D W Scheifele

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. doi request reprint Compatibility of ASO3-adjuvanted H1N1pdm09 and seasonal trivalent influenza vaccines in adults: results of a randomized, controlled trial
    David W Scheifele
    Vaccine Evaluation Center, University of British Columbia, Vancouver, BC, Canada
    Vaccine 30:4728-32. 2012
  2. pmc Seroprevalence of hepatitis A infection in a low endemicity country: a systematic review
    Ba Pham
    Biomedical Data Sciences, GlaxoSmithKline, Ontario, Canada
    BMC Infect Dis 5:56. 2005
  3. ncbi request reprint Ocular and respiratory symptoms attributable to inactivated split influenza vaccine: evidence from a controlled trial involving adults
    David W Scheifele
    Canadian Association for Immunization Research and Evaluation of Vancouver, British Columbia, Canada
    Clin Infect Dis 36:850-7. 2003
  4. ncbi request reprint Immunization Monitoring Program, Active: a model of active surveillance of vaccine safety
    David W Scheifele
    Immunization Monitoring Program, Active IMPACT, Ottawa, Ontario, Canada
    Semin Pediatr Infect Dis 14:213-9. 2003
  5. ncbi request reprint Safety and immunogenicity of a pentavalent combination vaccine (diphtheria, tetanus, acellular pertussis, polio, and haemophilus influenzae type B conjugate) when administered as a fourth dose at 15 to 18 months of age
    D W Scheifele
    Vaccine Evaluation Center, British Columbia s Children s Hospital, Vancouver, British Columbia, Canada
    Hum Vaccin 1:180-6. 2005
  6. ncbi request reprint Hepatitis A vaccines: the growing case for universal immunisation of children
    David W Scheifele
    BC Children s Hospital, Vaccine Evaluation Center, University of British Columbia, Vancouver, British Columbia, Canada
    Expert Opin Pharmacother 6:157-64. 2005
  7. ncbi request reprint A modified vaccine reduces the rate of large injection site reactions to the preschool booster dose of diphtheria-tetanus-acellular pertussis vaccine: results of a randomized, controlled trial
    David W Scheifele
    Canadian Association for Immunization Research and Evaluation CAIRE and the Vaccine Evaluation Center, BC Children s Hospital and the University of British Columbia, Vancouver, British Columbia, Canada
    Pediatr Infect Dis J 24:1059-66. 2005
  8. ncbi request reprint Assessment of the compatibility of co-administered 7-valent pneumococcal conjugate, DTaP.IPV/PRP-T Hib and hepatitis B vaccines in infants 2-7 months of age
    David W Scheifele
    Vaccine Evaluation Center, BC Children s Hospital, 4500 Oak Street, Vancouver, BC, Canada V6H 3N1
    Vaccine 24:2057-64. 2006
  9. pmc Invasive Haemophilus influenzae type b infections in vaccinated and unvaccinated children in Canada, 2001-2003
    David Scheifele
    British Columbia s Children s Hospital, 4500 Oak St, Vancouver BC V6H 3N1
    CMAJ 172:53-6. 2005
  10. ncbi request reprint Unique roles of a data and safety monitoring board in vaccine safety trials with compressed timelines and urgent implications
    David Scheifele
    Canadian Association for Immunization Research and Evaluation, Vancouver, British Columbia, Canada
    Control Clin Trials 24:99-104. 2003

Collaborators

Detail Information

Publications43

  1. doi request reprint Compatibility of ASO3-adjuvanted H1N1pdm09 and seasonal trivalent influenza vaccines in adults: results of a randomized, controlled trial
    David W Scheifele
    Vaccine Evaluation Center, University of British Columbia, Vancouver, BC, Canada
    Vaccine 30:4728-32. 2012
    ..Adverse event rates were not increased by concurrent vaccinations above those with H1N1pdm09 vaccine alone. This adjuvanted H1N1pdm09 vaccine was immunogenic and compatible with concurrently administered TIV...
  2. pmc Seroprevalence of hepatitis A infection in a low endemicity country: a systematic review
    Ba Pham
    Biomedical Data Sciences, GlaxoSmithKline, Ontario, Canada
    BMC Infect Dis 5:56. 2005
    ..This systematic review aimed to 1) estimate age-specific prevalence of HAV antibody in Canada and 2) evaluate infection-associated risk factors...
  3. ncbi request reprint Ocular and respiratory symptoms attributable to inactivated split influenza vaccine: evidence from a controlled trial involving adults
    David W Scheifele
    Canadian Association for Immunization Research and Evaluation of Vancouver, British Columbia, Canada
    Clin Infect Dis 36:850-7. 2003
    ..We conclude that certain mild oculorespiratory symptoms were triggered by an influenza vaccine that was otherwise minimally reactogenic and, hence, that such symptoms might be associated with influenza vaccines in general...
  4. ncbi request reprint Immunization Monitoring Program, Active: a model of active surveillance of vaccine safety
    David W Scheifele
    Immunization Monitoring Program, Active IMPACT, Ottawa, Ontario, Canada
    Semin Pediatr Infect Dis 14:213-9. 2003
    ..Concomitant disease surveillance has been important for sustaining the surveillance system because few postimmunization adverse events require hospital admission...
  5. ncbi request reprint Safety and immunogenicity of a pentavalent combination vaccine (diphtheria, tetanus, acellular pertussis, polio, and haemophilus influenzae type B conjugate) when administered as a fourth dose at 15 to 18 months of age
    D W Scheifele
    Vaccine Evaluation Center, British Columbia s Children s Hospital, Vancouver, British Columbia, Canada
    Hum Vaccin 1:180-6. 2005
    ..The fourth dose was well tolerated in all age groups. Toddlers at 15, 16, 17 or 18 months of age are equally suitable recipients for booster immunization with the DTaP-IPV//PRP-T vaccine...
  6. ncbi request reprint Hepatitis A vaccines: the growing case for universal immunisation of children
    David W Scheifele
    BC Children s Hospital, Vaccine Evaluation Center, University of British Columbia, Vancouver, British Columbia, Canada
    Expert Opin Pharmacother 6:157-64. 2005
    ..Universal programmes are cost-effective, especially when a combined hepatitis A and B vaccine can be used to minimise incremental costs, and deserve wider consideration in developed countries...
  7. ncbi request reprint A modified vaccine reduces the rate of large injection site reactions to the preschool booster dose of diphtheria-tetanus-acellular pertussis vaccine: results of a randomized, controlled trial
    David W Scheifele
    Canadian Association for Immunization Research and Evaluation CAIRE and the Vaccine Evaluation Center, BC Children s Hospital and the University of British Columbia, Vancouver, British Columbia, Canada
    Pediatr Infect Dis J 24:1059-66. 2005
    ..Large injection site reactions commonly follow booster doses of diphtheria-tetanus-acellular pertussis (DTaP) vaccines at 4-6 years of age. A vaccine with lower diphtheria and pertussis dosage (Tdap) might be better tolerated for this dose...
  8. ncbi request reprint Assessment of the compatibility of co-administered 7-valent pneumococcal conjugate, DTaP.IPV/PRP-T Hib and hepatitis B vaccines in infants 2-7 months of age
    David W Scheifele
    Vaccine Evaluation Center, BC Children s Hospital, 4500 Oak Street, Vancouver, BC, Canada V6H 3N1
    Vaccine 24:2057-64. 2006
    ..008) and HB responses were reduced (p=0.006) with concurrent dosing, the latter possibly from same thigh injection with DTaP.IPV/Hib. We conclude that PCV7, DTaP.IPV/Hib and HB are compatible with concurrent, separate injections...
  9. pmc Invasive Haemophilus influenzae type b infections in vaccinated and unvaccinated children in Canada, 2001-2003
    David Scheifele
    British Columbia s Children s Hospital, 4500 Oak St, Vancouver BC V6H 3N1
    CMAJ 172:53-6. 2005
    ..We report on the causes of Hib infections among vaccinated and unvaccinated children between 2001 and 2003 in Canada...
  10. ncbi request reprint Unique roles of a data and safety monitoring board in vaccine safety trials with compressed timelines and urgent implications
    David Scheifele
    Canadian Association for Immunization Research and Evaluation, Vancouver, British Columbia, Canada
    Control Clin Trials 24:99-104. 2003
    ..Providing a safety valve for inevitable tensions between investigators and sponsor was an understated but significant role. Lessons from our experience will be particularly pertinent to future studies of pandemic influenza vaccines...
  11. ncbi request reprint Immunologic considerations for the timing of the booster dose of 7-valent pneumococcal conjugate vaccine in young children
    David W Scheifele
    Vaccine Evaluation Center, BC Children s Hospital and the University of British Columbia, Vancouver, BC, Canada
    Pediatr Infect Dis J 26:387-92. 2007
    ....
  12. doi request reprint Cellular immunity as a potential cause of local reactions to booster vaccination with diphtheria and tetanus toxoids and acellular pertussis antigens
    David W Scheifele
    Vaccine Evaluation Center, BC Children s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Pediatr Infect Dis J 28:985-9. 2009
    ..Cell-mediated immunity (CMI) develops after primary DTaP vaccination and might contribute to local reactions to booster doses, a possibility explored in this study...
  13. doi request reprint A nationwide survey of past hepatitis A infections among Canadian adults
    David W Scheifele
    University of British Columbia, Vancouver, BC, Canada
    Vaccine 28:5174-8. 2010
    ..A nationwide pediatric serosurvey in 2003 confirmed that HAV infection is uncommon in children. Additional seroepidemiological data for adults would help to guide domestic use of HAV vaccines...
  14. ncbi request reprint Invasive pneumococcal infections in Canadian children, 1991-1998: implications for new vaccination strategies. Canadian Paediatric Society/Laboratory Centre for Disease Control Immunization Monitoring Program, Active (IMPACT)
    D Scheifele
    Canadian Paediatric Society, Ottawa, Ontario, Canada
    Clin Infect Dis 31:58-64. 2000
    ..New conjugate vaccines have great potential but their effectiveness and limitations require ongoing study...
  15. doi request reprint Ongoing control of Haemophilus influenzae type B infections in Canadian children, 2004-2007
    David W Scheifele
    Division of Pediatric Infectious and Immunologic Diseases, University of British Columbia, Vancouver, British Columbia
    Pediatr Infect Dis J 27:755-7. 2008
    ..Surveillance at 12 pediatric centers in 2004-2007 indicates that vaccine failures remain rare and case totals approach an irreducible minimum, with no age shift...
  16. ncbi request reprint Assessment of injection site reactions to an acellular pertussis-based combination vaccine, including novel use of skin tests with vaccine antigens
    D W Scheifele
    Vaccine Evaluation Center, BC s Children s Hospital, 4500 Oak Street and the University of British Columbia, BC, V6H 3V4, Vancouver, Canada
    Vaccine 19:4720-6. 2001
    ....
  17. pmc Hepatitis A vaccine: is it being used to best advantage?
    David W Scheifele
    Vaccine Evaluation Center, British Columbia s Children s Hospital, Department of Pediatrics, University of British Columbia, Vancouver
    CMAJ 167:44-5. 2002
  18. ncbi request reprint Evaluation of ready-to-use and multi-dose influenza vaccine formats in large clinic settings
    D W Scheifele
    Vaccine Evaluation Center, B C s Children s Hospital, Vancouver
    Can J Public Health 91:329-32. 2000
    ..Depending upon product and packaging style, programs using vials are cheaper by $709-$926 per 100 doses delivered compared to using pre-filled syringes...
  19. ncbi request reprint Comparative safety of tetanus-diphtheria toxoids booster immunization in students in Grades 6 and 9
    D W Scheifele
    Vaccine Evaluation Center, BC s Children s Hospital, University of British Columbia, Vancouver, Canada
    Pediatr Infect Dis J 17:1121-6. 1998
    ..However, earlier vaccination might cause greater side effects. This study was undertaken to compare the safety of Td vaccinations in students in Grade 6 (11 to 12 years old) and Grade 9...
  20. doi request reprint Postvaccination thrombocytopenia in Canada
    Laura J Sauve
    Vaccine Evaluation Center, BC Children s Hospital and the University of British Columbia, Vancouver, British Columbia, Canada
    Pediatr Infect Dis J 29:559-61. 2010
    ..With treatment, 28 children (26%) had normal platelet counts on discharge from hospital and 93% had documented recovery within 3 months...
  21. doi request reprint Cortisol, behavior, and heart rate reactivity to immunization pain at 4 months corrected age in infants born very preterm
    Ruth E Grunau
    Department of Pediatrics, University of British Columbia, Vancouver BC, Canada
    Clin J Pain 26:698-704. 2010
    ..To our knowledge, cortisol reactivity to pain has not been compared in preterm and full-term infants. We examined pain reactivity to immunization in preterm and full-term infants...
  22. pmc Adverse reactions to the preschool (fifth) dose of adsorbed diphtheria-pertussis-tetanus vaccine in Canadian children
    D W Scheifele
    Vaccine Evaluation Center, British Columbia s Children s Hospital, Vancouver
    CMAJ 145:641-7. 1991
    ....
  23. pmc New, ultrasensitive enzyme immunoassay for detecting vaccine- and disease-induced hepatitis A virus-specific immunoglobulin G in saliva
    J J Ochnio
    Vaccine Evaluation Center, BC s Children s Hospital, Vancouver, Canada
    J Clin Microbiol 35:98-101. 1997
    ..We conclude that this assay is sufficiently sensitive for reliable detection of both vaccine- and infection-induced HAV-specific immunoglobulin G in saliva, even when corresponding anti-HAV levels in serum are very low (< 1 IU/ml)...
  24. ncbi request reprint Assessment of parent education methods for infant immunization
    G L Bjornson
    Vaccine Evaluation Center, University of British Columbia, Vancouver
    Can J Public Health 88:405-8. 1997
    ..To assess whether a video about infant immunization could inform parents as well as human counselling (oral presentation)...
  25. pmc Emergence of penicillin-nonsusceptible Streptococcus pneumoniae invasive clones in Canada
    D Greenberg
    Division of Infectious and Immunological Diseases, Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada
    J Clin Microbiol 40:68-74. 2002
    ..The exact reasons for the successful spread of these clones within Canada and their contribution to increased resistance to antibiotics have yet to be explored...
  26. ncbi request reprint Decrease in hospital admissions for febrile seizures and reports of hypotonic-hyporesponsive episodes presenting to hospital emergency departments since switching to acellular pertussis vaccine in Canada: a report from IMPACT
    Nicole Le Saux
    Department of Pediatrics, University of Ottawa, Ottawa, Ontario, Canada
    Pediatrics 112:e348. 2003
    ..We hypothesized that the change would result in a decrease in hospitalization rates for seizures and reports of hypotonic-hyporesponsive episodes (HHEs) temporally related to pertussis vaccination...
  27. ncbi request reprint Injection-site reactions to booster doses of acellular pertussis vaccine: rate, severity, and anticipated impact
    Danuta M Skowronski
    University of British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada
    Pediatrics 112:e453. 2003
    ....
  28. ncbi request reprint Randomized, double-blind, placebo-controlled trial to assess the rate of recurrence of oculorespiratory syndrome following influenza vaccination among persons previously affected
    Danuta M Skowronski
    Canadian Association for Immunization Research and Evaluation, Vancouver, British Columbia, Canada
    Clin Infect Dis 37:1059-66. 2003
    ..Previously affected persons should be informed of the risk of ORS recurrence but also that episodes of such recurrence are mild and well tolerated...
  29. ncbi request reprint Serious adverse events associated with bacille Calmette-Guérin vaccine in Canada
    Shelley L Deeks
    Immunization and Respiratory Infections Division, Community Acquired Infections Division, Public Health Agency of Canada, Health Canada, Ottawa, Ontario
    Pediatr Infect Dis J 24:538-41. 2005
    ..Targeted Bacille Calmette-Guérin (BCG) vaccination is offered to neonates in some First Nations and Inuit (FNI) communities in Canada. Serious adverse events associated with BCG vaccine prompted a review to assess causality...
  30. ncbi request reprint Effectiveness of pneumococcal conjugate vaccine in Greater Vancouver, Canada: 2004-2005
    Gordean Bjornson
    Vaccine Evaluation Center, BC Children s Hospital, Vancouver, B C, Canada
    Pediatr Infect Dis J 26:540-2. 2007
    ..In the subpopulation with best case ascertainment disease rates for 6-23 month olds decreased 84.6% (92.5% for vaccine serotypes)...
  31. ncbi request reprint Outcome of penicillin-nonsusceptible Streptococcus pneumoniae meningitis: a nested case-control study
    James D Kellner
    Canadian Paediatric Society, Ottawa, Ontario, Canada
    Pediatr Infect Dis J 21:903-10. 2002
    ..There are few data comparing the clinical features, management and outcome of penicillin-nonsusceptible (PNSP) meningitis patients with penicillin-susceptible (PSSP) meningitis patients...
  32. ncbi request reprint Population-based epidemiology of invasive pneumococcal infection in children in nine urban centers in Canada, 1994 through 1998
    Gordean L Bjornson
    Vaccine Evaluation Center, University of British Columbia, Vancouver, British Columbia, Canada
    Pediatr Infect Dis J 21:947-50. 2002
    ..To describe the epidemiology of invasive pneumococcal infections in Canadian children 0 to 12 years old...
  33. ncbi request reprint Invasive pneumococcal infections in Canadian children, 1998-2003: implications for new vaccination programs
    Julie A Bettinger
    Vaccine Evaluation Centre, BC Children s Hospital and the University of British Columbia, Vancouver, BC
    Can J Public Health 98:111-5. 2007
    ..We conducted active surveillance for invasive pneumococcal disease to assess the serotype and antibiotic resistance patterns in Canada prior to universal infant immunization programs, in most provinces...
  34. ncbi request reprint Participant-collected, mail-delivered oral fluid specimens can replace traditional serosurveys: a demonstration-of-feasibility survey of hepatitis A virus-specific antibodies in adults
    Jan J Ochnio
    University of British Columbia, Department of Pediatrics, Vaccine Evaluation Centre, Vancouver
    Can J Public Health 98:37-40. 2007
    ..Use of participant self-collected oral fluid as a diagnostic specimen and mail for specimen delivery has the potential of generating reliable, population-representative data at limited cost...
  35. ncbi request reprint The effect of changing from whole-cell to acellular pertussis vaccine on the epidemiology of hospitalized children with pertussis in Canada
    Julie A Bettinger
    Vaccine Evaluation Center, BC Children s Hospital and the University of British Columbia, Vancouver, British Columbia, Canada
    Pediatr Infect Dis J 26:31-5. 2007
    ..To assess effects on pertussis epidemiology of this nationwide change, we analyzed hospitalizations during 1991-2004 using the Canadian Immunization Monitoring Program, Active (IMPACT) pertussis database...
  36. ncbi request reprint Oculorespiratory syndrome after influenza immunization in children
    Danuta M Skowronski
    Epidemiology Services, UBC Centre for Disease Control, 655 West 12t Avenue, Vancouver, BC, Canada V5Z 4R4
    Pediatr Infect Dis J 24:63-9. 2005
    ..ORS included bilateral red eyes, facial edema or respiratory symptoms beginning within 24 hours of influenza immunization. Few reports involved children. We assessed the rate of ORS in a pediatric cohort...
  37. ncbi request reprint Using vaccine responses to plumb the immunologic consequences of tumor necrosis factor blockade with etanercept
    David W Scheifele
    J Rheumatol 31:1238-40. 2004
  38. ncbi request reprint Comparative evaluation of two severe acute respiratory syndrome (SARS) vaccine candidates in mice challenged with SARS coronavirus
    Raymond H See
    University of British Columbia Centre for Disease Control, Vancouver, BC V5Z 4R4, Canada
    J Gen Virol 87:641-50. 2006
    ..Finally, the sera of vaccinated mice contained antibodies to S, further suggesting a role for this protein in conferring protective immunity against SARS-CoV infection...
  39. ncbi request reprint Surveillance for influenza admissions among children hospitalized in Canadian immunization monitoring program active centers, 2003-2004
    Dorothy L Moore
    Infectious Diseases Division, Montreal Children s Hospital, McGill University Health Centre, Montreal, Quebec, Canada
    Pediatrics 118:e610-9. 2006
    ....
  40. ncbi request reprint Prevalence of Toll-like receptor signalling defects in apparently healthy children who developed invasive pneumococcal infection
    Aaron F Hirschfeld
    Department of Paediatrics, BC Children s Hospital and Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada
    Clin Immunol 122:271-8. 2007
    ....
  41. doi request reprint Influenza vaccination in paediatric nurses: cross-sectional study of coverage, refusal, and factors in acceptance
    Seamus P Norton
    Department of Paediatrics, British Columbia s Children s Hospital, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Vaccine 26:2942-8. 2008
    ..We also sought to identify the reasons for which nurses refuse the influenza vaccine and predictors of future vaccination intent...
  42. doi request reprint The epidemiology of children hospitalized with herpes zoster in Canada: Immunization Monitoring Program, Active (IMPACT), 1991-2005
    Susan H Wootton
    University of British Columbia, Vancouver, British Columbia, Canada
    Pediatr Infect Dis J 27:112-8. 2008
    ..Varicella vaccine has had a profound impact on the incidence of varicella; however the impact on HZ remains uncertain...
  43. pmc Canada needs a national immunization program: an open letter to the Honourable Anne McLellan, federal minister of health
    Monika Naus
    Epidemiology Services, BC Centre for Disease Control and University of British Columbia, Vancouver, BC
    CMAJ 168:567-8. 2003