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Genomes and GenesSpecies | James A RussellSummaryAffiliation: University of British Columbia Country: Canada Publications
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Publications
Universal changes in biomarkers of coagulation and inflammation occur in patients with severe sepsis, regardless of causative micro-organism [ISRCTN74215569]Gary T Kinasewitz
Department of Medicine, Physiology and Biophysics, University of Oklahoma Health Science Center, and Cardiovascular Biology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
Crit Care 8:R82-90. 2004..Coagulopathy and inflammation were universal host responses to infection in patients with severe sepsis, which were similar across causative micro-organism groups...
Albumin resuscitation improves ventricular contractility and myocardial tissue oxygenation in rat endotoxemiaChiho Tokunaga
Critical Care Research Laboratories, University of British Columbia, Vancouver, Canada
Crit Care Med 35:1341-7. 2007..We hypothesized that albumin resuscitation would improve decreased ventricular contractility and myocardial tissue oxygenation in vivo...- Vasopressin in vasodilatory and septic shockJames A Russell
Division of Critical Care Medicine, University of British Columbia, Vancouver British Columbia, Canada
Curr Opin Crit Care 13:383-91. 2007..The aim of this article is to review mechanisms of action of vasopressin and clinical studies of vasopressin in septic shock... - Management of sepsisJames A Russell
University of British Columbia, Critical Care Medicine, St. Paul's Hospital, Vancouver, BC, Canada
N Engl J Med 355:1699-713. 2006 - Mechanisms of beta-receptor stimulation-induced improvement of acute lung injury and pulmonary edemaHoracio E Groshaus
Critical Care Research Laboratories, St Paul's Hospital and University of British Columbia, Vancouver, British Columbia, Canada
Crit Care 8:234-42. 2004..The available evidence suggests that beta-2 agonists may be efficacious therapy in ALI. Further randomized controlled trials of beta agonists in pulmonary edema and in acute lung injury are necessary... - The current management of septic shockJ A Russel
Critical Care Medicine, St Paul s Hospital, Vancouver, BC, Canada
Minerva Med 99:431-58. 2008..6% vs 51.5% respectively), duration of renal support, or rates of recovery of renal and non-renal organ dysfunction... 
Protein C rs2069912 C allele is associated with increased mortality from severe sepsis in North Americans of East Asian ancestryJames A Russell
University of British Columbia Critical Care Research Laboratories, 1081 Burrard Street, Vancouver, BC, Canada
Hum Genet 123:661-3. 2008..The C allele was associated with increased mortality and organ dysfunction, consistent with Chen et al...- Vasopressin versus norepinephrine infusion in patients with septic shockJames A Russell
iCAPTURE Centre, Vancouver, BC, Canada
N Engl J Med 358:877-87. 2008..We hypothesized that low-dose vasopressin as compared with norepinephrine would decrease mortality among patients with septic shock who were being treated with conventional (catecholamine) vasopressors... - Vasopressin in septic shockJames A Russell
Critical Care Medicine and James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St. Paul's Hospital and University of British Columbia, Vancouver, British Columbia, Canada
Crit Care Med 35:S609-15. 2007 - Bench-to-bedside review: Vasopressin in the management of septic shockJames A Russell
Critical Care Medicine, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
Crit Care 15:226. 2011..The interaction of vasopressin infusion and corticosteroid treatment in septic shock requires further study... - beta2-Adrenergic receptor gene polymorphism is associated with mortality in septic shockTaka aki Nakada
Critical Care Research Laboratories, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
Am J Respir Crit Care Med 181:143-9. 2010..Whether this functional haplotype alters outcome in patients receiving adrenergic agonists in septic shock is unknown... - Interaction of vasopressin infusion, corticosteroid treatment, and mortality of septic shockJames A Russell
St Paul s Hospital, iCAPTURE Centre, Canada
Crit Care Med 37:811-8. 2009..However, it is unknown whether vasopressin treatment interacts with corticosteroid treatment... - Fibrinogen-beta gene haplotype is associated with mortality in sepsisSanjay Manocha
Critical Care Research Laboratories, James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
J Infect 54:572-7. 2007..Our aim was to determine whether haplotypes of FGB are associated with mortality and organ dysfunction in a cohort of patients with sepsis... - AA genotype of IL-8 -251A/T is associated with low PaO(2)/FiO(2) in critically ill patients and with increased IL-8 expressionPetch Wacharasint
University of British Columbia, Critical Care Research Laboratories, Institute for Heart Lung Health, St Paul s Hospital, Vancouver, BC, Canada
Respirology 17:1253-60. 2012..We hypothesized that IL-8 -251A/T SNP is associated with PaO(2)/FiO(2) in critically ill patients... - Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortalityJohn H Boyd
University of British Columbia Critical Care Research Laboratories, Heart Lung Institute, St Paul s Hospital, Vancouver, British Columbia, Canada
Crit Care Med 39:259-65. 2011..To determine whether central venous pressure and fluid balance after resuscitation for septic shock are associated with mortality... - Association of angiotensin II type 1 receptor-associated protein gene polymorphism with increased mortality in septic shockTaka aki Nakada
University of British Columbia, Critical Care Research Laboratories, Heart Lung Institute, St Paul s Hospital, Vancouver, British Columbia, Canada
Crit Care Med 39:1641-8. 2011..The objective of this study was to test the hypothesis that single nucleotide polymorphisms in angiotensin II pathway genes alter outcome of septic shock... - Protein C -1641 AA is associated with decreased survival and more organ dysfunction in severe sepsisKeith R Walley
Critical Care Research Laboratories, St Paul s Hospital and University of British Columbia, Vancouver, British Columbia, Canada
Crit Care Med 35:12-7. 2007..We tested the hypothesis that these polymorphisms are associated with altered outcome in patients having severe sepsis, in which protein C is a central molecule... - Leucyl/cystinyl aminopeptidase gene variants in septic shockTaka aki Nakada
University of British Columbia, Vancouver, BC, Canada
Chest 139:1042-9. 2011..Vasopressin is an essential peptide hormone regulating cardiovascular homeostasis and an adjunctive vasopressor therapy for septic shock... - Normal-range blood lactate concentration in septic shock is prognostic and predictivePetch Wacharasint
University of British Columbia, Critical Care Research Laboratories, Institute for Heart Lung Health, St Paul s Hospital, Vancouver, British Columbia, Canada
Shock 38:4-10. 2012..05). Lactate concentrations within the "normal" range can be a useful prognostic indicator in septic shock. Furthermore, patients whose lactate level is less than or equal to 1.4 mmol/L may benefit from vasopressin infusion... - Novel polymorphism of interleukin-18 associated with greater inflammation after cardiac surgeryDavid M Shaw
Critical Care Research Laboratories, Heart Lung Institute, University of British Columbia, Vancouver, BC, Canada
Crit Care 13:R9. 2009..We hypothesised that variation in the pro-inflammatory gene IL-18 is associated with adverse clinical outcome because of a more intense inflammatory response... - A nonsynonymous polymorphism of IRAK4 associated with increased prevalence of gram-positive infection and decreased response to toll-like receptor ligandsAinsley M Sutherland
Critical Care Research Laboratories, Providence Heart and Lung Institute at St Paul s Hospital, University of British Columbia, Vancouver, B C, Canada ainsley sutherland utoronto ca
J Innate Immun 3:447-58. 2011..07). Our data suggest that the IRAK4 haplotype clade marked by 29429A (428Thr) alters susceptibility to Gram-positive bacteria, by decreasing cellular response to TLR ligands... - A single nucleotide polymorphism in NF-κB inducing kinase is associated with mortality in septic shockSimone A Thair
University of British Columbia Critical Care Research Laboratories, Heart and Lung Institute, St Paul s Hospital, Vancouver, British Columbia V6Z 1Y6, Canada
J Immunol 186:2321-8. 2011..017). This suggests that the CC genotype of NIK rs7222094 is associated with increased mortality and organ dysfunction in septic shock patients, perhaps due to altered regulation of NF-κB pathway genes, including CXCL10... - The prediction of adverse maternal outcomes in preeclampsiaPeter von Dadelszen
Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, BC
J Obstet Gynaecol Can 26:871-9. 2004..MPV:platelet ratio also showed promise as a marker of platelet consumption. A prospective study is required to develop a clinical prediction model for preeclampsia... - The association of interleukin 6 haplotype clades with mortality in critically ill adultsAinsley M Sutherland
University of British Columbia McDonald Research Laboratories The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Vancouver, British Columbia V6Z 1Y6, Canada
Arch Intern Med 165:75-82. 2005..We tested the hypothesis that specific haplotype clades of IL-6 may be associated with an outcome of SIRS... - Inhaled beta-2 agonist salbutamol and acute lung injury: an association with improvement in acute lung injurySanjay Manocha
Critical Care Research Laboratories, Centre for Cardiovascular and Pulmonary Research, University of British Columbia, Vancouver, BC, Canada
Crit Care 10:R12. 2006..A dose greater than 2.2 mg/day of inhaled salbutamol could be a minimal effective dose to evaluate in a randomized controlled trial... - Polymorphisms in CD14, mannose-binding lectin, and Toll-like receptor-2 are associated with increased prevalence of infection in critically ill adultsAinsley M Sutherland
University of British Columbia Critical Care Research Laboratories, James Hogg iCAPTURE Centre St Paul s Hospital, Vancouver, BC, Canada
Crit Care Med 33:638-44. 2005.... - Interleukin-10 haplotype associated with increased mortality in critically ill patients with sepsis from pneumonia but not in patients with extrapulmonary sepsisAnan Wattanathum
Critical Care Research Laboratories, 1081 Burrard St, Vancouver, BC, Canada V6Z 1Y6
Chest 128:1690-8. 2005..To test the hypothesis that haplotypes of the interleukin (IL)-10 gene are associated with clinical outcomes, comparing critically ill patients with sepsis from pneumonia vs those with extrapulmonary sepsis... - A common polymorphism in the 5' region of the human protein c gene binds USF1Katherine R Thain
Critical Care Research Laboratories, Institute for Heart Lung Health at St Paul s Hospital, University of British Columbia, Vancouver, Canada
Thromb Res 130:451-7. 2012..We tested the hypothesis that common SNPs (minor allele frequency >10%) between the frequently studied promoter SNPs -1654 (rs1799808) and -1641 (rs1799809), and the end of PROC intron 2 alter nuclear transcription factor binding... - IL17A genetic variation is associated with altered susceptibility to Gram-positive infection and mortality of severe sepsisTaka aki Nakada
University of British Columbia, Critical Care Research Laboratories, Heart Lung Institute, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada
Crit Care 15:R254. 2011..Therefore, we hypothesized that SNPs in the IL17A gene alter susceptibility to infection and clinical outcome of severe sepsis... - Neutrophil apoptosis in preeclampsia, do steroids confound the relationship?Akiko Fuchisawa
Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia V6H 3N1, Canada
J Obstet Gynaecol Res 30:342-8. 2004..To investigate the influence of maternal corticosteroid administration on neutrophil apoptosis in early onset preeclampsia... - Genetic polymorphisms in sepsis and septic shock: role in prognosis and potential for therapyCheryl L Holmes
McDonald Research Laboratories/The iCAPTURE Centre, University of British Columbia, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
Chest 124:1103-15. 2003.... - Issues with polymorphism analysis in sepsisAinsley M Sutherland
University of British Columbia, The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St. Paul's Hospital, Vancouver, British Columbia, Canada
Clin Infect Dis 41:S396-402. 2005.... - Molecular mechanisms of sepsisJames A Russell
Heart and Lung Institute, St Paul s Hospital, Vancouver, BC, Canada
Contrib Microbiol 17:48-85. 2011..Perhaps the paucity of approved therapies for sepsis is related in part to the underevaluation of novel pathways, to lack of understanding of interactions of pathways and to lack of interruption of key pathways of sepsis... - Severe acute respiratory distress syndrome (SARS): a critical care perspectiveSanjay Manocha
Department of Medicine, University of British Columbia, Vancouver, Canada
Crit Care Med 31:2684-92. 2003..Early recognition is critical for effective management and containment of this disease... - Goal directed therapy: how long can we wait?Anthony C Gordon
Centre for Cardiovascular and Pulmonary Research, University of British Columbia, Vancouver, BC, Canada
Crit Care 9:647-8. 2005..If this management cannot begin preoperatively, it is still worth beginning goal directed therapy in the immediate postoperative period... - The effects of steroids on the occurrence of postoperative atrial fibrillation after coronary artery bypass grafting surgery: a prospective randomized trialKriengchai Prasongsukarn
St. Paul's Hospital, University of British Columbia, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
J Thorac Cardiovasc Surg 130:93-8. 2005.... - Albumin resuscitation increases cardiomyocyte contractility and decreases nitric oxide synthase II expression in rat endotoxemiaKeith R Walley
University of British Columbia McDonald Research Laboratories iCAPTURE Center, Vancouver, Canada
Crit Care Med 31:187-94. 2003..Therefore, we hypothesized that crystalloid or colloid resuscitation may alter myocardial dysfunction... - Vasopressin and its immune effects in septic shockJames A Russell
Heart and Lung Institute, St Paul s Hospital, University of British Columbia, Vancouver, B C, Canada
J Innate Immun 2:446-60. 2010..Vasopressin plus corticosteroid treatment may decrease mortality compared to corticosteroids plus norepinephrine. Potential mechanisms are that vasopressin plus corticosteroids beneficially alter immunity in septic shock... - Genetics of coagulation factors in acute lung injuryJames A Russell
Division of Critical Care Medicine, Department of Medicine and UBC McDonald Research Laboratories, St. Paul's Hospital, Vancouver, BC, Canada
Crit Care Med 31:S243-7. 2003.... - Activated protein C in normal human pregnancy and pregnancies complicated by severe preeclampsia: a therapeutic opportunity?Peter von Dadelszen
Department of Obstetrics and Gynaecology, Division of Maternal Fetal Medicine, University of British Columbia, Vancouver, British Columbia, Canada
Crit Care Med 30:1883-92. 2002..To determine which patients would be offered rhAPC, the literature pertaining to fetal/neonatal outcomes for preeclampsia remote from term, transplacental transport of protein C, and pregnancy experience with the compound were reviewed... - Prediction of adverse maternal outcomes in pre-eclampsia: development and validation of the fullPIERS modelPeter von Dadelszen
Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, BC, Canada
Lancet 377:219-27. 2011..We developed and validated the fullPIERS model with the aim of identifying the risk of fatal or life-threatening complications in women with pre-eclampsia within 48 h of hospital admission for the disorder... - Gene expression in human sepsis: what have we learned?James A Russell
Critical Care Medicine, St, Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
Crit Care 15:121. 2011.... - Inotropes and vasopressors: more than haemodynamics!Hendrik Bracht
Klinik fur Anasthesiologie, Universitatsklinikum, Ulm, Germany
Br J Pharmacol 165:2009-11. 2012..Hence, further investigations are essential to determine which catecholamine, or, in a broader sense, which alternative vasopressor and/or inotrope is the most appropriate for a particular clinical condition... - Albumin versus crystalloid for pump priming in cardiac surgery: meta-analysis of controlled trialsJames A Russell
Program of Critical Care Medicine, Department of Medicine, St. Paul's Hospital and University of British Columbia, Vancouver, British Columbia, Canada
J Cardiothorac Vasc Anesth 18:429-37. 2004..Albumin also favorably influences colloid oncotic pressure, on-bypass positive fluid balance, postoperative weight gain, and colloid usage. The clinical significance of these observations merits further investigation... - Acute hypervolaemia improves arterial oxygen pressure in athletes with exercise-induced hypoxaemiaGerald S Zavorsky
Department of Experimental Medicine, University of British Columbia, Vancouver Hospital and Health Sciences Center, Koerner Pavillion, S154, 2211 Wesbrook Mall, Vancouver, BC, Canada V6T 1Z3
Exp Physiol 88:555-64. 2003..This suggests that arterial oxygen pressure is only minimally mediated by cardiac output... - Vasopressin in septic shock: clinical equipoise mandates a time for restraintJames A Russell
Crit Care Med 31:2707-9. 2003 - Beneficial effects of short-term vasopressin infusion during severe septic shockBhavesh M Patel
Department of Critical Care, Mayo Clinic Arizona, Scottsdale, Arizona, USA
Anesthesiology 96:576-82. 2002..CONCLUSIONS: The authors conclude that short-term vasopressin infusion spared conventional vasopressor use and improved some measures of renal function in patients with severe septic shock... - Pulmonary arterial contractility in neonatal lambs increases with 100% oxygen resuscitationSatyan Lakshminrusimha
Department of Pediatrics, University at Buffalo, New York 14222, USA
Pediatr Res 59:137-41. 2006..PA contractility to NE and KCl is increased following both brief (30 min) and prolonged (24 h) exposure to 100% oxygen during mechanical ventilation. In contrast, normoxic resuscitation and ventilation do not increase PA contractility... - Are vasopressin levels increased or decreased in septic shock?Ainsley M Sutherland
Crit Care Med 34:542-3. 2006 - Safety and efficacy of affinity-purified, anti-tumor necrosis factor-alpha, ovine fab for injection (CytoFab) in severe sepsisTodd W Rice
Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
Crit Care Med 34:2271-81. 2006..CONCLUSIONS: CytoFab is well tolerated in patients with severe sepsis, effectively reducing serum and BAL TNF-alpha and serum IL-6 concentrations and increasing the number of ventilator-free and ICU-free days at day 28... - Toll-like receptor 1 polymorphisms affect innate immune responses and outcomes in sepsisMark M Wurfel
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington, Seattle, Washington, USA
Am J Respir Crit Care Med 178:710-20. 2008..Polymorphisms affecting Toll-like receptor (TLR)-mediated responses could predispose to excessive inflammation during an infection and contribute to an increased risk for poor outcomes in patients with sepsis... - Type I nitric oxide synthase is decreased in the fetal pulmonary circulation of hypertensive lambsChing Tzao
Department of Pathology, State University of New York at Buffalo, Buffalo, New York, USA
Pediatr Pulmonol 33:437-42. 2002..We conclude that there is a heterogeneous distribution of NOS-I in the normal fetal sheep lung, but that NOS-I staining is significantly reduced in lambs with PPHN... - Comparison of outcome following allogeneic bone marrow transplantation with cyclophosphamide-total body irradiation versus busulphan-cyclophosphamide conditioning regimens for acute myelogenous leukaemia in first remissionMark R Litzow
Mayo Clinic and Foundation, Rochester, MN, USA
Br J Haematol 119:1115-24. 2002..016). There were no differences in TRM, LFS and OS. CyTBI conditioning may lower relapse risk but produces comparable TRM, LFS and OS to BuCy for HLA-matched sibling transplantation in first remission AML... - Increased superoxide generation is associated with pulmonary hypertension in fetal lambs: a role for NADPH oxidaseLisa A Brennan
Department of Pediatrics, Northwestern University, Ward 12-191, 303 E Chicago Ave, Chicago, Ill 60611-3008, USA
Circ Res 92:683-91. 2003.... - Paracrine role of soluble guanylate cyclase and type III nitric oxide synthase in ovine fetal pulmonary circulation: a double labeling immunohistochemical studyChing Tzao
Division of Thoracic Surgery, Tri Service General Hospital, 325, Section 2, Cheng Gong Road, Nei Hu, Taipei, Taiwan, ROC
Histochem Cell Biol 119:125-30. 2003..Our results provided an anatomic basis that supported previous functional studies on perinatal control of pulmonary circulation... - Drotrecogin alfa (activated) (recombinant human activated protein C) reduces host coagulopathy response in patients with severe sepsisJean Francois Dhainaut
Service de Reanimation Medicale, Centre Hospitalo Universitaire Cochin Port Royal, AP HP, Paris V University, Paris, France
Thromb Haemost 90:642-53. 2003..These latter two effects may occur at the local or cellular level. The systemic biomarkers reported here might not be the most appropriate approach to demonstrate these potential effects of drotrecogin alfa (activated)... - Allogeneic transplantation for adult acute leukemia in first and second remission with a novel regimen incorporating daily intravenous busulfan, fludarabine, 400 CGY total-body irradiation, and thymoglobulinJames A Russell
Alberta Blood and Bone Marrow Transplant Program, Department of Oncology, Foothills Hospital, Alberta, Canada
Biol Blood Marrow Transplant 13:814-21. 2007..04), respectively. This combination appears relatively well tolerated, gives equivalent final outcomes from MRD and AD, and may be a reasonable alternative to conventional myeloablative regimens... - Amyotrophic lateral sclerosis: an emerging era of collaborative gene discoveryKatrina Gwinn
National Institute for Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America
PLoS ONE 2:e1254. 2007..This resource should facilitate genetic discoveries which we anticipate will ultimately provide a better understanding of the biological mechanisms of neurodegeneration in ALS... - Superoxide dismutase improves oxygenation and reduces oxidation in neonatal pulmonary hypertensionSatyan Lakshminrusimha
Department of Pediatrics, State University of New York at Buffalo, NY, USA
Am J Respir Crit Care Med 174:1370-7. 2006.... - A double-blind placebo-controlled study to evaluate the safety and efficacy of L-2-oxothiazolidine-4-carboxylic acid in the treatment of patients with acute respiratory distress syndromePeter E Morris
Department of Pulmonary Critical Care, Wake Forest University School of Medicine, Winston Salem, NC, USA
Crit Care Med 36:782-8. 2008..We examined the efficacy and safety of oxothiazolidine-4-carboxylic acid (OTZ), a free radical scavenger, in treating acute respiratory distress syndrome... - Engineering of fibrin-based functional and implantable small-diameter blood vesselsDaniel D Swartz
Department of Physiology and Biophysics, State University of New York, Buffalo, New York 14260, USA
Am J Physiol Heart Circ Physiol 288:H1451-60. 2005..Our work demonstrates that fibrin-based TEVs hold significant promise for treatment of vascular disease and as a biological model for studying vascular development and pathophysiology... - eNOS function is developmentally regulated: uncoupling of eNOS occurs postnatallyEugenia Mata-Greenwood
Dept. of Pediatrics, Northwestern Univ, Ward 12-191, 303 E. Chicago Ave, Chicago, IL 60611-008, USA
Am J Physiol Lung Cell Mol Physiol 290:L232-41. 2006..We speculate this may be related to cellular production and/or maintenance of BH4 levels... - Early changes in organ function predict eventual survival in severe sepsisMitchell M Levy
Brown University School of Medicine, Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, USA
Crit Care Med 33:2194-201. 2005..We hypothesized that a risk prediction model based on early (baseline to day 1 of study) response to standard care should be significantly related to 28-day survival... - The role of nitric oxide synthase-derived reactive oxygen species in the altered relaxation of pulmonary arteries from lambs with increased pulmonary blood flowSatyan Lakshminrusimha
Department of Pediatrics, Women s and Children s Hospital of Buffalo, State University of New York at Buffalo, NY 14222, USA
Am J Physiol Heart Circ Physiol 293:H1491-7. 2007..The redox environment, influenced by the balance between production and scavenging of ROS, may have important consequences on pulmonary vascular reactivity in the setting of increased Q(p)... - Once daily i.v. busulfan and fludarabine (i.v. Bu-Flu) compares favorably with i.v. busulfan and cyclophosphamide (i.v. BuCy2) as pretransplant conditioning therapy in AML/MDSBorje S Andersson
Department of Stem Cell Transplantation and Cellular Therapy, U T M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 423, Houston, TX 77030 4009, USA
Biol Blood Marrow Transplant 14:672-84. 2008..These results support replacing BuCy +/- ATG with Bu-Flu +/- rabbit-antithymocyte globulin (ATG), and warrant a prospective comparison between allogeneic HSCT and conventional induction/consolidation chemotherapy for AML in CR1... - Ovine bronchial-derived relaxing factor: changes with development and hyperoxic ventilationSatyan Lakshminrusimha
Division of Neonatology, Department of Pediatrics, Center for Developmental Biology of the Lung, State University of New York at Buffalo, Women and Children s Hospital of Buffalo, 219 Bryant St, Buffalo, New York 14222, USA
J Appl Physiol 101:135-9. 2006..We speculate that BrDRF may have an important role in postnatal changes in pulmonary arterial reactivity... - Adjacent bronchus attenuates pulmonary arterial contractilitySatyan Lakshminrusimha
Department of Pediatrics, State University of New York at Buffalo, Center for Developmental Biology of the Lung, USA
Am J Physiol Lung Cell Mol Physiol 291:L473-8. 2006..NO gas relaxed PA when administered on the endothelial side only. We speculate that BrDRF is a diffusible factor that crosses the adventitia and stimulates production of NO within the PA... - Language and the perception of emotionKristen A Lindquist
Department of Psychology, Boston College, Chestnut Hill, MA 02467, USA
Emotion 6:125-38. 2006..In Study 3, participants were less accurate to categorize facial behaviors depicting emotion after an emotion word was satiated. The implications of these findings for a linguistically relative view of emotion perception are discussed... - Pulmonary hemodynamics in neonatal lambs resuscitated with 21%, 50%, and 100% oxygenSatyan Lakshminrusimha
Department of Pediatrics, State University of New York at Buffalo, Buffalo, New York 14214, USA
Pediatr Res 62:313-8. 2007..We conclude that, while ventilation with 100% O2 at birth results in a greater initial decrease in PVR, subsequent pulmonary vasodilation to NO/acetylcholine is impaired...