Affiliation: University of British Columbia
- The study of antiarrhythmic medications in infancy (SAMIS): a multicenter, randomized controlled trial comparing the efficacy and safety of digoxin versus propranolol for prophylaxis of supraventricular tachycardia in infantsShubhayan Sanatani
Division of Pediatric Cardiology, British Columbia Children s Hospital, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada
Circ Arrhythm Electrophysiol 5:984-91. 2012..The purpose of this study was to compare the efficacy and safety of the 2 most commonly used medications for antiarrhythmic prophylaxis of SVT in infants: digoxin and propranolol...
- The challenge of diagnosing arrhythmogenic right ventricular cardiomyopathy in the youngShubhayan Sanatani
Division of Pediatric Cardiology, Department of Pediatrics, University of British Columbia, British Columbia Children s Hospital, Vancouver, British Columbia, Canada
Pediatr Cardiol 29:800-3. 2008..The diagnosis was made based on the morphology of a single beat during exercise testing. We illustrate the difficulty of diagnosing ARVC in the young even with a heightened index of suspicion...
- The Brugada ECG pattern in a neonateShubhayan Sanatani
Division of Cardiology, British Columbia Children s Hospital, Vancouver, Canada
J Cardiovasc Electrophysiol 16:342-4. 2005..The baby was subsequently diagnosed with a fatty acid oxidation disorder (medium chain Acyl-CoA dehydrogenase deficiency or MCAD). We speculate that free fatty acid accumulation can give rise to the Brugada ECG pattern...
- Physical activity recommendations for patients with electrophysiologic and structural congenital heart disease: a survey of Canadian health care providersThomas M Roston
Children s Heart Centre, British Columbia Children s Hospital, University of British Columbia, 4480 Oak Street, 1F Clinic, Vancouver, BC, V6H 3V4, Canada
Pediatr Cardiol 34:1374-81. 2013....
- Lone atrial fibrillation in the pediatric populationLindsay C Mills
Division of Pediatric Cardiology, University of Ottawa, Ottawa, Ontario, Canada
Can J Cardiol 29:1227-33. 2013..We sought to describe the clinical characteristics, management strategies, and recurrence rates and to identify predictors of AF recurrence in a contemporary pediatric population...
- Biophysical properties of the aorta and left ventricle and exercise capacity in obese childrenKevin C Harris
Children s Heart Centre, British Columbia Children s Hospital, Vancouver, BC, Canada
Am J Cardiol 110:897-901. 2012..Obese children also had an increased LV mass, altered diastolic properties, and an abnormal exercise capacity. PWV might be useful in monitoring the progression of arterial disease or the effect of therapeutic interventions...
- A comparison of the effect on dispersion of repolarization of age-adjusted MAC values of sevoflurane in childrenSimon D Whyte
Department of Pediatric Anesthesia, British Columbia Children s Hospital, Vancouver, British Columbia, Canada
Anesth Analg 104:277-82. 2007..Thus Tp-e is a readily measured assay of drug torsadogenicity. Several anesthetic drugs prolong the QT interval, but their effect on TDR is largely unknown...
- Does biventricular pacing improve hemodynamics in children undergoing routine congenital heart surgery?Aamir Jeewa
Division of Cardiology, Department of Pediatrics, British Columbia Children s Hospital, The University of British Columbia, Vancouver, BC, Canada
Pediatr Cardiol 31:181-7. 2010..Further prospective studies are needed to assess the role of multisite pacing in children with ventricular dyssynchrony such as those with single ventricles, those undergoing reoperation or those with high RACHS scores...
- Postnatal outcome in patients with fetal tachycardiaShreya Moodley
Division of Pediatric Cardiology, British Columbia Children s Hospital and the University of British Columbia, Vancouver, BC V6H 3V4, Canada
Pediatr Cardiol 34:81-7. 2013..The majority of patients with postnatal arrhythmia present within 48 h of life, which has clinical implications for monitoring. Postnatal outcome is generally very good with most patients being weaned off medication in 6-12 months...
- Epinephrine infusion in the evaluation of unexplained cardiac arrest and familial sudden death: from the cardiac arrest survivors with preserved Ejection Fraction RegistryAndrew D Krahn
University of British Columbia, Vancouver, BC, Canada
Circ Arrhythm Electrophysiol 5:933-40. 2012..Epinephrine infusion may unmask latent genetic conditions associated with cardiac arrest, including long-QT syndrome and catecholaminergic polymorphic ventricular tachycardia (VT)...
- The Canadian experience with Durata and Riata ST Optim defibrillator leads: a report from the Canadian Heart Rhythm Society Device CommitteeMatthew T Bennett
University of British Columbia, Vancouver, British Columbia, Canada
Heart Rhythm 10:1478-81. 2013..The St. Jude Medical Riata family of implantable cardioverter-defibrillator (ICD) leads has demonstrated a high rate of externalized conductors and electrical failure...
- Assessment of genetic causes of cardiac arrestMatthew T Bennett
Division of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada
Can J Cardiol 29:100-10. 2013..This allows for the initiation of disease-specific treatments and enables family screening...
- Inherited heart rhythm disease: negotiating the minefield for the practicing cardiologistAndrew D Krahn
Division of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada
Can J Cardiol 29:122-5. 2013..Condition-specific treatment strategies that are deployed in regional clinics are discussed, including the role of the referring health care team...
- Are implantable loop recorders useful in detecting arrhythmias in children with unexplained syncope?Khalid N Al Dhahri
Division of Cardiology, B C Children s Hospital, Vancouver, British Columbia, Canada
Pacing Clin Electrophysiol 32:1422-7. 2009..The implantable loop recorder (ILR) is a medical device that was created for prolonged monitoring of heart rate and rhythm and has been used in a limited number of pediatric studies in which the cause of the syncope is unknown...
- Fascicular and nonfascicular left ventricular tachycardias in the young: an international multicenter studyKathryn K Collins
Division of Cardiology, Department of Pediatrics, The Children s Hospital, University of Colorado, Denver, CO, USA
J Cardiovasc Electrophysiol 24:640-8. 2013..The aim of this study was to evaluate the clinical presentation and outcomes of pediatric patients with ventricular tachycardia (VT) originating from left heart structures...
- Pacemaker therapy of postoperative arrhythmias after pediatric cardiac surgeryPeter Skippen
From the Pediatric Intensive Care Unit, Children s Heart Centre, British Columbia Children s Hospital, BC, Canada
Pediatr Crit Care Med 11:133-8. 2010..To summarize the practical operation of temporary pacemakers in common use pertinent to the intensivist caring for the postcardiac patient. Pacemaker therapy is commonly required in the postoperative period after congenital cardiac surgery...
- Benign cardiac tumours, malignant arrhythmiasKimberley A Myers
Children s Heart Center, 4480 Oak Street, Vancouver, British Columbia, Canada
Can J Cardiol 26:e58-61. 2010..The literature regarding the arrhythmogenic potential of PCTs and the use of implantable cardioverter defibrillators in these patients is reviewed. The series highlights the deficiency of prognostic information for this cohort...
- A novel mechanism for LQT3 with 2:1 block: a pore-lining mutation in Nav1.5 significantly affects voltage-dependence of activationAndrew J Horne
Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, B C, V6T 1Z3, Canada
Heart Rhythm 8:770-7. 2011..SCN5A mutations that cause a gain of function in the cardiac voltage-gated sodium channel (Nav1.5) lead to long QT syndrome and a higher risk for sudden cardiac death...
- The effects of droperidol and ondansetron on dispersion of myocardial repolarization in childrenDisha Mehta
Department of Pediatric Anesthesia, British Columbia s Children s Hospital, Vancouver, BC, Canada
Paediatr Anaesth 20:905-12. 2010..To compare the effects of droperidol and ondansetron on electrocardiographic indices of myocardial repolarization in children...
- Echocardiographic tools for pacemaker optimization of ventricular function in an infant following surgical repair for double outlet right ventricleAamir Jeewa
BC Children s Hospital, Department of Pediatrics, The University of British Columbia, Vancouver, Canada
Can J Cardiol 26:e353-5. 2010..The present case highlights the usefulness of newer echocardiographic techniques in pacemaker optimization in the acute postoperative setting...
- Use of an implantable loop recorder in the evaluation of children with congenital heart diseaseShubhayan Sanatani
Division of Cardiology, Department of Pediatrics, The Hospital for Sick Children and the University of Toronto, Ontario, Canada
Am Heart J 143:366-72. 2002..Syncope in the patient with congenital heart disease presents a diagnostic challenge. We applied this technology to a cohort of pediatric patients...
- The effect of propofol concentration on dispersion of myocardial repolarization in childrenHelen V Hume-Smith
Department of Pediatric Anesthesia, British Columbia Children s Hospital, 4480 Oak St, Vancouver, BC, V6H 3V4, Canada
Anesth Analg 107:806-10. 2008..In this randomized, double-blind, clinical study, we investigated the dose-response relationship between propofol, QTc, and Tp-e in a range of doses clinically relevant for surgical anesthesia...
- An alternate technique to pacing in complex congenital heart disease: assessment of the left thoracotomy approachAshley D Roberts
Department of Pediatrics, University of British Columbia, Vancouver
Can J Cardiol 22:481-4. 2006..The surgical approach used to implant the pacemaker leads has been shown to impact lead survival. There is a paucity of pediatric literature describing the experience using a left thoracotomy approach...
- Sudden unexpected death in children with heart diseaseShubhayan Sanatani
Children s Heart Center, British Columbia s Children s Hospital, Vancouver, BC, Canada
Congenit Heart Dis 1:89-97. 2006..To review a mortality database, and identify all sudden unexpected deaths in patients followed by the cardiac program...
- Pediatric nonpost-operative junctional ectopic tachycardia medical management and interventional therapiesKathryn K Collins
Department of Pediatrics, Division of Cardiology, The Children s Hospital, 13123 E 16th Avenue, Aurora, CO 80045, USA
J Am Coll Cardiol 53:690-7. 2009..To determine the outcomes of medical management, pacing, and catheter ablation for the treatment of nonpost-operative junctional ectopic tachycardia (JET) in a pediatric population...
- Mechanistic basis for LQT1 caused by S3 mutations in the KCNQ1 subunit of IKsJodene Eldstrom
Department of Anesthesiology, Pharmacology and Therapeutics, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
J Gen Physiol 135:433-48. 2010....
- A KCNQ1 V205M missense mutation causes a high rate of long QT syndrome in a First Nations community of northern British Columbia: a community-based approach to understanding the impactLaura Arbour
Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
Genet Med 10:545-50. 2008..Hereditary long QT syndrome is named for a prolonged QT interval reflecting predisposition to ventricular arrhythmias and sudden death. A high rate in a remote, northern Canadian First Nations community was brought to attention...
- Torsades de pointes with sevofluraneSimon D Whyte
Paediatr Anaesth 16:1199-201; author reply 1201. 2006
- Invasive measurements of atrioventricular conduction parameters prior to and following ventricular septal defect closure with the amplatzer deviceEuloge Kouadio Kramoh
Pediatric Cardiology 6th Floor, Bloc 9, Sainte Justine Hospital, 3175 Cote Sainte Catherine, Montreal, Quebec, Canada
J Invasive Cardiol 20:212-6. 2008..Because of anatomical proximity, closure of paramembranous ventricular septal defect (pm-VSD) with an Amplatzer occluder has the potential to affect the atrioventricular (AV) conduction system...
- Long QT syndrome in children in the era of implantable defibrillatorsSusan P Etheridge
University of Utah, Salt Lake City, Utah, USA
J Am Coll Cardiol 50:1335-40. 2007..We sought to assess the spectrum and outcome of young long QT syndrome (LQTS) patients, addressing treatment including device indications, risks, and benefits...
- Documenting junctional ectopic tachycardia following pediatric open heart surgeryAungkana Gengsakul
Division of Pediatric Cardiology, Phramongkutklao Hospital, Bangkok, Thailand
J Med Assoc Thai 88:S214-22. 2005..To determine appropriated documentations for diagnosis junctional ectopic tachycardia (JET) before treatment in post-operative open heart surgery and identify risk factors for post-operative cardiac arrhythmias in children...
- Long on QT and low on calciumTimothy J Bradley
Division of Cardiology, The Hospital for Sick Children, Toronto
Cardiol Young 14:667-70. 2004..We report four cases documenting the varied clinical spectrum in which hypocalcaemic-induced prolongation of the QT interval and arrhythmia can occur in childhood...
- Congenital long QT syndrome in children identified by family screeningColin Petko
University of Utah, Salt Lake City, Utah, USA
Am J Cardiol 101:1756-8. 2008..Appropriate implantable cardioverter-defibrillator discharges in the nonproband group underscore the importance of follow-up in this relatively asymptomatic population...