Anurag Saxena

Summary

Affiliation: University of Saskatchewan
Country: Canada

Publications

  1. ncbi request reprint Biologic and clinical significance of CD7 expression in acute myeloid leukemia
    A Saxena
    Department of Pathology and Laboratory Medicine, University of Saskatchewan, Saskatoon, Canada
    Am J Hematol 58:278-84. 1998
  2. pmc Initial diagnosis of small lymphocytic lymphoma in parotidectomy for Warthin tumour, a rare collision tumour
    A Saxena
    Department of Pathology, Royal University Hospital, 103 Hospital Drive, Saskatoon, SK, Canada, S7N 0W8
    J Clin Pathol 58:331-3. 2005
  3. pmc Clonal B cell populations in a minority of patients with Hashimoto's thyroiditis
    A Saxena
    Department of Pathology, Royal University Hospital, Saskatoon, Saskatchewan S7N 0W8, Canada
    J Clin Pathol 57:1258-63. 2004
  4. ncbi request reprint Mcl-1 and Bcl-2/Bax ratio are associated with treatment response but not with Rai stage in B-cell chronic lymphocytic leukemia
    Anurag Saxena
    Department of Pathology, Royal University Hospital and College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Am J Hematol 75:22-33. 2004
  5. ncbi request reprint Posttransplant diffuse large B-cell lymphoma of "lymphomatoid granulomatosis" type
    A Saxena
    Department of Pathology, Royal University Hospital, Saskatoon SK S7 N OW8, Canada
    Virchows Arch 441:622-8. 2002
  6. ncbi request reprint Association of a novel single nucleotide polymorphism, G(-248)A, in the 5'-UTR of BAX gene in chronic lymphocytic leukemia with disease progression and treatment resistance
    Anurag Saxena
    Department of Pathology, Royal University Hospital and College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Cancer Lett 187:199-205. 2002
  7. ncbi request reprint Expression of Bcl-x, Bcl-2, Bax, and Bak in endarterectomy and atherectomy specimens
    A Saxena
    Department of Pathology, College of Medicine, University of Saskatchewan, c o Royal University Hospital, 103 Hospital Drive, Saskatoon, Saskatchewan S7N 0W8, Canada
    J Pathol 196:335-42. 2002
  8. ncbi request reprint Molecular analysis of clonality of sporadic angiomyolipoma
    A Saxena
    Department of Pathology, Royal University Hospital, University of Saskatchewan, Saskatoon, Canada
    J Pathol 189:79-84. 1999
  9. ncbi request reprint Distinct B-cell clonal bands in Helicobacter pylori gastritis with lymphoid hyperplasia
    A Saxena
    Department of Pathology, Royal University Hospital, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    J Pathol 190:47-54. 2000
  10. ncbi request reprint Combined alpha tumor necrosis factor gene therapy and engineered dendritic cell vaccine in combating well-established tumors
    Yongqing Liu
    Research Unit, Saskatchewan Cancer Agency, Departments of Microbiology, Immunology and Oncology, University of Saskatchewan, Saskatoon, Saskatchewan S7N 4H4, Canada
    J Gene Med 6:857-68. 2004

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Biologic and clinical significance of CD7 expression in acute myeloid leukemia
    A Saxena
    Department of Pathology and Laboratory Medicine, University of Saskatchewan, Saskatoon, Canada
    Am J Hematol 58:278-84. 1998
    ..We suggest evaluation of CD7 in all patients with AML at the time of diagnosis in view of poor clinical outcome...
  2. pmc Initial diagnosis of small lymphocytic lymphoma in parotidectomy for Warthin tumour, a rare collision tumour
    A Saxena
    Department of Pathology, Royal University Hospital, 103 Hospital Drive, Saskatoon, SK, Canada, S7N 0W8
    J Clin Pathol 58:331-3. 2005
    ..This case highlights the extremely rare association of SLL with WT and the importance of evaluation of the WT stroma, where the pale proliferation centres of SLL may mimic germinal centres of reactive lymphoid nodules...
  3. pmc Clonal B cell populations in a minority of patients with Hashimoto's thyroiditis
    A Saxena
    Department of Pathology, Royal University Hospital, Saskatoon, Saskatchewan S7N 0W8, Canada
    J Clin Pathol 57:1258-63. 2004
    ..Hashimoto's thyroiditis (HT) is a risk factor for thyroid lymphoma, and clonal B cell populations in HT support this link. The literature on B cell clonality in HT is controversial...
  4. ncbi request reprint Mcl-1 and Bcl-2/Bax ratio are associated with treatment response but not with Rai stage in B-cell chronic lymphocytic leukemia
    Anurag Saxena
    Department of Pathology, Royal University Hospital and College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Am J Hematol 75:22-33. 2004
    ..89 +/- 0.53 [CR + PR] vs. 3.38 +/- 4.47 [NR], P = 0.0118). There was no association with Rai stage. Low Mcl-1 appears to be a requirement for CR, while low Bcl-2/Bax ratio is indicative of some response to conventional treatment...
  5. ncbi request reprint Posttransplant diffuse large B-cell lymphoma of "lymphomatoid granulomatosis" type
    A Saxena
    Department of Pathology, Royal University Hospital, Saskatoon SK S7 N OW8, Canada
    Virchows Arch 441:622-8. 2002
    ..This first report of systemic LyG variant of DLBCL in a posttransplant setting has features suggesting similarities and overlap between LyG and PTLD...
  6. ncbi request reprint Association of a novel single nucleotide polymorphism, G(-248)A, in the 5'-UTR of BAX gene in chronic lymphocytic leukemia with disease progression and treatment resistance
    Anurag Saxena
    Department of Pathology, Royal University Hospital and College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Cancer Lett 187:199-205. 2002
    ..5% of stage 0 patients, and in 4.0% of controls. It was associated with reduced protein expression (P=0.049), progression beyond Rai stage 0 (P=0.00018) and failure to achieve complete response (P=0.038)...
  7. ncbi request reprint Expression of Bcl-x, Bcl-2, Bax, and Bak in endarterectomy and atherectomy specimens
    A Saxena
    Department of Pathology, College of Medicine, University of Saskatchewan, c o Royal University Hospital, 103 Hospital Drive, Saskatoon, Saskatchewan S7N 0W8, Canada
    J Pathol 196:335-42. 2002
    ..In conclusion, increased Bax and Bak coupled with lack/paucity of Bcl-2 and Bcl-xL are associated with SMC apoptosis in advanced lesions. Bcl-xL in non-apoptotic cells appears to contribute to prolonged cell survival...
  8. ncbi request reprint Molecular analysis of clonality of sporadic angiomyolipoma
    A Saxena
    Department of Pathology, Royal University Hospital, University of Saskatchewan, Saskatoon, Canada
    J Pathol 189:79-84. 1999
    ..Angiomyolipomas are three clonal lesions due to a clonal smooth muscle cell and blood vessel component, while the polyclonal adipose tissue is probably metaplastic or reactive...
  9. ncbi request reprint Distinct B-cell clonal bands in Helicobacter pylori gastritis with lymphoid hyperplasia
    A Saxena
    Department of Pathology, Royal University Hospital, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    J Pathol 190:47-54. 2000
    ..In conclusion, B-cell clonal bands are common in H. pylori-gastritis with lymphoid hyperplasia. The irreproducibility of these bands is a useful feature in favouring a reactive process...
  10. ncbi request reprint Combined alpha tumor necrosis factor gene therapy and engineered dendritic cell vaccine in combating well-established tumors
    Yongqing Liu
    Research Unit, Saskatchewan Cancer Agency, Departments of Microbiology, Immunology and Oncology, University of Saskatchewan, Saskatoon, Saskatchewan S7N 4H4, Canada
    J Gene Med 6:857-68. 2004
    ..We hypothesized that a combined immunotherapy including gene therapy and DC vaccine would have some advantages over each modality administered as a monotherapy...
  11. ncbi request reprint Prognostic significance of a short sequence insertion in the MCL-1 promoter in chronic lymphocytic leukemia
    Oksana Moshynska
    Department of Pathology, Royal University Hospital and College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    J Natl Cancer Inst 96:673-82. 2004
    ..We sought structural changes in the MCL-1 gene in CLL patients and associated these with clinical parameters of the disease...
  12. ncbi request reprint Combined radiation therapy and dendritic cell vaccine for treating solid tumors with liver micro-metastasis
    Zhuang Chen
    Department of Oncology, Saskatoon Cancer Center, College of Medicine, University of Saskatchewan, 20 Campus Drive, Saskatoon, Saskatchewan S7N 4H4, Canada
    J Gene Med 7:506-17. 2005
    ..Hence, the strategy of combined irradiation and DC vaccine may be a novel approach for treating human malignancies and early metastasis...
  13. ncbi request reprint Short nucleotide polymorphic insertions in the MCL-1 promoter affect gene expression
    Anurag Saxena
    Department of Pathology and Laboratory Medicine, Royal University Hospital, College of Medicine, University of Saskatchewan, Saskatoon, Canada S7N 0W8
    Cancer Lett 251:114-31. 2007
    ..These results provide further evidence for the biological effect of MCL-1 promoter polymorphisms on gene expression...
  14. ncbi request reprint Requirement of N-myristoyltransferase 1 in the development of monocytic lineage
    Anuraag Shrivastav
    Department of Pathology, College of Medicine, University of Saskatchewan, Canada
    J Immunol 180:1019-28. 2008
    ..We report in this study novel observation that regulated total NMT activity and NMT1 is essential for proper monocytic differentiation of the mouse bone marrow cells...
  15. ncbi request reprint G125A single-nucleotide polymorphism in the human BAX promoter affects gene expression
    Oksana Moshynska
    Department of Pathology, Royal University Hospital, College of Medicine, University of Saskatchewan, Saskatoon, Canada S7N 0W8
    Oncogene 24:2042-9. 2005
    ..6-fold. These studies suggest a mechanism for the biological effect of the G125A...
  16. ncbi request reprint Engineered fusion hybrid vaccine of IL-4 gene-modified myeloma and relative mature dendritic cells enhances antitumor immunity
    Yongqing Liu
    Research Unit, Departments of Oncology and Pathology, College of Medicine, Saskatchewan Cancer Agency, University of Saskatchewan, 20 Campus Drive, Saskatoon, Saskatchewan, Canada S7N 4H4
    Leuk Res 26:757-63. 2002
    ....
  17. doi request reprint A case of deforming pachydermodactyly
    Regina Taylor-Gjevre
    Department of Medicine, University of Saskatchewan, Saskatoon, Canada
    J Clin Rheumatol 15:78-80. 2009
    ..This patient differs from cases previously reported as the extent of soft tissue involvement altered the integrity of the articular supporting structures. This has resulted in deformity and functional impairment...
  18. ncbi request reprint Analysis of the CD40/CD40L role in the sustenance of alloreactive antibody production
    A S Shoker
    Department of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Transpl Immunol 8:219-28. 2001
    ..Blocking the CD40/CD40L pathway may have a potential therapeutic benefit to treat sensitized uremic patients...
  19. pmc Disrupted RabGAP function of the p85 subunit of phosphatidylinositol 3-kinase results in cell transformation
    M Dean Chamberlain
    Cancer Research Unit, Health Research Division, Saskatchewan Cancer Agency, Saskatoon, Saskatchewan S7N 4H4, Canada
    J Biol Chem 283:15861-8. 2008
    ..This critical new role for p85 in the regulation of Rab function suggests a novel role for p85 in controlling receptor signaling and trafficking through its effects on Rab GTPases...
  20. ncbi request reprint Clonal relationship between Hashimoto thyroiditis and thyroid lymphoma
    O V Moshynska
    Department of Pathology and Laboratory Medicine, Royal University Hospital, College of Medicine, University of Saskatchewan, Saskatoon, Canada
    J Clin Pathol 61:438-44. 2008
    ..Although Hashimoto thyroiditis (HT) is a predisposing factor for B-lineage thyroid lymphoma, clonal B-cell populations in HT are rare...
  21. pmc N-myristoyltransferase: a potential novel diagnostic marker for colon cancer
    Anuraag Shrivastav
    Department of Pathology and Laboratory Medicine, College of Medicine, University of Saskatchewan, Saskatoon, Canada S7N 5E5
    J Transl Med 5:58. 2007
    ..We have demonstrated earlier the alteration of NMT activity during the progression of colorectal cancer and established NMT as a putative therapeutic target for cancer...
  22. pmc Molecular detection of the G(-248)A BAX promoter nucleotide change in B cell chronic lymphocytic leukaemia
    O Moshynska
    Department of Pathology, Royal University Hospital and College of Medicine, University of Saskatchewan, Saskatoon SK S7N 0W8, Saskatchewan, Canada
    Mol Pathol 56:205-9. 2003
    ....
  23. doi request reprint Crossword puzzles: active learning in undergraduate pathology and medical education
    Anurag Saxena
    Department of Pathology, College of Medicine, University of Saskatchewan, Saskatoon, Canada
    Arch Pathol Lab Med 133:1457-62. 2009
    ..It is a challenge to provide adequate practice and necessary repetition to reinforce key concepts...
  24. ncbi request reprint Enhanced HER-2/neu-specific antitumor immunity by cotransduction of mouse dendritic cells with two genes encoding HER-2/neu and alpha tumor necrosis factor
    Zhuang Chen
    Department of Oncology, Cancer Research Unit, Saskatchewan Cancer Agency, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Cancer Gene Ther 9:778-86. 2002
    ..Therefore, DCs genetically engineered to express both the tumor antigen and cytokines such as TNF-alpha as an immunoadjuvant are likely to represent a new direction in DC vaccine of cancer...
  25. ncbi request reprint Efficient antitumor immunity derived from maturation of dendritic cells that had phagocytosed apoptotic/necrotic tumor cells
    Z Chen
    Saskatoon Cancer Center, Saskatoon, Saskatchewan, Canada
    Int J Cancer 93:539-48. 2001
    ..Therefore, DCs that had phagocytosed apoptotic/necrotic tumor cells appear to offer new strategies in DC cancer vaccines...
  26. ncbi request reprint Intratumoral coinjection of two adenoviral vectors expressing functional interleukin-18 and inducible protein-10, respectively, synergizes to facilitate regression of established tumors
    Yongqing Liu
    Research Unit, Saskatchewan Cancer Agency, University of Saskatchewan, Saskatoon, Saskatchewan Canada S7N 4H4
    Cancer Gene Ther 9:533-42. 2002
    ..These observations also suggest the potential use of double-recombinant adenoviral vectors expressing chemokines and immunomodulatory cytokines in cancer gene therapy...
  27. ncbi request reprint Enhanced T-cell immunity induced by dendritic cells with phagocytosis of heat shock protein 70 gene-transfected tumor cells in early phase of apoptosis
    T Chan
    Research Unit, Saskatchewan Cancer Agency, Department of Oncology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Cancer Gene Ther 14:409-20. 2007
    ..These results may have an important impact in designing DC-based antitumor vaccines...
  28. ncbi request reprint Goblet cell carcinoids of the appendix: immunophenotype and ultrastructural study
    R Kanthan
    Department of Pathology, Royal University Hospital, University of Saskatchewan, Saakatoon, Canada
    Arch Pathol Lab Med 125:386-90. 2001
    ..Complete removal of the tumor is recommended because of the unpredictable biological behavior of this tumor, which includes delayed local recurrences and lung metastases...
  29. ncbi request reprint Neurocysticercosis in children: clinical characteristics and outcome
    Bibek Talukdar
    Department of Paediatrics, Maulana Azad Medical College, New Delhi 110002, India
    Ann Trop Paediatr 22:333-9. 2002
    ..Parenchymal neurocysticercosis in children commonly presents with partial seizures and ring lesions on CT. The disease can be managed well by anti-epileptic medication alone and the prognosis is good...