Claudia Schwab

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. doi request reprint GAD65, GAD67, and GABAT immunostaining in human brain and apparent GAD65 loss in Alzheimer's disease
    Claudia Schwab
    Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, BC, Canada
    J Alzheimers Dis 33:1073-88. 2013
  2. ncbi request reprint TDP-43 pathology in familial British dementia
    Claudia Schwab
    Department of Psychiatry, Kinsmen Laboratory of Neurological Research, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T1Z3, Canada
    Acta Neuropathol 118:303-11. 2009
  3. ncbi request reprint Colocalization of transactivation-responsive DNA-binding protein 43 and huntingtin in inclusions of Huntington disease
    Claudia Schwab
    Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, British Columbia, Canada
    J Neuropathol Exp Neurol 67:1159-65. 2008
  4. doi request reprint Differential expression of interferon-gamma receptor on human glial cells in vivo and in vitro
    Sadayuki Hashioka
    Department of Psychiatry, The University of British Columbia, Vancouver, BC, Canada
    J Neuroimmunol 225:91-9. 2010
  5. ncbi request reprint Interferon-gamma-dependent cytotoxic activation of human astrocytes and astrocytoma cells
    Sadayuki Hashioka
    Kinsmen Laboratory of Neurological Research, Department of Psychiatry, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, V6T 1W5 Canada
    Neurobiol Aging 30:1924-35. 2009
  6. doi request reprint Optineurin in Huntington's disease intranuclear inclusions
    Claudia Schwab
    Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, Canada
    Neurosci Lett 506:149-54. 2012
  7. ncbi request reprint Transgenic mice overexpressing amyloid beta protein are an incomplete model of Alzheimer disease
    Claudia Schwab
    Kinsmen Laboratory of Neurological Research, Division of Neurology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
    Exp Neurol 188:52-64. 2004
  8. doi request reprint Astrocytes are GABAergic cells that modulate microglial activity
    MoonHee Lee
    Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, BC, Canada
    Glia 59:152-65. 2011
  9. pmc Acidic fibroblast growth factor (FGF) potentiates glial-mediated neurotoxicity by activating FGFR2 IIIb protein
    MoonHee Lee
    Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Biol Chem 286:41230-45. 2011
  10. ncbi request reprint Adhesion of exogenous human microglia and THP-1 cells to amyloid plaques of postmortem Alzheimer's disease brain
    Sadayuki Hashioka
    Kinsmen Laboratory of Neurological Research, Department of Psychiatry, The University of British Columbia, Vancouver, BC, Canada
    J Alzheimers Dis 14:345-52. 2008

Collaborators

Detail Information

Publications19

  1. doi request reprint GAD65, GAD67, and GABAT immunostaining in human brain and apparent GAD65 loss in Alzheimer's disease
    Claudia Schwab
    Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, BC, Canada
    J Alzheimers Dis 33:1073-88. 2013
    ..Our results suggest that the GABAergic system is more severely affected in AD than previously reported. This deficit may contribute to AD pathogenesis by loss of GABAergic inhibitory activity...
  2. ncbi request reprint TDP-43 pathology in familial British dementia
    Claudia Schwab
    Department of Psychiatry, Kinsmen Laboratory of Neurological Research, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T1Z3, Canada
    Acta Neuropathol 118:303-11. 2009
    ..Our results support the concept that TDP-43 pathology is not narrowly restricted, but is involved in the etiology of many neurodegenerative disorders...
  3. ncbi request reprint Colocalization of transactivation-responsive DNA-binding protein 43 and huntingtin in inclusions of Huntington disease
    Claudia Schwab
    Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, British Columbia, Canada
    J Neuropathol Exp Neurol 67:1159-65. 2008
    ..Our results further add to the hypothesis that TDP-43 may be involved in the pathology of a variety of neurodegenerative disorders...
  4. doi request reprint Differential expression of interferon-gamma receptor on human glial cells in vivo and in vitro
    Sadayuki Hashioka
    Department of Psychiatry, The University of British Columbia, Vancouver, BC, Canada
    J Neuroimmunol 225:91-9. 2010
    ....
  5. ncbi request reprint Interferon-gamma-dependent cytotoxic activation of human astrocytes and astrocytoma cells
    Sadayuki Hashioka
    Kinsmen Laboratory of Neurological Research, Department of Psychiatry, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, V6T 1W5 Canada
    Neurobiol Aging 30:1924-35. 2009
    ..These findings suggest that activated astrocytes may become neurotoxic when stimulated by IFN-gamma and may therefore exacerbate the pathology in a spectrum of neurodegenerative diseases...
  6. doi request reprint Optineurin in Huntington's disease intranuclear inclusions
    Claudia Schwab
    Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, Canada
    Neurosci Lett 506:149-54. 2012
    ..It is not clear whether this indicates a primary involvement in the disease process. In HD, the known interaction of htt and optineurin may suggest that a different process takes place as compared to other neurodegenerative disorders...
  7. ncbi request reprint Transgenic mice overexpressing amyloid beta protein are an incomplete model of Alzheimer disease
    Claudia Schwab
    Kinsmen Laboratory of Neurological Research, Division of Neurology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
    Exp Neurol 188:52-64. 2004
    ..Therapeutic strategies for the treatment of AD based on tg mouse models that overexpress Abeta may be limited in their application...
  8. doi request reprint Astrocytes are GABAergic cells that modulate microglial activity
    MoonHee Lee
    Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, BC, Canada
    Glia 59:152-65. 2011
    ..We conclude that the antiinflammatory actions of GABA offer new therapeutic opportunities since agonists should enhance the effectiveness of other antiinflammatory agents that operate through non-GABA pathways...
  9. pmc Acidic fibroblast growth factor (FGF) potentiates glial-mediated neurotoxicity by activating FGFR2 IIIb protein
    MoonHee Lee
    Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Biol Chem 286:41230-45. 2011
    ....
  10. ncbi request reprint Adhesion of exogenous human microglia and THP-1 cells to amyloid plaques of postmortem Alzheimer's disease brain
    Sadayuki Hashioka
    Kinsmen Laboratory of Neurological Research, Department of Psychiatry, The University of British Columbia, Vancouver, BC, Canada
    J Alzheimers Dis 14:345-52. 2008
    ..These results suggest that human microglial cells are capable of adhering to and phagocytosing post mortem AD plaque material but activation may be necessary. Astrocytes may further enhance the process...
  11. ncbi request reprint Inflammatory aspects of Alzheimer disease and other neurodegenerative disorders
    Claudia Schwab
    Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, BC, Canada
    J Alzheimers Dis 13:359-69. 2008
    ..From a therapeutic point of view it is desirable to find methods of tipping the balance towards an anti-inflammatory state for both types of glia...
  12. ncbi request reprint Phenotypic abnormalities in the YAC128 mouse model of Huntington disease are penetrant on multiple genetic backgrounds and modulated by strain
    Jeremy M Van Raamsdonk
    Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
    Neurobiol Dis 26:189-200. 2007
    ..Importantly, the demonstration of penetrance across all three strains permits examining the effect of specific genes on the phenotypic severity in YAC128 mice without necessarily backcrossing onto the FVB/N strain background...
  13. doi request reprint Inflammation in transgenic mouse models of neurodegenerative disorders
    Claudia Schwab
    Department of Psychiatry, Kinsmen Laboratory of Neurological Research, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T1Z3, Canada
    Biochim Biophys Acta 1802:889-902. 2010
    ..In particular, the mouse models of Alzheimer disease have also led to the development of new therapeutic strategies such as vaccination and modulation of microglial activity...
  14. doi request reprint Selective inhibition of the membrane attack complex of complement by low molecular weight components of the aurin tricarboxylic acid synthetic complex
    MoonHee Lee
    Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, British Columbia, Canada
    Neurobiol Aging 33:2237-46. 2012
    ..Aurin tricarboxylic acid, aurin quadracarboxylic acid, and aurin hexacarboxylic acid may be effective therapeutic agents in Alzheimer disease and other degenerative disorders where self damage from the MAC occurs...
  15. doi request reprint Astrocytes produce the antiinflammatory and neuroprotective agent hydrogen sulfide
    MoonHee Lee
    Kinsmen Laboratory of Neurological Research, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, Canada
    Neurobiol Aging 30:1523-34. 2009
    ..H(2)S releasing drugs may have therapeutic potential in neurodegenerative disorders of aging such as Alzheimer disease and Parkinson disease...
  16. ncbi request reprint Cross-species characterization of the ALS2 gene and analysis of its pattern of expression in development and adulthood
    Rebecca S Devon
    Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia, and Children and Women s Hospital, 980 West 28th Avenue, Vancouver, BC, Canada V5Z 4H4
    Neurobiol Dis 18:243-57. 2005
    ..Additionally, the product of a second, widely expressed gene, ALS2 C-terminal like (ALS2CL), may subserve or modulate some of the functions of alsin as an activator of Rab and Rho GTPases...
  17. ncbi request reprint Familial British dementia: colocalization of furin and ABri amyloid
    Claudia Schwab
    Kinsmen Laboratory of Neurological Research, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, V6T 1Z3, Canada
    Acta Neuropathol 106:278-84. 2003
    ..These data suggest that furin may be involved in producing the pathological fragment of ABriPP in vivo and that inhibition of furin might be a method of treating this disorder...
  18. pmc Comparison of Vascular Perturbations in an Aβ-Injected Animal Model and in AD Brain
    Nattinee Jantaratnotai
    Department of Anesthesiology, Pharmacology and Therapeutics, Faculty of Medicine, The University of British Columbia, 2176 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada
    Int J Alzheimers Dis 2011:918280. 2011
    ..These results provide the first evidence that a peptide-injection animal model exhibits a commonality in perturbations of microvessels compared with those evident in AD brain...
  19. ncbi request reprint Presence of reactive microglia in monkey substantia nigra years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration
    Patrick L McGeer
    Kinsmen Laboratory of Neurological Research, Division of Neurology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
    Ann Neurol 54:599-604. 2003
    ..The mechanism is unknown but could have important implications regarding the cause of Parkinson's disease and possible approaches to therapy...