Jean A Saint-Cyr
Affiliation: University of Toronto
- Long-term follow up of bilateral deep brain stimulation of the subthalamic nucleus in patients with advanced Parkinson diseaseGalit Kleiner-Fisman
Division of Neurology and Neurosurgery, Toronto Western Hospital, University of Toronto, Ontario, Canada
J Neurosurg 99:489-95. 2003..The authors present the long-term results of a cohort of 25 individuals who underwent bilateral DBS of the STN between 1996 and 2001 and were followed up for 1 year or longer after implantation of the stimulator...
- Localization of clinically effective stimulating electrodes in the human subthalamic nucleus on magnetic resonance imagingJean A Saint-Cyr
Department of Surgery, Division of Neurosurgery, University of Toronto and University Health Network, Toronto, Ontario, Canada
J Neurosurg 97:1152-66. 2002..The authors sought to determine the location of deep brain stimulation (DBS) electrodes that were most effective in treating Parkinson disease (PD)...
- Frontal-striatal circuit functions: context, sequence, and consequenceJean A Saint-Cyr
Department of Surgery Division of Neurosurgery, University of Toronto, ON, Canada
J Int Neuropsychol Soc 9:103-27. 2003....
- Increased vesicular monoamine transporter binding during early abstinence in human methamphetamine users: Is VMAT2 a stable dopamine neuron biomarker?Isabelle Boileau
Human Neurochemical Pathology Laboratory, University of Toronto, Toronto, Ontario, Canada
J Neurosci 28:9850-6. 2008..If correct, (+)[(11)C]DTBZ might be a useful imaging probe to correlate changes in brain dopamine stores and behavior in users of methamphetamine...
- Involvement of the basal ganglia and cerebellar motor pathways in the preparation of self-initiated and externally triggered movements in humansJamie Purzner
The Krembil Neuroscience Centre and Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada M5T 2S8
J Neurosci 27:6029-36. 2007..The CTC pathway is involved in the preparation of self-paced but not externally cued movements, although the pathway may still be involved in the execution of these movements...
- Movement-related neurons of the subthalamic nucleus in patients with Parkinson diseaseAviva Abosch
Department of Surgery, Division of Neurosurgery, Toronto Western Hospital, Toronto Western Research Institute, Ontario, Canada
J Neurosurg 97:1167-72. 2002..The authors' goal was to examine the distribution of movement-related neurons within the STN of humans by using microelectrode recording to identify neuronal receptive fields...
- Subthalamic nucleus deep brain stimulation for parkinson's disease after successful pallidotomy: clinical and electrophysiological observationsGalit Kleiner-Fisman
Division of Neurology, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
Mov Disord 19:1209-14. 2004..017, 0.005). There were no side-to-side differences clinically or in the STN neuronal firing rates and patterns. Bilateral STN DBS is safe and efficacious in improving motor symptoms in patients with prior pallidotomy...
- Levodopa response in long-term bilateral subthalamic stimulation for Parkinson's diseasePanida Piboolnurak
Movement Disorders Center, Division of Neurology, University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada
Mov Disord 22:990-7. 2007..1% at 3 years and 19.2% at 5 years). Anti-PD drugs were significantly reduced by 47.9% at 3 years and 39.8% at 5 years. However, the magnitude of the preoperative response to levodopa did not predict DBS benefit at 3 and 5 years...
- Decreased cerebral cortical serotonin transporter binding in ecstasy users: a positron emission tomography/[(11)C]DASB and structural brain imaging studyStephen J Kish
Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario M5T 1R8, Canada
Brain 133:1779-97. 2010....
- Subthalamic nucleus stimulation: improvements in outcome with reprogrammingElena Moro
Movement Disorders Center and Department of Neurosurgery, Toronto Western Hospital, University Health Network, University of Toronto, 399 Bathurst Street, Toronto, Ontario
Arch Neurol 63:1266-72. 2006..Even when the electrode is well positioned in the target, the optimization of clinical results depends on careful programming of electrical parameters and changes in antiparkinsonian drug dosages...
- Psychiatric symptoms following surgery for Parkinson's disease with an emphasis on subthalamic stimulationValerie Voon
Department of Psychiatry, Toronto Western Hospital, UHN, Toronto, Canada
Adv Neurol 96:130-47. 2005..The paucity of the literature underscores the need for well-designed studies on psychiatric issues investigating both pathophysiology and clinical outcomes...
- Regional anatomy of the pedunculopontine nucleus: relevance for deep brain stimulationMarie Pierre Fournier-Gosselin
Division of Neurosurgery, Hopital Notre Dame, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
Mov Disord 28:1330-6. 2013..By providing a functional map and representative schematics of the PPN region, we hope to optimize the placement of deep brain stimulation electrodes, thereby maximizing safety and clinical efficacy...
- Correspondence of microelectrode mapping with magnetic resonance imaging for subthalamic nucleus proceduresClement Hamani
Division of Neurosurgery, University of Toronto, Toronto, ON M5T 2S8, Canada
Surg Neurol 63:249-53; discussion 253. 2005..Little is known about the correlation between the position of the STN as seen on MRI and that as determined by MER mapping. We compared these in 10 patients with Parkinson's disease...
- Involvement of human thalamus in the preparation of self-paced movementGuillermo Paradiso
The Krembil Neuroscience Centre and Toronto Western Research Institute, Toronto, Ontario, Canada
Brain 127:2717-31. 2004..Different cortico-subcortical circuits may mediate alpha and beta oscillations. During movement preparation, the motor thalamus and the supplementary motor area predominantly interact in the beta band...
- The subthalamic nucleus in the context of movement disordersClement Hamani
Division of Neurosurgery, Toronto Western Hospital, Toronto Western Research Institute, Ontario, Canada
Brain 127:4-20. 2004..The aim of the present article is to review briefly the major anatomical, pharmacological and physiological aspects of the STN, as well as its involvement in the pathophysiology and treatment of Parkinson's disease...
- Speech and nonspeech sequence skill learning in adults who stutterSarah Smits-Bandstra
Graduate Department of Speech Language Pathology, University of Toronto, Canada
J Fluency Disord 31:116-36. 2006..These results partially supported the inference that PWS demonstrated differences in early stages of sequence skill learning compared to PNS...
- Elevated serotonin transporter binding in depressed patients with Parkinson's disease: a preliminary PET study with [11C]DASBIsabelle Boileau
Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
Mov Disord 23:1776-80. 2008....
- Exploring the recognition memory deficit in Parkinson's disease: estimates of recollection versus familiarityPatrick S R Davidson
The Rotman Research Institute, Baycrest Centre for Geriatric Care Toronto, Ontario, Canada
Brain 129:1768-79. 2006..We discuss how this pattern may be related to dysfunction of striatal, prefrontal and/or medial temporal regions in Parkinson's disease...
- Neuropsychology for movement disorders neurosurgeryJean A Saint-Cyr
Department of Surgery, University Health Network, University of Toronto, Toronto Western Hospital, Toronto, ON, Canada
Can J Neurol Sci 30:S83-93. 2003..Neuropsychologists also study alteration of cognitive processing due to lesions or stimulation, which, in tandem with functional imaging, shed light on plasticity in cortical and subcortical processing...
- Basal ganglia: functional perspectives and behavioral domainsJean A Saint-Cyr
Departments of Surgery Division of Neurosurgery and Psychology, University of Toronto, Toronto, Canada
Adv Neurol 96:1-16. 2005
- Stimulation of the subthalamic nucleus in Parkinson's disease does not produce striatal dopamine releaseAviva Abosch
Department of Surgery, Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, and University Health Network, University of Toronto, Toronto, Ontario, Canada
Neurosurgery 53:1095-102; discussion 1102-5. 2003..We sought to determine whether STN stimulation could release endogenous striatal dopamine...
- Motor cortical stimulation for parkinsonism in multiple system atrophyGalit Kleiner-Fisman
Division of Neurology and Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario
Arch Neurol 60:1554-8. 2003..We hypothesized that direct cortical stimulation could alleviate the disability of the treatment-refractory parkinsonian symptoms commonly present in MSA...
- Long-term follow-up of thalamic deep brain stimulation for essential and parkinsonian tremorRajeev Kumar
Division of Neurology, Faculty of Medicine, University of Toronto, Canada
Neurology 61:1601-4. 2003..Two of five patients with essential tremor had contralateral tremor improvement after ongoing stimulation for 2 years; two developed marked tolerance to DBS...
- Longevity of batteries in internal pulse generators used for deep brain stimulationMohammed Bin-Mahfoodh
Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Canada
Stereotact Funct Neurosurg 80:56-60. 2003..In our series of patients who needed battery replacement, battery longevity varied with stimulation parameters but was longer than expected from the manufacturer's specifications...