Graham R Scott

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. doi request reprint Respiratory responses to progressive hypoxia in the Amazonian oscar, Astronotus ocellatus
    Graham R Scott
    Department of Zoology, University of British Columbia, Vancouver V6T 1Z4, Canada
    Respir Physiol Neurobiol 162:109-16. 2008
  2. ncbi request reprint Plasticity of osmoregulatory function in the killifish intestine: drinking rates, salt and water transport, and gene expression after freshwater transfer
    Graham R Scott
    Department of Zoology, University of British Columbia, Vancouver BC, V6T 1Z4, Canada
    J Exp Biol 209:4040-50. 2006
  3. ncbi request reprint Cadmium disrupts behavioural and physiological responses to alarm substance in juvenile rainbow trout (Oncorhynchus mykiss)
    Graham R Scott
    Department of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4K1, Canada
    J Exp Biol 206:1779-90. 2003
  4. doi request reprint Physiological and molecular mechanisms of osmoregulatory plasticity in killifish after seawater transfer
    Graham R Scott
    Department of Zoology, University of British Columbia, Vancouver BC, Canada V6T 1Z4
    J Exp Biol 211:2450-9. 2008
  5. doi request reprint Body temperature depression and peripheral heat loss accompany the metabolic and ventilatory responses to hypoxia in low and high altitude birds
    Graham R Scott
    Department of Zoology, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada
    J Exp Biol 211:1326-35. 2008
  6. ncbi request reprint Control of breathing and adaptation to high altitude in the bar-headed goose
    Graham R Scott
    Department of Zoology, University of British Columbia, Vancouver, BC, Canada
    Am J Physiol Regul Integr Comp Physiol 293:R379-91. 2007
  7. pmc Evolution of muscle phenotype for extreme high altitude flight in the bar-headed goose
    Graham R Scott
    Department of Zoology, University of British Columbia, Vancouver V6T 1Z4, Canada
    Proc Biol Sci 276:3645-53. 2009
  8. ncbi request reprint Flying high: a theoretical analysis of the factors limiting exercise performance in birds at altitude
    Graham R Scott
    Department of Zoology, University of British Columbia, Vancouver, BC, Canada
    Respir Physiol Neurobiol 154:284-301. 2006
  9. doi request reprint Control of respiration in flight muscle from the high-altitude bar-headed goose and low-altitude birds
    Graham R Scott
    Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Physiol Regul Integr Comp Physiol 297:R1066-74. 2009
  10. ncbi request reprint Effects of spironolactone and RU486 on gene expression and cell proliferation after freshwater transfer in the euryhaline killifish
    Graham R Scott
    Department of Zoology, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada
    J Comp Physiol B 175:499-510. 2005

Detail Information

Publications25

  1. doi request reprint Respiratory responses to progressive hypoxia in the Amazonian oscar, Astronotus ocellatus
    Graham R Scott
    Department of Zoology, University of British Columbia, Vancouver V6T 1Z4, Canada
    Respir Physiol Neurobiol 162:109-16. 2008
    ..We conclude that metabolic depression and tolerance of anaerobic bi-products, rather than a superior capacity for O2 supply, allow oscar to thrive in extreme hypoxia in the Amazon...
  2. ncbi request reprint Plasticity of osmoregulatory function in the killifish intestine: drinking rates, salt and water transport, and gene expression after freshwater transfer
    Graham R Scott
    Department of Zoology, University of British Columbia, Vancouver BC, V6T 1Z4, Canada
    J Exp Biol 209:4040-50. 2006
    ..Our results suggest that intestinal NaCl absorption from food is important during the period of greatest ionic disturbance after transfer to fresh water, and provide further insight into the mechanisms of euryhalinity in killifish...
  3. ncbi request reprint Cadmium disrupts behavioural and physiological responses to alarm substance in juvenile rainbow trout (Oncorhynchus mykiss)
    Graham R Scott
    Department of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4K1, Canada
    J Exp Biol 206:1779-90. 2003
    ....
  4. doi request reprint Physiological and molecular mechanisms of osmoregulatory plasticity in killifish after seawater transfer
    Graham R Scott
    Department of Zoology, University of British Columbia, Vancouver BC, Canada V6T 1Z4
    J Exp Biol 211:2450-9. 2008
    ..As such they provide further insight into the mechanisms of euryhalinity in killifish...
  5. doi request reprint Body temperature depression and peripheral heat loss accompany the metabolic and ventilatory responses to hypoxia in low and high altitude birds
    Graham R Scott
    Department of Zoology, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada
    J Exp Biol 211:1326-35. 2008
    ....
  6. ncbi request reprint Control of breathing and adaptation to high altitude in the bar-headed goose
    Graham R Scott
    Department of Zoology, University of British Columbia, Vancouver, BC, Canada
    Am J Physiol Regul Integr Comp Physiol 293:R379-91. 2007
    ..Overall, our results suggest that evolutionary changes in the respiratory control system of bar-headed geese enhance O(2) loading into the blood and may contribute to this species' exceptional ability to fly high...
  7. pmc Evolution of muscle phenotype for extreme high altitude flight in the bar-headed goose
    Graham R Scott
    Department of Zoology, University of British Columbia, Vancouver V6T 1Z4, Canada
    Proc Biol Sci 276:3645-53. 2009
    ..Bar-headed geese have therefore evolved for exercise in hypoxia by enhancing the O(2) supply to flight muscle...
  8. ncbi request reprint Flying high: a theoretical analysis of the factors limiting exercise performance in birds at altitude
    Graham R Scott
    Department of Zoology, University of British Columbia, Vancouver, BC, Canada
    Respir Physiol Neurobiol 154:284-301. 2006
    ..Our sensitivity analysis provides theoretical suggestions of the adaptations most likely to promote high altitude flight in birds and provides direction for future in vivo studies...
  9. doi request reprint Control of respiration in flight muscle from the high-altitude bar-headed goose and low-altitude birds
    Graham R Scott
    Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Physiol Regul Integr Comp Physiol 297:R1066-74. 2009
    ..The unique differences in bar-headed geese existed without prior exercise or hypoxia exposure and were not a result of phylogenetic history, and may, therefore, be important evolutionary specializations for high-altitude flight...
  10. ncbi request reprint Effects of spironolactone and RU486 on gene expression and cell proliferation after freshwater transfer in the euryhaline killifish
    Graham R Scott
    Department of Zoology, University of British Columbia, Vancouver, BC, V6T 1Z4, Canada
    J Comp Physiol B 175:499-510. 2005
    ..The effects of spironolactone suggest that MR is important for regulating ion transport in killifish gills after freshwater transfer...
  11. ncbi request reprint Gene expression after freshwater transfer in gills and opercular epithelia of killifish: insight into divergent mechanisms of ion transport
    Graham R Scott
    Department of Zoology, University of British Columbia, Vancouver BC, Canada V6T 1Z4
    J Exp Biol 208:2719-29. 2005
    ..These results provide insight into the mechanisms of ion transport by killifish gills and opercular epithelia, and demonstrate a potential molecular basis for the differences in physiological function between these two organs...
  12. ncbi request reprint Intraspecific variation in gene expression after seawater transfer in gills of the euryhaline killifish Fundulus heteroclitus
    Graham R Scott
    Department of Zoology, University of British Columbia, Vancouver, Canada
    Comp Biochem Physiol A Mol Integr Physiol 141:176-82. 2005
    ....
  13. ncbi request reprint Intraspecific divergence of ionoregulatory physiology in the euryhaline teleost Fundulus heteroclitus: possible mechanisms of freshwater adaptation
    Graham R Scott
    Department of Zoology, University of British Columbia, Vancouver BC, Canada
    J Exp Biol 207:3399-410. 2004
    ....
  14. ncbi request reprint The effects of environmental pollutants on complex fish behaviour: integrating behavioural and physiological indicators of toxicity
    Graham R Scott
    Department of Zoology, University of British Columbia, 6270 University Boulevard, Vancouver, BC, Canada V6T 1Z4
    Aquat Toxicol 68:369-92. 2004
    ..We conclude that future integrative, multidisciplinary research is clearly needed to increase the significance and usefulness of behavioural indicators for aquatic toxicology, and aim to highlight specific areas for consideration...
  15. ncbi request reprint Changes in gene expression in gills of the euryhaline killifish Fundulus heteroclitus after abrupt salinity transfer
    Graham R Scott
    Department of Zoology, University of British Columbia, Vancouver, BC, Canada V6T 1Z4
    Am J Physiol Cell Physiol 287:C300-9. 2004
    ..These findings demonstrate unique patterns of ion transporter expression in killifish gills after salinity transfer and illustrate important mechanisms of functional plasticity in ion-transporting epithelia...
  16. doi request reprint Have wing morphology or flight kinematics evolved for extreme high altitude migration in the bar-headed goose?
    Stella Y Lee
    Department of Zoology, University of British Columbia, Vancouver BC, Canada, V6T 1Z4
    Comp Biochem Physiol C Toxicol Pharmacol 148:324-31. 2008
    ..The apparent lack of morphological and kinematic adaptation emphasizes the importance of physiological adaptations for enhancing oxygen transport and utilization in this species...
  17. doi request reprint Regulation of gill transcellular permeability and renal function during acute hypoxia in the Amazonian oscar (Astronotus ocellatus): new angles to the osmorespiratory compromise
    Chris M Wood
    Department of Biology, McMaster University, Hamilton, Ontario, Canada, L8S 4K1
    J Exp Biol 212:1949-64. 2009
    ....
  18. doi request reprint Molecular evolution of cytochrome C oxidase underlies high-altitude adaptation in the bar-headed goose
    Graham R Scott
    Department of Zoology, University of British Columbia, Vancouver, BC, Canada
    Mol Biol Evol 28:351-63. 2011
    ..Adaptations in mitochondrial enzyme kinetics and O(2) transport capacity may therefore contribute to the exceptional ability of bar-headed geese to fly high...
  19. ncbi request reprint Rapid regulation of Na+ fluxes and ammonia excretion in response to acute environmental hypoxia in the Amazonian oscar, Astronotus ocellatus
    Chris M Wood
    Dept of Biology, McMaster Univ, Hamilton, ON, Canada
    Am J Physiol Regul Integr Comp Physiol 292:R2048-58. 2007
    ..Overall, the oscar maintains excellent homeostasis of ionoregulation and N-balance during severe hypoxia...
  20. pmc Temperature during embryonic development has persistent effects on thermal acclimation capacity in zebrafish
    Graham R Scott
    Department of Biology, McMaster University, Hamilton, ON L8S 4K1, Canada
    Proc Natl Acad Sci U S A 109:14247-52. 2012
    ..Developmental plasticity may thus help some ectothermic organisms cope with the more variable temperatures that are expected under future climate-change scenarios...
  21. ncbi request reprint Ventilatory roll off during sustained hypercapnia is gender specific in pekin ducks
    Graham A A Dodd
    Department of Zoology, University of British Columbia, Vancouver, BC, Canada V6T 1Z4
    Respir Physiol Neurobiol 156:47-60. 2007
    ..Furthermore, we suggest that this ventilatory response be considered a gender-specific hypercapnic ventilatory roll off, in the context of the various time domains of the hypercapnic ventilatory response...
  22. doi request reprint Elevated performance: the unique physiology of birds that fly at high altitudes
    Graham R Scott
    Department of Biology, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4K1, Canada
    J Exp Biol 214:2455-62. 2011
    ..Disentangling these roles will be instrumental if we are to understand the physiological basis of altitudinal range limits and how they might shift in response to climate change...
  23. ncbi request reprint Evolution of salinity tolerance from transcriptome to physiological system
    Graham R Scott
    Department of Biology, McMaster University, 1280 Main Street West, Hamilton, Ontario L8S 4K1, Canada
    Mol Ecol 22:3656-8. 2013
    ..The work of Whitehead et al. therefore emphasizes how the mechanisms of adaptive divergence between populations can be expanded over time to produce the more complex differences that can exist between species...
  24. ncbi request reprint Tribute to R. G. Boutilier: the effect of size on the physiological and behavioural responses of oscar, Astronotus ocellatus, to hypoxia
    Katherine A Sloman
    School of Biological Sciences, University of Plymouth, Devon, PL4 8AA, UK
    J Exp Biol 209:1197-205. 2006
    ....
  25. ncbi request reprint Cadmium affects the social behaviour of rainbow trout, Oncorhynchus mykiss
    Katherine A Sloman
    Department of Biological Sciences, Brunel University, Uxbridge, Middlesex UB8 3PH, UK
    Aquat Toxicol 65:171-85. 2003
    ....