Luis María Schang
Affiliation: University of Alberta
Shott R, Appanah C, Grenier C, Tremblay G, Roucou X, Schang L. Development of kinomic analyses to identify dysregulated signaling pathways in cells expressing cytoplasmic PrP. Virol J. 2014;11:175 pubmed publisher
..We conclude that the kinomic analyses are sensitive and specific to detect signaling pathways dysregulated in a simple in vitro model of PrP pathogenesis. ..
Schang L. Effects of pharmacological cyclin-dependent kinase inhibitors on viral transcription and replication. Biochim Biophys Acta. 2004;1697:197-209 pubmed
..Herein, we will review the involvement of CDKs in viral replication and the antiviral properties of the most extensively characterized PCIs, with special emphasis on the mechanisms of inhibition of viral transcription. ..
Schang L. First demonstration of the effectiveness of inhibitors of cellular protein kinases in antiviral therapy. Expert Rev Anti Infect Ther. 2006;4:953-6 pubmed
..The three papers discussed herein demonstrate that inhibitors of cellular protein kinases are indeed effective for the treatment of virus-induced disease in animal models and human clinical trials. ..
Schang L, St Vincent M, Lacasse J. Five years of progress on cyclin-dependent kinases and other cellular proteins as potential targets for antiviral drugs. Antivir Chem Chemother. 2006;17:293-320 pubmed
..We also highlight the major issues that still need to be addressed before PCIs or other drugs targeting cellular proteins can be developed as clinical antivirals. ..
Shott R, Majer A, Frost K, Booth S, Schang L. Activation of pro-survival CaMK4Î²/CREB and pro-death MST1 signaling at early and late times during a mouse model of prion disease. Virol J. 2014;11:160 pubmed publisher
..Pro-survival CaMK4Î²/CREB signaling is activated in mouse scrapie at earlier times and later inhibited, whereas pro-death MST1 signaling is activated at these later times. ..
Schang L, Bantly A, Schaffer P. Explant-induced reactivation of herpes simplex virus occurs in neurons expressing nuclear cdk2 and cdk4. J Virol. 2002;76:7724-35 pubmed
..We conclude that neuronal levels of cdk2 are among the factors that determine the outcome of HSV infections of neurons. ..