James A Russell

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. pmc Universal changes in biomarkers of coagulation and inflammation occur in patients with severe sepsis, regardless of causative micro-organism [ISRCTN74215569]
    Gary T Kinasewitz
    Department of Medicine, Physiology and Biophysics, University of Oklahoma Health Science Center, and Cardiovascular Biology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
    Crit Care 8:R82-90. 2004
  2. ncbi request reprint Albumin resuscitation improves ventricular contractility and myocardial tissue oxygenation in rat endotoxemia
    Chiho Tokunaga
    Critical Care Research Laboratories, University of British Columbia, Vancouver, Canada
    Crit Care Med 35:1341-7. 2007
  3. ncbi request reprint Vasopressin in vasodilatory and septic shock
    James A Russell
    Division of Critical Care Medicine, University of British Columbia, Vancouver British Columbia, Canada
    Curr Opin Crit Care 13:383-91. 2007
  4. ncbi request reprint Management of sepsis
    James A Russell
    University of British Columbia, Critical Care Medicine, St Paul s Hospital, Vancouver, BC, Canada
    N Engl J Med 355:1699-713. 2006
  5. pmc Mechanisms of beta-receptor stimulation-induced improvement of acute lung injury and pulmonary edema
    Horacio E Groshaus
    Critical Care Research Laboratories, St Paul s Hospital and University of British Columbia, Vancouver, British Columbia, Canada
    Crit Care 8:234-42. 2004
  6. doi request reprint Update in sepsis 2012
    James A Russell
    Critical Care Research Laboratories, Institute for Heart Lung Health, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 187:1303-7. 2013
  7. pmc Bench-to-bedside review: Vasopressin in the management of septic shock
    James A Russell
    Critical Care Medicine, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
    Crit Care 15:226. 2011
  8. ncbi request reprint Vasopressin versus norepinephrine infusion in patients with septic shock
    James A Russell
    iCAPTURE Centre, Vancouver, BC, Canada
    N Engl J Med 358:877-87. 2008
  9. ncbi request reprint Vasopressin in septic shock
    James A Russell
    Critical Care Medicine and James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital and University of British Columbia, Vancouver, British Columbia, Canada
    Crit Care Med 35:S609-15. 2007
  10. ncbi request reprint Protein C rs2069912 C allele is associated with increased mortality from severe sepsis in North Americans of East Asian ancestry
    James A Russell
    University of British Columbia Critical Care Research Laboratories, 1081 Burrard Street, Vancouver, BC, Canada
    Hum Genet 123:661-3. 2008

Collaborators

Detail Information

Publications78

  1. pmc Universal changes in biomarkers of coagulation and inflammation occur in patients with severe sepsis, regardless of causative micro-organism [ISRCTN74215569]
    Gary T Kinasewitz
    Department of Medicine, Physiology and Biophysics, University of Oklahoma Health Science Center, and Cardiovascular Biology, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
    Crit Care 8:R82-90. 2004
    ..Here we report data collected at study entry for 1690 patients and over the following 7 days for the 840 patients who received placebo (in addition to usual standard of care)...
  2. ncbi request reprint Albumin resuscitation improves ventricular contractility and myocardial tissue oxygenation in rat endotoxemia
    Chiho Tokunaga
    Critical Care Research Laboratories, University of British Columbia, Vancouver, Canada
    Crit Care Med 35:1341-7. 2007
    ..We hypothesized that albumin resuscitation would improve decreased ventricular contractility and myocardial tissue oxygenation in vivo...
  3. ncbi request reprint Vasopressin in vasodilatory and septic shock
    James A Russell
    Division of Critical Care Medicine, University of British Columbia, Vancouver British Columbia, Canada
    Curr Opin Crit Care 13:383-91. 2007
    ..The aim of this article is to review mechanisms of action of vasopressin and clinical studies of vasopressin in septic shock...
  4. ncbi request reprint Management of sepsis
    James A Russell
    University of British Columbia, Critical Care Medicine, St Paul s Hospital, Vancouver, BC, Canada
    N Engl J Med 355:1699-713. 2006
  5. pmc Mechanisms of beta-receptor stimulation-induced improvement of acute lung injury and pulmonary edema
    Horacio E Groshaus
    Critical Care Research Laboratories, St Paul s Hospital and University of British Columbia, Vancouver, British Columbia, Canada
    Crit Care 8:234-42. 2004
    ..The available evidence suggests that beta-2 agonists may be efficacious therapy in ALI. Further randomized controlled trials of beta agonists in pulmonary edema and in acute lung injury are necessary...
  6. doi request reprint Update in sepsis 2012
    James A Russell
    Critical Care Research Laboratories, Institute for Heart Lung Health, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 187:1303-7. 2013
    ..As a consequence, we suggest that sepsis may be the paradigm disease or condition requiring personalized care first to discover and validate new therapies and second to increase survival...
  7. pmc Bench-to-bedside review: Vasopressin in the management of septic shock
    James A Russell
    Critical Care Medicine, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
    Crit Care 15:226. 2011
    ..The interaction of vasopressin infusion and corticosteroid treatment in septic shock requires further study...
  8. ncbi request reprint Vasopressin versus norepinephrine infusion in patients with septic shock
    James A Russell
    iCAPTURE Centre, Vancouver, BC, Canada
    N Engl J Med 358:877-87. 2008
    ..We hypothesized that low-dose vasopressin as compared with norepinephrine would decrease mortality among patients with septic shock who were being treated with conventional (catecholamine) vasopressors...
  9. ncbi request reprint Vasopressin in septic shock
    James A Russell
    Critical Care Medicine and James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital and University of British Columbia, Vancouver, British Columbia, Canada
    Crit Care Med 35:S609-15. 2007
  10. ncbi request reprint Protein C rs2069912 C allele is associated with increased mortality from severe sepsis in North Americans of East Asian ancestry
    James A Russell
    University of British Columbia Critical Care Research Laboratories, 1081 Burrard Street, Vancouver, BC, Canada
    Hum Genet 123:661-3. 2008
    ..The C allele was associated with increased mortality and organ dysfunction, consistent with Chen et al...
  11. ncbi request reprint The current management of septic shock
    J A Russel
    Critical Care Medicine, St Paul s Hospital, Vancouver, BC, Canada
    Minerva Med 99:431-58. 2008
    ..6% vs 51.5% respectively), duration of renal support, or rates of recovery of renal and non-renal organ dysfunction...
  12. ncbi request reprint beta2-Adrenergic receptor gene polymorphism is associated with mortality in septic shock
    Taka aki Nakada
    Critical Care Research Laboratories, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
    Am J Respir Crit Care Med 181:143-9. 2010
    ..Whether this functional haplotype alters outcome in patients receiving adrenergic agonists in septic shock is unknown...
  13. ncbi request reprint Prolonged QTc affects short-term and long-term outcomes in patients with normal left ventricular function undergoing cardiac surgery
    Nattachai Anantasit
    Centre for Heart Lung Innovation, University of British Columbia, St Paul s Hospital, Vancouver, British Columbia, Canada
    J Thorac Cardiovasc Surg 147:1627-33. 2014
    ..This study examines whether a prolonged QTc interval is associated with adverse outcomes in patients with preoperative LVEF greater than 40% undergoing cardiac surgery...
  14. ncbi request reprint Interaction of vasopressin infusion, corticosteroid treatment, and mortality of septic shock
    James A Russell
    St Paul s Hospital, iCAPTURE Centre, Canada
    Crit Care Med 37:811-8. 2009
    ..However, it is unknown whether vasopressin treatment interacts with corticosteroid treatment...
  15. ncbi request reprint Fibrinogen-beta gene haplotype is associated with mortality in sepsis
    Sanjay Manocha
    Critical Care Research Laboratories, James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
    J Infect 54:572-7. 2007
    ..Our aim was to determine whether haplotypes of FGB are associated with mortality and organ dysfunction in a cohort of patients with sepsis...
  16. doi request reprint AA genotype of IL-8 -251A/T is associated with low PaO(2)/FiO(2) in critically ill patients and with increased IL-8 expression
    Petch Wacharasint
    University of British Columbia, Critical Care Research Laboratories, Institute for Heart Lung Health, St Paul s Hospital, Vancouver, BC, Canada
    Respirology 17:1253-60. 2012
    ..We hypothesized that IL-8 -251A/T SNP is associated with PaO(2)/FiO(2) in critically ill patients...
  17. doi request reprint Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortality
    John H Boyd
    University of British Columbia Critical Care Research Laboratories, Heart Lung Institute, St Paul s Hospital, Vancouver, British Columbia, Canada
    Crit Care Med 39:259-65. 2011
    ..To determine whether central venous pressure and fluid balance after resuscitation for septic shock are associated with mortality...
  18. doi request reprint Association of angiotensin II type 1 receptor-associated protein gene polymorphism with increased mortality in septic shock
    Taka aki Nakada
    University of British Columbia, Critical Care Research Laboratories, Heart Lung Institute, St Paul s Hospital, Vancouver, British Columbia, Canada
    Crit Care Med 39:1641-8. 2011
    ..The objective of this study was to test the hypothesis that single nucleotide polymorphisms in angiotensin II pathway genes alter outcome of septic shock...
  19. ncbi request reprint Protein C -1641 AA is associated with decreased survival and more organ dysfunction in severe sepsis
    Keith R Walley
    Critical Care Research Laboratories, St Paul s Hospital and University of British Columbia, Vancouver, British Columbia, Canada
    Crit Care Med 35:12-7. 2007
    ..We tested the hypothesis that these polymorphisms are associated with altered outcome in patients having severe sepsis, in which protein C is a central molecule...
  20. ncbi request reprint A multibiomarker-based outcome risk stratification model for adult septic shock*
    Hector R Wong
    1Division of Critical Care Medicine, Cincinnati Children s Hospital Medical Center and Cincinnati Children s Hospital Research Foundation, Cincinnati, OH 2Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 3Department of Emergency Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 4Intensive Care Units, Division of Anaesthesia and Intensive Care Medicine, Department of Surgery, Helsinki University Central Hospital, Helsinki, Finland 5Pulmonary, Allergy, and Critical Care Division, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 6University of British Columbia, Vancouver, BC, Canada 7Critical Care Research Laboratories, Centre for Heart Lung Innovation, St Paul s Hospital, Vancouver, BC, Canada 8Department of Intensive Care Medicine, Tampere University Hospital, Tampere, Finland 9Department of Intensive Care Medicine, Kuopio University Hospital, Kuopio, Finland 10Department of Epidemiology, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA
    Crit Care Med 42:781-9. 2014
    ..Investigators advocate that interventional trials in septic shock require effective outcome risk stratification. We derived and tested a multibiomarker-based approach to estimate mortality risk in adults with septic shock...
  21. doi request reprint Vasopressin compared with norepinephrine augments the decline of plasma cytokine levels in septic shock
    James A Russell
    James Hogg Research Centre, St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Respir Crit Care Med 188:356-64. 2013
    ..Changes in plasma cytokine levels may predict mortality, and therapies (vasopressin versus norepinephrine) could change plasma cytokine levels in early septic shock...
  22. doi request reprint Leucyl/cystinyl aminopeptidase gene variants in septic shock
    Taka aki Nakada
    University of British Columbia, Vancouver, BC, Canada
    Chest 139:1042-9. 2011
    ..Vasopressin is an essential peptide hormone regulating cardiovascular homeostasis and an adjunctive vasopressor therapy for septic shock...
  23. doi request reprint Normal-range blood lactate concentration in septic shock is prognostic and predictive
    Petch Wacharasint
    University of British Columbia, Critical Care Research Laboratories, Institute for Heart Lung Health, St Paul s Hospital, Vancouver, British Columbia, Canada
    Shock 38:4-10. 2012
    ..05). Lactate concentrations within the "normal" range can be a useful prognostic indicator in septic shock. Furthermore, patients whose lactate level is less than or equal to 1.4 mmol/L may benefit from vasopressin infusion...
  24. pmc Novel polymorphism of interleukin-18 associated with greater inflammation after cardiac surgery
    David M Shaw
    Critical Care Research Laboratories, Heart Lung Institute, University of British Columbia, Vancouver, BC, Canada
    Crit Care 13:R9. 2009
    ..We hypothesised that variation in the pro-inflammatory gene IL-18 is associated with adverse clinical outcome because of a more intense inflammatory response...
  25. pmc A nonsynonymous polymorphism of IRAK4 associated with increased prevalence of gram-positive infection and decreased response to toll-like receptor ligands
    Ainsley M Sutherland
    Critical Care Research Laboratories, Providence Heart and Lung Institute at St Paul s Hospital, University of British Columbia, Vancouver, B C, Canada ainsley sutherland utoronto ca
    J Innate Immun 3:447-58. 2011
    ..07). Our data suggest that the IRAK4 haplotype clade marked by 29429A (428Thr) alters susceptibility to Gram-positive bacteria, by decreasing cellular response to TLR ligands...
  26. doi request reprint A single nucleotide polymorphism in NF-κB inducing kinase is associated with mortality in septic shock
    Simone A Thair
    University of British Columbia Critical Care Research Laboratories, Heart and Lung Institute, St Paul s Hospital, Vancouver, British Columbia V6Z 1Y6, Canada
    J Immunol 186:2321-8. 2011
    ..017). This suggests that the CC genotype of NIK rs7222094 is associated with increased mortality and organ dysfunction in septic shock patients, perhaps due to altered regulation of NF-κB pathway genes, including CXCL10...
  27. ncbi request reprint The association of interleukin 6 haplotype clades with mortality in critically ill adults
    Ainsley M Sutherland
    University of British Columbia McDonald Research Laboratories The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Vancouver, British Columbia V6Z 1Y6, Canada
    Arch Intern Med 165:75-82. 2005
    ..We tested the hypothesis that specific haplotype clades of IL-6 may be associated with an outcome of SIRS...
  28. ncbi request reprint Interleukin-10 haplotype associated with increased mortality in critically ill patients with sepsis from pneumonia but not in patients with extrapulmonary sepsis
    Anan Wattanathum
    Critical Care Research Laboratories, 1081 Burrard St, Vancouver, BC, Canada V6Z 1Y6
    Chest 128:1690-8. 2005
    ..To test the hypothesis that haplotypes of the interleukin (IL)-10 gene are associated with clinical outcomes, comparing critically ill patients with sepsis from pneumonia vs those with extrapulmonary sepsis...
  29. pmc Inhaled beta-2 agonist salbutamol and acute lung injury: an association with improvement in acute lung injury
    Sanjay Manocha
    Critical Care Research Laboratories, Centre for Cardiovascular and Pulmonary Research, University of British Columbia, Vancouver, BC, Canada
    Crit Care 10:R12. 2006
    ..Beta2 agonists have several properties that could be beneficial in acute lung injury (ALI). We therefore chose to study the effect of inhaled beta2 agonist use (salbutamol) on duration and severity of ALI...
  30. ncbi request reprint Polymorphisms in CD14, mannose-binding lectin, and Toll-like receptor-2 are associated with increased prevalence of infection in critically ill adults
    Ainsley M Sutherland
    University of British Columbia Critical Care Research Laboratories, James Hogg iCAPTURE Centre St Paul s Hospital, Vancouver, BC, Canada
    Crit Care Med 33:638-44. 2005
    ....
  31. ncbi request reprint The prediction of adverse maternal outcomes in preeclampsia
    Peter von Dadelszen
    Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, BC
    J Obstet Gynaecol Can 26:871-9. 2004
    ....
  32. ncbi request reprint A common polymorphism in the 5' region of the human protein c gene binds USF1
    Katherine R Thain
    Critical Care Research Laboratories, Institute for Heart Lung Health at St Paul s Hospital, University of British Columbia, Vancouver, Canada
    Thromb Res 130:451-7. 2012
    ..We tested the hypothesis that common SNPs (minor allele frequency >10%) between the frequently studied promoter SNPs -1654 (rs1799808) and -1641 (rs1799809), and the end of PROC intron 2 alter nuclear transcription factor binding...
  33. pmc IL17A genetic variation is associated with altered susceptibility to Gram-positive infection and mortality of severe sepsis
    Taka aki Nakada
    University of British Columbia, Critical Care Research Laboratories, Heart Lung Institute, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada
    Crit Care 15:R254. 2011
    ..Therefore, we hypothesized that SNPs in the IL17A gene alter susceptibility to infection and clinical outcome of severe sepsis...
  34. ncbi request reprint Issues with polymorphism analysis in sepsis
    Ainsley M Sutherland
    University of British Columbia, The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Vancouver, British Columbia, Canada
    Clin Infect Dis 41:S396-402. 2005
    ....
  35. ncbi request reprint Neutrophil apoptosis in preeclampsia, do steroids confound the relationship?
    Akiko Fuchisawa
    Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia V6H 3N1, Canada
    J Obstet Gynaecol Res 30:342-8. 2004
    ..To investigate the influence of maternal corticosteroid administration on neutrophil apoptosis in early onset preeclampsia...
  36. ncbi request reprint Genetic polymorphisms in sepsis and septic shock: role in prognosis and potential for therapy
    Cheryl L Holmes
    McDonald Research Laboratories The iCapture Centre, University of British Columbia, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
    Chest 124:1103-15. 2003
    ....
  37. pmc Cytokines and signaling molecules predict clinical outcomes in sepsis
    Christopher D Fjell
    James Hogg Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
    PLoS ONE 8:e79207. 2013
    ..Clinical features relating to both underlying health and the acute organ dysfunction induced by the severe infection were collected during the first 28 days of admission...
  38. doi request reprint Molecular mechanisms of sepsis
    James A Russell
    Heart and Lung Institute, St Paul s Hospital, Vancouver, BC, Canada
    Contrib Microbiol 17:48-85. 2011
    ..Perhaps the paucity of approved therapies for sepsis is related in part to the underevaluation of novel pathways, to lack of understanding of interactions of pathways and to lack of interruption of key pathways of sepsis...
  39. ncbi request reprint Serious adverse events associated with vasopressin and norepinephrine infusion in septic shock*
    Nattachai Anantasit
    1Centre for Heart Lung Innovation, St Paul s Hospital, Vancouver, BC, Canada 2Division of Critical Care Medicine, St Paul s Hospital, University of British Columbia, Vancouver, BC, Canada
    Crit Care Med 42:1812-20. 2014
    ..The objectives of this study were to determine frequency, risk factors (including candidate gene polymorphisms), and outcomes of serious adverse events in septic shock patients...
  40. ncbi request reprint Severe acute respiratory distress syndrome (SARS): a critical care perspective
    Sanjay Manocha
    Department of Medicine, University of British Columbia, Vancouver, Canada
    Crit Care Med 31:2684-92. 2003
    ..To review the epidemiology, clinical features, etiology, diagnosis, and management of severe acute respiratory syndrome (SARS) from a critical care perspective...
  41. doi request reprint Evaluating the efficacy and safety of two doses of the polyclonal anti-tumor necrosis factor-α fragment antibody AZD9773 in adult patients with severe sepsis and/or septic shock: randomized, double-blind, placebo-controlled phase IIb study*
    Gordon R Bernard
    1Division of Pulmonary and Critical Care Medicine, Vanderbilt University, Nashville, TN 2Service de Réanimation Polyvalente, CIC P 0801, CHU Dupuytren, Limoges, Cedex, France 3Hôpitaux Paris Centre, AP HP Universite Paris Descartes, Faculte de Medecine, Paris, France and Cochin Institute, INSERM U567, CNRS UMR 8104, Paris, France 4Department of Intensive Care, Erasme Hospital, Universite Libre de Bruxelles, Brussels, Belgium 5Department of Medicine, Cooper University Hospital, Camden, NJ 6Centre for Heart Lung Innovation, University of British Columbia, Vancouver, BC, Canada 7Division of Infectious Diseases, Beverly Hospital, Beverly, MA 8Critical Care Department, St Luc University Hospital, Universite Catholique de Louvain, Brussels, Belgium 9Department of Medicine, Brown University, Providence, RI 10Worldwide Medical Services Department, PAREXEL International, Durham, NC 11AstraZeneca, Alderley Park, India
    Crit Care Med 42:504-11. 2014
    ..This trial compared the efficacy/safety of two IV doses of AZD9773, a polyclonal antibody to tumor necrosis factor-α, in adult patients with severe sepsis/septic shock...
  42. doi request reprint Prediction of adverse maternal outcomes in pre-eclampsia: development and validation of the fullPIERS model
    Peter von Dadelszen
    Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, BC, Canada
    Lancet 377:219-27. 2011
    ..We developed and validated the fullPIERS model with the aim of identifying the risk of fatal or life-threatening complications in women with pre-eclampsia within 48 h of hospital admission for the disorder...
  43. pmc Goal directed therapy: how long can we wait?
    Anthony C Gordon
    Centre for Cardiovascular and Pulmonary Research, University of British Columbia, Vancouver, BC, Canada
    Crit Care 9:647-8. 2005
    ..If this management cannot begin preoperatively, it is still worth beginning goal directed therapy in the immediate postoperative period...
  44. ncbi request reprint Albumin resuscitation increases cardiomyocyte contractility and decreases nitric oxide synthase II expression in rat endotoxemia
    Keith R Walley
    University of British Columbia McDonald Research Laboratories iCAPTURE Center, Vancouver, Canada
    Crit Care Med 31:187-94. 2003
    ..Therefore, we hypothesized that crystalloid or colloid resuscitation may alter myocardial dysfunction...
  45. doi request reprint Vasopressin and its immune effects in septic shock
    James A Russell
    Heart and Lung Institute, St Paul s Hospital, University of British Columbia, Vancouver, B C, Canada
    J Innate Immun 2:446-60. 2010
    ..Vasopressin plus corticosteroid treatment may decrease mortality compared to corticosteroids plus norepinephrine. Potential mechanisms are that vasopressin plus corticosteroids beneficially alter immunity in septic shock...
  46. ncbi request reprint The effects of steroids on the occurrence of postoperative atrial fibrillation after coronary artery bypass grafting surgery: a prospective randomized trial
    Kriengchai Prasongsukarn
    St Paul s Hospital, University of British Columbia, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
    J Thorac Cardiovasc Surg 130:93-8. 2005
    ..A randomized, double-blind, placebo-controlled trial was conducted to determine the effect of steroids on the occurrence of atrial fibrillation after elective coronary artery bypass grafting...
  47. ncbi request reprint Genetics of coagulation factors in acute lung injury
    James A Russell
    Division of Critical Care Medicine, Department of Medicine and UBC McDonald Research Laboratories, St Paul s Hospital, Vancouver, BC, Canada
    Crit Care Med 31:S243-7. 2003
    ..To review the role of coagulation and of single nucleotide polymorphisms of coagulation factors in acute lung injury...
  48. ncbi request reprint Activated protein C in normal human pregnancy and pregnancies complicated by severe preeclampsia: a therapeutic opportunity?
    Peter von Dadelszen
    Department of Obstetrics and Gynaecology, Division of Maternal Fetal Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Crit Care Med 30:1883-92. 2002
    ..To determine which patients would be offered rhAPC, the literature pertaining to fetal/neonatal outcomes for preeclampsia remote from term, transplacental transport of protein C, and pregnancy experience with the compound were reviewed...
  49. ncbi request reprint The meta-genome of sepsis: host genetics, pathogens and the acute immune response
    John H Boyd
    Division of Critical Care Medicine, St Paul s Hospital, Vancouver, B C, Canada
    J Innate Immun 6:272-83. 2014
    ..Finally, we discuss the host clinical and immune responses and present new data to suggest that the immune response is the key to understanding sepsis and improving a death rate of nearly 30%...
  50. pmc Gene expression in human sepsis: what have we learned?
    James A Russell
    Critical Care Medicine, St, Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
    Crit Care 15:121. 2011
    ....
  51. pmc Inotropes and vasopressors: more than haemodynamics!
    Hendrik Bracht
    Klinik fur Anasthesiologie, Universitatsklinikum, Ulm, Germany
    Br J Pharmacol 165:2009-11. 2012
    ..Hence, further investigations are essential to determine which catecholamine, or, in a broader sense, which alternative vasopressor and/or inotrope is the most appropriate for a particular clinical condition...
  52. ncbi request reprint Albumin versus crystalloid for pump priming in cardiac surgery: meta-analysis of controlled trials
    James A Russell
    Program of Critical Care Medicine, Department of Medicine, St Paul s Hospital and University of British Columbia, Vancouver, British Columbia, Canada
    J Cardiothorac Vasc Anesth 18:429-37. 2004
    ..To determine the effects of pump priming fluid choice on platelets, fluid balance, and clinical outcomes...
  53. ncbi request reprint Acute hypervolaemia improves arterial oxygen pressure in athletes with exercise-induced hypoxaemia
    Gerald S Zavorsky
    Department of Experimental Medicine, University of British Columbia, Vancouver Hospital and Health Sciences Center, Koerner Pavillion, S154, 2211 Wesbrook Mall, Vancouver, BC, Canada V6T 1Z3
    Exp Physiol 88:555-64. 2003
    ..This suggests that arterial oxygen pressure is only minimally mediated by cardiac output...
  54. ncbi request reprint Vasopressin in septic shock: clinical equipoise mandates a time for restraint
    James A Russell
    Crit Care Med 31:2707-9. 2003
  55. ncbi request reprint Beneficial effects of short-term vasopressin infusion during severe septic shock
    Bhavesh M Patel
    Department of Critical Care, Mayo Clinic Arizona, Scottsdale, Arizona, USA
    Anesthesiology 96:576-82. 2002
    ....
  56. pmc Pulmonary arterial contractility in neonatal lambs increases with 100% oxygen resuscitation
    Satyan Lakshminrusimha
    Department of Pediatrics, University at Buffalo, New York 14222, USA
    Pediatr Res 59:137-41. 2006
    ..PA contractility to NE and KCl is increased following both brief (30 min) and prolonged (24 h) exposure to 100% oxygen during mechanical ventilation. In contrast, normoxic resuscitation and ventilation do not increase PA contractility...
  57. ncbi request reprint Are vasopressin levels increased or decreased in septic shock?
    Ainsley M Sutherland
    Crit Care Med 34:542-3. 2006
  58. ncbi request reprint Safety and efficacy of affinity-purified, anti-tumor necrosis factor-alpha, ovine fab for injection (CytoFab) in severe sepsis
    Todd W Rice
    Division of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Crit Care Med 34:2271-81. 2006
    ....
  59. pmc eNOS function is developmentally regulated: uncoupling of eNOS occurs postnatally
    Eugenia Mata-Greenwood
    Dept of Pediatrics, Northwestern Univ, Ward 12 191, 303 E Chicago Ave, Chicago, IL 60611 008, USA
    Am J Physiol Lung Cell Mol Physiol 290:L232-41. 2006
    ..We speculate this may be related to cellular production and/or maintenance of BH4 levels...
  60. ncbi request reprint Paracrine role of soluble guanylate cyclase and type III nitric oxide synthase in ovine fetal pulmonary circulation: a double labeling immunohistochemical study
    Ching Tzao
    Division of Thoracic Surgery, Tri Service General Hospital, 325, Section 2, Cheng Gong Road, Nei Hu, Taipei, Taiwan, ROC
    Histochem Cell Biol 119:125-30. 2003
    ..Our results provided an anatomic basis that supported previous functional studies on perinatal control of pulmonary circulation...
  61. ncbi request reprint Increased superoxide generation is associated with pulmonary hypertension in fetal lambs: a role for NADPH oxidase
    Lisa A Brennan
    Department of Pediatrics, Northwestern University, Ward 12 191, 303 E Chicago Ave, Chicago, Ill 60611 3008, USA
    Circ Res 92:683-91. 2003
    ....
  62. ncbi request reprint Language and the perception of emotion
    Kristen A Lindquist
    Department of Psychology, Boston College, Chestnut Hill, MA 02467, USA
    Emotion 6:125-38. 2006
    ..In Study 3, participants were less accurate to categorize facial behaviors depicting emotion after an emotion word was satiated. The implications of these findings for a linguistically relative view of emotion perception are discussed...
  63. ncbi request reprint Comparison of outcome following allogeneic bone marrow transplantation with cyclophosphamide-total body irradiation versus busulphan-cyclophosphamide conditioning regimens for acute myelogenous leukaemia in first remission
    Mark R Litzow
    Mayo Clinic and Foundation, Rochester, MN, USA
    Br J Haematol 119:1115-24. 2002
    ..016). There were no differences in TRM, LFS and OS. CyTBI conditioning may lower relapse risk but produces comparable TRM, LFS and OS to BuCy for HLA-matched sibling transplantation in first remission AML...
  64. pmc Pulmonary hemodynamics in neonatal lambs resuscitated with 21%, 50%, and 100% oxygen
    Satyan Lakshminrusimha
    Department of Pediatrics, State University of New York at Buffalo, Buffalo, New York 14214, USA
    Pediatr Res 62:313-8. 2007
    ..We conclude that, while ventilation with 100% O2 at birth results in a greater initial decrease in PVR, subsequent pulmonary vasodilation to NO/acetylcholine is impaired...
  65. ncbi request reprint Type I nitric oxide synthase is decreased in the fetal pulmonary circulation of hypertensive lambs
    Ching Tzao
    Department of Pathology, State University of New York at Buffalo, Buffalo, New York, USA
    Pediatr Pulmonol 33:437-42. 2002
    ..We conclude that there is a heterogeneous distribution of NOS-I in the normal fetal sheep lung, but that NOS-I staining is significantly reduced in lambs with PPHN...
  66. ncbi request reprint Allogeneic transplantation for adult acute leukemia in first and second remission with a novel regimen incorporating daily intravenous busulfan, fludarabine, 400 CGY total-body irradiation, and thymoglobulin
    James A Russell
    Alberta Blood and Bone Marrow Transplant Program, Department of Oncology, Foothills Hospital, Alberta, Canada
    Biol Blood Marrow Transplant 13:814-21. 2007
    ..04), respectively. This combination appears relatively well tolerated, gives equivalent final outcomes from MRD and AD, and may be a reasonable alternative to conventional myeloablative regimens...
  67. pmc The role of nitric oxide synthase-derived reactive oxygen species in the altered relaxation of pulmonary arteries from lambs with increased pulmonary blood flow
    Satyan Lakshminrusimha
    Department of Pediatrics, Women s and Children s Hospital of Buffalo, State University of New York at Buffalo, NY 14222, USA
    Am J Physiol Heart Circ Physiol 293:H1491-7. 2007
    ..The redox environment, influenced by the balance between production and scavenging of ROS, may have important consequences on pulmonary vascular reactivity in the setting of increased Q(p)...
  68. pmc Amyotrophic lateral sclerosis: an emerging era of collaborative gene discovery
    Katrina Gwinn
    National Institute for Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 2:e1254. 2007
    ..This resource should facilitate genetic discoveries which we anticipate will ultimately provide a better understanding of the biological mechanisms of neurodegeneration in ALS...
  69. ncbi request reprint Early changes in organ function predict eventual survival in severe sepsis
    Mitchell M Levy
    Brown University School of Medicine, Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, USA
    Crit Care Med 33:2194-201. 2005
    ..We hypothesized that a risk prediction model based on early (baseline to day 1 of study) response to standard care should be significantly related to 28-day survival...
  70. ncbi request reprint Engineering of fibrin-based functional and implantable small-diameter blood vessels
    Daniel D Swartz
    Department of Physiology and Biophysics, State University of New York, Buffalo, New York 14260, USA
    Am J Physiol Heart Circ Physiol 288:H1451-60. 2005
    ..Our work demonstrates that fibrin-based TEVs hold significant promise for treatment of vascular disease and as a biological model for studying vascular development and pathophysiology...
  71. pmc Toll-like receptor 1 polymorphisms affect innate immune responses and outcomes in sepsis
    Mark M Wurfel
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington, Seattle, Washington, USA
    Am J Respir Crit Care Med 178:710-20. 2008
    ..Polymorphisms affecting Toll-like receptor (TLR)-mediated responses could predispose to excessive inflammation during an infection and contribute to an increased risk for poor outcomes in patients with sepsis...
  72. pmc Ovine bronchial-derived relaxing factor: changes with development and hyperoxic ventilation
    Satyan Lakshminrusimha
    Division of Neonatology, Department of Pediatrics, Center for Developmental Biology of the Lung, State University of New York at Buffalo, Women and Children s Hospital of Buffalo, 219 Bryant St, Buffalo, New York 14222, USA
    J Appl Physiol (1985) 101:135-9. 2006
    ..We speculate that BrDRF may have an important role in postnatal changes in pulmonary arterial reactivity...
  73. doi request reprint Once daily i.v. busulfan and fludarabine (i.v. Bu-Flu) compares favorably with i.v. busulfan and cyclophosphamide (i.v. BuCy2) as pretransplant conditioning therapy in AML/MDS
    Borje S Andersson
    Department of Stem Cell Transplantation and Cellular Therapy, U T M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 423, Houston, TX 77030 4009, USA
    Biol Blood Marrow Transplant 14:672-84. 2008
    ..These results support replacing BuCy +/- ATG with Bu-Flu +/- rabbit-antithymocyte globulin (ATG), and warrant a prospective comparison between allogeneic HSCT and conventional induction/consolidation chemotherapy for AML in CR1...
  74. ncbi request reprint Drotrecogin alfa (activated) (recombinant human activated protein C) reduces host coagulopathy response in patients with severe sepsis
    Jean Francois Dhainaut
    Service de Reanimation Medicale, Centre Hospitalo Universitaire Cochin Port Royal, AP HP, Paris V University, Paris, France
    Thromb Haemost 90:642-53. 2003
    ..These latter two effects may occur at the local or cellular level. The systemic biomarkers reported here might not be the most appropriate approach to demonstrate these potential effects of drotrecogin alfa (activated)...
  75. ncbi request reprint Adjacent bronchus attenuates pulmonary arterial contractility
    Satyan Lakshminrusimha
    Department of Pediatrics, State University of New York at Buffalo, Center for Developmental Biology of the Lung, USA
    Am J Physiol Lung Cell Mol Physiol 291:L473-8. 2006
    ..NO gas relaxed PA when administered on the endothelial side only. We speculate that BrDRF is a diffusible factor that crosses the adventitia and stimulates production of NO within the PA...
  76. ncbi request reprint A double-blind placebo-controlled study to evaluate the safety and efficacy of L-2-oxothiazolidine-4-carboxylic acid in the treatment of patients with acute respiratory distress syndrome
    Peter E Morris
    Department of Pulmonary Critical Care, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Crit Care Med 36:782-8. 2008
    ..We examined the efficacy and safety of oxothiazolidine-4-carboxylic acid (OTZ), a free radical scavenger, in treating acute respiratory distress syndrome...
  77. pmc Superoxide dismutase improves oxygenation and reduces oxidation in neonatal pulmonary hypertension
    Satyan Lakshminrusimha
    Department of Pediatrics, State University of New York at Buffalo, NY, USA
    Am J Respir Crit Care Med 174:1370-7. 2006
    ....