Sheila M Schmutz

Summary

Affiliation: University of Saskatchewan
Country: Canada

Publications

  1. ncbi request reprint The genetics of cream coat color in dogs
    Sheila M Schmutz
    Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, Canada S7N 5A8
    J Hered 98:544-8. 2007
  2. doi request reprint Interaction of MC1R and PMEL alleles on solid coat colors in Highland cattle
    Sheila M Schmutz
    Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, SK, S7N 5A8, Canada
    Anim Genet 44:9-13. 2013
  3. doi request reprint Coat color DNA testing in dogs: theory meets practice
    Sheila M Schmutz
    Department of Animal and Poultry Science, University of Saskatchewan, 51 Campus Dr, Saskatoon, Saskatchewan S7N 5A8, Canada
    Mol Cell Probes 26:238-42. 2012
  4. ncbi request reprint Agouti sequence polymorphisms in coyotes, wolves and dogs suggest hybridization
    Sheila M Schmutz
    Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, Canada S7N 5A8
    J Hered 98:351-5. 2007
  5. ncbi request reprint Genes affecting coat colour and pattern in domestic dogs: a review
    S M Schmutz
    Department of Animal and Poultry Science, University of Saskatchewan, 51 Campus Drive, Saskatoon, SK, Canada S7N 5A8
    Anim Genet 38:539-49. 2007
  6. doi request reprint A SINE insertion causes the black-and-tan and saddle tan phenotypes in domestic dogs
    Dayna L Dreger
    Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, Canada
    J Hered 102:S11-8. 2011
  7. ncbi request reprint TYRP1 and MC1R genotypes and their effects on coat color in dogs
    Sheila M Schmutz
    Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5A8
    Mamm Genome 13:380-7. 2002
  8. ncbi request reprint TYRP1 is associated with dun coat colour in Dexter cattle or how now brown cow?
    T G Berryere
    Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Anim Genet 34:169-75. 2003
  9. ncbi request reprint Association of an Agouti allele with fawn or sable coat color in domestic dogs
    Tom G Berryere
    Department of Animal and Poultry Science, University of Saskatchewan, 51 Campus Drive, Saskatoon, Saskatchewan, Canada S7N 5A8
    Mamm Genome 16:262-72. 2005
  10. ncbi request reprint Linkage mapping of Microphthalmia-associated transcription factor to cattle chromosome 22
    S A Strom
    Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, Sask, Canada S7N 5A8
    Anim Genet 35:257-8. 2004

Collaborators

Detail Information

Publications42

  1. ncbi request reprint The genetics of cream coat color in dogs
    Sheila M Schmutz
    Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, Canada S7N 5A8
    J Hered 98:544-8. 2007
    ..A microsatellite was detected in a published BAC sequence (GenBank no. AAEX01017083) in intron 2 and was used to map SLC45A2 to CFA4...
  2. doi request reprint Interaction of MC1R and PMEL alleles on solid coat colors in Highland cattle
    Sheila M Schmutz
    Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, SK, S7N 5A8, Canada
    Anim Genet 44:9-13. 2013
    ..50_51delTTC alleles, as Charolais cattle with PMEL :c.64G>A alleles. The PMEL :c.64G>A allele was not found in Highland or Galloway cattle...
  3. doi request reprint Coat color DNA testing in dogs: theory meets practice
    Sheila M Schmutz
    Department of Animal and Poultry Science, University of Saskatchewan, 51 Campus Dr, Saskatoon, Saskatchewan S7N 5A8, Canada
    Mol Cell Probes 26:238-42. 2012
    ..A robust protocol with DNA obtained by cheek brushes and interchanges among dog owners via the internet, have likely lead to this expanded use by clients...
  4. ncbi request reprint Agouti sequence polymorphisms in coyotes, wolves and dogs suggest hybridization
    Sheila M Schmutz
    Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, Canada S7N 5A8
    J Hered 98:351-5. 2007
    ..We could conclude that these were coyote-dog hybrids because both were heterozygous for 2 mutations causing fawn coat color in dogs...
  5. ncbi request reprint Genes affecting coat colour and pattern in domestic dogs: a review
    S M Schmutz
    Department of Animal and Poultry Science, University of Saskatchewan, 51 Campus Drive, Saskatoon, SK, Canada S7N 5A8
    Anim Genet 38:539-49. 2007
    ..Because coat colour is such a visible trait, this information will also be a valuable teaching resource...
  6. doi request reprint A SINE insertion causes the black-and-tan and saddle tan phenotypes in domestic dogs
    Dayna L Dreger
    Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, Canada
    J Hered 102:S11-8. 2011
    ..Genotypes of 201 dogs of 35 breeds suggest that there are only 4 ASIP alleles, as opposed to the 5 or 6 predicted in previous literature. These data demonstrate that the dominance hierarchy of ASIP is a(y) > a(w) > a(t) > a...
  7. ncbi request reprint TYRP1 and MC1R genotypes and their effects on coat color in dogs
    Sheila M Schmutz
    Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5A8
    Mamm Genome 13:380-7. 2002
    ..The black or brown nose correlated perfectly with the absence or presence of the same three TYRP1 variants described above. TYRP1 was linkage mapped to dog chromosome 11, with a SNP in exon 7...
  8. ncbi request reprint TYRP1 is associated with dun coat colour in Dexter cattle or how now brown cow?
    T G Berryere
    Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Anim Genet 34:169-75. 2003
    ..None of the 70 remaining black or red Dexter cattle were homozygous for Y434. This tyrosine mutation was not found in any of the 121 cattle of other breeds that were examined...
  9. ncbi request reprint Association of an Agouti allele with fawn or sable coat color in domestic dogs
    Tom G Berryere
    Department of Animal and Poultry Science, University of Saskatchewan, 51 Campus Drive, Saskatoon, Saskatchewan, Canada S7N 5A8
    Mamm Genome 16:262-72. 2005
    ..This work resolves some of the complexity in dog coat color genetics and provides diagnostic opportunities and practical guidelines for breeders...
  10. ncbi request reprint Linkage mapping of Microphthalmia-associated transcription factor to cattle chromosome 22
    S A Strom
    Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, Sask, Canada S7N 5A8
    Anim Genet 35:257-8. 2004
  11. ncbi request reprint Linkage mapping of IGF2 on cattle chromosome 29
    J J Goodall
    Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, Canada S7N 5A8
    Anim Genet 34:313. 2003
  12. ncbi request reprint A form of albinism in cattle is caused by a tyrosinase frameshift mutation
    Sheila M Schmutz
    Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5A8
    Mamm Genome 15:62-7. 2004
    ..Diagnostic genotyping tests were developed to detect this mutation in Braunvieh cattle...
  13. doi request reprint A new mutation in MC1R explains a coat color phenotype in 2 "old" breeds: Saluki and Afghan hound
    Dayna L Dreger
    Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, Canada
    J Hered 101:644-9. 2010
    ..Arg306ter) alleles at MC1R but recessive to the E(M) (p.Met264Val) allele. The K(B) allele (p.Gly23del) at DEFB103 and the a(y) allele (p.Ala82Ser and p.Arg83His) of ASIP are epistatic to grizzle and domino...
  14. ncbi request reprint The scurs locus in cattle maps to bovine chromosome 19
    M Asai
    Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Anim Genet 35:34-9. 2004
    ..Because the polled locus has been mapped to the centromeric end of chromosome 1 and scurs has now been mapped to chromosome 19, these two traits are not linked in Bos taurus...
  15. ncbi request reprint A missense mutation in the bovine MGF gene is associated with the roan phenotype in Belgian Blue and Shorthorn cattle
    J J Seitz
    Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, SK Canada S7N 5B5
    Mamm Genome 10:710-2. 1999
    ..usask.ca/ approximately schmutz) was used to verify Mendelian inheritance of this marker with the phenotypic inheritance of roan. Our data suggest that this mutation in the bovine MGF gene is responsible for the roan phenotype...
  16. doi request reprint A case of canine chimerism diagnosed using coat color tests
    Dayna L Dreger
    Department of Animal and Poultry Science, College of Agriculture and Bioresources, University of Saskatchewan, 51 Campus Drive, Saskatoon, SK, Canada S7N 5A8
    Mol Cell Probes 26:253-5. 2012
    ..Coat color alleles vary widely among dog breeds, presenting a novel method for detecting chimerism using diagnostic tests for known coat color alleles...
  17. ncbi request reprint Linkage mapping of TYR to dog chromosome 21
    B H Schmidtz
    Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, S7N 5A8 Canada
    Anim Genet 33:476-7. 2002
  18. ncbi request reprint Development of the Canadian beef reference herd for gene mapping studies
    S M Schmutz
    Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, Canada
    Theriogenology 55:963-72. 2001
    ..Response to superovulation was negatively correlated with backfat of the donor. Crossbred embryos were found to have higher survival than purebred embryos...
  19. ncbi request reprint No association between the neurotensin (NTS ) gene and production traits in beef cattle
    K D Reddick
    Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon S7N 5A8, Canada
    Anim Genet 38:427-8. 2007
  20. ncbi request reprint In situ hybridization of five loci to cattle chromosome 1
    S M Schmutz
    Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, Saskatchewan Canada
    Cytogenet Cell Genet 81:51-3. 1998
    ..These localizations agree with the homology previously shown between BTA 1 and human chromosome 3 (HSA 3). Some homology with HSA 1 has been established with the mapping of THH and IVL to BTA 1q4...
  21. doi request reprint Genetic variation in the pro-melanin-concentrating hormone gene affects carcass traits in Bos taurus cattle
    S C Helgeson
    Department of Animal and Poultry Science, University of Saskatchewan, 72 Campus Drive, Saskatoon, SK S7N 5A8, Canada
    Anim Genet 39:310-5. 2008
    ..The g.-134A allele occurred in 67% of cattle examined and was associated with higher fat levels...
  22. ncbi request reprint An SNP in DCT is used for linkage mapping on cattle chromosome 12
    S M Schmutz
    Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, Canada
    Anim Genet 31:336. 2000
  23. ncbi request reprint Physical mapping of SOD1 to bovine chromosome 1
    S M Schmutz
    Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, Canada
    Cytogenet Cell Genet 72:37-9. 1996
    ..The map location of SOD1 is close to collagen 6A1. SOD1 is a potentially important type 1 anchor locus in the region where the gene for horns in cattle was recently mapped (Georges et al., 1993; Schmutz et al., 1995)...
  24. ncbi request reprint IGF2 gene characterization and association with rib eye area in beef cattle
    J J Goodall
    Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, SK S7N 5A8, Canada
    Anim Genet 38:154-61. 2007
    ..292C>T SNP was associated with an increase in rib eye area (REA) in two populations of cattle, with the C.-292C allele associated with a 10% increase. A significant association with per cent fat was found in one of the populations...
  25. ncbi request reprint Hot topic: an association between a leptin single nucleotide polymorphism and milk and protein yield
    F C Buchanan
    Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, Canada
    J Dairy Sci 86:3164-6. 2003
    ..44 kg/d), declining to 1.74 kg/d between 101 and 200 d in lactation. The milk yield advantage, observed in cows homozygous for the T allele, could represent a major economic advantage to dairy producers...
  26. ncbi request reprint KITLG maps to canine chromosome 15 and is excluded as a candidate gene for merle in dogs
    S M Schmutz
    Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5A8
    Anim Genet 34:75-6. 2003
  27. ncbi request reprint MC1R studies in dogs with melanistic mask or brindle patterns
    S M Schmutz
    Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5A8
    J Hered 94:69-73. 2003
    ..These results suggest that black mask, but not brindle, is caused by a specific MC1R allele...
  28. ncbi request reprint A QTL study of cattle behavioral traits in embryo transfer families
    S M Schmutz
    Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, Canada
    J Hered 92:290-2. 2001
    ..36 for temperament and 0.46 for habituation. Genotyping of 162 microsatellites at approximately 20 cM intervals allowed the detection of six quantitative trait loci (QTL) for behavior traits on cattle chromosomes 1, 5, 9, 11, 14, 15...
  29. ncbi request reprint Linkage mapping of the tyrosinase gene to bovine chromosome 29
    B H Schmidtz
    Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, Canada
    Anim Genet 32:119-20. 2001
  30. ncbi request reprint Linkage mapping of MMP1 to cattle chromosome 15
    K M Christison
    Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, S7N 5A8 Canada
    Anim Genet 32:316. 2001
  31. pmc Association of a missense mutation in the bovine leptin gene with carcass fat content and leptin mRNA levels
    Fiona C Buchanan
    Department of Animal and Poultry Science, 51 Campus Drive, University of Saskatchewan, Saskatoon, S7N 5A8, Canada
    Genet Sel Evol 34:105-16. 2002
    ..This may suggest that the T allele, which adds an extra cysteine to the protein, imparts a partial loss of biological function and hence could be the causative mutation...
  32. ncbi request reprint Beta-mannosidase maps to cattle chromosome 6
    S M Schmutz
    Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, Canada
    Mamm Genome 7:474. 1996
  33. ncbi request reprint In situ hybridization mapping of LDHA and IGF2 to cattle chromosome 29
    S M Schmutz
    Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, Canada
    Mamm Genome 7:473. 1996
  34. doi request reprint The variant red coat colour phenotype of Holstein cattle maps to BTA27
    D L Dreger
    Department of Animal and Poultry Science, University of Saskatchewan, Saskatoon, Canada
    Anim Genet 41:109-12. 2010
    ..Two newly identified microsatellites and 5 SNPs 5' of DEFB103 were used for linkage mapping in four segregating families (LOD = 3.26). One haplotype was inherited in VR cattle in a 6-generation pedigree...
  35. doi request reprint Identification of a mutation that is associated with the saddle tan and black-and-tan phenotypes in Basset Hounds and Pembroke Welsh Corgis
    Dayna L Dreger
    Department of Animal and Poultry Science, University of Saskatchewan, 51 Campus Dr, Saskatoon, SK, Canada
    J Hered 104:399-406. 2013
    ..We suggest that a multi-gene interaction involving ASIP, RALY, MC1R, DEFB103, and a yet-unidentified modifier gene is required for expression of saddle tan...
  36. ncbi request reprint Genetic mapping of the ADRB2 gene on cattle chromosome 7
    R J Schimpf
    Department of Animal and Poultry Science, College of Agriculture, University of Sakskatchewan, Saskatoon SK, Canada S7N 5A8
    Anim Genet 32:390. 2001
  37. pmc Polymorphisms within the canine MLPH gene are associated with dilute coat color in dogs
    Ute Philipp
    Institute of Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Bunteweg 17p, 30559 Hannover, Germany
    BMC Genet 6:34. 2005
    ..In humans and mice a comparable pigmentation phenotype without any documented hair loss is caused by mutations within the melanophilin gene (MLPH)...
  38. pmc A -defensin mutation causes black coat color in domestic dogs
    Sophie I Candille
    Departments of Genetics and Pediatrics, Stanford University, Stanford, CA, USA
    Science 318:1418-23. 2007
    ..These results expand the functional role of beta-defensins, a protein family previously implicated in innate immunity, and identify an additional class of ligands for signaling through melanocortin receptors...
  39. pmc Linkage and segregation analysis of black and brindle coat color in domestic dogs
    Julie A Kerns
    Department of Genetics, Stanford University, Stanford, California 94035, USA
    Genetics 176:1679-89. 2007
    ..These findings suggest a molecular model for a new component of the melanocortin signaling pathway and reveal how coat-color patterns and pigmentary diversity have been shaped by recent selection...
  40. ncbi request reprint Characterization of the dog Agouti gene and a nonagoutimutation in German Shepherd Dogs
    Julie A Kerns
    Departments of Genetics and Pediatrics, Stanford University, Stanford, California 94305, USA
    Mamm Genome 15:798-808. 2004
    ....
  41. ncbi request reprint Fatty acid composition of muscle fat and enzymes of storage lipid synthesis in whole muscle from beef cattle
    E Chris Kazala
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton AB T6G 2P5, Canada
    Lipids 41:1049-57. 2006
    ..The increased proportion of oleic acid associated with enhanced lipid content of whole muscle is noteworthy given the known health benefits of this FA...
  42. pmc Black hair follicular dysplasia in Large Münsterländer dogs: clinical, histological and ultrastructural features
    Wolf von Bomhard
    Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, 19104, USA
    Vet Dermatol 17:182-8. 2006
    ..In view of the correlation in the phenotype, histology and ultrastructure between both disorders, a defect in intracellular melanosome transport is postulated as the pathogenic mechanism in BHFD...