Research Topics
| Chun Y SeowSummaryAffiliation: University of British Columbia Country: Canada Publications
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Detail Information
Publications
Ultrastructural basis of airway smooth muscle contractionChun Y Seow
Department of Pathology and Laboratory Medicine and the James Hogg iCAPTURE Centre, St Paul s Hospital, University of British Columbia, Vancouver, BC, Canada
Can J Physiol Pharmacol 85:659-65. 2007..A list of unanswered questions regarding smooth muscle ultrastructure is also proposed in this review, in the hope that it will provide some guidance for future research...
Adaptive response of pulmonary arterial smooth muscle to length changeHarley Syyong
The iCAPTURE Centre St Paul s Hospital, Univ of British Columbia 1081 Burrard St, Rm 166, Vancouver, BC, Canada
J Appl Physiol 104:1014-20. 2008..It is concluded that, like many smooth muscles, PASM possesses substantial capability to adapt to changes in length. Under pathological conditions, this could contribute to hypervasoconstriction in pulmonary hypertension...- Electron microscopic study of actin polymerization in airway smooth muscleAna M Herrera
Department of Pathology, Laboratory Medicine, James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul Hospital Providence Health Care, University of British Columbia, Vancouver, BC, Canada V6Z 1Y6
Am J Physiol Lung Cell Mol Physiol 286:L1161-8. 2004.... - Myosin filament assembly in an ever-changing myofilament lattice of smooth muscleChun Y Seow
Department of Pathology and Laboratory Medicine, James Hogg iCAPTURE Centre, St Paul s Hospital, Rm 166, 1081 Burrard St, Vancouver, BC, Canada V6Z 1Y6
Am J Physiol Cell Physiol 289:C1363-8. 2005.... - Increase in passive stiffness at reduced airway smooth muscle length: potential impact on airway responsivenessYnuk Bosse
James Hogg iCAPTURE Centre St Paul s Hospital, 1081 Burrard St, Vancouver, BC, Canada
Am J Physiol Lung Cell Mol Physiol 298:L277-87. 2010..Redevelopment and maintenance of passive stiffness following muscle shortening could contribute to airway hyperresponsiveness by attenuating the airway wall strain induced by tidal breathing and DI... - Structure-function correlation in airway smooth muscle adapted to different lengthsKuo Hsing Kuo
Department of Anatomy, University of British Columbia, Vancouver, BC, Canada V6T 1Y6
Am J Physiol Cell Physiol 285:C384-90. 2003..The data can be explained by a model in which additional contractile units containing myosin filaments are formed and placed in series with existing contractile units when the muscle is adapted at a longer length... - Length adaptation of airway smooth muscleYnuk Bosse
The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, Providence Health Care St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada, V6Z 1Y6
Proc Am Thorac Soc 5:62-7. 2008.... - Regulatable stiffness in relaxed airway smooth muscle: a target for asthma treatment?Abdul Raqeeb
James Hogg Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
J Appl Physiol 112:337-46. 2012..The results suggest that airway stiffness can be readily modulated by targeting the calcium-sensitive component of the passive stiffness within the muscle layer... - Time course of isotonic shortening and the underlying contraction mechanism in airway smooth muscleHarley T Syyong
James Hogg Research Centre St Paul s Hospital, Univ of British Columbia, 1081 Burrard St, Rm 166, Vancouver, BC, Canada
J Appl Physiol 111:642-56. 2011.... - Force oscillations simulating breathing maneuvers do not prevent force adaptationChris Pascoe
University of British Columbia, James Hogg Research Center, St Paul s Hospital Vancouver, Canada
Am J Respir Cell Mol Biol 47:44-9. 2012..The lack of effect of simulated breathing maneuvers on force adaptation suggests that this gain in ASM force may occur in vivo and could contribute to the development of airway hyperresponsiveness... - Chronic activation in shortened airway smooth muscle: a synergistic combination underlying airway hyperresponsiveness?Ynuk Bosse
The James Hogg iCAPTURE Centre, Providence Health Care St Paul s Hospital, Vancouver, BC, V6Z 1Y6 Canada
Am J Respir Cell Mol Biol 42:341-8. 2010..In vivo these changes will be translated into excessive airway narrowing in response to naturally occurring and pharmacological bronchoconstricting stimuli... - Mechanism of partial adaptation in airway smooth muscle after a step change in lengthFarah Ali
Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
J Appl Physiol 103:569-77. 2007..The partially adapted intermediate state is perhaps more physiologically relevant than the fully adapted state seen under static conditions, and it simulates a more realistic behavior for ASM in vivo... - Influence of calcium on myosin thick filament formation in intact airway smooth muscleAna M Herrera
Department of Anatomy, St. Paul's Hospital/Providence Health Care, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
Am J Physiol Cell Physiol 282:C310-6. 2002.... - Dense-body aggregates as plastic structures supporting tension in smooth muscle cellsJie Zhang
James Hogg Centre for Cardiovascular and Pulmonary Research, Providence Heart and Lung Institute, Vancouver, British Columbia, Canada
Am J Physiol Lung Cell Mol Physiol 299:L631-8. 2010..The finding suggests that the structural plasticity of hollow organs may originate from the dense-body cables within the smooth muscle cells... - Length oscillation mimicking periodic individual deep inspirations during tidal breathing attenuates force recovery and adaptation in airway smooth muscleAbdul Raqeeb
Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
J Appl Physiol 109:1476-82. 2010.... - The role of airway smooth muscle during an attack of asthma simulated in vitroBrent E McParland
Department of Medicine, James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St. Paul's Hospital/Providence Health Care, University of British Columbia, Vancouver, British Columbia, Canada
Am J Respir Cell Mol Biol 33:500-4. 2005..75 +/- 0.2-fold, respectively. Shortening of ASM in response to contractile agonists can lead to adaptation of the muscle to the shortened length that, in turn, can result in further shortening and the potential for airway closure... - 'Sarcomeres' of smooth muscle: functional characteristics and ultrastructural evidenceAna M Herrera
Department of Pathology and Laboratory Medicine, St Paul's Hospital/Providence Health Care, University of British Columbia, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
J Cell Sci 118:2381-92. 2005..The structural malleability necessary for length adaptation precludes formation of a permanent filament lattice and explains the lack of aligned filament arrays in registers, which also explains why smooth muscle is 'smooth'... - Models of contractile units and their assembly in smooth muscleFarah Ali
Department of Experimental Medicine, University of British Columbia, Vancouver, Canada
Can J Physiol Pharmacol 83:825-31. 2005..The contractile apparatus is assumed malleable in that the number of contractile units in series and in parallel can be altered to accommodate strains on the muscle and to maintain the muscle's optimal mechanical function... - Adaptation of airway smooth muscle to basal tone: relevance to airway hyperresponsivenessYnuk Bosse
the James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research St Paul s Hospital, Room 166 1081, Burrard Street, Vancouver, BC, V6Z 1Y6 Canada
Am J Respir Cell Mol Biol 40:13-8. 2009..Force adaptation in ASM as a consequence of prolonged exposure to the many spasmogens found in asthmatic airways could be a mechanism contributing to AHR seen in asthma... - Contractile filament architecture and force transmission in swine airway smooth muscleKuo-Hsing Kuo
Department of Anatomy and Cell Biology, and James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul's Hospital/Providence Health Care, University of British Columbia, Vancouver, BC, V6Z 1Y6, Canada
J Cell Sci 117:1503-11. 2004..The results suggest that smooth muscle cells in tissue form a mechanical syncytium and are able to function properly only as a group... - Changes in force-velocity properties of trachealis due to oscillatory strainsLu Wang
Department of Medicine, iCAPTURE Center, St. Paul's Hospital, Providence Health Care, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
J Appl Physiol 92:1865-72. 2002..The results, however, could be explained if the possibility of reorganization of the contractile filaments due to oscillatory strains was considered... - Mechanical properties of asthmatic airway smooth muscleLeslie Y M Chin
Dept of Pathology and Laboratory Medicine, St Paul s Hospital, Vancouver, BC, Canada
Eur Respir J 40:45-54. 2012..These data may relate to reduced bronchodilation induced by a deep inspiration in asthmatic subjects... 
Emergence of airway smooth muscle functions related to structural malleabilityChun Y Seow
Department of Pathology, James Hogg Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
J Appl Physiol 110:1130-5. 2011..Understanding how smooth muscle works may hinge on how well we can relate molecular events to its emergent macroscopic functions...- Airway wall remodeling in asthma: from the epithelial layer to the adventitiaYnuk Bosse
James Hogg iCAPTURE Centre St Paul s Hospital, Room 166, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada
Curr Allergy Asthma Rep 8:357-66. 2008..This review describes the tissue remodeling observed in different compartments of the asthmatic airway wall, from the airway lumen to adventitia. The underlying mechanisms driving the remodeling processes are also briefly reviewed... - Structural basis for exaggerated airway narrowingPeter D Pare
Department of Medicine and Respiratory Division and The James Hogg iCAPTURE Centre, St Paul s Hospital, University of British Columbia, Vancouver, BC, Canada
Can J Physiol Pharmacol 85:653-8. 2007..This brief review summarizes the quantitative changes in the dimensions and organization of the airway wall compartments that have been described and explains how structural alterations may lead to the exaggerated airway narrowing... - Physical integrity of smooth muscle myosin filaments is enhanced by phosphorylation of the regulatory myosin light chainKelvin Ip
James Hogg iCAPTURE Centre, St Paul s Hospital, Vancouver, Canada
Cell Physiol Biochem 20:649-58. 2007..Phosphorylation of the 20-kD regulatory myosin light chain (MLC20) enhances filament formation. It is not known whether the phosphorylated and non-phosphorylated filaments possess the same structural integrity... - Mathematical simulation of muscle cross-bridge cycle and force-velocity relationshipLeslie Chin
Department of Pathology/Laboratory Medicine, Department of Mathematics, Department of Chemical and Biological Engineering, The James Hogg iCAPTURE Centre, University of British Columbia, Vancouver, British Columbia, Canada
Biophys J 91:3653-63. 2006..The model has revealed new insights on how the force-velocity characteristics are related to the state transitions in the cross-bridge cycle... - On the terminology for describing the length-force relationship and its changes in airway smooth muscleTony R Bai
James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, Vancouver, Canada
J Appl Physiol 97:2029-34. 2004..We also discuss frequently used terms that do not have commonly accepted definitions that should be used cautiously... - Cardiotrophin-1 alters airway smooth muscle structure and mechanical properties in airway explantsXueyan Zheng
The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St. Paul's Hospital, 1081 Burrard St, Vancouver, B. C, Canada V6Z 1Y6
Am J Physiol Lung Cell Mol Physiol 287:L1165-71. 2004..These data indicate that CT-1 alters ASM structural and mechanical properties in the tissue environment and suggest that structural changes found in the airway wall in asthma are not necessarily associated with increased responsiveness... - Decrease of airway smooth muscle contractility induced by simulated breathing maneuvers is not simply proportional to strainChris D Pascoe
University of British Columbia, James Hogg Research Center, St Paul s Hospital Vancouver, British Columbia, Canada
J Appl Physiol 114:335-43. 2013..More surprisingly, the reduction of strain induced by tone was not proportional to its effect on the decline of force induced by simulated breathing maneuvers... - Length-dependent filament formation assessed from birefringence increases during activation of porcine tracheal muscleAlexander V Smolensky
Krannert Institute of Cardiology, Department of Medicine, Indiana University School of Medicine, 1800 N. Capitol Ave, Indianapolis, IN 46202, USA
J Physiol 563:517-27. 2005..The results further suggest that thick-filament formation is sufficiently rapid to account for the velocity slowing and some of the force increase observed during the rise of activation of tracheal smooth muscle... - Comments on point: counterpoint: "airway smooth muscle is/is not useful"Chun Y Seow
J Appl Physiol 102:1712. 2007 - Adaptation to chronic length change in explanted airway smooth muscleJahanbakhsh Naghshin
Department of Medicine, University of British Columbia, V6T 1Z3
J Appl Physiol 95:448-53; discussion 435. 2003..Under in vivo condition, this could translate into resistance to stretch-induced relaxation and excessive airway narrowing... - Biophysics: fashionable cellsChun Y Seow
Nature 435:1172-3. 2005