Research Topics
| M K RomachSummaryAffiliation: University of Toronto Country: Canada Publications
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Detail Information
Publications
Efficacy of dexfenfluramine in the treatment of alcohol dependenceM K Romach
Psychopharmacology and Dependence Research Unit, Centre for Research in Women s Health, Sunnybrook, Toronto, Ontario
Alcohol Clin Exp Res 24:1534-41. 2000..Its greater potency and several mechanisms of action suggest it should be more effective in treating alcohol dependence than drugs that only inhibit serotonin reuptake...
Long-term codeine use is associated with depressive symptomsM K Romach
Department of Pharmacology, Faculty of Pharmacy, University of Toronto, Centre for Addictions and Mental Health, Ontario, Canada
J Clin Psychopharmacol 19:373-6. 1999..2 +/- 0.9). Long-term codeine use is strongly associated with dependence. Depression and depressive symptoms are common. These data suggest that dysphoric mood states may be significant in maintaining long-term codeine use...
Naltrexone in the treatment of alcohol dependence: a Canadian trialMyroslava K Romach
Department of Psychiatry, University of Toronto
Can J Clin Pharmacol 9:130-6. 2002..The first Canadian clinical trial with naltrexone, an opiate antagonist, was conducted to evaluate its safety and usefulness as an adjunctive treatment in the management of alcohol dependence...
Attenuation of the euphoric effects of cocaine by the dopamine D1/D5 antagonist ecopipam (SCH 39166)M K Romach
Psychopharmacology and Dependence Research Unit, Centre for Research in Women s Health, Sunnybrook and Women s College Health Sciences Centre, Women s College Campus, Toronto, Ontario, Canada
Arch Gen Psychiatry 56:1101-6. 1999....
Cytochrome P450 2D6 and treatment of codeine dependenceM K Romach
Department of Psychiatry, Centre for Research in Women s Health, University of Toronto, Ontario, Canada
J Clin Psychopharmacol 20:43-5. 2000..Opiate use decreased by 30% to 100% of baseline use (p < 0.0001) in parallel with a decrease in CYP2D6 activity. Fluoxetine may have a role in the treatment of opiate dependence by decreasing opiate-reinforcing properties...
Characteristics of dependent and nondependent regular users of codeineB A Sproule
Psychopharmacology Research Program, Sunnybrook Health Science Centre, Toronto, Ontario, Canada
J Clin Psychopharmacol 19:367-72. 1999..There is a need to identify individuals experiencing problems with their codeine use and to develop optimal prevention and treatment strategies...
Comparative drug effects and abuse liability of lorazepam, buspirone, and secobarbital in nondependent subjectsE M Sellers
Clinical Psychopharmacology Program, Addiction Research Foundation, University of Toronto, Canada
J Clin Psychopharmacol 12:79-85. 1992..Lorazepam also was not particularly liked and was not different from placebo on most subjective abuse-relevant measures...
Measurement issues in postpartum depression part 1: anxiety as a feature of postpartum depressionL E Ross
Sunnybrook and Women s College Health Sciences Centre, Women s College Campus, Toronto, Canada
Arch Womens Ment Health 6:51-7. 2003..A strong role for anxiety symptoms in postpartum depression, and implications for its etiology and treatment, are discussed...
Measurement issues in postpartum depression part 2: assessment of somatic symptoms using the Hamilton Rating Scale for DepressionL E Ross
Sunnybrook and Women s College Health Sciences Centre, Women s College Campus, Toronto, Canada
Arch Womens Ment Health 6:59-64. 2003..Implications for the assessment of depression in this population are discussed...
Mood changes during pregnancy and the postpartum period: development of a biopsychosocial modelL E Ross
Sunnybrook and Women s College Health Sciences Centre, Women s College Campus and Departments of Psychiatry, Pharmacology and Medicine, and Institute of Medical Science, University of Toronto, Toronto, Canada
Acta Psychiatr Scand 109:457-66. 2004..Women are vulnerable to mood changes during pregnancy and the postpartum period. We set out to empirically test the hypothesis that biological and psychosocial variables interact to result in this vulnerability...
Risk of drug dependence and abuse posed by barbiturate-containing analgesicsE M Sellers
Department of Pharmacology, Faculty of Pharmacy, University of Toronto, Ontario
Can J Clin Pharmacol 6:18-25. 1999..Codeine-containing combination analgesics have the potential to be a more important public health problem than those with only barbiturate in the combination...
Oral ketamine as a positive control in human abuse potential studiesM J Shram
Kendle Early Stage Toronto, Toronto, Ontario, Canada
Drug Alcohol Depend 114:185-93. 2011....
Relative abuse potential of opioid formulations in Canada: a structured field studyEdward M Sellers
Ventana Clinical Research Corporation, Toronto, Ontario, Canada
J Opioid Manag 2:219-27. 2006..These findings should be confirmed by epidemiological studies. Comparative risk management programs should be part of the development of any new narcotic delivery system...
