Marc Ruel

Summary

Affiliation: University of Ottawa Heart Institute
Country: Canada

Publications

  1. ncbi request reprint Late incidence and determinants of reoperation in patients with prosthetic heart valves
    Marc Ruel
    Division of Cardiac Surgery, University of Ottawa Heart Institute, 40 Ruskin Street, Suite 3403, Ottawa, Ont, Canada K1Y 4W7
    Eur J Cardiothorac Surg 25:364-70. 2004
  2. ncbi request reprint Long-term outcomes after valve replacement for low-gradient aortic stenosis: impact of prosthesis-patient mismatch
    Alexander Kulik
    Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    Circulation 114:I553-8. 2006
  3. doi request reprint Results of the Minimally Invasive Coronary Artery Bypass Grafting Angiographic Patency Study
    Marc Ruel
    University of Ottawa Heart Institute, Ottawa, Ontario, Canada Electronic address
    J Thorac Cardiovasc Surg 147:203-8. 2014
  4. doi request reprint Cell-based vasculogenic studies in preclinical models of chronic myocardial ischaemia and hibernation
    Celine Giordano
    University of Ottawa Heart Institute, Division of Cardiac Surgery, 40 Ruskin Street, Suite 3403, Ottawa, Ontario, K1Y 4W7, Canada
    Expert Opin Biol Ther 13:411-28. 2013
  5. ncbi request reprint Invited commentary
    Marc Ruel
    Department of Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, K1Y 4W7, Canada
    Ann Thorac Surg 81:167-8. 2006
  6. ncbi request reprint Late incidence and predictors of persistent or recurrent heart failure in patients with aortic prosthetic valves
    Marc Ruel
    Division of Cardiac Surgery, Department of Epidemiology, University of Ottawa, Ontario, Canada
    J Thorac Cardiovasc Surg 127:149-59. 2004
  7. ncbi request reprint Late incidence and determinants of stroke after aortic and mitral valve replacement
    Marc Ruel
    Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Ann Thorac Surg 78:77-83; discussion 83-4. 2004
  8. ncbi request reprint Late incidence and predictors of persistent or recurrent heart failure in patients with mitral prosthetic valves
    Marc Ruel
    Division of Cardiac Surgery, Department of Epidemiology, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario, Canada K1Y 4W7
    J Thorac Cardiovasc Surg 128:278-83. 2004
  9. ncbi request reprint Long-term outcomes of valve replacement with modern prostheses in young adults
    Marc Ruel
    Division of Cardiac Surgery, University of Ottawa Heart Institute, 40 Ruskin Street, Suite 3403, Ottawa, Ontario, Canada K1Y 4W7
    Eur J Cardiothorac Surg 27:425-33; discussion 433. 2005
  10. doi request reprint Interventional valve surgery: building a team and working together
    Marc Ruel
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Semin Thorac Cardiovasc Surg 22:145-9. 2010

Detail Information

Publications112 found, 100 shown here

  1. ncbi request reprint Late incidence and determinants of reoperation in patients with prosthetic heart valves
    Marc Ruel
    Division of Cardiac Surgery, University of Ottawa Heart Institute, 40 Ruskin Street, Suite 3403, Ottawa, Ont, Canada K1Y 4W7
    Eur J Cardiothorac Surg 25:364-70. 2004
    ..With a focus on bioprosthetic valves, this study examines risk factors for reoperation in a large patient cohort...
  2. ncbi request reprint Long-term outcomes after valve replacement for low-gradient aortic stenosis: impact of prosthesis-patient mismatch
    Alexander Kulik
    Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    Circulation 114:I553-8. 2006
    ..The purpose of this study was to define the long-term outcomes of LGAS patients after AVR and to evaluate the potential impact of prosthesis-patient mismatch (PPM) in these patients...
  3. doi request reprint Results of the Minimally Invasive Coronary Artery Bypass Grafting Angiographic Patency Study
    Marc Ruel
    University of Ottawa Heart Institute, Ottawa, Ontario, Canada Electronic address
    J Thorac Cardiovasc Surg 147:203-8. 2014
    ..However, graft patency rates remain unknown. The Minimally Invasive Coronary Artery Bypass Grafting Patency Study prospectively evaluated angiographic graft patency 6 months after minimally invasive coronary artery bypass grafting...
  4. doi request reprint Cell-based vasculogenic studies in preclinical models of chronic myocardial ischaemia and hibernation
    Celine Giordano
    University of Ottawa Heart Institute, Division of Cardiac Surgery, 40 Ruskin Street, Suite 3403, Ottawa, Ontario, K1Y 4W7, Canada
    Expert Opin Biol Ther 13:411-28. 2013
    ..Coronary artery disease commonly leads to myocardial ischaemia and hibernation. Relevant preclinical models of these conditions are essential to evaluate new therapeutic options such as cell-based vasculogenic therapies...
  5. ncbi request reprint Invited commentary
    Marc Ruel
    Department of Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, K1Y 4W7, Canada
    Ann Thorac Surg 81:167-8. 2006
  6. ncbi request reprint Late incidence and predictors of persistent or recurrent heart failure in patients with aortic prosthetic valves
    Marc Ruel
    Division of Cardiac Surgery, Department of Epidemiology, University of Ottawa, Ontario, Canada
    J Thorac Cardiovasc Surg 127:149-59. 2004
    ..We examined factors associated with persistent or recurrent congestive heart failure after aortic valve replacement...
  7. ncbi request reprint Late incidence and determinants of stroke after aortic and mitral valve replacement
    Marc Ruel
    Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Ann Thorac Surg 78:77-83; discussion 83-4. 2004
    ..Stroke is a devastating complication in patients with prosthetic valves, but characterization of its late occurrence from a large cohort is lacking...
  8. ncbi request reprint Late incidence and predictors of persistent or recurrent heart failure in patients with mitral prosthetic valves
    Marc Ruel
    Division of Cardiac Surgery, Department of Epidemiology, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario, Canada K1Y 4W7
    J Thorac Cardiovasc Surg 128:278-83. 2004
    ..The study's objective was to examine factors associated with persistent or recurrent congestive heart failure after mitral valve replacement...
  9. ncbi request reprint Long-term outcomes of valve replacement with modern prostheses in young adults
    Marc Ruel
    Division of Cardiac Surgery, University of Ottawa Heart Institute, 40 Ruskin Street, Suite 3403, Ottawa, Ontario, Canada K1Y 4W7
    Eur J Cardiothorac Surg 27:425-33; discussion 433. 2005
    ..To examine the multiple impacts of valve replacement on the lives of young adults...
  10. doi request reprint Interventional valve surgery: building a team and working together
    Marc Ruel
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Semin Thorac Cardiovasc Surg 22:145-9. 2010
    ....
  11. ncbi request reprint Effects of off-pump versus on-pump coronary artery bypass grafting on function and viability of circulating endothelial progenitor cells
    Marc Ruel
    Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    J Thorac Cardiovasc Surg 130:633-9. 2005
    ..We sought to examine endothelial progenitor cell characteristics after off-pump versus on-pump coronary artery bypass grafting...
  12. doi request reprint Transcatheter aortic-valve replacement: a cardiac surgeon and cardiologist team perspective
    Marc Ruel
    Division of Cardiac Surgery, University of Ottawa, Ontario, Canada
    Curr Opin Cardiol 25:107-13. 2010
    ..Transcatheter aortic-valve implantation is a promising new treatment modality for patients with aortic-valve disease, where it may revolutionize the treatment of elderly and high-risk patients...
  13. doi request reprint Concomitant treatment with oral L-arginine improves the efficacy of surgical angiogenesis in patients with severe diffuse coronary artery disease: the Endothelial Modulation in Angiogenic Therapy randomized controlled trial
    Marc Ruel
    Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    J Thorac Cardiovasc Surg 135:762-70, 770.e1. 2008
    ....
  14. ncbi request reprint Very long-term survival implications of heart valve replacement with tissue versus mechanical prostheses in adults <60 years of age
    Marc Ruel
    Division of Cardiac Surgery, and the Department of Epidemiology, University of Ottawa, Ottawa, Ontario, Canada
    Circulation 116:I294-300. 2007
    ..We examined the survival implications of selecting a tissue versus a mechanical prosthesis at initial left-heart valve replacement in a cohort of adults <60 years of age who were followed for over 20 years...
  15. ncbi request reprint Natural history and predictors of outcome in patients with concomitant functional mitral regurgitation at the time of aortic valve replacement
    Marc Ruel
    Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    Circulation 114:I541-6. 2006
    ..We ascertained the impact of clinical and echocardiographic parameters on the outcome of patients with or without concomitant FMR at the time of AVR...
  16. ncbi request reprint Prosthesis-patient mismatch after aortic valve replacement predominantly affects patients with preexisting left ventricular dysfunction: effect on survival, freedom from heart failure, and left ventricular mass regression
    Marc Ruel
    Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    J Thorac Cardiovasc Surg 131:1036-44. 2006
    ..This study examined the long-term clinical and echocardiographic effects of prosthesis-patient mismatch in patients with and without left ventricular systolic dysfunction at the time of aortic valve replacement...
  17. doi request reprint Effects of shed mediastinal blood on cardiovascular and pulmonary function: a randomized, double-blind study
    Munir Boodhwani
    Divisions of Cardiac Surgery and Cardiac Anesthesia, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Ann Thorac Surg 86:1167-73. 2008
    ..Our aim was to evaluate the effects of processing cardiotomy blood on cardiovascular and pulmonary function after cardiac surgery...
  18. ncbi request reprint Cerebral microembolization after bioprosthetic aortic valve replacement: comparison of warfarin plus aspirin versus aspirin only
    Talal Al-Atassi
    Division of Cardiac Surgery, University of Ottawa, Ottawa, Canada
    Circulation 126:S239-44. 2012
    ..No human physiological data exists on whether aspirin only is as effective as warfarin plus aspirin in preventing cerebral microembolization in the early postoperative period after bioprosthetic aortic valve replacement (bAVR)...
  19. doi request reprint In vitro functional comparison of therapeutically relevant human vasculogenic progenitor cells used for cardiac cell therapy
    Yan Zhang
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Thorac Cardiovasc Surg 140:216-24, 224.e1-4. 2010
    ..This study describes the expansion of peripheral blood CD133(+) cells and compares their functional properties with those of other commonly used human progenitor cell populations...
  20. doi request reprint Ex vivo generation of a highly potent population of circulating angiogenic cells using a collagen matrix
    Drew Kuraitis
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada K1Y 4W7
    J Mol Cell Cardiol 51:187-97. 2011
    ..This work suggests that a collagen-based matrix, as a novel substrate for CAC culture, possesses the ability to enrich endothelial and angiogenic populations and lead to clinically relevant functional enhancements...
  21. ncbi request reprint Enlargement of the small aortic root during aortic valve replacement: is there a benefit?
    Alexander Kulik
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Ann Thorac Surg 85:94-100. 2008
    ..To evaluate the risks and benefits of ARE, we examined the outcomes of patients with small aortic roots who underwent AVR with or without the use of ARE...
  22. ncbi request reprint Mechanical versus bioprosthetic valve replacement in middle-aged patients
    Alexander Kulik
    Division of Cardiac Surgery, University of Ottawa Heart Institute, 40 Ruskin Street, Suite 3403, Ottawa, Ont K1Y 4W7, Canada
    Eur J Cardiothorac Surg 30:485-91. 2006
    ..This cohort study examines the long-term outcomes of mechanical versus bioprosthetic valves in middle-aged patients...
  23. ncbi request reprint The impact of patient-prosthesis mismatch on late outcomes after mitral valve replacement
    Buu Khanh Lam
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Thorac Cardiovasc Surg 133:1464-73. 2007
    ..This study was conducted to determine the impact of patient-prosthesis mismatch on recurrent congestive heart failure, postoperative pulmonary hypertension, and late survival after mitral valve replacement...
  24. doi request reprint Long-term evaluation of biological versus mechanical prosthesis use at reoperative aortic valve replacement
    Vincent Chan
    Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    J Thorac Cardiovasc Surg 144:146-51. 2012
    ..However, at reoperative AVR, follow-up data by prosthesis type have been lacking from the literature. Therefore, we examined long-term survival and valve-related complications according to the type of prosthesis used at reoperative AVR...
  25. doi request reprint An acellular matrix-bound ligand enhances the mobilization, recruitment and therapeutic effects of circulating progenitor cells in a hindlimb ischemia model
    Erik J Suuronen
    Division of Cardiac Surgery, University of Ottawa Heart Institute, 40 Ruskin St, Ottawa, ON, K1Y 4W7, Canada
    FASEB J 23:1447-58. 2009
    ....
  26. doi request reprint Postoperative lipid-lowering therapy and bioprosthesis structural valve deterioration: justification for a randomised trial?
    Alexander Kulik
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, ON, Canada
    Eur J Cardiothorac Surg 37:139-44. 2010
    ..The purpose of this observational study was to evaluate if an association exists between early LLT and a slowing of bioprosthesis SVD, with a view to designing a prospective trial...
  27. doi request reprint Reoperation of left heart valve bioprostheses according to age at implantation
    Vincent Chan
    Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    Circulation 124:S75-80. 2011
    ..Evidence supporting the use of bioprostheses for heart valve replacement in young adults is accumulating. However, reoperation data, which may help guide clinical decision making in young patients, remains poorly defined in the literature...
  28. doi request reprint Influence of the On-X mechanical prosthesis on intermediate-term major thromboembolism and hemorrhage: a prospective multicenter study
    Vincent Chan
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Thorac Cardiovasc Surg 140:1053-8.e2. 2010
    ....
  29. doi request reprint A method to distinguish between gaseous and solid cerebral emboli in patients with prosthetic heart valves
    Rosendo A Rodriguez
    Division of Cardiac Surgery, Department of Surgery, University of Ottawa Heart Institute, Ottawa, Ontario K1Y 4W7, Canada
    Eur J Cardiothorac Surg 35:89-95. 2009
    ..Since inhalation of 100% oxygen reduces the amount of air bubbles in mechanical heart valve patients, the ultrasonic features of the remaining emboli would be characteristic of solid particulates...
  30. ncbi request reprint Comparative effects of mesenchymal progenitor cells, endothelial progenitor cells, or their combination on myocardial infarct regeneration and cardiac function
    Erik J Suuronen
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Thorac Cardiovasc Surg 134:1249-58. 2007
    ..We compared the effects of mesenchymal progenitor cell transplantation versus those of a primarily angiogenic cell, the endothelial progenitor cell, in a rat model of myocardial infarction...
  31. pmc Impact of mitral annular calcification on early and late outcomes following mitral valve repair of myxomatous degeneration
    Vincent Chan
    Division of Cardiac Surgery, University of Ottawa, Ottawa, ON, Canada
    Interact Cardiovasc Thorac Surg 17:120-5. 2013
    ..However, few data are available describing the impact of mitral annular calcification on early and late outcomes following mitral valve repair in the current era...
  32. ncbi request reprint Tissue-engineered injectable collagen-based matrices for improved cell delivery and vascularization of ischemic tissue using CD133+ progenitors expanded from the peripheral blood
    Erik J Suuronen
    Division of Cardiac Surgery, University of Ottawa Heart Institute, 40 Ruskin St, Laboratory H553, Ottawa, Ontario, Canada, K1Y 4W7
    Circulation 114:I138-44. 2006
    ..This study investigated the expansion of CD133+ cells and the use of an injectable collagen-based tissue engineered matrix to support cell delivery and implantation within target ischemic tissue...
  33. doi request reprint Clinical evaluation of functional mitral stenosis after mitral valve repair for degenerative disease: potential affect on surgical strategy
    Thierry G Mesana
    Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada Electronic address
    J Thorac Cardiovasc Surg 146:1418-23; discussion 1423-5. 2013
    ..The objective of our study was to compare echocardiographic and functional characteristics of patients who underwent mitral repair with either a complete ring or a partial band...
  34. doi request reprint Injectable small intestine submucosal extracellular matrix in an acute myocardial infarction model
    Hadi Daood Toeg
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Ann Thorac Surg 96:1686-94; discussion 1694. 2013
    ....
  35. doi request reprint Prosthesis-patient mismatch is less frequent and more clinically indolent in patients operated for aortic insufficiency
    Joel Price
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Thorac Cardiovasc Surg 138:639-45. 2009
    ....
  36. doi request reprint Clinical and echocardiographic outcomes after repair of mitral valve bileaflet prolapse due to myxomatous disease
    Vincent Chan
    Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    J Thorac Cardiovasc Surg 143:S8-11. 2012
    ..Myxomatous disease represents an important cause of bileaflet prolapse and MR and, thus, served as the focus of the present study...
  37. doi request reprint Impairment of human cell-based vasculogenesis in rats by hypercholesterolemia-induced endothelial dysfunction and rescue with L-arginine supplementation
    Erik J Suuronen
    Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    J Thorac Cardiovasc Surg 139:209-216.e2. 2010
    ..We examined whether hypercholesterolemia inhibits vasculogenic effects of transplanted human circulating progenitor cells in ischemic tissue and whether L-arginine, a nitric oxide donor, might prevent impairment...
  38. doi request reprint A collagen–chitosan hydrogel for endothelial differentiation and angiogenesis
    Chao Deng
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Canada
    Tissue Eng Part A 16:3099-109. 2010
    ....
  39. ncbi request reprint Frequency and surgical management of complex posterior leaflet prolapse of the mitral valve
    Dominique Grisoli
    Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    J Heart Valve Dis 19:568-75. 2010
    ..The study aim was to describe the incidence and surgical management of extensive or commissural posterior leaflet prolapse, in addition to long-term outcomes following repair...
  40. ncbi request reprint Should we anticoagulate after bioprosthetic aortic valve replacement?
    Talal Al-Atassi
    Division of Cardiac Surgery, University of Ottawa, Heart Institute, 40 Ruskin Street, Suite 3402, Ottawa, Ontario, K1Y 4W7, Canada
    Expert Rev Cardiovasc Ther 11:1649-57. 2013
    ..Based on the evidence presented, the authors recommend using aspirin only after bioprosthetic aortic valve replacement in patients at low risk of thromboembolism...
  41. ncbi request reprint Combined atrial fibrillation ablation with mitral valve surgery
    Thierry G Mesana
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Heart Valve Dis 15:515-20. 2006
    ..The study aim was to evaluate the efficacy and outcome of radiofrequency (RF) atrial fibrillation (AF) ablation in patients undergoing mitral valve (MV) surgery...
  42. doi request reprint Long-term clinical and hemodynamic performance of the Hancock II versus the Perimount aortic bioprostheses
    Vincent Chan
    Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    Circulation 122:S10-6. 2010
    ..However, a direct comparison of their clinical performance is lacking. To minimize biases inherent to between-center comparisons, we examined these prostheses within a large, contemporary, single-center cohort...
  43. doi request reprint Collagen-based matrices improve the delivery of transplanted circulating progenitor cells: development and demonstration by ex vivo radionuclide cell labeling and in vivo tracking with positron-emission tomography
    Yan Zhang
    Division of Cardiac Surgery, University of Ottawa, Ottawa, Canada
    Circ Cardiovasc Imaging 1:197-204. 2008
    ....
  44. ncbi request reprint Surgery for chronic thromboembolic pulmonary hypertension--inclusive experience from a national referral center
    Fraser D Rubens
    Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    Ann Thorac Surg 83:1075-81. 2007
    ..The purpose of this report is to provide a review of the inclusive results from our moderately sized national program for all PTE, with a particular emphasize on the aspects of the learning curve in terms of patient management...
  45. ncbi request reprint Clopidogrel is safe early after on- and off-pump coronary artery bypass surgery
    Vincent Chan
    Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    J Card Surg 22:493-7. 2007
    ..The goal of this study was to assess the safety of early postoperative clopidogrel in patients undergoing on-pump and off-pump coronary artery bypass graft (CABG) surgery...
  46. pmc The effect of encapsulation of cardiac stem cells within matrix-enriched hydrogel capsules on cell survival, post-ischemic cell retention and cardiac function
    Audrey E Mayfield
    University of Ottawa Heart Institute, Ottawa, Canada K1Y4W7
    Biomaterials 35:133-42. 2014
    ..Single cell encapsulation prevents detachment induced cell death while boosting the mechanical retention of CSCs to enhance repair of damaged myocardium. ..
  47. doi request reprint Aortic valve cusp shearing and migration into the left main coronary artery during transcatheter aortic valve implantation
    Hadi Daood Toeg
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Can J Cardiol 28:611.e1-3. 2012
    ..With this case report, we illustrate the etiology and management of this complication, which can be recognized nonsurgically only if a high index of suspicion exists...
  48. doi request reprint Preclinical evaluation of biopolymer-delivered circulating angiogenic cells in a swine model of hibernating myocardium
    Celine Giordano
    Division of Cardiac Surgery, Molecular Function and Imaging Program at the Cardiac PET Centre, Division of Cardiology, and Department of Cellular and Molecular Medicine, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Circ Cardiovasc Imaging 6:982-91. 2013
    ..However, to date, no experimental data have been available in this context; we therefore examined the biopolymer-supported delivery of circulating angiogenic cells using a clinically relevant swine model of hibernating myocardium...
  49. doi request reprint Knowledge, attitudes, and practice patterns in surgical management of bicuspid aortopathy: a survey of 100 cardiac surgeons
    Subodh Verma
    Division of Cardiac Surgery, St Michael s Hospital, University of Toronto, Toronto, Ontario, Canada
    J Thorac Cardiovasc Surg 146:1033-1040.e4. 2013
    ..We hypothesized that surgeons' knowledge of and attitudes toward bicuspid aortic valve aortopathy influence their surgical approaches...
  50. doi request reprint (18)F-FDG cell labeling may underestimate transplanted cell homing: more accurate, efficient, and stable cell labeling with hexadecyl-4-[(18)F]fluorobenzoate for in vivo tracking of transplanted human progenitor cells by positron emission tomography
    Yan Zhang
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Canada
    Cell Transplant 21:1821-35. 2012
    ..18)F-HFB cell labeling with PET imaging offers a better modality to enhance our understanding of early retention, homing, and engraftment with cardiac cell therapy...
  51. doi request reprint Minimally invasive coronary artery bypass grafting via a small thoracotomy versus off-pump: a case-matched study
    Harry Lapierre
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, ON, Canada
    Eur J Cardiothorac Surg 40:804-10. 2011
    ..The minimally invasive coronary artery bypass grafting (MICS CABG) operation performed via a small thoracotomy has not previously been examined in a direct comparison to sternotomy off-pump coronary artery bypass grafting (OPCAB)...
  52. ncbi request reprint Clinically relevant extracellular-matrix scaffolds for cell transplantation and vascular repair
    Rashmi Tiwari-Pandey
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, ON, Canada
    Curr Vasc Pharmacol 10:322-30. 2012
    ....
  53. doi request reprint Comparison of the EuroSCORE and Cardiac Anesthesia Risk Evaluation (CARE) score for risk-adjusted mortality analysis in cardiac surgery
    Diem T T Tran
    Cardiac Division of Anesthesiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Eur J Cardiothorac Surg 41:307-13. 2012
    ..This study assesses their ability to provide risk-adjusted mortality in a contemporary cardiac surgical population...
  54. ncbi request reprint Skeletonized internal thoracic artery harvest reduces pain and dysesthesia and improves sternal perfusion after coronary artery bypass surgery: a randomized, double-blind, within-patient comparison
    Munir Boodhwani
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Circulation 114:766-73. 2006
    ..We performed a randomized, double-blind, within-patient comparison of skeletonized and nonskeletonized ITAs in patients undergoing coronary surgery...
  55. pmc Insulin treatment enhances the myocardial angiogenic response in diabetes
    Munir Boodhwani
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Thorac Cardiovasc Surg 134:1453-60; discussion 1460. 2007
    ..The aim of this study was to determine the effects of insulin treatment on the diabetic angiogenic response to chronic myocardial ischemia...
  56. doi request reprint Clinical and echocardiographic impact of functional tricuspid regurgitation repair at the time of mitral valve replacement
    Vincent Chan
    Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    Ann Thorac Surg 88:1209-15. 2009
    ..We examined patients undergoing mitral valve replacement (MVR) to determine the effect of TR and tricuspid valve repair on survival, functional status, and postoperative TR...
  57. ncbi request reprint The role of integrin α2 in cell and matrix therapy that improves perfusion, viability and function of infarcted myocardium
    Ali Ahmadi
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa K1Y 4W7, Canada Molecular Function and Imaging Program, University of Ottawa Heart Institute, Ottawa K1Y 4W7, Canada
    Biomaterials 35:4749-58. 2014
    ..These findings indicate that the synergistic therapeutic effect of CACs + matrix therapy in MI requires the matrix to enhance CAC function via α2β1 and α5 integrin signaling mechanisms, rather than simply delivering the cells. ..
  58. doi request reprint Handsewn proximal anastomoses onto the ascending aorta through a small left thoracotomy during minimally invasive multivessel coronary artery bypass grafting: a stepwise approach to safety and reproducibility
    Vincent Chan
    Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    Semin Thorac Cardiovasc Surg 24:79-83. 2012
    ..There were no preoperative deaths, 2 reoperations for bleeding, and 2 superficial wound infections. The median length of hospital stay was 4 days. MICS CABG is a safe alternative to conventional CABG, with excellent short-term results...
  59. doi request reprint Repeat cardiac surgery in a Jehovah's Witness patient with thrombocytopenia
    Elsayed Elmistekawy
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Can J Cardiol 27:869.e7-8. 2011
    ..In addition to being of Jehovah's Witness faith, the patient had chronic thrombocytopenia. We describe our strategy in managing this situation...
  60. ncbi request reprint Nitric oxide and the angiogenic response: can we improve the results of therapeutic angiogenesis?
    Varun Kapila
    University of Ottawa Heart Institute, Division of Cardiac Surgery, 40 Ruskin Street, Suite 3403, Ottawa, Ontario, K1Y 4W7, Canada
    Expert Opin Investig Drugs 14:37-44. 2005
    ..This article outlines the role of NO in the angiogenic response and discusses possible therapeutic options to optimise endothelial dysfunction and NO availability in patients undergoing angiogenic therapy...
  61. ncbi request reprint Transcranial Doppler and acoustic pressure fluctuations for the assessment of cavitation and thromboembolism in patients with mechanical heart valves
    Rosendo A Rodriguez
    Department of Surgery, Division of Cardiac Surgery, University of Ottawa Heart Institute, Room H 4403, 40 Ruskin Street, Ottawa, Ontario, K1Y 4W7, Canada
    Interact Cardiovasc Thorac Surg 7:179-83. 2008
    ..A better understanding of cavitation is important in order to adequately investigate its role in the overall pro-thrombotic effects in mechanical valve patients. Such studies may allow establishing guidelines for new valve designs...
  62. ncbi request reprint Radial artery graft treatment with phenoxybenzamine is clinically safe and may reduce perioperative myocardial injury
    Alexander Kulik
    Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    Ann Thorac Surg 83:502-9. 2007
    ..Therefore, the purpose of this study was to evaluate the clinical safety and efficacy of RA treatment with phenoxybenzamine...
  63. doi request reprint Aspirin plus clopidogrel versus aspirin alone after coronary artery bypass grafting: the clopidogrel after surgery for coronary artery disease (CASCADE) Trial
    Alexander Kulik
    Lynn Heart and Vascular Institute, University of Ottawa Heart Institute, Ontario, Canada
    Circulation 122:2680-7. 2010
    ....
  64. ncbi request reprint Generation of CD133+ cells from CD133- peripheral blood mononuclear cells and their properties
    Erik J Suuronen
    Division of Cardiac Surgery, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario, Canada K1Y 4W7
    Cardiovasc Res 70:126-35. 2006
    ..This study reports on the phenotypic characterization and functional analysis of human CD133+ cells and their generation from cells in the peripheral circulation...
  65. pmc Human blood and cardiac stem cells synergize to enhance cardiac repair when cotransplanted into ischemic myocardium
    Nicholas Latham
    University of Ottawa Heart Institute, Department of Cardiology, Ottawa, Ontario, Canada N L, B Y, R J, B K L, D K, M R, E J S, D R D and Ottawa Hospital Research Institute, Department of Medicine, Ottawa, Ontario, Canada D J S
    Circulation 128:S105-12. 2013
    ..In this study, we compared the effect of human CACs and CSCs, alone or in combination, on myocardial function in an immunodeficient mouse model of myocardial infarction...
  66. doi request reprint Exploiting extracellular matrix-stem cell interactions: a review of natural materials for therapeutic muscle regeneration
    Drew Kuraitis
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, ON K1Y 4W7, Canada
    Biomaterials 33:428-43. 2012
    ..Future material-based therapies will benefit from a more precise control over therapeutic cell populations implicated in the regenerative response...
  67. ncbi request reprint Improving cell engraftment with tissue engineering
    Erik J Suuronen
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Semin Thorac Cardiovasc Surg 20:110-4. 2008
    ....
  68. doi request reprint Use of bilateral internal thoracic artery during coronary artery bypass graft surgery in Canada: The bilateral internal thoracic artery survey
    Stefano Mastrobuoni
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Thorac Cardiovasc Surg 144:874-9. 2012
    ..The aim of this study was to determine the current use of the bilateral internal thoracic artery during coronary artery bypass grafting among cardiac surgeons in Canada and identify the main concerns that limit the use of these conduits...
  69. doi request reprint Heart valve prosthesis selection in patients with end-stage renal disease requiring dialysis: a systematic review and meta-analysis
    Vincent Chan
    Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    Heart 97:2033-7. 2011
    ..There is little evidence guiding heart valve prosthesis selection in patients with end-stage renal disease (ESRD) on dialysis...
  70. doi request reprint Off-pump coronary artery bypass grafting does not preserve renal function better than on-pump coronary artery bypass grafting: results of a case-matched study
    Elsayed Elmistekawy
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Thorac Cardiovasc Surg 143:85-92. 2012
    ..Large case-matched and randomized comparisons have shown conflicting results. This study focuses on this clinical controversy...
  71. ncbi request reprint Protein-, gene-, and cell-based therapeutic angiogenesis for the treatment of myocardial ischemia
    Marc Ruel
    University of Ottawa, Ottawa, Ontario, Canada
    Mol Cell Biochem 264:119-31. 2004
    ..This review summarizes current knowledge in therapeutic angiogenesis research...
  72. doi request reprint Mitral valve replacement is a viable alternative to mitral valve repair for ischemic mitral regurgitation: a case-matched study
    Vincent Chan
    Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    Ann Thorac Surg 92:1358-65; discussion 1365-6. 2011
    ..We performed a propensity-based, case-matched analysis to examine whether patients who undergo mitral valve repair and those who undergo mitral valve replacement for IMR have similar long-term outcomes...
  73. doi request reprint Urgent replacement of a mechanical mitral prosthesis in an anticoagulated patient with Bombay red blood cell phenotype
    Travis K Nairn
    Department of Anesthesiology, University of Ottawa, ON, Canada
    Can J Anaesth 57:583-7. 2010
    ..We report a case of urgent repeat sternotomy for replacement of a mechanical mitral prosthesis in a patient with Bombay phenotype anticoagulated with warfarin, to emphasize the transfusion challenges in such patients...
  74. ncbi request reprint CD117-positive cells and mast cells in adult human cardiac valves--observations and implications for the creation of bioengineered grafts
    John P Veinot
    Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Cardiovasc Pathol 15:36-40. 2006
    ..There is no report to date of stem cells in human cardiac valves. We examined their possible presence, number, and distribution in valves removed at cardiac surgery from patients with a variety of underlying valve pathologies...
  75. ncbi request reprint Tracking stem cell therapy in the myocardium: applications of positron emission tomography
    Yan Zhang
    National Cardiac PET Centre, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario, Canada
    Curr Pharm Des 14:3835-53. 2008
    ..These two cell tracking approaches used for PET imaging are reviewed here and compared against other imaging modalities...
  76. doi request reprint Collagen scaffolds with or without the addition of RGD peptides support cardiomyogenesis after aggregation of mouse embryonic stem cells
    Jennifer Dawson
    Department of Cellular and Molecular Medicine, University of Ottawa, 451 Smyth Road, Ottawa, ON, Canada
    In Vitro Cell Dev Biol Anim 47:653-64. 2011
    ....
  77. ncbi request reprint Infected right ventricular myxoma and pulmonary valve endocarditis
    Vincent Chan
    University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Thorac Cardiovasc Surg 134:248-9. 2007
  78. ncbi request reprint Mesenchymal stem cells for cardiovascular regeneration
    Drew Kuraitis
    Division of Cardiac Surgery, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada
    Cardiovasc Drugs Ther 25:349-62. 2011
    ..Herein, we review the evidence of MSCs as a cell source for cardiovascular regeneration, as well as their limitations that may prevent them from being effectively used in the clinic...
  79. ncbi request reprint Patterns and predictors of statin use after coronary artery bypass graft surgery
    Alexander Kulik
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Canada
    J Thorac Cardiovasc Surg 134:932-8. 2007
    ..The purposes of this study were to assess statin prescription rates in patients who have undergone coronary artery bypass graft surgery and to identify the determinants of postoperative statin administration...
  80. doi request reprint 3-dimensional structures to enhance cell therapy and engineer contractile tissue
    Olivier Schussler
    Division of Cardiac Surgery, University of Ottawa Heart Institute, 40 Ruskin Street, Suite 3403, Ottawa, ON, K1Y 4W7, Canada
    Asian Cardiovasc Thorac Ann 18:188-98. 2010
    ....
  81. ncbi request reprint Off-pump coronary surgery through mini-incisions: is it reasonable?
    Harry Lapierre
    Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    Curr Opin Cardiol 21:578-83. 2006
    ..The efficacy of these techniques is emerging in the literature. Our aim is to describe the new technique that we are using, and provide an objective review of the recent literature with regards to safety and related surgical outcomes...
  82. doi request reprint The future of regenerating the myocardium
    Drew Kuraitis
    Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Curr Opin Cardiol 25:575-82. 2010
    ....
  83. doi request reprint Malignant invasion of sternotomy incision after cardiac operation
    Vincent Chan
    Division of Cardiac Surgery, Department of Radiology, University of Ottawa, Ottawa, Ontario, Canada
    Ann Thorac Surg 89:1295-6. 2010
    ..Neoplastic involvement should, therefore, remain part of the differential diagnosis for incisional drainage or induration, especially beyond the initial postoperative period...
  84. ncbi request reprint Postoperative naproxen after coronary artery bypass surgery: a double-blind randomized controlled trial
    Alexander Kulik
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ont, Canada
    Eur J Cardiothorac Surg 26:694-700. 2004
    ..The aim of this study was to examine the efficacy and safety of a commonly used NSAID, naproxen. We hypothesized that naproxen would reduce postoperative pain following CABG without increasing complications...
  85. ncbi request reprint High flow rates during modified ultrafiltration decrease cerebral blood flow velocity and venous oxygen saturation in infants
    Rosendo A Rodriguez
    Department of Anesthesiology, Cardiac Division, Ottawa, Ontario, Canada
    Ann Thorac Surg 80:22-8. 2005
    ..We investigated the effects of different blood flow rates during modified ultrafiltration on the cerebral hemodynamics of children with weights above and below 10 kg...
  86. ncbi request reprint The "hybrid flip-over" technique for anterior leaflet prolapse repair
    Thierry G Mesana
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Ann Thorac Surg 83:322-3. 2007
    ..Herein we describe a novel and reproducible technique for bi-leaflet mitral valve repair, including those with extensive anterior mitral leaflet prolapse...
  87. pmc Minimally invasive direct coronary artery bypass for the treatment of isolated disease of the left anterior descending coronary artery
    Munir Boodhwani
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, ON
    Can J Surg 48:307-10. 2005
    ..We reviewed our experience with the minimally invasive direct coronary artery bypass (MIDCAB) procedure...
  88. ncbi request reprint Effects of methylprednisolone and a biocompatible copolymer circuit on blood activation during cardiopulmonary bypass
    Fraser D Rubens
    Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    Ann Thorac Surg 79:655-65. 2005
    ..This trial addresses the efficacy of a biocompatible surface alone and in combination with steroids in inhibiting these changes...
  89. ncbi request reprint A new and simplified method for coronary and graft imaging during CABG
    Fraser D Rubens
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario
    Heart Surg Forum 5:141-4. 2002
    ..This report examines the initial clinical use of fluorescent cardiac imaging, a technology that uses indocyanine green (ICG) with a portable imaging device to visualize coronary anatomy and grafts intraoperatively...
  90. ncbi request reprint Angiogenic protein therapy
    Marc Ruel
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Canada
    Semin Thorac Cardiovasc Surg 15:222-35. 2003
    ....
  91. ncbi request reprint Poly(ADP-ribose) polymerase inhibition improves postischemic myocardial function after cardioplegia-cardiopulmonary bypass
    Tanveer A Khan
    Division of Cardiothoracic Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115, USA
    J Am Coll Surg 197:270-7. 2003
    ..We hypothesized that a novel poly(ADP-ribose) polymerase inhibitor, INO-1001, provides myocardial protection and improves cardiac function after regional ischemia and cardioplegia-cardiopulmonary bypass (CPB)...
  92. ncbi request reprint Inhibition of the cardiac angiogenic response to surgical FGF-2 therapy in a Swine endothelial dysfunction model
    Marc Ruel
    Center for Minimally Invasive Surgery, Harvard Medical School, Boston, MA, USA
    Circulation 108:II335-40. 2003
    ..We compared the effects of clinically applicable angiogenesis methods in swine in which endothelial dysfunction was experimentally induced to that observed in normal swine...
  93. ncbi request reprint Vascular growth factors and angiogenesis in cardiac surgery
    Frank W Sellke
    Division of Cardiothoracic Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Ann Thorac Surg 75:S685-90. 2003
    ....
  94. ncbi request reprint Activation of pulmonary mitogen-activated protein kinases during cardiopulmonary bypass
    Tanveer A Khan
    Division of Cardiothoracic Surgery, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    J Surg Res 115:56-62. 2003
    ..Mitogen-activated protein kinases (MAPK) have been shown to mediate pulmonary injury. We hypothesized that MAPK are activated during CPB and potentially contribute to lung injury...
  95. ncbi request reprint Internal thoracic artery flow competition: studies in a canine H-graft model
    William E Cohn
    Division of Cardiothoracic Surgery, Beth Israel Deaconess Medical Center, LMOB 2A, 110 Francis Street, Boston, MA 02215, USA
    Eur J Cardiothorac Surg 23:56-9. 2003
    ..Although a widely acknowledged phenomenon, the conditions under which flow competition occurs have not been established. This is examined in a canine H-graft model...
  96. ncbi request reprint Angiogenesis for the treatment of inoperable coronary disease: the future
    Frank W Sellke
    Division of Cardiothoracic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Semin Cardiothorac Vasc Anesth 10:184-8. 2006
    ....
  97. ncbi request reprint Inhibition of the cardiac angiogenic response to exogenous vascular endothelial growth factor
    Pierre Voisine
    Divisions of Cardiothoracic Surgery and Cardiology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Surgery 136:407-15. 2004
    ..Nitric oxide availability is decreased in patients with coronary disease, a possible explanation for the humble results of VEGF in clinical trials. We sought to examine the effects of exogenous VEGF in a model of endothelial dysfunction...
  98. ncbi request reprint Intracardiac ultrasonic suture welding for knotless mitral valve replacement
    Marc Ruel
    Division of Cardiothoracic Surgery, Beth Israel Deaconess Medical Center, LMOB 2A, 110 Francis Street, Boston, MA 02215, USA
    Eur J Cardiothorac Surg 21:245-8. 2002
    ..The following set of experiments was undertaken to ascertain the in-vivo feasibility of using an intracardiac ultrasonic welding device for knotless suture fixation during mitral valve replacement (MVR)...
  99. ncbi request reprint Effects of L-arginine on fibroblast growth factor 2-induced angiogenesis in a model of endothelial dysfunction
    Pierre Voisine
    Division of Cardiothoracic Surgery, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Circulation 112:I202-7. 2005
    ..We examined the influence of L-arginine supplementation to FGF-2 therapy on myocardial microvascular reactivity and perfusion in a porcine model of endothelial dysfunction...
  100. ncbi request reprint Mortality and myocardial infarction following surgical versus percutaneous revascularization of isolated left anterior descending artery disease: a meta-analysis
    Munir Boodhwani
    Division of Cardiothoracic Surgery, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA, USA
    Eur J Cardiothorac Surg 29:65-70. 2006
    ..We conducted a meta-analysis to study the early and mid-term outcomes following percutaneous and surgical treatment of isolated LAD disease...
  101. ncbi request reprint Differences in gene expression profiles of diabetic and nondiabetic patients undergoing cardiopulmonary bypass and cardioplegic arrest
    Pierre Voisine
    Division of Cardiothoracic Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass 02215, USA
    Circulation 110:II280-6. 2004
    ..We sought to compare the cardiac gene expression responses to cardiopulmonary bypass (CPB) and cardioplegic arrest (C) in patients with and without diabetes...