Andre C Schuh

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi Aberrant regulation of superantigen responses during T-cell reconstitution and graft-versus-host disease in immunodeficient mice
    David Spaner
    Division of Molecular and Cellular Biology, Research Institute S 116A, Sunnybrook and Women s College Health Sciences Center, 2075 Bayview Avenue, Toronto, Ontario, Canada M4N 3M5
    Blood 100:2216-24. 2002
  2. ncbi A tyrosine703serine polymorphism of CD109 defines the Gov platelet alloantigens
    Andre C Schuh
    Institute of Medical Science and the Department of Medicine, University of Toronto, ON, Canada
    Blood 99:1692-8. 2002
  3. doi High-dose cytarabine-based consolidation shows superior results for older AML patients with intermediate risk cytogenetics in first complete remission
    Mona Hassanein
    Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada
    Leuk Res 37:556-60. 2013
  4. doi Outcomes of adult patients with relapsed acute lymphoblastic leukemia following frontline treatment with a pediatric regimen
    Elena Liew
    Department of Medical Oncology and Hematology, Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada
    Leuk Res 36:1517-20. 2012
  5. doi Treatment of Philadelphia chromosome-positive acute lymphoblastic leukaemia with imatinib combined with a paediatric-based protocol
    Santhosh Thyagu
    Department of Medical Oncology and Hematology, Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada
    Br J Haematol 158:506-14. 2012
  6. ncbi Treatment of elderly patients with acute lymphoblastic leukaemia using a paediatric-based protocol
    Marc Poch Martell
    Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada
    Br J Haematol 163:458-64. 2013
  7. ncbi Outcomes of older patients (> or = 60 years) with acquired aplastic anaemia treated with immunosuppressive therapy
    Susan Y Kao
    Department of Medical Oncology and Hematology, Princess Margaret Hospital, Toronto, ON, Canada
    Br J Haematol 143:738-43. 2008
  8. ncbi Predictors of outcome in adults with BCR-ABL negative acute lymphoblastic leukemia treated with a pediatric-based regimen
    Joseph M Brandwein
    Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada Electronic address
    Leuk Res 38:532-6. 2014
  9. doi Influence of FLT3-internal tandem duplication allele burden and white blood cell count on the outcome in patients with intermediate-risk karyotype acute myeloid leukemia
    Jonathan How
    Department of Medical Oncology and Hematology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Cancer 118:6110-7. 2012
  10. doi Feasibility of outpatient consolidation chemotherapy in older versus younger patients with acute myeloid leukemia
    Lalit Saini
    Department of Medical Oncology and Hematology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    Am J Hematol 87:323-6. 2012

Collaborators

  • Vikas Gupta
  • Aaron D Schimmer
  • Mark D Minden
  • Karen W L Yee
  • Wei Xu
  • D Robert Sutherland
  • Hong Chang
  • D E Spaner
  • Michael Shurin
  • Suzanne Kamel-Reid
  • Joseph M Brandwein
  • Eshetu G Atenafu
  • Hans A Messner
  • Jeffrey H Lipton
  • Mona Hassanein
  • Marc Poch Martell
  • Jonathan How
  • Santhosh Thyagu
  • Lalit Saini
  • Elena Liew
  • Murtadha Al-Khabori
  • John M Storring
  • Susan Y Kao
  • Zoya R Yurkovetsky
  • Caitlin Hammond
  • Christina Giesert
  • Martin Lin
  • Cindy Murray
  • Shannon Nixon
  • Jenna Sykes
  • Susan Kao
  • Denise A Barry
  • Paul D Robbins
  • Galina V Shurin
  • Jenny Mena
  • Paul A Wender
  • Amanda E Millar
  • Laszlo Radvanyi
  • Jelena Tomic
  • David Cervi
  • Mark DeBenedette
  • Yonghong Shi
  • Jeremy L Baryza
  • Liwei He
  • Lothar Kanz
  • Anke Marxer
  • Hans Jorg Buhring
  • Wendy Horsfall
  • Rakash Nayar
  • Xiang Fu Wu
  • Erik Yeo
  • Nicholas Totty

Detail Information

Publications18

  1. ncbi Aberrant regulation of superantigen responses during T-cell reconstitution and graft-versus-host disease in immunodeficient mice
    David Spaner
    Division of Molecular and Cellular Biology, Research Institute S 116A, Sunnybrook and Women s College Health Sciences Center, 2075 Bayview Avenue, Toronto, Ontario, Canada M4N 3M5
    Blood 100:2216-24. 2002
    ....
  2. ncbi A tyrosine703serine polymorphism of CD109 defines the Gov platelet alloantigens
    Andre C Schuh
    Institute of Medical Science and the Department of Medicine, University of Toronto, ON, Canada
    Blood 99:1692-8. 2002
    ..We conclude that the Gov alleles are defined by a 2108 A>C SNP that results in a Tyr703Ser substitution of CD109 and that genotyping studies are more accurate for Gov alloantigen determination than are conventional serologic methods...
  3. doi High-dose cytarabine-based consolidation shows superior results for older AML patients with intermediate risk cytogenetics in first complete remission
    Mona Hassanein
    Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada
    Leuk Res 37:556-60. 2013
    ..The results indicate that a high-dose cytarabine-containing consolidation regimen produces superior outcomes in AML patients age>60 years with intermediate-risk cytogenetics...
  4. doi Outcomes of adult patients with relapsed acute lymphoblastic leukemia following frontline treatment with a pediatric regimen
    Elena Liew
    Department of Medical Oncology and Hematology, Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada
    Leuk Res 36:1517-20. 2012
    ..The outcome of adult ALL relapsing after treatment was therefore poor, and novel salvage strategies are needed to improve outcomes...
  5. doi Treatment of Philadelphia chromosome-positive acute lymphoblastic leukaemia with imatinib combined with a paediatric-based protocol
    Santhosh Thyagu
    Department of Medical Oncology and Hematology, Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada
    Br J Haematol 158:506-14. 2012
    ..The combination of imatinib with a paediatric-based regimen in adults produced high response rates, but was associated with considerable toxicity and high non-relapse mortality post-HSCT...
  6. ncbi Treatment of elderly patients with acute lymphoblastic leukaemia using a paediatric-based protocol
    Marc Poch Martell
    Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada
    Br J Haematol 163:458-64. 2013
    ..Survival is superior to most previously reported series in this age group, but remains worse compared to younger patients. Further improvement of the toxicity profile, particularly during induction, is required to improve outcomes...
  7. ncbi Outcomes of older patients (> or = 60 years) with acquired aplastic anaemia treated with immunosuppressive therapy
    Susan Y Kao
    Department of Medical Oncology and Hematology, Princess Margaret Hospital, Toronto, ON, Canada
    Br J Haematol 143:738-43. 2008
    ..Nine out of 14 evaluable patients in the attenuated IST group had durable responses to treatment, suggesting that patients not suitable for standard IST can still benefit from attenuated IST...
  8. ncbi Predictors of outcome in adults with BCR-ABL negative acute lymphoblastic leukemia treated with a pediatric-based regimen
    Joseph M Brandwein
    Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada Electronic address
    Leuk Res 38:532-6. 2014
    ..Cytogenetics and phenotype were not independent predictors of OS. ..
  9. doi Influence of FLT3-internal tandem duplication allele burden and white blood cell count on the outcome in patients with intermediate-risk karyotype acute myeloid leukemia
    Jonathan How
    Department of Medical Oncology and Hematology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Cancer 118:6110-7. 2012
    ....
  10. doi Feasibility of outpatient consolidation chemotherapy in older versus younger patients with acute myeloid leukemia
    Lalit Saini
    Department of Medical Oncology and Hematology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    Am J Hematol 87:323-6. 2012
    ..We conclude that outpatient-based consolidation therapy can be safely undertaken in a substantial proportion of fit older patients with AML...
  11. ncbi Improved survival using an intensive, pediatric-based chemotherapy regimen in adults with T-cell acute lymphoblastic leukemia
    Murtadha Al-Khabori
    Department of Medical Oncology and Hematology, Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada
    Leuk Lymphoma 51:61-5. 2010
    ..non-DFCI) was the major prognostic factor influencing both RFS and OS. The results provide evidence supporting the superior efficacy of asparaginase-intensive pediatric-based regimens for adults with T-ALL...
  12. ncbi Treatment of adults with BCR-ABL negative acute lymphoblastic leukaemia with a modified paediatric regimen
    John M Storring
    Department of Medical Oncology and Haematology, Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada
    Br J Haematol 146:76-85. 2009
    ..Effective delivery of asparaginase dosing appears to be important in achieving an optimal antileukaemic effect...
  13. ncbi Cell surface antigen CD109 is a novel member of the alpha(2) macroglobulin/C3, C4, C5 family of thioester-containing proteins
    Martin Lin
    Department of Medical Biophysics, University of Toronto, ON, Canada
    Blood 99:1683-91. 2002
    ....
  14. ncbi Predictors of response to reinduction chemotherapy for patients with acute myeloid leukemia who do not achieve complete remission with frontline induction chemotherapy
    Joseph M Brandwein
    Department of Medical Oncology and Hematology, Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Am J Hematol 83:54-8. 2008
    ..Patients achieving CR are at high risk of relapse and should be considered for allogeneic BMT or novel strategies to attempt to reduce relapse rates...
  15. ncbi Clinico-biological features and prognostic significance of PML/RARalpha isoforms in adult patients with acute promyelocytic leukemia treated with all trans retinoic acid (ATRA) and chemotherapy
    Vikas Gupta
    Department of Medical Oncology and Hematology, Princess Margaret Hospital, University of Toronto, Canada
    Leuk Lymphoma 45:469-80. 2004
    ..No difference in overall survival was seen between the two isoform groups (P 0.35). Our results suggest that based on molecular characterization, it may be possible to identify a subgroup of APL patients at higher-risk of relapse...
  16. ncbi Effect of serum and antioxidants on the immunogenicity of protein kinase C-activated chronic lymphocytic leukemia cells
    Caitlin Hammond
    Division of Molecular and Cellular Biology, Research Institute, Sunnybrook and Women s College Health Sciences Center, 2075 Bayview Avenue, Toronto, Canada M4N 3M5
    J Immunother 28:28-39. 2005
    ..The observation that CLL cells can acquire features of dendritic cells that promote type 1 immunity may find clinical application in immunotherapeutic strategies for this disease...
  17. ncbi Antibody W7C5 defines a CD109 epitope expressed on CD34+ and CD34- hematopoietic and mesenchymal stem cell subsets
    Christina Giesert
    University of Tubingen, Department of Internal Medicine II, Division of Hematology, Immunology, and Oncology, Tubingen, Germany
    Ann N Y Acad Sci 996:227-30. 2003
    ..The specificity of MoAb W7C5 was further confirmed by the selective recognition of CHO cells transfected with human CD109 cDNA...
  18. ncbi Comparative analysis of antitumor activity of CD40L, RANKL, and 4-1BBL in vivo following intratumoral administration of viral vectors or transduced dendritic cells
    Zoya R Yurkovetsky
    Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA
    J Gene Med 8:129-37. 2006
    ..Taken together, these results demonstrate that adenoviral gene transfer of CD40L, RANKL or 4-1BBL elicit a significant antitumor effect in two different tumor models, with CD40L gene transfer inducing the strongest antitumor effect...