Chun Y Seow

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. doi request reprint Mechanical and structural plasticity
    Chun Y Seow
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Compr Physiol 1:283-93. 2011
  2. ncbi request reprint Myosin filament assembly in an ever-changing myofilament lattice of smooth muscle
    Chun Y Seow
    Department of Pathology and Laboratory Medicine, James Hogg iCAPTURE Centre, St Paul s Hospital, Rm 166, 1081 Burrard St, Vancouver, BC, Canada V6Z 1Y6
    Am J Physiol Cell Physiol 289:C1363-8. 2005
  3. ncbi request reprint Ultrastructural basis of airway smooth muscle contraction
    Chun Y Seow
    Department of Pathology and Laboratory Medicine and the James Hogg iCAPTURE Centre, St Paul s Hospital, University of British Columbia, Vancouver, BC, Canada
    Can J Physiol Pharmacol 85:659-65. 2007
  4. ncbi request reprint Electron microscopic study of actin polymerization in airway smooth muscle
    Ana M Herrera
    Department of Pathology, Laboratory Medicine, James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul Hospital Providence Health Care, University of British Columbia, Vancouver, BC, Canada V6Z 1Y6
    Am J Physiol Lung Cell Mol Physiol 286:L1161-8. 2004
  5. doi request reprint Adaptive response of pulmonary arterial smooth muscle to length change
    Harley Syyong
    The iCAPTURE Centre St Paul s Hospital, Univ of British Columbia 1081 Burrard St, Rm 166, Vancouver, BC, Canada
    J Appl Physiol (1985) 104:1014-20. 2008
  6. doi request reprint Increase in passive stiffness at reduced airway smooth muscle length: potential impact on airway responsiveness
    Ynuk Bosse
    James Hogg iCAPTURE Centre St Paul s Hospital, 1081 Burrard St, Vancouver, BC, Canada
    Am J Physiol Lung Cell Mol Physiol 298:L277-87. 2010
  7. ncbi request reprint Structure-function correlation in airway smooth muscle adapted to different lengths
    Kuo Hsing Kuo
    Department of Anatomy, University of British Columbia, Vancouver, BC, Canada V6T 1Y6
    Am J Physiol Cell Physiol 285:C384-90. 2003
  8. ncbi request reprint Length adaptation of airway smooth muscle
    Ynuk Bosse
    The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, Providence Health Care St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada, V6Z 1Y6
    Proc Am Thorac Soc 5:62-7. 2008
  9. doi request reprint Mechanical properties of asthmatic airway smooth muscle
    Leslie Y M Chin
    Dept of Pathology and Laboratory Medicine, St Paul s Hospital, Vancouver, BC, Canada
    Eur Respir J 40:45-54. 2012
  10. doi request reprint Regulatable stiffness in relaxed airway smooth muscle: a target for asthma treatment?
    Abdul Raqeeb
    James Hogg Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
    J Appl Physiol (1985) 112:337-46. 2012

Collaborators

Detail Information

Publications37

  1. doi request reprint Mechanical and structural plasticity
    Chun Y Seow
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Compr Physiol 1:283-93. 2011
    ....
  2. ncbi request reprint Myosin filament assembly in an ever-changing myofilament lattice of smooth muscle
    Chun Y Seow
    Department of Pathology and Laboratory Medicine, James Hogg iCAPTURE Centre, St Paul s Hospital, Rm 166, 1081 Burrard St, Vancouver, BC, Canada V6Z 1Y6
    Am J Physiol Cell Physiol 289:C1363-8. 2005
    ....
  3. ncbi request reprint Ultrastructural basis of airway smooth muscle contraction
    Chun Y Seow
    Department of Pathology and Laboratory Medicine and the James Hogg iCAPTURE Centre, St Paul s Hospital, University of British Columbia, Vancouver, BC, Canada
    Can J Physiol Pharmacol 85:659-65. 2007
    ..A list of unanswered questions regarding smooth muscle ultrastructure is also proposed in this review, in the hope that it will provide some guidance for future research...
  4. ncbi request reprint Electron microscopic study of actin polymerization in airway smooth muscle
    Ana M Herrera
    Department of Pathology, Laboratory Medicine, James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul Hospital Providence Health Care, University of British Columbia, Vancouver, BC, Canada V6Z 1Y6
    Am J Physiol Lung Cell Mol Physiol 286:L1161-8. 2004
    ....
  5. doi request reprint Adaptive response of pulmonary arterial smooth muscle to length change
    Harley Syyong
    The iCAPTURE Centre St Paul s Hospital, Univ of British Columbia 1081 Burrard St, Rm 166, Vancouver, BC, Canada
    J Appl Physiol (1985) 104:1014-20. 2008
    ..It is concluded that, like many smooth muscles, PASM possesses substantial capability to adapt to changes in length. Under pathological conditions, this could contribute to hypervasoconstriction in pulmonary hypertension...
  6. doi request reprint Increase in passive stiffness at reduced airway smooth muscle length: potential impact on airway responsiveness
    Ynuk Bosse
    James Hogg iCAPTURE Centre St Paul s Hospital, 1081 Burrard St, Vancouver, BC, Canada
    Am J Physiol Lung Cell Mol Physiol 298:L277-87. 2010
    ..Redevelopment and maintenance of passive stiffness following muscle shortening could contribute to airway hyperresponsiveness by attenuating the airway wall strain induced by tidal breathing and DI...
  7. ncbi request reprint Structure-function correlation in airway smooth muscle adapted to different lengths
    Kuo Hsing Kuo
    Department of Anatomy, University of British Columbia, Vancouver, BC, Canada V6T 1Y6
    Am J Physiol Cell Physiol 285:C384-90. 2003
    ..The data can be explained by a model in which additional contractile units containing myosin filaments are formed and placed in series with existing contractile units when the muscle is adapted at a longer length...
  8. ncbi request reprint Length adaptation of airway smooth muscle
    Ynuk Bosse
    The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, Providence Health Care St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada, V6Z 1Y6
    Proc Am Thorac Soc 5:62-7. 2008
    ....
  9. doi request reprint Mechanical properties of asthmatic airway smooth muscle
    Leslie Y M Chin
    Dept of Pathology and Laboratory Medicine, St Paul s Hospital, Vancouver, BC, Canada
    Eur Respir J 40:45-54. 2012
    ..These data may relate to reduced bronchodilation induced by a deep inspiration in asthmatic subjects...
  10. doi request reprint Regulatable stiffness in relaxed airway smooth muscle: a target for asthma treatment?
    Abdul Raqeeb
    James Hogg Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
    J Appl Physiol (1985) 112:337-46. 2012
    ..The results suggest that airway stiffness can be readily modulated by targeting the calcium-sensitive component of the passive stiffness within the muscle layer...
  11. doi request reprint Time course of isotonic shortening and the underlying contraction mechanism in airway smooth muscle
    Harley T Syyong
    James Hogg Research Centre St Paul s Hospital, Univ of British Columbia, 1081 Burrard St, Rm 166, Vancouver, BC, Canada
    J Appl Physiol (1985) 111:642-56. 2011
    ....
  12. doi request reprint Force oscillations simulating breathing maneuvers do not prevent force adaptation
    Chris Pascoe
    University of British Columbia, James Hogg Research Center, St Paul s Hospital Vancouver, Canada
    Am J Respir Cell Mol Biol 47:44-9. 2012
    ..The lack of effect of simulated breathing maneuvers on force adaptation suggests that this gain in ASM force may occur in vivo and could contribute to the development of airway hyperresponsiveness...
  13. ncbi request reprint Mechanism of partial adaptation in airway smooth muscle after a step change in length
    Farah Ali
    Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    J Appl Physiol 103:569-77. 2007
    ..The partially adapted intermediate state is perhaps more physiologically relevant than the fully adapted state seen under static conditions, and it simulates a more realistic behavior for ASM in vivo...
  14. doi request reprint Chronic activation in shortened airway smooth muscle: a synergistic combination underlying airway hyperresponsiveness?
    Ynuk Bosse
    The James Hogg iCAPTURE Centre, Providence Health Care St Paul s Hospital, Vancouver, BC, V6Z 1Y6 Canada
    Am J Respir Cell Mol Biol 42:341-8. 2010
    ..In vivo these changes will be translated into excessive airway narrowing in response to naturally occurring and pharmacological bronchoconstricting stimuli...
  15. doi request reprint Decrease of airway smooth muscle contractility induced by simulated breathing maneuvers is not simply proportional to strain
    Chris D Pascoe
    University of British Columbia, James Hogg Research Center, St Paul s Hospital Vancouver, British Columbia, Canada
    J Appl Physiol (1985) 114:335-43. 2013
    ..More surprisingly, the reduction of strain induced by tone was not proportional to its effect on the decline of force induced by simulated breathing maneuvers...
  16. ncbi request reprint Influence of calcium on myosin thick filament formation in intact airway smooth muscle
    Ana M Herrera
    Department of Anatomy, St Paul s Hospital Providence Health Care, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
    Am J Physiol Cell Physiol 282:C310-6. 2002
    ....
  17. ncbi request reprint 'Sarcomeres' of smooth muscle: functional characteristics and ultrastructural evidence
    Ana M Herrera
    Department of Pathology and Laboratory Medicine, St Paul s Hospital Providence Health Care, University of British Columbia, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
    J Cell Sci 118:2381-92. 2005
    ..The structural malleability necessary for length adaptation precludes formation of a permanent filament lattice and explains the lack of aligned filament arrays in registers, which also explains why smooth muscle is 'smooth'...
  18. doi request reprint Dense-body aggregates as plastic structures supporting tension in smooth muscle cells
    Jie Zhang
    James Hogg Centre for Cardiovascular and Pulmonary Research, Providence Heart and Lung Institute, Vancouver, British Columbia, Canada
    Am J Physiol Lung Cell Mol Physiol 299:L631-8. 2010
    ..The finding suggests that the structural plasticity of hollow organs may originate from the dense-body cables within the smooth muscle cells...
  19. ncbi request reprint The role of airway smooth muscle during an attack of asthma simulated in vitro
    Brent E McParland
    Department of Medicine, James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital Providence Health Care, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Respir Cell Mol Biol 33:500-4. 2005
    ..75 +/- 0.2-fold, respectively. Shortening of ASM in response to contractile agonists can lead to adaptation of the muscle to the shortened length that, in turn, can result in further shortening and the potential for airway closure...
  20. doi request reprint Length oscillation mimicking periodic individual deep inspirations during tidal breathing attenuates force recovery and adaptation in airway smooth muscle
    Abdul Raqeeb
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    J Appl Physiol (1985) 109:1476-82. 2010
    ....
  21. doi request reprint Adaptation of airway smooth muscle to basal tone: relevance to airway hyperresponsiveness
    Ynuk Bosse
    the James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research St Paul s Hospital, Room 166 1081, Burrard Street, Vancouver, BC, V6Z 1Y6 Canada
    Am J Respir Cell Mol Biol 40:13-8. 2009
    ..Force adaptation in ASM as a consequence of prolonged exposure to the many spasmogens found in asthmatic airways could be a mechanism contributing to AHR seen in asthma...
  22. ncbi request reprint Models of contractile units and their assembly in smooth muscle
    Farah Ali
    Department of Experimental Medicine, University of British Columbia, Vancouver, Canada
    Can J Physiol Pharmacol 83:825-31. 2005
    ..The contractile apparatus is assumed malleable in that the number of contractile units in series and in parallel can be altered to accommodate strains on the muscle and to maintain the muscle's optimal mechanical function...
  23. ncbi request reprint Changes in force-velocity properties of trachealis due to oscillatory strains
    Lu Wang
    Department of Medicine, iCAPTURE Center, St Paul s Hospital, Providence Health Care, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
    J Appl Physiol 92:1865-72. 2002
    ..The results, however, could be explained if the possibility of reorganization of the contractile filaments due to oscillatory strains was considered...
  24. ncbi request reprint Airway wall remodeling in asthma: from the epithelial layer to the adventitia
    Ynuk Bosse
    James Hogg iCAPTURE Centre St Paul s Hospital, Room 166, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada
    Curr Allergy Asthma Rep 8:357-66. 2008
    ..This review describes the tissue remodeling observed in different compartments of the asthmatic airway wall, from the airway lumen to adventitia. The underlying mechanisms driving the remodeling processes are also briefly reviewed...
  25. ncbi request reprint Contractile filament architecture and force transmission in swine airway smooth muscle
    Kuo Hsing Kuo
    Department of Anatomy and Cell Biology, and James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital Providence Health Care, University of British Columbia, Vancouver, BC, V6Z 1Y6, Canada
    J Cell Sci 117:1503-11. 2004
    ..The results suggest that smooth muscle cells in tissue form a mechanical syncytium and are able to function properly only as a group...
  26. pmc Myosin filaments in smooth muscle cells do not have a constant length
    Jeffrey C Y Liu
    C Y Seow James Hogg Research Centre, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada, V6Z 1Y6
    J Physiol 591:5867-78. 2013
    ....
  27. doi request reprint Passive stiffness of airway smooth muscle: the next target for improving airway distensibility and treatment for asthma?
    Chun Y Seow
    Department of Pathology and Laboratory Medicine, The James Hogg Research Centre St Paul s Hospital, University of British Columbia, 1081 Burrard Street, Rm 166, Vancouver, BC V6Z 1Y6, Canada
    Pulm Pharmacol Ther 26:37-41. 2013
    ..To improve airway distensibility during asthma exacerbation, a comprehensive approach to reduce overall airway stiffness should therefore include a strategy for targeting the regulatable passive stiffness...
  28. ncbi request reprint On the terminology for describing the length-force relationship and its changes in airway smooth muscle
    Tony R Bai
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, Vancouver, Canada
    J Appl Physiol 97:2029-34. 2004
    ..We also discuss frequently used terms that do not have commonly accepted definitions that should be used cautiously...
  29. ncbi request reprint Structural basis for exaggerated airway narrowing
    Peter D Pare
    Department of Medicine and Respiratory Division and The James Hogg iCAPTURE Centre, St Paul s Hospital, University of British Columbia, Vancouver, BC, Canada
    Can J Physiol Pharmacol 85:653-8. 2007
    ..This brief review summarizes the quantitative changes in the dimensions and organization of the airway wall compartments that have been described and explains how structural alterations may lead to the exaggerated airway narrowing...
  30. pmc Mathematical simulation of muscle cross-bridge cycle and force-velocity relationship
    Leslie Chin
    Department of Pathology Laboratory Medicine, Department of Mathematics, Department of Chemical and Biological Engineering, The James Hogg iCAPTURE Centre, University of British Columbia, Vancouver, British Columbia, Canada
    Biophys J 91:3653-63. 2006
    ..The model has revealed new insights on how the force-velocity characteristics are related to the state transitions in the cross-bridge cycle...
  31. pmc Emergence of airway smooth muscle functions related to structural malleability
    Chun Y Seow
    Department of Pathology, James Hogg Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
    J Appl Physiol (1985) 110:1130-5. 2011
    ..Understanding how smooth muscle works may hinge on how well we can relate molecular events to its emergent macroscopic functions...
  32. ncbi request reprint Physical integrity of smooth muscle myosin filaments is enhanced by phosphorylation of the regulatory myosin light chain
    Kelvin Ip
    James Hogg iCAPTURE Centre, St Paul s Hospital, Vancouver, Canada
    Cell Physiol Biochem 20:649-58. 2007
    ..Phosphorylation of the 20-kD regulatory myosin light chain (MLC20) enhances filament formation. It is not known whether the phosphorylated and non-phosphorylated filaments possess the same structural integrity...
  33. ncbi request reprint Cardiotrophin-1 alters airway smooth muscle structure and mechanical properties in airway explants
    Xueyan Zheng
    The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St Paul s Hospital, 1081 Burrard St, Vancouver, B C, Canada V6Z 1Y6
    Am J Physiol Lung Cell Mol Physiol 287:L1165-71. 2004
    ..These data indicate that CT-1 alters ASM structural and mechanical properties in the tissue environment and suggest that structural changes found in the airway wall in asthma are not necessarily associated with increased responsiveness...
  34. ncbi request reprint Comments on point: counterpoint: "airway smooth muscle is/is not useful"
    Chun Y Seow
    J Appl Physiol 102:1712. 2007
  35. ncbi request reprint Adaptation to chronic length change in explanted airway smooth muscle
    Jahanbakhsh Naghshin
    Department of Medicine, University of British Columbia, V6T 1Z3
    J Appl Physiol 95:448-53; discussion 435. 2003
    ..Under in vivo condition, this could translate into resistance to stretch-induced relaxation and excessive airway narrowing...
  36. pmc Length-dependent filament formation assessed from birefringence increases during activation of porcine tracheal muscle
    Alexander V Smolensky
    Krannert Institute of Cardiology, Department of Medicine, Indiana University School of Medicine, 1800 N Capitol Ave, Indianapolis, IN 46202, USA
    J Physiol 563:517-27. 2005
    ..The results further suggest that thick-filament formation is sufficiently rapid to account for the velocity slowing and some of the force increase observed during the rise of activation of tracheal smooth muscle...
  37. ncbi request reprint Biophysics: fashionable cells
    Chun Y Seow
    Nature 435:1172-3. 2005