Genomes and Genes
Affiliation: University of Calgary
- Members of the Plag gene family are expressed in complementary and overlapping regions in the developing murine nervous systemSharmila Alam
Department of Biochemistry and Molecular Biology, Institute of Maternal and Child Health, University of Calgary, Calgary, AB, Canada
Dev Dyn 234:772-82. 2005....
- Neurog1 and Neurog2 coordinately regulate development of the olfactory systemTarek Shaker
Hotchkiss Brain Institute, Alberta Children s Hospital Research Institute, University of Calgary, Health Sciences Centre, 3330 Hospital Drive NW, Calgary, Alberta, T2N 4N1, Canada
Neural Dev 7:28. 2012....
- Molecular mechanisms underlying cell fate specification in the developing telencephalonCarol Schuurmans
Department of Biochemistry and Molecular Biology, University of Calgary, Room 2221, Health Sciences Center, 3330 Hospital Drive NW, Calgary, Alberta, T2N 1N8, Canada
Curr Opin Neurobiol 12:26-34. 2002..These include the specification of positional identity, the proliferation of neural stem cells and their commitment to a neuronal or glial fate, and the differentiation of layer-specific neuronal phenotypes in the cerebral cortex...
- Basic helix-loop-helix transcription factors cooperate to specify a cortical projection neuron identityPierre Mattar
Institute of Maternal and Child Health, Hotchkiss Brain Institute, University of Calgary, 2277 HSC, 3330 Hospital Dr NW, Calgary, Alberta, Canada
Mol Cell Biol 28:1456-69. 2008..Cortical bHLH genes thus cooperate to control transcriptional strength, thereby temporally coordinating downstream gene expression...
- Zac1 functions through TGFbetaII to negatively regulate cell number in the developing retinaLin Ma
IMCH, HBI, University of Calgary, T2N 4N1, Canada
Neural Dev 2:11. 2007..Here we report a similar role for two tumor suppressor genes, the Zac1 zinc finger transcription factor and that encoding the cytokine TGFbetaII, in the developing retina...
- Ascl1 participates in Cajal-Retzius cell development in the neocortexRajiv Dixit
Hotchkiss Brain Institute, Alberta Children s Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada T2N 4N1
Cereb Cortex 21:2599-611. 2011..Notably, this is the first study that reports a function for Ascl1 in the pallium, as this gene is best known for its role in specifying subpallial neuronal identities...
- Neural stem cell self-renewal requires the Mrj co-chaperoneErica D Watson
Department of Comparative Biology and Experimental Medicine, Faculty of Veterinary Medicine, University of Calgary, Calgary, Alberta, Canada
Dev Dyn 238:2564-74. 2009..Regardless, Mrj plays an important role in neural stem cell self-renewal...
- GSK3 temporally regulates neurogenin 2 proneural activity in the neocortexSaiqun Li
Hotchkiss Brain Institute and Alberta Children s Hospital Research Institute, Department of Biochemistry, University of Calgary, Calgary, Alberta T2N 4N1, Canada
J Neurosci 32:7791-805. 2012..We thus conclude that the temporal regulation of Neurog2-E47 heterodimerization by GSK3 is a central component of the neuronal differentiation "clock" that coordinates the timing and tempo of neocortical neurogenesis in mouse...
- Zac1 plays a key role in the development of specific neuronal subsets in the mouse cerebellumSeung Hyuk Chung
Department of Cell Biology and Anatomy, Hotchkiss Brain Institute, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada
Neural Dev 6:25. 2011....
- Rax is a selector gene for mediobasal hypothalamic cell typesFuqu Lu
Department of Medical Genetics, Alberta Children s Hospital Research Institute, University of Calgary, Calgary, Alberta T2N 4N1, Canada
J Neurosci 33:259-72. 2013..Rax thus provides a molecular entry point for further study of the ontology and establishment of hypothalamic feeding circuits...
- Validating in utero electroporation for the rapid analysis of gene regulatory elements in the murine telencephalonLisa Marie Langevin
Institute of Maternal and Child Health, HBI, University of Calgary, Calgary, Canada
Dev Dyn 236:1273-86. 2007..Taken together, our data supports the contention that in utero technology can be exploited to rapidly examine the architecture and evolution of pallial-specific cis-regulatory elements...
- Cell-type specific roles for PTEN in establishing a functional retinal architectureRobert Cantrup
Department of Biochemistry and Molecular Biology, Hotchkiss Brain Institute, Alberta Children s Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada
PLoS ONE 7:e32795. 2012..Here we investigated the role of the PTEN phosphatase in establishing a functional retinal architecture...
- STAT5A/B activity is required in the developing forebrain and spinal cordKathryn Markham
Hotchkiss Brain Institute, Faculty of Medicine, University of Calgary, HSC 2153, 3330 Hospital Drive NW, Calgary, AB, Canada T2N 4N1
Mol Cell Neurosci 35:272-82. 2007..Taken together, we provide the first evidence that STAT5 is a key effector molecule in the developing mammalian CNS...
- Zac1 promotes a Müller glial cell fate and interferes with retinal ganglion cell differentiation in Xenopus retinaLin Ma
Genes and Development Research Group, HBI, IMCH, 2207 HSC, University of Calgary, Calgary, AB, Canada
Dev Dyn 236:192-202. 2007....
- Neurog2 simultaneously activates and represses alternative gene expression programs in the developing neocortexChristopher Kovach
University of Calgary, Hotchkiss Brain Institute, Alberta Children s Hospital Research Institute, Health Sciences Centre, Calgary, Alberta, Canada
Cereb Cortex 23:1884-900. 2013..Neurog2 thus activates several genetic off-switches, each with distinct transcriptional targets, revealing an unappreciated level of specificity for how Neurog2 prevents inappropriate gene expression during neocortical development. ..
- A screen for downstream effectors of Neurogenin2 in the embryonic neocortexPierre Mattar
University of Calgary, Calgary, Alberta, Canada T2N 4N1
Dev Biol 273:373-89. 2004..Further analysis of the genes isolated in our screen should provide a fertile basis for understanding the molecular mechanisms underlying corticogenesis...
- A role for proneural genes in the maturation of cortical progenitor cellsOlivier Britz
Division of Molecular Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London, UK
Cereb Cortex 16:i138-51. 2006..Taken together, these data support a model whereby Ngn2 and Mash1 function together to regulate the zonal distribution of progenitors in the developing neocortex...
- Neurogenin2 specifies the connectivity of thalamic neurons by controlling axon responsiveness to intermediate target cuesJulie Seibt
INSERM U371, 18 Avenue Doyen Lepine, 69675 Bron, France
Neuron 39:439-52. 2003..Our results thus demonstrate that in parallel to their well-documented proneural function, bHLH transcription factors also contribute to the specification of neuronal connectivity in the mammalian brain...
- Sequential phases of cortical specification involve Neurogenin-dependent and -independent pathwaysCarol Schuurmans
IGBMC, Illkirch, CU de Strasbourg, France
EMBO J 23:2892-902. 2004..Our study thus reveals an unanticipated heterogeneity in the genetic mechanisms specifying the identity of neocortical projection neurons...
- Divergent functions of the proneural genes Mash1 and Ngn2 in the specification of neuronal subtype identityCarlos M Parras
Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, 67404 Illkirch Cedex, C U de Strasbourg, France
Genes Dev 16:324-38. 2002....
- Phosphorylation of Neurogenin2 specifies the migration properties and the dendritic morphology of pyramidal neurons in the neocortexRandal Hand
Department of Phamacology, Neuroscience Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA
Neuron 48:45-62. 2005....
- A cell-autonomous requirement for the cell cycle regulatory protein, Rb, in neuronal migrationKerry L Ferguson
Ottawa Health Research Institute, University of Ottawa, Ottawa, Ontario, Canada
EMBO J 24:4381-91. 2005..These results revealed a cell-autonomous role for Rb in regulating the tangential migration of cortical interneurons. Taken together, we reveal a novel requirement for the cell cycle protein, Rb, in the regulation of neuronal migration...
- p27kip1 independently promotes neuronal differentiation and migration in the cerebral cortexLaurent Nguyen
Division of Molecular Neurobiology, National Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, United Kingdom
Genes Dev 20:1511-24. 2006..Thus, p27(Kip1) plays a key role in cortical development, acting as a modular protein that independently regulates and couples multiple cellular pathways contributing to neurogenesis...
- Conserved and acquired features of neurogenin1 regulationPatrick Blader
Institut de Genetique et de Biologie Moleculaire et Cellulaire, 1 rue Laurent Fries, 67404 Illkirch Cedex, CU de Strasbourg, France
Development 131:5627-37. 2004..Our data provide evidence for the co-option of regulatory regions as a mechanism of evolutionary diversification of expression patterns, and suggest that an alteration in Pax6 expression was crucial in neocortex evolution...