Baljinder Salh

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. ncbi PD98059 attenuates hydrogen peroxide-induced cell death through inhibition of Jun N-Terminal Kinase in HT29 cells
    B S Salh
    Jack Bell Research Centre, 2660 Oak Street, Vancouver, British Columbia, Canada V6H 3Z6
    Mol Cell Biol Res Commun 4:158-65. 2000
  2. ncbi Autoimmune cholangitis mimicking a klatskin tumor: a case report
    Alexandra Shingina
    Division of Gastroenterology, 2775, Laurel Street, Vancouver, British Columbia, V5Z 1M9, Canada
    J Med Case Reports 5:485. 2011
  3. ncbi c-Jun N-terminal kinases as potential therapeutic targets
    Baljinder Salh
    University of British Columbia, Department of Medicine, Vancouver, BC, Canada
    Expert Opin Ther Targets 11:1339-53. 2007
  4. ncbi Dissociated ROS production and ceramide generation in sulfasalazine-induced cell death in Raw 264.7 cells
    B Salh
    The Jack Bell Research Centre, Vancouver, British Columbia, Canada
    J Leukoc Biol 72:790-9. 2002
  5. ncbi Investigation of interleukin 1beta-mediated regulation of NF-kappaB activation in colonic cells reveals divergence between PKB and PDK-transduced events
    Kuljit Parhar
    Division of Gastroenterology, Faculty of Medicine, The Jack Bell Research Centre, 2660 Oak Street, Vancouver, BC, Canada
    Mol Cell Biochem 300:113-27. 2007
  6. ncbi The specific JNK inhibitor SP600125 targets tumour necrosis factor-alpha production and epithelial cell apoptosis in acute murine colitis
    Kiran Assi
    The Jack Bell Research Centre, Vancouver, BC, Canada
    Immunology 118:112-21. 2006
  7. ncbi The role of protein kinase CK2 in intestinal epithelial cell inflammatory signaling
    Kuljit Parhar
    The Jack Bell Research Center, 2660 Oak Street, V6H 3Z6, Vancouver, British Columbia, Canada
    Int J Colorectal Dis 22:601-9. 2007
  8. ncbi 5,6-Dichloro-ribifuranosylbenzimidazole- and apigenin-induced sensitization of colon cancer cells to TNF-alpha-mediated apoptosis
    Myriam Farah
    Division of Gastroenterology, Univ. of British Columbia, 100-2647 Willow St, Vancouver BC V5Z 3P1, Canada
    Am J Physiol Gastrointest Liver Physiol 285:G919-28. 2003
  9. ncbi Role of epithelial integrin-linked kinase in promoting intestinal inflammation: effects on CCL2, fibronectin and the T cell repertoire
    Kiran Assi
    Department of Medicine, The Jack Bell Research Centre, 2660 Oak Street, Vancouver, British Columbia, V6H 3Z6, Canada
    BMC Immunol 12:42. 2011
  10. ncbi Curcumin mediates ceramide generation via the de novo pathway in colon cancer cells
    Maryam Moussavi
    The Jack Bell Research Centre, 2660 Oak Street, Vancouver, BC, Canada
    Carcinogenesis 27:1636-44. 2006

Collaborators

  • Yi Tzu Nancy Fu
  • David G Huntsman
  • John C T Wong
  • Vincent Duronio
  • Alan I So
  • Antonio Gomez-Munoz
  • S Huang
  • Steven Pelech
  • Kiran Assi
  • Kuljit Parhar
  • David Owen
  • Eric M Yoshida
  • Maryam Moussavi
  • Yoshiyuki Matsui
  • Shoukat Dedhar
  • Birinder K Mangat
  • Alexandra Shingina
  • Pongphob Intaraprasong
  • Anthony Marotta
  • Sharlene Eivemark
  • Victor K Wong
  • Myriam Farah
  • Osamu Ogawa
  • Peter A Raven
  • A Marotta
  • Martin E Gleave
  • Charles Zwirewich
  • Chad Evaschen
  • Megan Levings
  • Tim Lee
  • Scott Patterson
  • Jennifer Morse
  • Charles H Scudamore
  • Arthur Yee
  • Stephen W Chung
  • David A Owen
  • Rex Pillai
  • Rajinder Hundal
  • Anthony G Ryan
  • Stephen G F Ho
  • Urs Steinbrecher
  • Andrew Ray
  • Colleen Nelson
  • C Tan
  • D Owen
  • J Sanghera
  • B Dupuis
  • S Malik
  • S Dedhar
  • V Gray
  • S Gallinger

Detail Information

Publications22

  1. ncbi PD98059 attenuates hydrogen peroxide-induced cell death through inhibition of Jun N-Terminal Kinase in HT29 cells
    B S Salh
    Jack Bell Research Centre, 2660 Oak Street, Vancouver, British Columbia, Canada V6H 3Z6
    Mol Cell Biol Res Commun 4:158-65. 2000
    ....
  2. ncbi Autoimmune cholangitis mimicking a klatskin tumor: a case report
    Alexandra Shingina
    Division of Gastroenterology, 2775, Laurel Street, Vancouver, British Columbia, V5Z 1M9, Canada
    J Med Case Reports 5:485. 2011
    ..abstract:..
  3. ncbi c-Jun N-terminal kinases as potential therapeutic targets
    Baljinder Salh
    University of British Columbia, Department of Medicine, Vancouver, BC, Canada
    Expert Opin Ther Targets 11:1339-53. 2007
    ..With roles described in almost all classes of disease, the main questions are what type of inhibitor to use and when exactly to use it during the disease course?..
  4. ncbi Dissociated ROS production and ceramide generation in sulfasalazine-induced cell death in Raw 264.7 cells
    B Salh
    The Jack Bell Research Centre, Vancouver, British Columbia, Canada
    J Leukoc Biol 72:790-9. 2002
    ..In conclusion, the cell-death response induced by SSZ in Raw 264.7 cells involves ROS in the apoptotic limb but is independent of ceramide formation...
  5. ncbi Investigation of interleukin 1beta-mediated regulation of NF-kappaB activation in colonic cells reveals divergence between PKB and PDK-transduced events
    Kuljit Parhar
    Division of Gastroenterology, Faculty of Medicine, The Jack Bell Research Centre, 2660 Oak Street, Vancouver, BC, Canada
    Mol Cell Biochem 300:113-27. 2007
    ..Our data reveals for the first time that PDK1 and PKB may differentially activate NF-kappaB, and that TPCK may subserve a useful anti-inflammatory function by inhibiting IKKbeta...
  6. ncbi The specific JNK inhibitor SP600125 targets tumour necrosis factor-alpha production and epithelial cell apoptosis in acute murine colitis
    Kiran Assi
    The Jack Bell Research Centre, Vancouver, BC, Canada
    Immunology 118:112-21. 2006
    ..Strikingly, we also demonstrate reduced epithelial cell apoptosis in response to treatment with SP600125. We conclude that specific inhibition of JNK is beneficial in the DSS model of colitis, and may be of value in human IBD...
  7. ncbi The role of protein kinase CK2 in intestinal epithelial cell inflammatory signaling
    Kuljit Parhar
    The Jack Bell Research Center, 2660 Oak Street, V6H 3Z6, Vancouver, British Columbia, Canada
    Int J Colorectal Dis 22:601-9. 2007
    ..One such potential signaling candidate is the protein kinase CK2. Despite its known ability to influence NF-kappaB activation, it has received no attention in this particular setting...
  8. ncbi 5,6-Dichloro-ribifuranosylbenzimidazole- and apigenin-induced sensitization of colon cancer cells to TNF-alpha-mediated apoptosis
    Myriam Farah
    Division of Gastroenterology, Univ. of British Columbia, 100-2647 Willow St, Vancouver BC V5Z 3P1, Canada
    Am J Physiol Gastrointest Liver Physiol 285:G919-28. 2003
    ..Our findings indicate a potentially novel strategy for the treatment of colon cancer, one that targets CK2 simultaneous with TNF-alpha administration...
  9. ncbi Role of epithelial integrin-linked kinase in promoting intestinal inflammation: effects on CCL2, fibronectin and the T cell repertoire
    Kiran Assi
    Department of Medicine, The Jack Bell Research Centre, 2660 Oak Street, Vancouver, British Columbia, V6H 3Z6, Canada
    BMC Immunol 12:42. 2011
    ..Hence, we aimed to investigate the role of epithelial-derived integrin-linked kinase (ILK), a critical integrin signaling intermediary molecule, in colonic inflammation...
  10. ncbi Curcumin mediates ceramide generation via the de novo pathway in colon cancer cells
    Maryam Moussavi
    The Jack Bell Research Centre, 2660 Oak Street, Vancouver, BC, Canada
    Carcinogenesis 27:1636-44. 2006
    ..Hence, we conclude that curcumin induces apoptosis via a ROS-associated mechanism that converges on JNK activation, and to a lesser extent via a parallel ceramide-associated pathway...
  11. ncbi Differential targeting of protein kinase B in cell death induced by sulindac and its metabolite sulindac sulfide
    Anthony Marotta
    Department of Medicine, University of British Columbia, Jack Bell Research Center, Vancouver, BC V6H 3Z6, Canada
    Int J Oncol 28:1471-9. 2006
    ....
  12. ncbi The importance of integrin-linked kinase in the regulation of bladder cancer invasion
    Yoshiyuki Matsui
    The Vancouver Prostate Centre, University of British Columbia, Vancouver, British Columbia, Canada
    Int J Cancer 130:521-31. 2012
    ..ILK may be a new molecular target to suppress tumor progression in advanced and high-risk bladder cancer patients...
  13. ncbi Expression of integrin-linked kinase is not a useful prognostic marker in resected hepatocellular cancer
    Pongphob Intaraprasong
    Department of Medicine, University of British Columbia, Vancouver BC, Canada
    Anticancer Res 27:4371-6. 2007
    ..Unfortunately there are no available reliable markers of prognosis. The aim of this study was to determine whether integrin-linked kinase (ILK) expression correlates with post-resection survival from HCC. Patients and..
  14. ncbi Hypovitaminosis D in adults with inflammatory bowel disease: potential role of ethnicity
    Yi Tzu Nancy Fu
    Division of Gastroenterology, Department of Medicine, Gordon and Leslie Diamond Health Care Centre, University of British Columbia, 5th Floor, 2775 Laurel St, Vancouver, BC, V5Z 1M9, Canada
    Dig Dis Sci 57:2144-8. 2012
    ..Our aim was therefore to determine the ethnic variation in serum 25-hydroxyvitamin D status and its association with disease severity in adults with IBD...
  15. ncbi The p38 mitogen-activated protein kinase regulates interleukin-1beta-induced IL-8 expression via an effect on the IL-8 promoter in intestinal epithelial cells
    Kuljit Parhar
    Department of Medicine, The Jack Bell Research Centre, Vancouver, British Columbia, Canada
    Immunology 108:502-12. 2003
    ....
  16. ncbi 5-Aminosalicylate stimulates phospholipase D activity in macrophages
    A Gomez-Munoz
    Division of Gastroenterology, Department of Medicine, University of British Columbia, 100 2647 Willow St, V5Z 3P1, Vancouver, BC, Canada
    Biochim Biophys Acta 1533:110-8. 2001
    ....
  17. ncbi Ethnic variation in the annual rates of adult inflammatory bowel disease in hospitalized patients in Vancouver, British Columbia
    Birinder K Mangat
    Department of Medicine, University of British Columbia, Vancouver, British Columbia
    Can J Gastroenterol 25:73-7. 2011
    ..Migrating populations and changing demographics in Vancouver, British Columbia (BC) provide a unique opportunity to examine the role of ethnicity in the prevalence, expression and complications of IBD...
  18. ncbi Dysregulation of phosphatidylinositol 3-kinase and downstream effectors in human breast cancer
    Baljinder Salh
    The Department of Medicine, Jack Bell Research Center, University of British Columbia, Vancouver, British Columbia, Canada
    Int J Cancer 98:148-54. 2002
    ..It is proposed that this pathway may serve as a useful targeting nexus for investigation of small molecule inhibitors in human breast cancer...
  19. ncbi Development of testicular germ cell cancer following successful infliximab induction therapy for ulcerative colitis
    John C T Wong
    Department of Medicine, University of British Columbia, Vancouver, Canada
    J Crohns Colitis 5:162-4. 2011
    ..Given the prevalence of IBD in young men and recent suggestions for "top-down therapy," testicular cancer as a potential complication of anti-TNFα agents should be further explored on a population basis...
  20. ncbi Advanced colon cancer before the age of 20 years: a case for extension of the current colonoscopy surveillance guidelines in hereditary nonpolyposis colorectal cancer syndrome
    Victor K Wong
    Division of Gastroenterology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada
    Can J Gastroenterol 18:319-20. 2004
    ..It is suggested that in similar patients, even if they do not fulfill all the criteria for HNPCC, it would be appropriate to consider screening well before the recommended lower age...
  21. ncbi Dysregulation of integrin-linked kinase (ILK) signaling in colonic polyposis
    A Marotta
    Jack Bell Research Center, 2660 Oak Street, Vancouver, BC, Canada V6H 3Z6
    Oncogene 20:6250-7. 2001
    ..Additionally, ILK signaling is shown to undergo modulation by sulindac (and aspirin) for the first time, indicating that it is likely to be one of the targets affected by these agents in vivo...
  22. ncbi Curcumin attenuates DNB-induced murine colitis
    B Salh
    Jack Bell Research Centre, Children and Women's Hospital, Vancouver, BC, Canada V5Z 3P1
    Am J Physiol Gastrointest Liver Physiol 285:G235-43. 2003
    ..We propose that this agent may have therapeutic implications for human IBD...