Baljinder Salh

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. ncbi request reprint PD98059 attenuates hydrogen peroxide-induced cell death through inhibition of Jun N-Terminal Kinase in HT29 cells
    B S Salh
    Jack Bell Research Centre, 2660 Oak Street, Vancouver, British Columbia, Canada V6H 3Z6
    Mol Cell Biol Res Commun 4:158-65. 2000
  2. pmc Autoimmune cholangitis mimicking a klatskin tumor: a case report
    Alexandra Shingina
    Division of Gastroenterology, 2775, Laurel Street, Vancouver, British Columbia, V5Z 1M9, Canada
    J Med Case Reports 5:485. 2011
  3. ncbi request reprint c-Jun N-terminal kinases as potential therapeutic targets
    Baljinder Salh
    University of British Columbia, Department of Medicine, Vancouver, BC, Canada
    Expert Opin Ther Targets 11:1339-53. 2007
  4. ncbi request reprint Dissociated ROS production and ceramide generation in sulfasalazine-induced cell death in Raw 264.7 cells
    B Salh
    The Jack Bell Research Centre, Vancouver, British Columbia, Canada
    J Leukoc Biol 72:790-9. 2002
  5. ncbi request reprint Investigation of interleukin 1beta-mediated regulation of NF-kappaB activation in colonic cells reveals divergence between PKB and PDK-transduced events
    Kuljit Parhar
    Division of Gastroenterology, Faculty of Medicine, The Jack Bell Research Centre, 2660 Oak Street, Vancouver, BC, Canada
    Mol Cell Biochem 300:113-27. 2007
  6. pmc The specific JNK inhibitor SP600125 targets tumour necrosis factor-alpha production and epithelial cell apoptosis in acute murine colitis
    Kiran Assi
    The Jack Bell Research Centre, Vancouver, BC, Canada
    Immunology 118:112-21. 2006
  7. ncbi request reprint The role of protein kinase CK2 in intestinal epithelial cell inflammatory signaling
    Kuljit Parhar
    The Jack Bell Research Center, 2660 Oak Street, V6H 3Z6, Vancouver, British Columbia, Canada
    Int J Colorectal Dis 22:601-9. 2007
  8. ncbi request reprint 5,6-Dichloro-ribifuranosylbenzimidazole- and apigenin-induced sensitization of colon cancer cells to TNF-alpha-mediated apoptosis
    Myriam Farah
    Division of Gastroenterology, Univ of British Columbia, 100 2647 Willow St, Vancouver BC V5Z 3P1, Canada
    Am J Physiol Gastrointest Liver Physiol 285:G919-28. 2003
  9. pmc Role of epithelial integrin-linked kinase in promoting intestinal inflammation: effects on CCL2, fibronectin and the T cell repertoire
    Kiran Assi
    Department of Medicine, The Jack Bell Research Centre, 2660 Oak Street, Vancouver, British Columbia, V6H 3Z6, Canada
    BMC Immunol 12:42. 2011
  10. ncbi request reprint Curcumin mediates ceramide generation via the de novo pathway in colon cancer cells
    Maryam Moussavi
    The Jack Bell Research Centre, 2660 Oak Street, Vancouver, BC, Canada
    Carcinogenesis 27:1636-44. 2006

Collaborators

  • Antonio Gomez-Munoz
  • Yi Tzu Nancy Fu
  • David G Huntsman
  • John C T Wong
  • Vincent Duronio
  • Alan I So
  • S Huang
  • Steven Pelech
  • Kiran Assi
  • Kuljit Parhar
  • David Owen
  • Eric M Yoshida
  • Maryam Moussavi
  • Yoshiyuki Matsui
  • Shoukat Dedhar
  • Birinder K Mangat
  • Alexandra Shingina
  • Pongphob Intaraprasong
  • Anthony Marotta
  • Sharlene Eivemark
  • Victor K Wong
  • Myriam Farah
  • A Marotta
  • Osamu Ogawa
  • Martin E Gleave
  • Peter A Raven
  • Megan Levings
  • Charles Zwirewich
  • Scott Patterson
  • Tim Lee
  • Chad Evaschen
  • Jennifer Morse
  • David A Owen
  • Charles H Scudamore
  • Arthur Yee
  • Stephen W Chung
  • Rex Pillai
  • Rajinder Hundal
  • Anthony G Ryan
  • Stephen G F Ho
  • Colleen Nelson
  • Urs Steinbrecher
  • Andrew Ray
  • V Gray
  • B Dupuis
  • S Gallinger
  • S Dedhar
  • J Sanghera
  • C Tan
  • S Malik
  • D Owen

Detail Information

Publications22

  1. ncbi request reprint PD98059 attenuates hydrogen peroxide-induced cell death through inhibition of Jun N-Terminal Kinase in HT29 cells
    B S Salh
    Jack Bell Research Centre, 2660 Oak Street, Vancouver, British Columbia, Canada V6H 3Z6
    Mol Cell Biol Res Commun 4:158-65. 2000
    ....
  2. pmc Autoimmune cholangitis mimicking a klatskin tumor: a case report
    Alexandra Shingina
    Division of Gastroenterology, 2775, Laurel Street, Vancouver, British Columbia, V5Z 1M9, Canada
    J Med Case Reports 5:485. 2011
    ..abstract:..
  3. ncbi request reprint c-Jun N-terminal kinases as potential therapeutic targets
    Baljinder Salh
    University of British Columbia, Department of Medicine, Vancouver, BC, Canada
    Expert Opin Ther Targets 11:1339-53. 2007
    ..With roles described in almost all classes of disease, the main questions are what type of inhibitor to use and when exactly to use it during the disease course?..
  4. ncbi request reprint Dissociated ROS production and ceramide generation in sulfasalazine-induced cell death in Raw 264.7 cells
    B Salh
    The Jack Bell Research Centre, Vancouver, British Columbia, Canada
    J Leukoc Biol 72:790-9. 2002
    ..In conclusion, the cell-death response induced by SSZ in Raw 264.7 cells involves ROS in the apoptotic limb but is independent of ceramide formation...
  5. ncbi request reprint Investigation of interleukin 1beta-mediated regulation of NF-kappaB activation in colonic cells reveals divergence between PKB and PDK-transduced events
    Kuljit Parhar
    Division of Gastroenterology, Faculty of Medicine, The Jack Bell Research Centre, 2660 Oak Street, Vancouver, BC, Canada
    Mol Cell Biochem 300:113-27. 2007
    ..Our data reveals for the first time that PDK1 and PKB may differentially activate NF-kappaB, and that TPCK may subserve a useful anti-inflammatory function by inhibiting IKKbeta...
  6. pmc The specific JNK inhibitor SP600125 targets tumour necrosis factor-alpha production and epithelial cell apoptosis in acute murine colitis
    Kiran Assi
    The Jack Bell Research Centre, Vancouver, BC, Canada
    Immunology 118:112-21. 2006
    ..Strikingly, we also demonstrate reduced epithelial cell apoptosis in response to treatment with SP600125. We conclude that specific inhibition of JNK is beneficial in the DSS model of colitis, and may be of value in human IBD...
  7. ncbi request reprint The role of protein kinase CK2 in intestinal epithelial cell inflammatory signaling
    Kuljit Parhar
    The Jack Bell Research Center, 2660 Oak Street, V6H 3Z6, Vancouver, British Columbia, Canada
    Int J Colorectal Dis 22:601-9. 2007
    ..One such potential signaling candidate is the protein kinase CK2. Despite its known ability to influence NF-kappaB activation, it has received no attention in this particular setting...
  8. ncbi request reprint 5,6-Dichloro-ribifuranosylbenzimidazole- and apigenin-induced sensitization of colon cancer cells to TNF-alpha-mediated apoptosis
    Myriam Farah
    Division of Gastroenterology, Univ of British Columbia, 100 2647 Willow St, Vancouver BC V5Z 3P1, Canada
    Am J Physiol Gastrointest Liver Physiol 285:G919-28. 2003
    ..Our findings indicate a potentially novel strategy for the treatment of colon cancer, one that targets CK2 simultaneous with TNF-alpha administration...
  9. pmc Role of epithelial integrin-linked kinase in promoting intestinal inflammation: effects on CCL2, fibronectin and the T cell repertoire
    Kiran Assi
    Department of Medicine, The Jack Bell Research Centre, 2660 Oak Street, Vancouver, British Columbia, V6H 3Z6, Canada
    BMC Immunol 12:42. 2011
    ..Hence, we aimed to investigate the role of epithelial-derived integrin-linked kinase (ILK), a critical integrin signaling intermediary molecule, in colonic inflammation...
  10. ncbi request reprint Curcumin mediates ceramide generation via the de novo pathway in colon cancer cells
    Maryam Moussavi
    The Jack Bell Research Centre, 2660 Oak Street, Vancouver, BC, Canada
    Carcinogenesis 27:1636-44. 2006
    ..Hence, we conclude that curcumin induces apoptosis via a ROS-associated mechanism that converges on JNK activation, and to a lesser extent via a parallel ceramide-associated pathway...
  11. ncbi request reprint Differential targeting of protein kinase B in cell death induced by sulindac and its metabolite sulindac sulfide
    Anthony Marotta
    Department of Medicine, University of British Columbia, Jack Bell Research Center, Vancouver, BC V6H 3Z6, Canada
    Int J Oncol 28:1471-9. 2006
    ....
  12. doi request reprint The importance of integrin-linked kinase in the regulation of bladder cancer invasion
    Yoshiyuki Matsui
    The Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia, Canada
    Int J Cancer 130:521-31. 2012
    ..ILK may be a new molecular target to suppress tumor progression in advanced and high-risk bladder cancer patients...
  13. ncbi request reprint Expression of integrin-linked kinase is not a useful prognostic marker in resected hepatocellular cancer
    Pongphob Intaraprasong
    Department of Medicine, University of British Columbia, Vancouver BC, Canada
    Anticancer Res 27:4371-6. 2007
    ..Unfortunately there are no available reliable markers of prognosis. The aim of this study was to determine whether integrin-linked kinase (ILK) expression correlates with post-resection survival from HCC. Patients and..
  14. doi request reprint Hypovitaminosis D in adults with inflammatory bowel disease: potential role of ethnicity
    Yi Tzu Nancy Fu
    Division of Gastroenterology, Department of Medicine, Gordon and Leslie Diamond Health Care Centre, University of British Columbia, 5th Floor, 2775 Laurel St, Vancouver, BC, V5Z 1M9, Canada
    Dig Dis Sci 57:2144-8. 2012
    ..Our aim was therefore to determine the ethnic variation in serum 25-hydroxyvitamin D status and its association with disease severity in adults with IBD...
  15. pmc The p38 mitogen-activated protein kinase regulates interleukin-1beta-induced IL-8 expression via an effect on the IL-8 promoter in intestinal epithelial cells
    Kuljit Parhar
    Department of Medicine, The Jack Bell Research Centre, Vancouver, British Columbia, Canada
    Immunology 108:502-12. 2003
    ....
  16. ncbi request reprint 5-Aminosalicylate stimulates phospholipase D activity in macrophages
    A Gomez-Munoz
    Division of Gastroenterology, Department of Medicine, University of British Columbia, 100 2647 Willow St, V5Z 3P1, Vancouver, BC, Canada
    Biochim Biophys Acta 1533:110-8. 2001
    ....
  17. pmc Ethnic variation in the annual rates of adult inflammatory bowel disease in hospitalized patients in Vancouver, British Columbia
    Birinder K Mangat
    Department of Medicine, University of British Columbia, Vancouver, British Columbia
    Can J Gastroenterol 25:73-7. 2011
    ..Migrating populations and changing demographics in Vancouver, British Columbia (BC) provide a unique opportunity to examine the role of ethnicity in the prevalence, expression and complications of IBD...
  18. ncbi request reprint Dysregulation of phosphatidylinositol 3-kinase and downstream effectors in human breast cancer
    Baljinder Salh
    The Department of Medicine, Jack Bell Research Center, University of British Columbia, Vancouver, British Columbia, Canada
    Int J Cancer 98:148-54. 2002
    ..It is proposed that this pathway may serve as a useful targeting nexus for investigation of small molecule inhibitors in human breast cancer...
  19. doi request reprint Development of testicular germ cell cancer following successful infliximab induction therapy for ulcerative colitis
    John C T Wong
    Department of Medicine, University of British Columbia, Vancouver, Canada
    J Crohns Colitis 5:162-4. 2011
    ..Given the prevalence of IBD in young men and recent suggestions for "top-down therapy," testicular cancer as a potential complication of anti-TNF╬▒ agents should be further explored on a population basis...
  20. ncbi request reprint Advanced colon cancer before the age of 20 years: a case for extension of the current colonoscopy surveillance guidelines in hereditary nonpolyposis colorectal cancer syndrome
    Victor K Wong
    Division of Gastroenterology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada
    Can J Gastroenterol 18:319-20. 2004
    ..Hereditary nonpolyposis colorectal cancer (HNPCC) currently accounts for between 2% to 6% of all colorectal adenocarcinomas. Controversies exist regarding the current guidelines for colonoscopic screening for colon cancer...
  21. ncbi request reprint Dysregulation of integrin-linked kinase (ILK) signaling in colonic polyposis
    A Marotta
    Jack Bell Research Center, 2660 Oak Street, Vancouver, BC, Canada V6H 3Z6
    Oncogene 20:6250-7. 2001
    ..Additionally, ILK signaling is shown to undergo modulation by sulindac (and aspirin) for the first time, indicating that it is likely to be one of the targets affected by these agents in vivo...
  22. ncbi request reprint Curcumin attenuates DNB-induced murine colitis
    B Salh
    Jack Bell Research Centre, Children and Women s Hospital, Vancouver, BC, Canada V5Z 3P1
    Am J Physiol Gastrointest Liver Physiol 285:G235-43. 2003
    ..We propose that this agent may have therapeutic implications for human IBD...