F Rubens

Summary

Affiliation: University of Ottawa Heart Institute
Country: Canada

Publications

  1. ncbi request reprint A new and simplified method for coronary and graft imaging during CABG
    Fraser D Rubens
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario
    Heart Surg Forum 5:141-4. 2002
  2. ncbi request reprint Surgery for chronic thromboembolic pulmonary hypertension--inclusive experience from a national referral center
    Fraser D Rubens
    Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    Ann Thorac Surg 83:1075-81. 2007
  3. ncbi request reprint Surgical treatment of chronic thromboembolic pulmonary hypertension
    F Rubens
    University of Ottawa Heart Institute, Ottawa, Canada
    Can Respir J 7:49-57. 2000
  4. ncbi request reprint Effects of methylprednisolone and a biocompatible copolymer circuit on blood activation during cardiopulmonary bypass
    Fraser D Rubens
    Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    Ann Thorac Surg 79:655-65. 2005
  5. ncbi request reprint The cardiotomy trial: a randomized, double-blind study to assess the effect of processing of shed blood during cardiopulmonary bypass on transfusion and neurocognitive function
    Fraser D Rubens
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Circulation 116:I89-97. 2007
  6. ncbi request reprint Lessons learned on the path to a healthier brain: dispelling the myths and challenging the hypotheses
    Fraser D Rubens
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Canada
    Perfusion 22:153-60. 2007
  7. ncbi request reprint Interpreting studies of cognitive function following cardiac surgery: a guide for surgical teams
    Fraser D Rubens
    Divisions of Cardiac Surgery, University of Ottawa Heart Institute Ottawa, Canada
    Perfusion 22:185-92. 2007
  8. ncbi request reprint Perioperative red blood cell salvage
    Fraser D Rubens
    University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Can J Anaesth 50:S31-40. 2003
  9. ncbi request reprint The inflammatory response to cardiopulmonary bypass: a therapeutic overview
    F D Rubens
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Perfusion 19:S5-12. 2004
  10. ncbi request reprint Cardiopulmonary bypass technology transfer: musings of a cardiac surgeon
    F D Rubens
    Ottawa Heart Institute, Ontario, Canada
    J Biomater Sci Polym Ed 13:485-99. 2002

Detail Information

Publications54

  1. ncbi request reprint A new and simplified method for coronary and graft imaging during CABG
    Fraser D Rubens
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario
    Heart Surg Forum 5:141-4. 2002
    ..This report examines the initial clinical use of fluorescent cardiac imaging, a technology that uses indocyanine green (ICG) with a portable imaging device to visualize coronary anatomy and grafts intraoperatively...
  2. ncbi request reprint Surgery for chronic thromboembolic pulmonary hypertension--inclusive experience from a national referral center
    Fraser D Rubens
    Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    Ann Thorac Surg 83:1075-81. 2007
    ..The purpose of this report is to provide a review of the inclusive results from our moderately sized national program for all PTE, with a particular emphasize on the aspects of the learning curve in terms of patient management...
  3. ncbi request reprint Surgical treatment of chronic thromboembolic pulmonary hypertension
    F Rubens
    University of Ottawa Heart Institute, Ottawa, Canada
    Can Respir J 7:49-57. 2000
    ..There are only limited treatment options for patients with chronic thromboembolic pulmonary hypertension in Canada...
  4. ncbi request reprint Effects of methylprednisolone and a biocompatible copolymer circuit on blood activation during cardiopulmonary bypass
    Fraser D Rubens
    Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    Ann Thorac Surg 79:655-65. 2005
    ..This trial addresses the efficacy of a biocompatible surface alone and in combination with steroids in inhibiting these changes...
  5. ncbi request reprint The cardiotomy trial: a randomized, double-blind study to assess the effect of processing of shed blood during cardiopulmonary bypass on transfusion and neurocognitive function
    Fraser D Rubens
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Circulation 116:I89-97. 2007
    ..We sought to evaluate the effects of cardiotomy blood processing on blood product use and neurocognitive functioning after cardiac surgery...
  6. ncbi request reprint Lessons learned on the path to a healthier brain: dispelling the myths and challenging the hypotheses
    Fraser D Rubens
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Canada
    Perfusion 22:153-60. 2007
    ..They have also confirmed that, when high standards in trial design are applied, the results can have universal implications in terms of our practice...
  7. ncbi request reprint Interpreting studies of cognitive function following cardiac surgery: a guide for surgical teams
    Fraser D Rubens
    Divisions of Cardiac Surgery, University of Ottawa Heart Institute Ottawa, Canada
    Perfusion 22:185-92. 2007
    ..It is only through the understanding of their limitations and the implications of trial design that we can translate these results to provide the best therapeutic options for our patients in unbiased manner...
  8. ncbi request reprint Perioperative red blood cell salvage
    Fraser D Rubens
    University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Can J Anaesth 50:S31-40. 2003
  9. ncbi request reprint The inflammatory response to cardiopulmonary bypass: a therapeutic overview
    F D Rubens
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Perfusion 19:S5-12. 2004
    ..Only if we are armed with a comprehensive knowledge of the molecular and cellular basis for these strategies will we be able to continue to evolve our treatment in parallel with our patients to achieve these goals...
  10. ncbi request reprint Cardiopulmonary bypass technology transfer: musings of a cardiac surgeon
    F D Rubens
    Ottawa Heart Institute, Ontario, Canada
    J Biomater Sci Polym Ed 13:485-99. 2002
    ....
  11. doi request reprint Skeletonization of the internal thoracic artery for coronary artery bypass grafting
    Fraser D Rubens
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Curr Opin Cardiol 24:559-66. 2009
    ..Skeletonization is a technique of internal thoracic artery (ITA) harvest that has been proposed to reduce chest wall ischemia and thus minimize these problems...
  12. ncbi request reprint Feasibility of blinding in a randomized controlled trial comparing preoperative autologous blood donation and acute normovolemic hemodilution in adult cardiac surgery
    F D Rubens
    Departments of Surgery, Anaesthesia, and Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Transfusion 40:1058-62. 2000
    ..They have not, however, been compared to each other, because of perceived difficulties in blinding in such a clinical study. The feasibility of blinding was tested in a pilot trial...
  13. ncbi request reprint Use of recombinant-hirudin in pulmonary thromboendarterectomy
    F D Rubens
    Department of Surgery, University of Ottawa, Ontario, Canada
    Ann Thorac Surg 69:1942-3. 2000
    ..Techniques for administration as well as monitoring of this drug's effects are discussed...
  14. ncbi request reprint Delayed thrombin generation with hirudin anticoagulation during prolonged cardiopulmonary bypass
    Fraser D Rubens
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Ann Thorac Surg 79:334-6. 2005
    ..In this report we describe the efficacy of this drug in inhibiting thrombin during a case requiring prolonged cardiopulmonary bypass...
  15. ncbi request reprint Early postoperative anticoagulation after mechanical valve replacement: a Canadian survey
    Alexander Kulik
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Heart Valve Dis 15:581-7. 2006
    ..The study aim was to examine the practice patterns of Canadian cardiac surgeons with regard to early postoperative anticoagulation after mechanical valve implantation...
  16. ncbi request reprint Predictors of early neurocognitive deficits in low-risk patients undergoing on-pump coronary artery bypass surgery
    Munir Boodhwani
    Divisions of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Canada
    Circulation 114:I461-6. 2006
    ..Predictors of neurocognitive deficits can identify potentially modifiable risk factors as well as high-risk patients in whom alternate revascularization strategies may be considered...
  17. ncbi request reprint Mechanical versus bioprosthetic valve replacement in middle-aged patients
    Alexander Kulik
    Division of Cardiac Surgery, University of Ottawa Heart Institute, 40 Ruskin Street, Suite 3403, Ottawa, Ont K1Y 4W7, Canada
    Eur J Cardiothorac Surg 30:485-91. 2006
    ..This cohort study examines the long-term outcomes of mechanical versus bioprosthetic valves in middle-aged patients...
  18. ncbi request reprint Early postoperative anticoagulation after mechanical valve replacement: a systematic review
    Alexander Kulik
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa Hospital, Ottawa, Canada
    Ann Thorac Surg 81:770-81. 2006
    ....
  19. doi request reprint Effects of shed mediastinal blood on cardiovascular and pulmonary function: a randomized, double-blind study
    Munir Boodhwani
    Divisions of Cardiac Surgery and Cardiac Anesthesia, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Ann Thorac Surg 86:1167-73. 2008
    ..Our aim was to evaluate the effects of processing cardiotomy blood on cardiovascular and pulmonary function after cardiac surgery...
  20. doi request reprint Effects of mild hypothermia and rewarming on renal function after coronary artery bypass grafting
    Munir Boodhwani
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Ann Thorac Surg 87:489-95. 2009
    ..We report data from two randomized studies evaluating mild hypothermia and rewarming on postoperative renal function in cardiac surgical patients...
  21. doi request reprint Current use of prophylactic strategies for postoperative atrial fibrillation: a survey of Canadian cardiac surgeons
    Joel Price
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Ann Thorac Surg 88:106-10. 2009
    ..This study was designed to assess the frequency with which these prophylactic strategies are currently being used and to identify concerns and barriers to more widespread application...
  22. ncbi request reprint Enlargement of the small aortic root during aortic valve replacement: is there a benefit?
    Alexander Kulik
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Ann Thorac Surg 85:94-100. 2008
    ..To evaluate the risks and benefits of ARE, we examined the outcomes of patients with small aortic roots who underwent AVR with or without the use of ARE...
  23. ncbi request reprint Chronic thromboembolic pulmonary arterial hypertension: correlation of postoperative results of thromboendarterectomy with preoperative helical contrast-enhanced computed tomography
    Anastasia Oikonomou
    Department of Radiology, The Ottawa Hospital, Ontario, Canada
    J Thorac Imaging 19:67-73. 2004
    ..The purpose of this study was to correlate preoperative findings on helical contrast-enhanced computed tomography (CT) with surgical outcome...
  24. ncbi request reprint Very long-term survival implications of heart valve replacement with tissue versus mechanical prostheses in adults <60 years of age
    Marc Ruel
    Division of Cardiac Surgery, and the Department of Epidemiology, University of Ottawa, Ottawa, Ontario, Canada
    Circulation 116:I294-300. 2007
    ..We examined the survival implications of selecting a tissue versus a mechanical prosthesis at initial left-heart valve replacement in a cohort of adults <60 years of age who were followed for over 20 years...
  25. ncbi request reprint Late incidence and determinants of reoperation in patients with prosthetic heart valves
    Marc Ruel
    Division of Cardiac Surgery, University of Ottawa Heart Institute, 40 Ruskin Street, Suite 3403, Ottawa, Ont, Canada K1Y 4W7
    Eur J Cardiothorac Surg 25:364-70. 2004
    ..With a focus on bioprosthetic valves, this study examines risk factors for reoperation in a large patient cohort...
  26. ncbi request reprint Late incidence and predictors of persistent or recurrent heart failure in patients with aortic prosthetic valves
    Marc Ruel
    Division of Cardiac Surgery, Department of Epidemiology, University of Ottawa, Ontario, Canada
    J Thorac Cardiovasc Surg 127:149-59. 2004
    ..We examined factors associated with persistent or recurrent congestive heart failure after aortic valve replacement...
  27. ncbi request reprint Late incidence and predictors of persistent or recurrent heart failure in patients with mitral prosthetic valves
    Marc Ruel
    Division of Cardiac Surgery, Department of Epidemiology, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario, Canada K1Y 4W7
    J Thorac Cardiovasc Surg 128:278-83. 2004
    ..The study's objective was to examine factors associated with persistent or recurrent congestive heart failure after mitral valve replacement...
  28. doi request reprint Clinical benefit of steroid use in patients undergoing cardiopulmonary bypass: a meta-analysis of randomized trials
    Richard P Whitlock
    Division of Cardiac Surgery, McMaster University, Hamilton, Ontario, Canada
    Eur Heart J 29:2592-600. 2008
    ..These data do not raise major safety concerns, however, a sufficiently powered trial is warranted to confirm or refute these findings...
  29. doi request reprint Concomitant treatment with oral L-arginine improves the efficacy of surgical angiogenesis in patients with severe diffuse coronary artery disease: the Endothelial Modulation in Angiogenic Therapy randomized controlled trial
    Marc Ruel
    Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    J Thorac Cardiovasc Surg 135:762-70, 770.e1. 2008
    ....
  30. ncbi request reprint Neuroprotective effect of mild hypothermia in patients undergoing coronary artery surgery with cardiopulmonary bypass: five-year follow-up of a randomized trial
    Howard J Nathan
    Department of Anesthesiology, University of Ottawa, Ottawa, Canada
    J Thorac Cardiovasc Surg 133:1206-11. 2007
    ..To determine whether the beneficial effect of mild hypothermia was long-lasting, we repeated the psychometric tests in 131 patients after 5 years...
  31. doi request reprint Cerebral emboli detected by transcranial Doppler during cardiopulmonary bypass are not correlated with postoperative cognitive deficits
    Rosendo A Rodriguez
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Room H 5508, 40 Ruskin Street, Ottawa, Ontario K1Y 4W7, Canada
    Stroke 41:2229-35. 2010
    ..We studied the frequency of HITS associated with different surgical maneuvers during cardiopulmonary bypass for coronary artery bypass graft surgery and their association with postoperative cognitive dysfunction (POCD)...
  32. ncbi request reprint Late incidence and determinants of stroke after aortic and mitral valve replacement
    Marc Ruel
    Department of Epidemiology and Community Medicine, University of Ottawa, Ottawa, Ontario, Canada
    Ann Thorac Surg 78:77-83; discussion 83-4. 2004
    ..Stroke is a devastating complication in patients with prosthetic valves, but characterization of its late occurrence from a large cohort is lacking...
  33. ncbi request reprint Long-term outcomes of valve replacement with modern prostheses in young adults
    Marc Ruel
    Division of Cardiac Surgery, University of Ottawa Heart Institute, 40 Ruskin Street, Suite 3403, Ottawa, Ontario, Canada K1Y 4W7
    Eur J Cardiothorac Surg 27:425-33; discussion 433. 2005
    ..To examine the multiple impacts of valve replacement on the lives of young adults...
  34. pmc Minimally invasive direct coronary artery bypass for the treatment of isolated disease of the left anterior descending coronary artery
    Munir Boodhwani
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, ON
    Can J Surg 48:307-10. 2005
    ..We reviewed our experience with the minimally invasive direct coronary artery bypass (MIDCAB) procedure...
  35. ncbi request reprint Effects of off-pump versus on-pump coronary artery bypass grafting on function and viability of circulating endothelial progenitor cells
    Marc Ruel
    Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    J Thorac Cardiovasc Surg 130:633-9. 2005
    ..We sought to examine endothelial progenitor cell characteristics after off-pump versus on-pump coronary artery bypass grafting...
  36. ncbi request reprint Safety of deliberate intraoperative and postoperative hypothermia for patients undergoing coronary artery surgery: a randomized trial
    Howard J Nathan
    Division of Cardiac Anaesthesia, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Thorac Cardiovasc Surg 127:1270-5. 2004
    ..We present safety outcomes from a trial in which patients undergoing coronary artery surgery were randomly assigned to normothermia or hypothermia for the entire surgical procedure...
  37. ncbi request reprint Combined atrial fibrillation ablation with mitral valve surgery
    Thierry G Mesana
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Heart Valve Dis 15:515-20. 2006
    ..The study aim was to evaluate the efficacy and outcome of radiofrequency (RF) atrial fibrillation (AF) ablation in patients undergoing mitral valve (MV) surgery...
  38. ncbi request reprint Ultrafiltration reduces blood transfusions following cardiac surgery: A meta-analysis
    Munir Boodhwani
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Canada
    Eur J Cardiothorac Surg 30:892-7. 2006
    ..We conducted a meta-analysis of randomized trials to evaluate the effects of ultrafiltration on blood transfusions and blood loss following adult cardiac surgery...
  39. ncbi request reprint A strategy of hypothermic circulatory arrest for difficult heart transplant postventricular assist device
    Eric Charbonneau
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ontario, Ottawa, Canada
    Ann Thorac Surg 76:611-4. 2003
    ..This approach permits controlled excision of the recipient heart and device, easy access to convert to standard ascending aorta and bicaval cannulation, and minimizes the donor graft anoxia time. Two case reports are presented...
  40. ncbi request reprint Skeletonized internal thoracic artery harvest reduces pain and dysesthesia and improves sternal perfusion after coronary artery bypass surgery: a randomized, double-blind, within-patient comparison
    Munir Boodhwani
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Circulation 114:766-73. 2006
    ..We performed a randomized, double-blind, within-patient comparison of skeletonized and nonskeletonized ITAs in patients undergoing coronary surgery...
  41. ncbi request reprint Variability and predictability of large-volume red blood cell transfusion in cardiac surgery: a multicenter study
    Keyvan Karkouti
    University Health Network, Toronto General Hospital, Department of Anesthesia, Ontario, Canada
    Transfusion 47:2081-8. 2007
    ..The objectives of this study were to measure the interinstitution variation and predictability of large-volume RBC transfusion...
  42. doi request reprint A multicenter randomized controlled trial to assess the feasibility of testing modified ultrafiltration as a blood conservation technology in cardiac surgery
    Munir Boodhwani
    Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottowa, Ontario K1Y 4W7, Canada
    J Thorac Cardiovasc Surg 139:701-6. 2010
    ..The objective of this trial was to assess the feasibility of a model testing modified ultrafiltration in which all members of the surgical team were blinded to the intervention...
  43. ncbi request reprint Currently available biomaterials for use in cardiopulmonary bypass
    Dean Belway
    University of Ottawa Heart Institute, Department of Cardiovascular Perfusion, 40 Ruskin St, Ottawa, Ontario K1Y 4W7, Canada
    Expert Rev Med Devices 3:345-55. 2006
    ..Some discussion of the underlying mechanisms of action as presently understood is provided and the current limitations of biomaterial-dependent strategies to improve outcome following CPB are addressed...
  44. ncbi request reprint Radial artery graft treatment with phenoxybenzamine is clinically safe and may reduce perioperative myocardial injury
    Alexander Kulik
    Division of Cardiac Surgery, University of Ottawa, Ottawa, Ontario, Canada
    Ann Thorac Surg 83:502-9. 2007
    ..Therefore, the purpose of this study was to evaluate the clinical safety and efficacy of RA treatment with phenoxybenzamine...
  45. ncbi request reprint Pro: Steroids should be used for cardiopulmonary bypass
    Richard P Whitlock
    Division of Cardiac Surgery, McMaster University, Hamilton Health Sciences Corporation, Hamilton, Ontario, Canada
    J Cardiothorac Vasc Anesth 19:250-4. 2005
  46. ncbi request reprint Prosthetic valve fungal endocarditis due to histoplasmosis
    P A Isotalo
    Department of Pathology and Laboratory Medicine, University of Ottawa, Ottawa, Canada
    Can J Cardiol 17:297-303. 2001
    ..The patient was treated with amphotericin and has been doing well in the two years since his surgery. The diagnosis and management of fungal endocarditis are emphasized...
  47. doi request reprint Malignant invasion of sternotomy incision after cardiac operation
    Vincent Chan
    Division of Cardiac Surgery, Department of Radiology, University of Ottawa, Ottawa, Ontario, Canada
    Ann Thorac Surg 89:1295-6. 2010
    ..Neoplastic involvement should, therefore, remain part of the differential diagnosis for incisional drainage or induration, especially beyond the initial postoperative period...
  48. doi request reprint Cardiac tamponade caused by incarcerated small bowel in the pericardium after coronary bypass grafting using the right gastroepiploic artery
    Beverley Chan
    Division of General Surgery, The Ottawa Hospital, Ottawa, Ontario, Canada
    Ann Thorac Surg 90:641-2. 2010
    ..We report a patient who presented with cardiac tamponade secondary to incarceration of the small bowel in the pericardium 1 year after coronary artery bypass grafting utilizing the right gastroepiploic artery...
  49. ncbi request reprint Mortality and myocardial infarction following surgical versus percutaneous revascularization of isolated left anterior descending artery disease: a meta-analysis
    Munir Boodhwani
    Division of Cardiothoracic Surgery, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA, USA
    Eur J Cardiothorac Surg 29:65-70. 2006
    ..We conducted a meta-analysis to study the early and mid-term outcomes following percutaneous and surgical treatment of isolated LAD disease...
  50. doi request reprint Comprehensive Canadian review of the off-label use of recombinant activated factor VII in cardiac surgery
    Keyvan Karkouti
    University Health Network, Toronto General Hospital, Department of Anesthesia, EN 3 402, 200 Elizabeth St, Toronto, Ontario, Canada M5G 2C4
    Circulation 118:331-8. 2008
    ..This observational study sought to identify the off-label use pattern of recombinant activated factor VII (rFVIIa) in cardiac surgery and to identify predictors of its effectiveness and risk...
  51. ncbi request reprint Intraoperative indocyanine green angiography: ready for prime time?
    Alexander Kulik
    J Thorac Cardiovasc Surg 133:592-3. 2007
  52. ncbi request reprint Early postoperative anticoagulation: more questions than answers?
    Alexander Kulik
    Ann Thorac Surg 82:1573-4; author reply 1574-5. 2006
  53. doi request reprint Letter by Rubens et al regarding article, "Continuous-flow cell saver reduces cognitive decline in elderly patients after coronary bypass surgery"
    Fraser D Rubens
    Circulation 117:e348; author reply e349. 2008
  54. doi request reprint Relationship between preventability of death after coronary artery bypass graft surgery and all-cause risk-adjusted mortality rates
    Veena Guru
    Institute for Clinical Evaluative Sciences, G 106, 2075 Bayview Ave, Toronto, Ontario M4N 3M5 Canada
    Circulation 117:2969-76. 2008
    ....