Invest Ophthalmol Vis Sci 43:99-111. 2002
    ..The effects of paralytic strabismus on the vestibulo-ocular reflex (VOR) have not been systematically investigated in humans. The purpose of this study was to analyze the VOR in patients with unilateral peripheral sixth nerve palsy...
  13. ncbi request reprint Cerebellar skew deviation and the torsional vestibuloocular reflex
    Agnes M F Wong
    Division of Neurology, Department of Ophthalmology and Vision Science, University Health Network, University of Toronto, Ontario, Canada
    Neurology 65:412-9. 2005
    ....
  14. ncbi request reprint Vertical misalignment in unilateral sixth nerve palsy
    Agnes M F Wong
    Division of Neurology, University Health Network Toronto Western Hospital, University of Toronto, 399 Bathurst Street, Toronto, Ontario, Canada M5T 2S8
    Ophthalmology 109:1315-25. 2002
    ..To detect and determine the magnitude of vertical deviation in patients with unilateral sixth nerve palsy...
  15. ncbi request reprint Hyperdeviation and static ocular counterroll in unilateral abducens nerve palsy
    Agnes M F Wong
    Division of Neurology, The University of Toronto, and University Health Network Toronto Western Hospital, Toronto, Ontario, Canada
    Ann N Y Acad Sci 956:523-6. 2002
  16. ncbi request reprint The vertical vestibulo-ocular reflex, and visual-vestibular interaction during active head motion
    Ji Soo Kim
    Division of Neurology, University Health Network, University of Toronto, Canada
    Ann N Y Acad Sci 956:533-6. 2002
  17. ncbi request reprint Adaptations and deficits in the vestibulo-ocular reflex after third nerve palsy
    Agnes M F Wong
    Division of Neurology, University Health Network, EC 5 042, Toronto Western Hospital, 399 Bathurst St, Toronto, Ontario, Canada M5T 2S8
    Arch Ophthalmol 120:360-8. 2002
    ..To analyze the vestibulo-ocular reflex (VOR) in patients with unilateral peripheral third nerve palsy...
  18. ncbi request reprint Adaptive neural mechanism for listing's law revealed in patients with fourth nerve palsy
    Agnes M F Wong
    Division of Neurology, University of Toronto and University Health Network, Toronto, Ontario, Canada
    Invest Ophthalmol Vis Sci 43:1796-803. 2002
    ..Torsion of the eye is in part controlled by the fourth nerve. This study investigates whether the brain adapts to defective torsional control after fourth nerve palsy...
  19. doi request reprint Posterior reversible encephalopathy syndrome presenting as Balint syndrome
    Sunil Kumar
    Division of Neurology and Department of Ophthalmology and Vision Sciences, University Health Network, University of Toronto, Toronto, Ontario, Canada
    J Neuroophthalmol 31:224-7. 2011
    ..We report Balint syndrome associated with PRES in a 37-year-old woman with acute hypertension and systemic lupus erythematosus. Balint syndrome can be an initial presentation of PRES...
  20. ncbi request reprint Cerebellar vermis morphology in children with spina bifida and Chiari type II malformation
    Michael S Salman
    Division of Neurology, The Hospital for Sick Children, Toronto, Canada
    Childs Nerv Syst 22:385-93. 2006
    ..This is assumed to affect the cerebellum uniformly. We quantified the presumed reduction in vermis size on magnetic resonance imaging (MRI)...
  21. ncbi request reprint Implementation of Listing's law in patients with unilateral sixth nerve palsy
    Agnes M F Wong
    Division of Neurology, University of Toronto, and University Health Network Toronto Western Hospital, Toronto, Ontario, Canada
    Ann N Y Acad Sci 956:520-2. 2002
  22. doi request reprint Antisaccade generation is impaired after parietal lobe lesions
    James A Sharpe
    Division of Neurology, University Health Network, Toronto, Ontario, Canada
    Ann N Y Acad Sci 1233:194-9. 2011
    ..Impaired suppression of reflexive saccades and generation of antisaccades is attributed to disconnection of parietal lobe from frontal lobe ocular motor areas...
  23. ncbi request reprint Effect of aging on visual shape distortion
    Josée Rivest
    Department of Psychology, Glendon College, York University, Toronto, Ontario, Canada
    Gerontology 50:142-51. 2004
    ..While age-related deterioration in performance is found in various aspects of visual perception, the effect of aging on the shape distortion effect has not been evaluated...
  24. ncbi request reprint Saccades in children
    Michael S Salman
    Division of Neurology, The Hospital for Sick Children, Toronto, Canada
    Vision Res 46:1432-9. 2006
    ..Saccadic gains and peak velocities in children are similar to reported adult values. This implies maturity of the neural circuits responsible for making saccades accurate and fast. Saccade latency decreases as the brain matures...
  25. doi request reprint Ocular torsion and vertical misalignment
    James A Sharpe
    Division of Neurology, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Curr Opin Neurol 24:18-24. 2011
    ..This article considers vertical misalignment and torsion of the eyes that arise from disorders of vestibulo-ocular reflex (VOR) pathways...
  26. ncbi request reprint Smooth ocular pursuit in Chiari type II malformation
    Michael S Salman
    Section of Paediatric Neurology, Children s Hospital, University of Manitoba, Winnipeg, Manitoba, Canada
    Dev Med Child Neurol 49:289-93. 2007
    ..The lack of effect of shunt revisions and abnormal tracking in participants with nystagmus provide evidence that it is related primarily to the cerebellar and brainstem malformation...
  27. pmc The vestibulo-ocular reflex during active head motion in Chiari II malformation
    Michael S Salman
    Section of Pediatric Neurology, Children s Hospital, University of Manitoba, Winnipeg, Manitoba, Canada
    Can J Neurol Sci 35:495-500. 2008
    ..We investigated the effects of the deformity of CII on the angular VOR during active head motion...
  28. ncbi request reprint What's up, doc? Altered perception of the haptic, postural, and visual vertical
    James A Sharpe
    Neurology 61:1172-3. 2003
  29. doi request reprint Dissociated palsy of vertical saccades: loss of voluntary and visually guided saccades with preservation of reflexive vestibular quick phases
    Ji Hoon Kang
    Department of Neurology, Cheju National University College of Medicine, Cheju, Republic of Korea
    J Neuroophthalmol 28:97-103. 2008
    ....
  30. ncbi request reprint Square wave jerks in children and adolescents
    Michael S Salman
    Section of Pediatric Neurology, Children s Hospital, University of Manitoba, Winnipeg, Manitoba, Canada
    Pediatr Neurol 38:16-9. 2008
    ..The prevalence of square wave jerks is high in children and adolescents. This finding may be a feature of the less mature brain, and may reflect an inability to suppress unwanted supranuclear triggers for saccades...
  31. ncbi request reprint Smooth pursuit eye movements in children
    Michael S Salman
    Section of Pediatric Neurology, Children s Hospital, University of Manitoba, AE 108, Harry Medovy House 820 Sherbrook St, R3A 1R9 Winnipeg, MB, Canada
    Exp Brain Res 169:139-43. 2006
    ..Gains improve with age and approach adult values in mid adolescence. Children have larger phases than reported adults values indicating that prediction in the smooth pursuit system is less mature in children...
  32. ncbi request reprint Progressive ataxia and palatal tremor (PAPT): clinical and MRI assessment with review of palatal tremors
    Michael Samuel
    MRCP UK, Department of Neurology, King s College Hospital, Denmark Hill, London SE5 9RS, UK
    Brain 127:1252-68. 2004
    ..Familial PAPT differs from sporadic PAPT in having marked atrophy of cervical cord and brainstem with corticospinal signs but without hypertrophic olivary appearance on MRI...
  33. ncbi request reprint The vestibulo-ocular reflex during active head motion in children and adolescents
    Michael S Salman
    Section of Pediatric Neurology, Children s Hospital, AE 308, 820 Sherbrook St, Winnipeg, MB R3A 1R9, Canada
    Childs Nerv Syst 23:1269-74. 2007
    ..We investigated the active VOR performance in children and adolescents to determine its norm and variation with age...