Research Topics
| D W ScheifeleSummaryAffiliation: University of British Columbia Country: Canada Publications
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Detail Information
Publications
Compatibility of ASO3-adjuvanted H1N1pdm09 and seasonal trivalent influenza vaccines in adults: results of a randomized, controlled trialDavid W Scheifele
Vaccine Evaluation Center, University of British Columbia, Vancouver, BC, Canada
Vaccine 30:4728-32. 2012..Adverse event rates were not increased by concurrent vaccinations above those with H1N1pdm09 vaccine alone. This adjuvanted H1N1pdm09 vaccine was immunogenic and compatible with concurrently administered TIV...
Seroprevalence of hepatitis A infection in a low endemicity country: a systematic reviewBa Pham
Biomedical Data Sciences, GlaxoSmithKline, Ontario, Canada
BMC Infect Dis 5:56. 2005..This systematic review aimed to 1) estimate age-specific prevalence of HAV antibody in Canada and 2) evaluate infection-associated risk factors...
Ocular and respiratory symptoms attributable to inactivated split influenza vaccine: evidence from a controlled trial involving adultsDavid W Scheifele
Canadian Association for Immunization Research and Evaluation of Vancouver, British Columbia, Canada
Clin Infect Dis 36:850-7. 2003..We conclude that certain mild oculorespiratory symptoms were triggered by an influenza vaccine that was otherwise minimally reactogenic and, hence, that such symptoms might be associated with influenza vaccines in general...- Immunization Monitoring Program, Active: a model of active surveillance of vaccine safetyDavid W Scheifele
Immunization Monitoring Program, Active IMPACT, Ottawa, Ontario, Canada
Semin Pediatr Infect Dis 14:213-9. 2003..Concomitant disease surveillance has been important for sustaining the surveillance system because few postimmunization adverse events require hospital admission... - Safety and immunogenicity of a pentavalent combination vaccine (diphtheria, tetanus, acellular pertussis, polio, and haemophilus influenzae type B conjugate) when administered as a fourth dose at 15 to 18 months of ageD W Scheifele
Vaccine Evaluation Center, British Columbia s Children s Hospital, Vancouver, British Columbia, Canada
Hum Vaccin 1:180-6. 2005..The fourth dose was well tolerated in all age groups. Toddlers at 15, 16, 17 or 18 months of age are equally suitable recipients for booster immunization with the DTaP-IPV//PRP-T vaccine... - Hepatitis A vaccines: the growing case for universal immunisation of childrenDavid W Scheifele
BC Children s Hospital, Vaccine Evaluation Center, University of British Columbia, Vancouver, British Columbia, Canada
Expert Opin Pharmacother 6:157-64. 2005..Universal programmes are cost-effective, especially when a combined hepatitis A and B vaccine can be used to minimise incremental costs, and deserve wider consideration in developed countries... - A modified vaccine reduces the rate of large injection site reactions to the preschool booster dose of diphtheria-tetanus-acellular pertussis vaccine: results of a randomized, controlled trialDavid W Scheifele
Canadian Association for Immunization Research and Evaluation CAIRE and the Vaccine Evaluation Center, BC Children s Hospital and the University of British Columbia, Vancouver, British Columbia, Canada
Pediatr Infect Dis J 24:1059-66. 2005..Large injection site reactions commonly follow booster doses of diphtheria-tetanus-acellular pertussis (DTaP) vaccines at 4-6 years of age. A vaccine with lower diphtheria and pertussis dosage (Tdap) might be better tolerated for this dose... - Assessment of the compatibility of co-administered 7-valent pneumococcal conjugate, DTaP.IPV/PRP-T Hib and hepatitis B vaccines in infants 2-7 months of ageDavid W Scheifele
Vaccine Evaluation Center, BC Children s Hospital, 4500 Oak Street, Vancouver, BC, Canada V6H 3N1
Vaccine 24:2057-64. 2006..008) and HB responses were reduced (p=0.006) with concurrent dosing, the latter possibly from same thigh injection with DTaP.IPV/Hib. We conclude that PCV7, DTaP.IPV/Hib and HB are compatible with concurrent, separate injections... 
Invasive Haemophilus influenzae type b infections in vaccinated and unvaccinated children in Canada, 2001-2003David Scheifele
British Columbia s Children s Hospital, 4500 Oak St, Vancouver BC V6H 3N1
CMAJ 172:53-6. 2005..We report on the causes of Hib infections among vaccinated and unvaccinated children between 2001 and 2003 in Canada...- Unique roles of a data and safety monitoring board in vaccine safety trials with compressed timelines and urgent implicationsDavid Scheifele
Canadian Association for Immunization Research and Evaluation, Vancouver, British Columbia, Canada
Control Clin Trials 24:99-104. 2003..Providing a safety valve for inevitable tensions between investigators and sponsor was an understated but significant role. Lessons from our experience will be particularly pertinent to future studies of pandemic influenza vaccines... - Immunologic considerations for the timing of the booster dose of 7-valent pneumococcal conjugate vaccine in young childrenDavid W Scheifele
Vaccine Evaluation Center, BC Children s Hospital and the University of British Columbia, Vancouver, BC, Canada
Pediatr Infect Dis J 26:387-92. 2007.... - Cellular immunity as a potential cause of local reactions to booster vaccination with diphtheria and tetanus toxoids and acellular pertussis antigensDavid W Scheifele
Vaccine Evaluation Center, BC Children s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
Pediatr Infect Dis J 28:985-9. 2009..Cell-mediated immunity (CMI) develops after primary DTaP vaccination and might contribute to local reactions to booster doses, a possibility explored in this study... - A nationwide survey of past hepatitis A infections among Canadian adultsDavid W Scheifele
University of British Columbia, Vancouver, BC, Canada
Vaccine 28:5174-8. 2010..A nationwide pediatric serosurvey in 2003 confirmed that HAV infection is uncommon in children. Additional seroepidemiological data for adults would help to guide domestic use of HAV vaccines... - Invasive pneumococcal infections in Canadian children, 1991-1998: implications for new vaccination strategies. Canadian Paediatric Society/Laboratory Centre for Disease Control Immunization Monitoring Program, Active (IMPACT)D Scheifele
Canadian Paediatric Society, Ottawa, Ontario, Canada
Clin Infect Dis 31:58-64. 2000..New conjugate vaccines have great potential but their effectiveness and limitations require ongoing study... - Ongoing control of Haemophilus influenzae type B infections in Canadian children, 2004-2007David W Scheifele
Division of Pediatric Infectious and Immunologic Diseases, University of British Columbia, Vancouver, British Columbia
Pediatr Infect Dis J 27:755-7. 2008..Surveillance at 12 pediatric centers in 2004-2007 indicates that vaccine failures remain rare and case totals approach an irreducible minimum, with no age shift... - Assessment of injection site reactions to an acellular pertussis-based combination vaccine, including novel use of skin tests with vaccine antigensD W Scheifele
Vaccine Evaluation Center, BC s Children s Hospital, 4500 Oak Street and the University of British Columbia, BC, V6H 3V4, Vancouver, Canada
Vaccine 19:4720-6. 2001.... - Hepatitis A vaccine: is it being used to best advantage?David W Scheifele
Vaccine Evaluation Center, British Columbia s Children s Hospital, Department of Pediatrics, University of British Columbia, Vancouver
CMAJ 167:44-5. 2002 - Evaluation of ready-to-use and multi-dose influenza vaccine formats in large clinic settingsD W Scheifele
Vaccine Evaluation Center, B C s Children s Hospital, Vancouver
Can J Public Health 91:329-32. 2000..Depending upon product and packaging style, programs using vials are cheaper by $709-$926 per 100 doses delivered compared to using pre-filled syringes... - Comparative safety of tetanus-diphtheria toxoids booster immunization in students in Grades 6 and 9D W Scheifele
Vaccine Evaluation Center, BC s Children s Hospital, University of British Columbia, Vancouver, Canada
Pediatr Infect Dis J 17:1121-6. 1998..However, earlier vaccination might cause greater side effects. This study was undertaken to compare the safety of Td vaccinations in students in Grade 6 (11 to 12 years old) and Grade 9... - Postvaccination thrombocytopenia in CanadaLaura J Sauve
Vaccine Evaluation Center, BC Children s Hospital and the University of British Columbia, Vancouver, British Columbia, Canada
Pediatr Infect Dis J 29:559-61. 2010..With treatment, 28 children (26%) had normal platelet counts on discharge from hospital and 93% had documented recovery within 3 months... - Cortisol, behavior, and heart rate reactivity to immunization pain at 4 months corrected age in infants born very pretermRuth E Grunau
Department of Pediatrics, University of British Columbia, Vancouver BC, Canada
Clin J Pain 26:698-704. 2010..To our knowledge, cortisol reactivity to pain has not been compared in preterm and full-term infants. We examined pain reactivity to immunization in preterm and full-term infants... - Adverse reactions to the preschool (fifth) dose of adsorbed diphtheria-pertussis-tetanus vaccine in Canadian childrenD W Scheifele
Vaccine Evaluation Center, British Columbia s Children s Hospital, Vancouver
CMAJ 145:641-7. 1991.... - New, ultrasensitive enzyme immunoassay for detecting vaccine- and disease-induced hepatitis A virus-specific immunoglobulin G in salivaJ J Ochnio
Vaccine Evaluation Center, BC s Children s Hospital, Vancouver, Canada
J Clin Microbiol 35:98-101. 1997..We conclude that this assay is sufficiently sensitive for reliable detection of both vaccine- and infection-induced HAV-specific immunoglobulin G in saliva, even when corresponding anti-HAV levels in serum are very low (< 1 IU/ml)... - Assessment of parent education methods for infant immunizationG L Bjornson
Vaccine Evaluation Center, University of British Columbia, Vancouver
Can J Public Health 88:405-8. 1997..To assess whether a video about infant immunization could inform parents as well as human counselling (oral presentation)... - Emergence of penicillin-nonsusceptible Streptococcus pneumoniae invasive clones in CanadaD Greenberg
Division of Infectious and Immunological Diseases, Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada
J Clin Microbiol 40:68-74. 2002..The exact reasons for the successful spread of these clones within Canada and their contribution to increased resistance to antibiotics have yet to be explored... - Decrease in hospital admissions for febrile seizures and reports of hypotonic-hyporesponsive episodes presenting to hospital emergency departments since switching to acellular pertussis vaccine in Canada: a report from IMPACTNicole Le Saux
Department of Pediatrics, University of Ottawa, Ottawa, Ontario, Canada
Pediatrics 112:e348. 2003..We hypothesized that the change would result in a decrease in hospitalization rates for seizures and reports of hypotonic-hyporesponsive episodes (HHEs) temporally related to pertussis vaccination... - Injection-site reactions to booster doses of acellular pertussis vaccine: rate, severity, and anticipated impactDanuta M Skowronski
University of British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada
Pediatrics 112:e453. 2003.... - Randomized, double-blind, placebo-controlled trial to assess the rate of recurrence of oculorespiratory syndrome following influenza vaccination among persons previously affectedDanuta M Skowronski
Canadian Association for Immunization Research and Evaluation, Vancouver, British Columbia, Canada
Clin Infect Dis 37:1059-66. 2003..Previously affected persons should be informed of the risk of ORS recurrence but also that episodes of such recurrence are mild and well tolerated... - Serious adverse events associated with bacille Calmette-Guérin vaccine in CanadaShelley L Deeks
Immunization and Respiratory Infections Division, Community Acquired Infections Division, Public Health Agency of Canada, Health Canada, Ottawa, Ontario
Pediatr Infect Dis J 24:538-41. 2005..CONCLUSIONS: Serious BCG vaccine-associated complications continue to occur in Canada. The numbers of FNI children with disseminated disease was greater than expected from reported rates in the literature... - Effectiveness of pneumococcal conjugate vaccine in Greater Vancouver, Canada: 2004-2005Gordean Bjornson
Vaccine Evaluation Center, BC Children s Hospital, Vancouver, B C, Canada
Pediatr Infect Dis J 26:540-2. 2007..In the subpopulation with best case ascertainment disease rates for 6-23 month olds decreased 84.6% (92.5% for vaccine serotypes)... - Outcome of penicillin-nonsusceptible Streptococcus pneumoniae meningitis: a nested case-control studyJames D Kellner
Canadian Paediatric Society, Ottawa, Ontario, Canada
Pediatr Infect Dis J 21:903-10. 2002..These changes have occurred in response to the emergence of PNSP in Canada. Neurologic sequelae remain common after meningitis, but there are no differences between PNSP cases and PSSP cases... - Population-based epidemiology of invasive pneumococcal infection in children in nine urban centers in Canada, 1994 through 1998Gordean L Bjornson
Vaccine Evaluation Center, University of British Columbia, Vancouver, British Columbia, Canada
Pediatr Infect Dis J 21:947-50. 2002..These data will be valuable for calculating the economic case for universal infant vaccination with newly available vaccines... - Invasive pneumococcal infections in Canadian children, 1998-2003: implications for new vaccination programsJulie A Bettinger
Vaccine Evaluation Centre, BC Children s Hospital and the University of British Columbia, Vancouver, BC
Can J Public Health 98:111-5. 2007..We conducted active surveillance for invasive pneumococcal disease to assess the serotype and antibiotic resistance patterns in Canada prior to universal infant immunization programs, in most provinces... - Participant-collected, mail-delivered oral fluid specimens can replace traditional serosurveys: a demonstration-of-feasibility survey of hepatitis A virus-specific antibodies in adultsJan J Ochnio
University of British Columbia, Department of Pediatrics, Vaccine Evaluation Centre, Vancouver
Can J Public Health 98:37-40. 2007..Use of participant self-collected oral fluid as a diagnostic specimen and mail for specimen delivery has the potential of generating reliable, population-representative data at limited cost... - The effect of changing from whole-cell to acellular pertussis vaccine on the epidemiology of hospitalized children with pertussis in CanadaJulie A Bettinger
Vaccine Evaluation Center, BC Children s Hospital and the University of British Columbia, Vancouver, British Columbia, Canada
Pediatr Infect Dis J 26:31-5. 2007..To assess effects on pertussis epidemiology of this nationwide change, we analyzed hospitalizations during 1991-2004 using the Canadian Immunization Monitoring Program, Active (IMPACT) pertussis database... - Oculorespiratory syndrome after influenza immunization in childrenDanuta M Skowronski
Epidemiology Services, UBC Centre for Disease Control, 655 West 12t Avenue, Vancouver, BC, Canada V5Z 4R4
Pediatr Infect Dis J 24:63-9. 2005..ORS included bilateral red eyes, facial edema or respiratory symptoms beginning within 24 hours of influenza immunization. Few reports involved children. We assessed the rate of ORS in a pediatric cohort... - Using vaccine responses to plumb the immunologic consequences of tumor necrosis factor blockade with etanerceptDavid W Scheifele
J Rheumatol 31:1238-40. 2004 - Comparative evaluation of two severe acute respiratory syndrome (SARS) vaccine candidates in mice challenged with SARS coronavirusRaymond H See
University of British Columbia Centre for Disease Control, Vancouver, BC V5Z 4R4, Canada
J Gen Virol 87:641-50. 2006..Finally, the sera of vaccinated mice contained antibodies to S, further suggesting a role for this protein in conferring protective immunity against SARS-CoV infection... - Surveillance for influenza admissions among children hospitalized in Canadian immunization monitoring program active centers, 2003-2004Dorothy L Moore
Infectious Diseases Division, Montreal Children s Hospital, McGill University Health Centre, Montreal, Quebec, Canada
Pediatrics 118:e610-9. 2006.... - Prevalence of Toll-like receptor signalling defects in apparently healthy children who developed invasive pneumococcal infectionAaron F Hirschfeld
Department of Paediatrics, BC Children s Hospital and Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada
Clin Immunol 122:271-8. 2007.... - Influenza vaccination in paediatric nurses: cross-sectional study of coverage, refusal, and factors in acceptanceSeamus P Norton
Department of Paediatrics, British Columbia s Children s Hospital, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
Vaccine 26:2942-8. 2008..We also sought to identify the reasons for which nurses refuse the influenza vaccine and predictors of future vaccination intent... - The epidemiology of children hospitalized with herpes zoster in Canada: Immunization Monitoring Program, Active (IMPACT), 1991-2005Susan H Wootton
University of British Columbia, Vancouver, British Columbia, Canada
Pediatr Infect Dis J 27:112-8. 2008..Varicella vaccine has had a profound impact on the incidence of varicella; however the impact on HZ remains uncertain... - Canada needs a national immunization program: an open letter to the Honourable Anne McLellan, federal minister of healthMonika Naus
Epidemiology Services, BC Centre for Disease Control and University of British Columbia, Vancouver, BC
CMAJ 168:567-8. 2003