Affiliation: University of Ottawa
Alturki N, McComb S, Ariana A, Rijal D, Korneluk R, Sun S, et al
. Triad3a induces the degradation of early necrosome to limit RipK1-dependent cytokine production and necroptosis. Cell Death Dis. 2018;9:592 pubmed publisher
..These results reveal a new mechanism of shutting off necrosome signaling and may pave the way to new strategies for therapeutic manipulation of inflammatory responses. ..
Rijal D, Ariana A, Wight A, Kim K, Alturki N, Aamir Z, et al
. Differentiated macrophages acquire a pro-inflammatory and cell death-resistant phenotype due to increasing XIAP and p38-mediated inhibition of RipK1. J Biol Chem. 2018;293:11913-11927 pubmed publisher
Huus K, Joseph J, Zhang L, Wong A, Aaron S, Mah T, et al
. Clinical Isolates of Pseudomonas aeruginosa from Chronically Infected Cystic Fibrosis Patients Fail To Activate the Inflammasome during Both Stable Infection and Pulmonary Exacerbation. J Immunol. 2016;196:3097-108 pubmed publisher
..These results reveal a novel mechanism of pathogen adaptation by P. aeruginosa to avoid detection by inflammasomes in CF patients and indicate that P. aeruginosa-activated inflammasomes are not involved in CF pulmonary exacerbations. ..
McComb S, Shutinoski B, Thurston S, Cessford E, Kumar K, Sad S. Cathepsins limit macrophage necroptosis through cleavage of Rip1 kinase. J Immunol. 2014;192:5671-8 pubmed publisher
..These data reveal a novel mechanism of regulation of necroptosis by cathepsins within macrophage cells. ..
McComb S, Cessford E, Alturki N, Joseph J, Shutinoski B, Startek J, et al
. Type-I interferon signaling through ISGF3 complex is required for sustained Rip3 activation and necroptosis in macrophages. Proc Natl Acad Sci U S A. 2014;111:E3206-13 pubmed publisher
..Induction of IFNAR1/Rip3-dependent necroptosis also resulted in potent inflammatory pathology in vivo. These results reveal how IFN-I mediates acute inflammation through macrophage necroptosis. ..