Carol Schuurmans

Summary

Affiliation: University of Calgary
Country: Canada

Publications

  1. ncbi request reprint Members of the Plag gene family are expressed in complementary and overlapping regions in the developing murine nervous system
    Sharmila Alam
    Department of Biochemistry and Molecular Biology, Institute of Maternal and Child Health, University of Calgary, Calgary, AB, Canada
    Dev Dyn 234:772-82. 2005
  2. pmc Cell-type specific roles for PTEN in establishing a functional retinal architecture
    Robert Cantrup
    Department of Biochemistry and Molecular Biology, Hotchkiss Brain Institute, Alberta Children s Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada
    PLoS ONE 7:e32795. 2012
  3. ncbi request reprint Molecular mechanisms underlying cell fate specification in the developing telencephalon
    Carol Schuurmans
    Department of Biochemistry and Molecular Biology, University of Calgary, Room 2221, Health Sciences Center, 3330 Hospital Drive NW, Calgary, Alberta, T2N 1N8, Canada
    Curr Opin Neurobiol 12:26-34. 2002
  4. pmc Zac1 functions through TGFbetaII to negatively regulate cell number in the developing retina
    Lin Ma
    IMCH, HBI, University of Calgary, T2N 4N1, Canada
    Neural Dev 2:11. 2007
  5. pmc Basic helix-loop-helix transcription factors cooperate to specify a cortical projection neuron identity
    Pierre Mattar
    Institute of Maternal and Child Health, Hotchkiss Brain Institute, University of Calgary, 2277 HSC, 3330 Hospital Dr NW, Calgary, Alberta, Canada
    Mol Cell Biol 28:1456-69. 2008
  6. doi request reprint Ascl1 participates in Cajal-Retzius cell development in the neocortex
    Rajiv Dixit
    Hotchkiss Brain Institute, Alberta Children s Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Cereb Cortex 21:2599-611. 2011
  7. doi request reprint Neural stem cell self-renewal requires the Mrj co-chaperone
    Erica D Watson
    Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada
    Dev Dyn 238:2564-74. 2009
  8. doi request reprint Neurog1 and Neurog2 control two waves of neuronal differentiation in the piriform cortex
    Rajiv Dixit
    Departments of Biochemistry and Molecular Biology and Medical Genetics, Hotchkiss Brain Institute and Alberta Children s Hospital Research Institute, Department of Pathology and Laboratory Medicine, Southern Alberta Cancer Research Institute, University of Calgary, Alberta T2N 4N1, Canada, Programs in Cell Biology, and Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto M5G 1L7, Canada, Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, New York 13210, Institute of Medical Science and Department of Molecular Genetics, University of Toronto, Toronto M5S 1A8, Canada, and Division of Molecular Neurobiology, National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom
    J Neurosci 34:539-53. 2014
  9. pmc Zac1 plays a key role in the development of specific neuronal subsets in the mouse cerebellum
    Seung Hyuk Chung
    Department of Cell Biology and Anatomy, Hotchkiss Brain Institute, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    Neural Dev 6:25. 2011
  10. ncbi request reprint GSK3 temporally regulates neurogenin 2 proneural activity in the neocortex
    Saiqun Li
    Hotchkiss Brain Institute and Alberta Children s Hospital Research Institute, Department of Biochemistry, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    J Neurosci 32:7791-805. 2012

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Members of the Plag gene family are expressed in complementary and overlapping regions in the developing murine nervous system
    Sharmila Alam
    Department of Biochemistry and Molecular Biology, Institute of Maternal and Child Health, University of Calgary, Calgary, AB, Canada
    Dev Dyn 234:772-82. 2005
    ....
  2. pmc Cell-type specific roles for PTEN in establishing a functional retinal architecture
    Robert Cantrup
    Department of Biochemistry and Molecular Biology, Hotchkiss Brain Institute, Alberta Children s Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada
    PLoS ONE 7:e32795. 2012
    ..Here we investigated the role of the PTEN phosphatase in establishing a functional retinal architecture...
  3. ncbi request reprint Molecular mechanisms underlying cell fate specification in the developing telencephalon
    Carol Schuurmans
    Department of Biochemistry and Molecular Biology, University of Calgary, Room 2221, Health Sciences Center, 3330 Hospital Drive NW, Calgary, Alberta, T2N 1N8, Canada
    Curr Opin Neurobiol 12:26-34. 2002
    ..These include the specification of positional identity, the proliferation of neural stem cells and their commitment to a neuronal or glial fate, and the differentiation of layer-specific neuronal phenotypes in the cerebral cortex...
  4. pmc Zac1 functions through TGFbetaII to negatively regulate cell number in the developing retina
    Lin Ma
    IMCH, HBI, University of Calgary, T2N 4N1, Canada
    Neural Dev 2:11. 2007
    ..Here we report a similar role for two tumor suppressor genes, the Zac1 zinc finger transcription factor and that encoding the cytokine TGFbetaII, in the developing retina...
  5. pmc Basic helix-loop-helix transcription factors cooperate to specify a cortical projection neuron identity
    Pierre Mattar
    Institute of Maternal and Child Health, Hotchkiss Brain Institute, University of Calgary, 2277 HSC, 3330 Hospital Dr NW, Calgary, Alberta, Canada
    Mol Cell Biol 28:1456-69. 2008
    ..Cortical bHLH genes thus cooperate to control transcriptional strength, thereby temporally coordinating downstream gene expression...
  6. doi request reprint Ascl1 participates in Cajal-Retzius cell development in the neocortex
    Rajiv Dixit
    Hotchkiss Brain Institute, Alberta Children s Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Cereb Cortex 21:2599-611. 2011
    ..Notably, this is the first study that reports a function for Ascl1 in the pallium, as this gene is best known for its role in specifying subpallial neuronal identities...
  7. doi request reprint Neural stem cell self-renewal requires the Mrj co-chaperone
    Erica D Watson
    Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada
    Dev Dyn 238:2564-74. 2009
    ..Regardless, Mrj plays an important role in neural stem cell self-renewal...
  8. doi request reprint Neurog1 and Neurog2 control two waves of neuronal differentiation in the piriform cortex
    Rajiv Dixit
    Departments of Biochemistry and Molecular Biology and Medical Genetics, Hotchkiss Brain Institute and Alberta Children s Hospital Research Institute, Department of Pathology and Laboratory Medicine, Southern Alberta Cancer Research Institute, University of Calgary, Alberta T2N 4N1, Canada, Programs in Cell Biology, and Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto M5G 1L7, Canada, Department of Neuroscience and Physiology, SUNY Upstate Medical University, Syracuse, New York 13210, Institute of Medical Science and Department of Molecular Genetics, University of Toronto, Toronto M5S 1A8, Canada, and Division of Molecular Neurobiology, National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom
    J Neurosci 34:539-53. 2014
    ..Neurog1 and Neurog2 thus have unique and redundant functions in the piriform cortex, controlling the timing of differentiation of early-born CR/lot cells and specifying the identities of later-born layer II/III neurons. ..
  9. pmc Zac1 plays a key role in the development of specific neuronal subsets in the mouse cerebellum
    Seung Hyuk Chung
    Department of Cell Biology and Anatomy, Hotchkiss Brain Institute, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    Neural Dev 6:25. 2011
    ....
  10. ncbi request reprint GSK3 temporally regulates neurogenin 2 proneural activity in the neocortex
    Saiqun Li
    Hotchkiss Brain Institute and Alberta Children s Hospital Research Institute, Department of Biochemistry, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    J Neurosci 32:7791-805. 2012
    ..We thus conclude that the temporal regulation of Neurog2-E47 heterodimerization by GSK3 is a central component of the neuronal differentiation "clock" that coordinates the timing and tempo of neocortical neurogenesis in mouse...
  11. doi request reprint Neurog2 simultaneously activates and represses alternative gene expression programs in the developing neocortex
    Christopher Kovach
    University of Calgary, Hotchkiss Brain Institute, Alberta Children s Hospital Research Institute, Health Sciences Centre, Calgary, Alberta, Canada
    Cereb Cortex 23:1884-900. 2013
    ..Neurog2 thus activates several genetic off-switches, each with distinct transcriptional targets, revealing an unappreciated level of specificity for how Neurog2 prevents inappropriate gene expression during neocortical development. ..
  12. pmc Neurog1 and Neurog2 coordinately regulate development of the olfactory system
    Tarek Shaker
    Hotchkiss Brain Institute, Alberta Children s Hospital Research Institute, University of Calgary, Health Sciences Centre, 3330 Hospital Drive NW, Calgary, Alberta, T2N 4N1, Canada
    Neural Dev 7:28. 2012
    ....
  13. doi request reprint RAS/ERK signaling controls proneural genetic programs in cortical development and gliomagenesis
    Saiqun Li
    Departments of Biochemistry and Molecular Biology, Departments of Pathology and Laboratory Medicine, Department of Medical Genetics, Hotchkiss Brain Institute, Alberta Children s Hospital Research Institute, and Southern Alberta Cancer Research Institute, University of Calgary, Calgary, Alberta, Canada, T2N 4N1, and Departments of Pediatrics and Medical Genetics, University of Alberta, Edmonton, Alberta, Canada, T6G 2H7
    J Neurosci 34:2169-90. 2014
    ..RAS/ERK signaling thus acts as a rheostat to influence neural cell fate selection in both normal cortical development and gliomagenesis, controlling Neurog2-Ascl1 expression and Ascl1 function...
  14. pmc Rax is a selector gene for mediobasal hypothalamic cell types
    Fuqu Lu
    Department of Medical Genetics, Alberta Children s Hospital Research Institute, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    J Neurosci 33:259-72. 2013
    ..Rax thus provides a molecular entry point for further study of the ontology and establishment of hypothalamic feeding circuits...
  15. ncbi request reprint STAT5A/B activity is required in the developing forebrain and spinal cord
    Kathryn Markham
    Hotchkiss Brain Institute, Faculty of Medicine, University of Calgary, HSC 2153, 3330 Hospital Drive NW, Calgary, AB, Canada T2N 4N1
    Mol Cell Neurosci 35:272-82. 2007
    ..Taken together, we provide the first evidence that STAT5 is a key effector molecule in the developing mammalian CNS...
  16. ncbi request reprint Zac1 promotes a Müller glial cell fate and interferes with retinal ganglion cell differentiation in Xenopus retina
    Lin Ma
    Genes and Development Research Group, HBI, IMCH, 2207 HSC, University of Calgary, Calgary, AB, Canada
    Dev Dyn 236:192-202. 2007
    ....
  17. ncbi request reprint Validating in utero electroporation for the rapid analysis of gene regulatory elements in the murine telencephalon
    Lisa Marie Langevin
    Institute of Maternal and Child Health, HBI, University of Calgary, Calgary, Canada
    Dev Dyn 236:1273-86. 2007
    ..Taken together, our data supports the contention that in utero technology can be exploited to rapidly examine the architecture and evolution of pallial-specific cis-regulatory elements...
  18. doi request reprint Gene expression is dynamically regulated in retinal progenitor cells prior to and during overt cellular differentiation
    Rajiv Dixit
    Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, AB, Canada Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada Electronic address
    Gene Expr Patterns 14:42-54. 2014
    ....
  19. ncbi request reprint A screen for downstream effectors of Neurogenin2 in the embryonic neocortex
    Pierre Mattar
    University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Dev Biol 273:373-89. 2004
    ..Further analysis of the genes isolated in our screen should provide a fertile basis for understanding the molecular mechanisms underlying corticogenesis...
  20. ncbi request reprint Neurogenin2 specifies the connectivity of thalamic neurons by controlling axon responsiveness to intermediate target cues
    Julie Seibt
    INSERM U371, 18 Avenue Doyen Lepine, 69675 Bron, France
    Neuron 39:439-52. 2003
    ..Our results thus demonstrate that in parallel to their well-documented proneural function, bHLH transcription factors also contribute to the specification of neuronal connectivity in the mammalian brain...
  21. pmc Sequential phases of cortical specification involve Neurogenin-dependent and -independent pathways
    Carol Schuurmans
    IGBMC, Illkirch, CU de Strasbourg, France
    EMBO J 23:2892-902. 2004
    ..Our study thus reveals an unanticipated heterogeneity in the genetic mechanisms specifying the identity of neocortical projection neurons...
  22. pmc p27kip1 independently promotes neuronal differentiation and migration in the cerebral cortex
    Laurent Nguyen
    Division of Molecular Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
    Genes Dev 20:1511-24. 2006
    ..Thus, p27(Kip1) plays a key role in cortical development, acting as a modular protein that independently regulates and couples multiple cellular pathways contributing to neurogenesis...
  23. ncbi request reprint A role for proneural genes in the maturation of cortical progenitor cells
    Olivier Britz
    Division of Molecular Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK
    Cereb Cortex 16:i138-51. 2006
    ..Taken together, these data support a model whereby Ngn2 and Mash1 function together to regulate the zonal distribution of progenitors in the developing neocortex...
  24. ncbi request reprint Phosphorylation of Neurogenin2 specifies the migration properties and the dendritic morphology of pyramidal neurons in the neocortex
    Randal Hand
    Department of Phamacology, Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Neuron 48:45-62. 2005
    ....
  25. pmc A cell-autonomous requirement for the cell cycle regulatory protein, Rb, in neuronal migration
    Kerry L Ferguson
    Ottawa Health Research Institute, University of Ottawa, Ottawa, Ontario, Canada
    EMBO J 24:4381-91. 2005
    ..These results revealed a cell-autonomous role for Rb in regulating the tangential migration of cortical interneurons. Taken together, we reveal a novel requirement for the cell cycle protein, Rb, in the regulation of neuronal migration...
  26. pmc Divergent functions of the proneural genes Mash1 and Ngn2 in the specification of neuronal subtype identity
    Carlos M Parras
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, 67404 Illkirch Cedex, C U de Strasbourg, France
    Genes Dev 16:324-38. 2002
    ....
  27. ncbi request reprint Conserved and acquired features of neurogenin1 regulation
    Patrick Blader
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, 1 rue Laurent Fries, 67404 Illkirch Cedex, CU de Strasbourg, France
    Development 131:5627-37. 2004
    ..Our data provide evidence for the co-option of regulatory regions as a mechanism of evolutionary diversification of expression patterns, and suggest that an alteration in Pax6 expression was crucial in neocortex evolution...