Barry Sessle

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi Mechanisms of oral somatosensory and motor functions and their clinical correlates
    B J Sessle
    Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada
    J Oral Rehabil 33:243-61. 2006
  2. ncbi Integration of basic sciences into the predoctoral curriculum to study temporomandibular disorders and orofacial pain
    Barry J Sessle
    Faculty of Dentistry, University of Toronto, 124 Edward Street, Toronto, Ontario, Canada M5G 1G6
    J Orofac Pain 16:181-4. 2002
  3. ncbi Peripheral and central mechanisms of orofacial pain and their clinical correlates
    B J Sessle
    Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada M5G 1G6
    Minerva Anestesiol 71:117-36. 2005
  4. ncbi Properties and plasticity of the primate somatosensory and motor cortex related to orofacial sensorimotor function
    Barry J Sessle
    University of Toronto, Toronto, Ontario, Canada
    Clin Exp Pharmacol Physiol 32:109-14. 2005
  5. ncbi Recent insights into brainstem mechanisms underlying craniofacial pain
    Barry J Sessle
    Department of Physiology, Faculty of Dentistry, University of Toronto, Ontario, Canada
    J Dent Educ 66:108-12. 2002
  6. ncbi Neuroplasticity of face primary motor cortex control of orofacial movements
    B J Sessle
    Faculty of Dentistry, University of Toronto, 124 Edward Street, Toronto, Ontario, Canada M5G 1G6
    Arch Oral Biol 52:334-7. 2007
  7. ncbi Cortical orofacial motor representation: effect of diet consistency
    L Avivi-Arber
    Department of Prosthodontics, Faculty of Dentistry, University of Toronto, 124 Edward Street, Toronto, ON M5G 1G6, Canada
    J Dent Res 89:1142-7. 2010
  8. ncbi Central sensitization in thalamic nociceptive neurons induced by mustard oil application to rat molar tooth pulp
    S Zhang
    Faculty of Dentistry, University of Toronto, 124 Edward Street, Toronto, Ontario, Canada M5G 1G6
    Neuroscience 142:833-42. 2006
  9. ncbi Craniofacial inputs to upper cervical dorsal horn: implications for somatosensory information processing
    J W Hu
    Faculty of Dentistry, University of Toronto, 124 Edward Street, Toronto, Ontario, M5G 1G6, Canada
    Brain Res 1044:93-106. 2005
  10. ncbi Central mu opioid receptor mechanisms modulate mustard oil-evoked jaw muscle activity
    C H Tambeli
    Faculty of Dentistry, University of Toronto, 124 Edward Street, Toronto, Ontario, Canada M5G 1G6
    Brain Res 913:90-4. 2001

Research Grants

  1. Dental and Craniofacial Pain: Afferent and Brainstem Mechanisms
    Barry J Sessle; Fiscal Year: 2010
  2. DENTAL & OROFACIAL PAIN: BRAINSTEM & THALAMIC MECHANISMS
    Barry Sessle; Fiscal Year: 2001
  3. Dental and Orofacial Pain:Brainstem Mechanisms
    Barry Sessle; Fiscal Year: 2005
  4. PERIPHERAL NMDA RECEPTORS AND TMD PAIN MECHANISMS
    Barry Sessle; Fiscal Year: 2006
  5. Dental and Craniofacial Pain: Afferent and Brainstem Mechanisms
    Barry Sessle; Fiscal Year: 2007
  6. Dental and Craniofacial Pain: Afferent and Brainstem Mechanisms
    Barry Sessle; Fiscal Year: 2009
  7. DENTAL AND OROFACIAL PAIN BRAIN STEM MECHANISMS
    Barry Sessle; Fiscal Year: 1992
  8. DENTAL AND OROFACIAL PAIN: BRAIN STEM MECHANISMS
    Barry Sessle; Fiscal Year: 1980

Collaborators

Detail Information

Publications57

  1. ncbi Mechanisms of oral somatosensory and motor functions and their clinical correlates
    B J Sessle
    Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada
    J Oral Rehabil 33:243-61. 2006
    ....
  2. ncbi Integration of basic sciences into the predoctoral curriculum to study temporomandibular disorders and orofacial pain
    Barry J Sessle
    Faculty of Dentistry, University of Toronto, 124 Edward Street, Toronto, Ontario, Canada M5G 1G6
    J Orofac Pain 16:181-4. 2002
    ..Under the term "basic sciences" are included not only relevant biomedical or biologic sciences such as physiology and anatomy, but also the behavioral sciences such as psychology and cognitive science...
  3. ncbi Peripheral and central mechanisms of orofacial pain and their clinical correlates
    B J Sessle
    Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada M5G 1G6
    Minerva Anestesiol 71:117-36. 2005
    ..The paper also outlines some of the clinical correlates of these research advances...
  4. ncbi Properties and plasticity of the primate somatosensory and motor cortex related to orofacial sensorimotor function
    Barry J Sessle
    University of Toronto, Toronto, Ontario, Canada
    Clin Exp Pharmacol Physiol 32:109-14. 2005
    ....
  5. ncbi Recent insights into brainstem mechanisms underlying craniofacial pain
    Barry J Sessle
    Department of Physiology, Faculty of Dentistry, University of Toronto, Ontario, Canada
    J Dent Educ 66:108-12. 2002
    ..Insights into these processes hold promise of the development of new or improved therapeutic procedures for the relief of pain...
  6. ncbi Neuroplasticity of face primary motor cortex control of orofacial movements
    B J Sessle
    Faculty of Dentistry, University of Toronto, 124 Edward Street, Toronto, Ontario, Canada M5G 1G6
    Arch Oral Biol 52:334-7. 2007
    ....
  7. ncbi Cortical orofacial motor representation: effect of diet consistency
    L Avivi-Arber
    Department of Prosthodontics, Faculty of Dentistry, University of Toronto, 124 Edward Street, Toronto, ON M5G 1G6, Canada
    J Dent Res 89:1142-7. 2010
    ....
  8. ncbi Central sensitization in thalamic nociceptive neurons induced by mustard oil application to rat molar tooth pulp
    S Zhang
    Faculty of Dentistry, University of Toronto, 124 Edward Street, Toronto, Ontario, Canada M5G 1G6
    Neuroscience 142:833-42. 2006
    ....
  9. ncbi Craniofacial inputs to upper cervical dorsal horn: implications for somatosensory information processing
    J W Hu
    Faculty of Dentistry, University of Toronto, 124 Edward Street, Toronto, Ontario, M5G 1G6, Canada
    Brain Res 1044:93-106. 2005
    ....
  10. ncbi Central mu opioid receptor mechanisms modulate mustard oil-evoked jaw muscle activity
    C H Tambeli
    Faculty of Dentistry, University of Toronto, 124 Edward Street, Toronto, Ontario, Canada M5G 1G6
    Brain Res 913:90-4. 2001
    ..t.) administration of the opiate antagonist naloxone and mu but not delta and kappa selective opioid antagonist, suggests that it may be modulated by endogenous opioid inhibitory mechanisms...
  11. ncbi Endogenous ATP involvement in mustard-oil-induced central sensitization in trigeminal subnucleus caudalis (medullary dorsal horn)
    C Y Chiang
    Faculty of Dentistry, University of Toronto, 124 Edward St, Toronto, ON M5G 1G6, Canada
    J Neurophysiol 94:1751-60. 2005
    ..These findings implicate endogenous ATP as an important mediator contributing to the development of central sensitization in nociceptive neurons of the deep laminae of the dorsal horn...
  12. ncbi Neuroplasticity induced by tooth pulp stimulation in trigeminal subnucleus oralis involves NMDA receptor mechanisms
    S J Park
    Faculty of Dentistry, University of Toronto, Toronto, Ontario M5G 1G6, Canada
    J Neurophysiol 85:1836-46. 2001
    ..These findings indicate that the application of MO to the tooth pulp can induce significant neuroplastic changes in oralis nociceptive neurons and that central NMDA receptor mechanisms may be involved in these neuroplastic changes...
  13. ncbi P2X and NMDA receptor involvement in temporomandibular joint-evoked reflex activity in rat jaw muscles
    T Watanabe
    Faculty of Dentistry, University of Toronto, Toronto, ON, Canada
    Brain Res 1346:83-91. 2010
    ..These results indicate the interaction of peripheral purinergic as well as glutamatergic receptor mechanisms in the processing of TMJ nociceptive afferent inputs that evoke reflex activity in jaw muscles...
  14. ncbi Temporomandibular-evoked jaw muscle reflex: role of brain stem NMDA and non-NMDA receptors
    B E Cairns
    Faculty of Dentistry, The University of Toronto, 124 Edward Street, Toronto, Ontario M5G 1G6, Canada
    Neuroreport 12:1875-8. 2001
    ..These results provide evidence that Vc is a critical relay in the TMJ-evoked reflex activation of the jaw muscles, and that both NMDA and non-NMDA receptor mechanisms may contribute to these effects...
  15. ncbi Surgical incision can alter capsaicin-induced central sensitization in rat brainstem nociceptive neurons
    D K Lam
    Faculty of Dentistry, University of Toronto, 124 Edward Street, Toronto, Ontario, Canada M5G 1G6
    Neuroscience 156:737-47. 2008
    ....
  16. ncbi The effects of training time, sensory loss and pain on human motor learning
    S A Boudreau
    Faculty of Dentistry, University of Toronto, Toronto, ON, Canada
    J Oral Rehabil 37:704-18. 2010
    ..It is concluded that extended within-session task repetitions do not facilitate additional long-term gains in overall motor performance and intra-oral sensory loss or pain hinders motor learning...
  17. ncbi Characteristics of glutamate-evoked temporomandibular joint afferent activity in the rat
    B E Cairns
    Faculty of Dentistry, The University of Toronto, Toronto, Ontario M5G 1G6, Canada
    J Neurophysiol 85:2446-54. 2001
    ..This sex-related difference in afferent discharge may, in part, underlie sex-related differences in glutamate-evoked jaw muscle EMG activity...
  18. ncbi Effects of noxious stimulation of orofacial tissues on rat licking behaviour
    G Bejat
    Faculty of Dentistry, University of Toronto, 124 Edward Street, M5G 1G6, Toronto, Ontario, Canada
    Arch Oral Biol 53:361-8. 2008
    ..Since there is limited information of the effects of orofacial pain on oromotor behaviour, the aim of this study was to test the effects of injection of the algesic chemical glutamate into orofacial tissues on licking behaviour in rats...
  19. ncbi Sex-related differences in human pain and rat afferent discharge evoked by injection of glutamate into the masseter muscle
    B E Cairns
    Faculty of Dentistry, The University of Toronto, Ontario M5G 1G6, Canada
    J Neurophysiol 86:782-91. 2001
    ..These sex-related differences in acute experimental masseter muscle pain are particularly interesting given the higher prevalence of many chronic muscle pain conditions in women...
  20. ncbi Sex-related suppression of reflex jaw muscle activity by peripheral morphine but not GABA
    B B Cai
    Faculty of Dentistry, University of Toronto, 124 Edward Street, Toronto, Ontario M5G 1G6, Canada
    Neuroreport 12:3457-60. 2001
    ..These data suggest that female rats are considerably less sensitive than male rats to the suppressive effects of peripherally applied morphine, but both sexes are equally affected by peripherally applied GABA...
  21. ncbi Involvement of glia in central sensitization in trigeminal subnucleus caudalis (medullary dorsal horn)
    Y F Xie
    Department of Oral Physiology, Faculty of Dentistry, University of Toronto, 124 Edward Street, Toronto, Ont, Canada M5G 1G6
    Brain Behav Immun 21:634-41. 2007
    ..Neither SB nor FA application significantly affected the baseline (i.e., pre-MO application) RF and response properties. These results suggest that glial metabolic processes are important in the development of Vc central sensitization...
  22. ncbi A functional perspective on oral implants - state-of-the-science and future recommendations
    J Feine
    Faculty of Dentistry, McGill University, Montreal, Quebec, Canada
    J Oral Rehabil 33:309-12. 2006
  23. ncbi Peripheral NMDA receptor modulation of jaw muscle electromyographic activity induced by capsaicin injection into the temporomandibular joint of rats
    David K Lam
    Faculty of Dentistry, University of Toronto, Ontario, Canada
    Brain Res 1046:68-76. 2005
    ....
  24. ncbi Glutamine uptake contributes to central sensitization in the medullary dorsal horn
    Chen Yu Chiang
    Faculty of Dentistry, Department of Oral Physiology, University of Toronto, Toronto, Ontario, Canada
    Neuroreport 19:1151-4. 2008
    ....
  25. ncbi Unilateral application of an inflammatory irritant to the rat temporomandibular joint region produces bilateral modulation of the jaw-opening reflex
    Makiko Noguchi
    Division of Oral Physiology, Department of Oral Biological Science, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8514, Japan
    Brain Res Bull 67:182-8. 2005
    ....
  26. ncbi Central sensitization induced in thalamic nociceptive neurons by tooth pulp stimulation is dependent on the functional integrity of trigeminal brainstem subnucleus caudalis but not subnucleus oralis
    Soo Joung Park
    Faculty of Dentistry, University of Toronto, 124 Edward Street, Toronto, ON, Canada M5G 1G6
    Brain Res 1112:134-45. 2006
    ..These findings indicate that central sensitization induced in nociceptive neurons within VPM and PO by noxious stimulation of the tooth pulp is dependent upon the functional integrity of Vc but not Vo...
  27. ncbi Motor cortex neuroplasticity associated with lingual nerve injury in rats
    Kazunori Adachi
    Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada
    Somatosens Mot Res 24:97-109. 2007
    ..These findings suggest that lingual nerve transection is associated with significant time-dependent neuroplastic changes in the tongue motor representations in face MI...
  28. ncbi The effects of intra-oral pain on motor cortex neuroplasticity associated with short-term novel tongue-protrusion training in humans
    Shellie Boudreau
    Faculty of Dentistry, University of Toronto, Canada
    Pain 132:169-78. 2007
    ..These findings suggest that nociceptive input modulates MI neuroplasticity associated with novel motor training and may impair the ability to learn a new motor task...
  29. ncbi Organization of pERK-immunoreactive cells in trigeminal spinal nucleus caudalis and upper cervical cord following capsaicin injection into oral and craniofacial regions in rats
    Noboru Noma
    Department of Oral and Maxirofacial Curgery, Nihon University School of Dentistry, Chiyoda ku, Tokyo 101 8310, Japan
    J Comp Neurol 507:1428-40. 2008
    ....
  30. ncbi Associations between pain and neuromuscular activity in the human jaw and neck muscles
    Peter Svensson
    Center for Sensory Motor Interaction, Orofacial Pain Laboratory, Aalborg University, DK 9220 Aalborg, Denmark
    Pain 109:225-32. 2004
    ..In conclusion, experimental neck pain is not associated with tonic increases in jaw EMG activity although jaw muscle pain can be linked to increases in neck EMG activity with the head and jaw at rest...
  31. ncbi Influence of sex on reflex jaw muscle activity evoked from the rat temporomandibular joint
    Brian E Cairns
    Department of Oral Physiology, Faculty of Dentistry, The University of Toronto, 124 Edward Street, Toronto, ON, Canada
    Brain Res 957:338-44. 2002
    ..These findings indicate that there are sex-related differences in glutamate-evoked jaw muscle activity that are dependent on female sex hormones, and increased glutamate concentrations sensitize the TMJ to noxious chemical stimuli...
  32. ncbi Effects of reversible cold block of face primary somatosensory cortex on orofacial movements and related face primary motor cortex neuronal activity
    Dongyuan Yao
    Faculty of Dentistry, University of Toronto, 124 Edward Street, Toronto, Ontario, Canada M5G 1G6
    Somatosens Mot Res 19:261-71. 2002
    ..These findings suggest that movement-induced reafferentation via face SI may not be a significant factor in accounting for the activity of the majority of ipsilateral face MI neurons related to trained movements, chewing and swallowing...
  33. ncbi Orofacial pain: an educational focus
    Barry J Sessle
    J Orofac Pain 16:169. 2002
  34. ncbi P2X receptors in trigeminal subnucleus caudalis modulate central sensitization in trigeminal subnucleus oralis
    Bo Hu
    Faculty of Dentistry, University of Toronto, Ontario M5G 1G6, Canada
    J Neurophysiol 88:1614-24. 2002
    ..These results suggest that P2X(3) and possibly also the P2X(2/3) receptor subtypes in Vc may play a role in the initiation and maintenance of central sensitization in Vo nociceptive neurons induced by MO application to the pulp...
  35. ncbi Neck muscle length modulates nociceptive reflex evoked by noxious irritant application to rat neck tissues
    Paul Shin
    Faculty of Dentistry, University of Toronto, 124 Edward St, Toronto, Ontario, M5G 1G6, Canada
    Exp Brain Res 163:314-23. 2005
    ..This enhanced muscle activity could be associated with changes in the susceptibility of the neck muscles to pain or damage...
  36. ncbi Effects of reversible bilateral inactivation of face primary motor cortex on mastication and swallowing
    Kensuke Yamamura
    Faculty of Dentistry, University of Toronto, Ontario, Canada
    Brain Res 944:40-55. 2002
    ..These findings provide further evidence that the primate face MI plays a critical role in the regulation of mastication and that it plays a role in the preparation for swallowing...
  37. ncbi Central sensitization of nociceptive neurons in trigeminal subnucleus oralis depends on integrity of subnucleus caudalis
    Chen Yu Chiang
    Faculty of Dentistry, University of Toronto, Ontario M5G 1G6, Canada
    J Neurophysiol 88:256-64. 2002
    ..These findings indicate that inflammatory pulp-induced central sensitization in Vo is dependent on the functional integrity of Vc...
  38. ncbi Neuronal activity patterns in primate primary motor cortex related to trained or semiautomatic jaw and tongue movements
    Dongyuan Yao
    Faculty of Dentistry, University of Toronto, Toronto, Ontario M5G 1G6, Canada
    J Neurophysiol 87:2531-41. 2002
    ....
  39. ncbi Glia: non-neural players in orofacial pain
    Barry J Sessle
    J Orofac Pain 21:169-70. 2007
  40. ncbi The effect of glutamate-evoked masseter muscle pain on the human jaw-stretch reflex differs in men and women
    Brian E Cairns
    Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada
    J Orofac Pain 17:317-25. 2003
    ....
  41. ncbi Effects on mastication of reversible bilateral inactivation of the lateral pericentral cortex in the monkey (Macaca fascicularis)
    Noriyuki Narita
    Faculty of Dentistry, University of Toronto, 124 Edward Street, Ont, M5G 1G6, Toronto, Canada
    Arch Oral Biol 47:673-88. 2002
    ....
  42. ncbi Pain effects of glutamate injections into human jaw or neck muscles
    Peter Svensson
    Department of Clinical Oral Physiology, Royal Dental College, University of Aarhus, Aarhus, Denmark
    J Orofac Pain 19:109-18. 2005
    ....
  43. ncbi The orofacial pain publication profile
    Barry J Sessle
    J Orofac Pain 22:177. 2008
  44. ncbi Astroglial glutamate-glutamine shuttle is involved in central sensitization of nociceptive neurons in rat medullary dorsal horn
    Chen Yu Chiang
    Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada M5G 1G6
    J Neurosci 27:9068-76. 2007
    ..These findings suggest that the astroglial glutamate-glutamine shuttle is essential for the initiation of inflammation-induced central sensitization but that inhibition of astroglial function may not affect normal nociceptive processing...
  45. ncbi Systemic administration of monosodium glutamate elevates intramuscular glutamate levels and sensitizes rat masseter muscle afferent fibers
    Brian E Cairns
    Faculty of Pharmaceutical Sciences, The University of British Columbia, 2146 East Mall, Vancouver, BC, Canada
    Pain 132:33-41. 2007
    ..These findings suggest that modest elevations of interstitial glutamate concentration could alter musculoskeletal pain sensitivity in humans...
  46. ncbi Animal models of chronic orofacial pain
    Barry J Sessle
    J Orofac Pain 21:5. 2007
  47. ncbi Awareness of pain awareness
    Barry J Sessle
    J Orofac Pain 19:5. 2005
  48. ncbi Biological adaptation and normative values
    Barry J Sessle
    Faculty of Dentistry, University of Toronto Ontario, Canada
    Int J Prosthodont 18:280-2. 2005
  49. ncbi Neural mechanisms of temporomandibular joint and masticatory muscle pain: a possible role for peripheral glutamate receptor mechanisms
    David K Lam
    Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada
    Pain Res Manag 10:145-52. 2005
    ....
  50. ncbi Quantitative analysis of surface EMG activity of cranial and leg muscles across sleep stages in human
    Kazuo Okura
    , , CP 6128, Succursale Centre-Ville, , Que, Canada H3C 3J7
    Clin Neurophysiol 117:269-78. 2006
    ....
  51. ncbi Simultaneous modulation of the exteroceptive suppression periods in the trapezius and temporalis muscles by experimental muscle pain
    Hong-You Ge
    Laboratory for Experimental Pain Research, Center for Sensory-Motor Interaction (SMI, Aalborg University, Fredrik Bajers Vej 7 D-3, DK-9220 Aalborg, Denmark
    Clin Neurophysiol 115:1399-408. 2004
    ....
  52. ncbi Biological adaptation and normative values
    Barry J Sessle
    Faculty of Dentistry, University of Toronto, Ontario, Canada
    Int J Prosthodont 16:72-3; discussion 89-90. 2003
  53. ncbi Plasticity in corticomotor control of the human tongue musculature induced by tongue-task training
    Peter Svensson
    Orofacial Pain Laboratory, Center for Sensory Motor Interaction, Aalborg University, Aalborg, Denmark
    Exp Brain Res 152:42-51. 2003
    ..The present findings suggest that a specific and reversible plasticity of the corticomotor excitability related to tongue muscle control can be induced when humans learn to perform successfully a novel tongue task...
  54. ncbi ATP potentiates neurotransmission in the rat trigeminal subnucleus caudalis
    Ernest A Jennings
    Department of Anatomy and Cell Biology, University of Melbourne, Parkville, Victoria, Australia
    Neuroreport 17:1507-10. 2006
    ..These data suggest that alpha,beta methylene adenosine 5'-triphosphate acts on presynaptic terminals to increase glutamatergic neurotransmission in deep Vc neurons...
  55. ncbi Activation of peripheral NMDA receptors contributes to human pain and rat afferent discharges evoked by injection of glutamate into the masseter muscle
    Brian E Cairns
    Department of Anesthesia, Harvard Medical School Children s Hospital, Boston, Massachusetts 02115, USA
    J Neurophysiol 90:2098-105. 2003
    ..It is conceivable that activation of peripheral NMDA receptors may contribute to masticatory muscle pain and that peripherally acting NMDA receptor antagonists could prove to be effective analgesics for this type of pain...
  56. ncbi Impact--a new "high" for the Journal of Orofacial Pain
    Barry J Sessle
    J Orofac Pain 17:5-6. 2003
  57. ncbi The evolution of a scientific journal
    Barry J Sessle
    J Orofac Pain 16:5-6. 2002

Research Grants36

  1. Dental and Craniofacial Pain: Afferent and Brainstem Mechanisms
    Barry J Sessle; Fiscal Year: 2010
    ..These insights could be important in the development of improved therapeutic approaches for the prevention of pain associated with pulpal inflammation and for the relief of pain once it has been initiated. ..
  2. DENTAL & OROFACIAL PAIN: BRAINSTEM & THALAMIC MECHANISMS
    Barry Sessle; Fiscal Year: 2001
    ..This project will provide further new insights into the central processing of pulp afferent information and its relationship to orofacial pain and inflammation. ..
  3. Dental and Orofacial Pain:Brainstem Mechanisms
    Barry Sessle; Fiscal Year: 2005
    ..These insights could be important in the development of improved therapeutic approaches for the prevention of pain associated with pulpal inflammation and for the relief of pain once it has been initiated. ..
  4. PERIPHERAL NMDA RECEPTORS AND TMD PAIN MECHANISMS
    Barry Sessle; Fiscal Year: 2006
    ..abstract_text> ..
  5. Dental and Craniofacial Pain: Afferent and Brainstem Mechanisms
    Barry Sessle; Fiscal Year: 2007
    ..These insights could be important in the development of improved therapeutic approaches for the prevention of pain associated with pulpal inflammation and for the relief of pain once it has been initiated. ..
  6. Dental and Craniofacial Pain: Afferent and Brainstem Mechanisms
    Barry Sessle; Fiscal Year: 2009
    ..These insights could be important in the development of improved therapeutic approaches for the prevention of pain associated with pulpal inflammation and for the relief of pain once it has been initiated. ..
  7. DENTAL AND OROFACIAL PAIN BRAIN STEM MECHANISMS
    Barry Sessle; Fiscal Year: 1992
    ..these studies will clarify some of the mechanisms that may be involved in neuroplastic responses of the v brainstem complex to injury of the tooth pulp and that may underlie the development of chronic orofacial pain...
  8. DENTAL AND OROFACIAL PAIN: BRAIN STEM MECHANISMS
    Barry Sessle; Fiscal Year: 1980
    ..We have preliminary published evidence that presynaptic regulatory mechanisms contribute to the observed suppressive influences on orofacial nociceptive transmission, and we intend to study these mechanisms further...