E Rogaeva

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. pmc Role of p73 in Alzheimer disease: lack of association in mouse models or in human cohorts
    Badri Vardarajan
    Department of Medicine Biomedical Genetics, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Mol Neurodegener 8:10. 2013
  2. pmc Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk
    Karolien Bettens
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, 2610 Antwerpen, Belgium
    Mol Neurodegener 7:3. 2012
  3. pmc Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD
    Parastoo Momeni
    Laboratory of Neurogenetics, National Institute of Aging, NIH, Bethesda, MD, USA
    BMC Neurol 6:44. 2006
  4. ncbi request reprint The solved and unsolved mysteries of the genetics of early-onset Alzheimer's disease
    Ekaterina Rogaeva
    Neuromolecular Med 2:1-10. 2002
  5. ncbi request reprint PS1 Alzheimer's disease family with spastic paraplegia: the search for a gene modifier
    E Rogaeva
    Centre for Research in Neurodegenerative Diseases, University of Toronto, and Department of Medicine Division of Neurology, Ontario, Canada
    Neurology 61:1005-7. 2003
  6. ncbi request reprint Screening for PS1 mutations in a referral-based series of AD cases: 21 novel mutations
    E A Rogaeva
    Centre for Research in Neurodegenerative Diseases and Division of Neurology, Department of Medicine, The University Health Network, Toronto, Ontario, Canada
    Neurology 57:621-5. 2001
  7. ncbi request reprint Nicastrin binds to membrane-tethered Notch
    F Chen
    Centre for Research in Neurodegenerative Diseases Departments of Medicine and Medical Biophysics, University of Toronto, Tanz Neuroscience Building, 6 Queen s Park Crescent West, Toronto, Ontario M5S 3H2, Canada
    Nat Cell Biol 3:751-4. 2001
  8. ncbi request reprint Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-catenin
    G Levesque
    Centre for Research in Neurodegenerative Diseases, Department of Medicine Neurology, University of Toronto, and Toronto Hospital, Ontario, Canada
    J Neurochem 72:999-1008. 1999
  9. ncbi request reprint Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing
    G Yu
    Centre for Research in Neurodegenerative Diseases, Toronto Western Hospital, and Department of Medicine Neurology, University of Toronto, Ontario, Canada
    Nature 407:48-54. 2000
  10. ncbi request reprint Presenilin structure, function and role in Alzheimer disease
    P E Fraser
    Centre for Research in Neurodegenerative Diseases, University of Toronto, Ont, Canada
    Biochim Biophys Acta 1502:1-15. 2000

Detail Information

Publications52

  1. pmc Role of p73 in Alzheimer disease: lack of association in mouse models or in human cohorts
    Badri Vardarajan
    Department of Medicine Biomedical Genetics, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Mol Neurodegener 8:10. 2013
    ..Here, we reevaluated tau pathologies in the same TgCRND8 mouse model as the previous studies...
  2. pmc Both common variations and rare non-synonymous substitutions and small insertion/deletions in CLU are associated with increased Alzheimer risk
    Karolien Bettens
    Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, 2610 Antwerpen, Belgium
    Mol Neurodegener 7:3. 2012
    ....
  3. pmc Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD
    Parastoo Momeni
    Laboratory of Neurogenetics, National Institute of Aging, NIH, Bethesda, MD, USA
    BMC Neurol 6:44. 2006
    ..A new locus for amyotrophic lateral sclerosis--frontotemporal dementia (ALS-FTD) has recently been ascribed to chromosome 9p...
  4. ncbi request reprint The solved and unsolved mysteries of the genetics of early-onset Alzheimer's disease
    Ekaterina Rogaeva
    Neuromolecular Med 2:1-10. 2002
    ..This review provides an update on the pathological consequences of mutations in early-onset AD genes, the phenotypic heterogeneity of those cases, and future directions for research and clinical practice...
  5. ncbi request reprint PS1 Alzheimer's disease family with spastic paraplegia: the search for a gene modifier
    E Rogaeva
    Centre for Research in Neurodegenerative Diseases, University of Toronto, and Department of Medicine Division of Neurology, Ontario, Canada
    Neurology 61:1005-7. 2003
    ..The authors have excluded that this modifier effect originates from coding sequence variations in three SP genes or from a second mutation in the other AD genes...
  6. ncbi request reprint Screening for PS1 mutations in a referral-based series of AD cases: 21 novel mutations
    E A Rogaeva
    Centre for Research in Neurodegenerative Diseases and Division of Neurology, Department of Medicine, The University Health Network, Toronto, Ontario, Canada
    Neurology 57:621-5. 2001
    ..Mutations in the presenilin-1 gene (PS1) account for a majority of patients with early-onset familial AD. However, the clinical indications and algorithms for genetic testing in dementia are still evolving...
  7. ncbi request reprint Nicastrin binds to membrane-tethered Notch
    F Chen
    Centre for Research in Neurodegenerative Diseases Departments of Medicine and Medical Biophysics, University of Toronto, Tanz Neuroscience Building, 6 Queen s Park Crescent West, Toronto, Ontario M5S 3H2, Canada
    Nat Cell Biol 3:751-4. 2001
    ..In addition, we report that the Notch and betaAPP pathways do not significantly compete with each other...
  8. ncbi request reprint Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta-catenin
    G Levesque
    Centre for Research in Neurodegenerative Diseases, Department of Medicine Neurology, University of Toronto, and Toronto Hospital, Ontario, Canada
    J Neurochem 72:999-1008. 1999
    ..The latter residues contain a single arm-like domain and are highly conserved in the presenilins, suggesting that they form a functional armadillo protein binding site for the presenilins...
  9. ncbi request reprint Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing
    G Yu
    Centre for Research in Neurodegenerative Diseases, Toronto Western Hospital, and Department of Medicine Neurology, University of Toronto, Ontario, Canada
    Nature 407:48-54. 2000
    ..Nicastrin and presenilins are therefore likely to be functional components of a multimeric complex necessary for the intramembranous proteolysis of proteins such as Notch/GLP-1 and betaAPP...
  10. ncbi request reprint Presenilin structure, function and role in Alzheimer disease
    P E Fraser
    Centre for Research in Neurodegenerative Diseases, University of Toronto, Ont, Canada
    Biochim Biophys Acta 1502:1-15. 2000
    ..Furthermore, presenilins interact with beta-catenin to form presenilin complexes, and the physiological and mutational effects are also observed in the catenin signal transduction pathway...
  11. ncbi request reprint Carboxyl-terminal fragments of Alzheimer beta-amyloid precursor protein accumulate in restricted and unpredicted intracellular compartments in presenilin 1-deficient cells
    F Chen
    Centre for Research in Neurodegenerative Diseases, Departments of Laboratory Medicine and Pathobiology, Medical Biophysics and Medicine, University of Toronto, Ontario, Canada
    J Biol Chem 275:36794-802. 2000
    ..g. an activator of gamma-secretase, a substrate adaptor for gamma-secretase, or delivery of gamma-secretase to betaAPP-containing compartments)...
  12. doi request reprint A novel double mutation in FUS gene causing sporadic ALS
    J Robertson
    University of Toronto, Department of Medicine, Centre for Research in Neurodegenerative Diseases, Toronto, ON, Canada
    Neurobiol Aging 32:553.e27-30. 2011
    ..Of interest, a significant number of neuronal and glial FUS-positive inclusions were found in the tegmentum of the brainstem. Importantly, some neurons with inclusions showed retention of the normal nuclear FUS immunostaining...
  13. ncbi request reprint Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14
    P St George-Hyslop
    Dept of Medicine, University of Toronto, Ontario, Canada
    Nat Genet 2:330-4. 1992
    ..4) and suggest that the inheritance of FAD may be more complex than had initially been suspected...
  14. ncbi request reprint The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin
    G Yu
    Centre for Research in Neurodegenerative Diseases, Departments of Medicine and Medical Biophysics, University of Toronto, Toronto, Ontario M5S 3H2, Canada
    J Biol Chem 273:16470-5. 1998
    ....
  15. pmc A mechanism for low penetrance in an ALS family with a novel SOD1 deletion
    L Zinman
    Centre for Neurodegenerative Diseases, Department of Medicine, University of Toronto, 6 Queen s Park Crescent West, Toronto, Ontario, Canada, M5S 3H2
    Neurology 72:1153-9. 2009
    ..However, due to reduced mutation penetrance, the disease may present in a recessive or sporadic manner...
  16. doi request reprint Bilateral subthalamic stimulation in Parkin and PINK1 parkinsonism
    E Moro
    Movement Disorder Centre, Toronto Western Hospital, University of Toronto, Ontario, Canada
    Neurology 70:1186-91. 2008
    ....
  17. ncbi request reprint No evidence for tau duplications in frontal temporal dementia families showing genetic linkage to the tau locus in which tau mutations have not been found
    Janel Johnson
    Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Building 10, Room 6C103, MSC1589, Bethesda, MD 20892, USA
    Neurosci Lett 363:99-101. 2004
    ..We did not find any such mutations...
  18. ncbi request reprint Genetic complexity of Alzheimer's disease: successes and challenges
    Ekaterina Rogaeva
    Centre for Research in Neurodegenerative Diseases, Department of Medicine, University of Toronto, 6 Queen s Park Crescent West, Toronto, ON, Canada M5S 3H2
    J Alzheimers Dis 9:381-7. 2006
    ..In at least half of the AD cases, there is no known cause of the disease. Here we provide an overview on known AD-linked genes and discuss the strategies of searching for novel AD genetic risk factors...
  19. ncbi request reprint Novel splicing mutation in the progranulin gene causing familial corticobasal syndrome
    Mario Masellis
    Linda C Campbell Cognitive Neurology Research Unit, Sunnybrook Health Sciences Centre Toronto, Canada
    Brain 129:3115-23. 2006
    ..This report of mutation in the PGRN gene in CBS extends the evidence for genetic and phenotypic heterogeneity in FTLD spectrum disorders...
  20. ncbi request reprint T313M PINK1 mutation in an extended highly consanguineous Saudi family with early-onset Parkinson disease
    Muhammad A Chishti
    Departments of Comparative Medicine and Neuroscience, and Aragene Laboratory, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Arch Neurol 63:1483-5. 2006
    ....
  21. ncbi request reprint Expanded genomewide scan implicates a novel locus at 3q28 among Caribbean hispanics with familial Alzheimer disease
    Joseph H Lee
    Gertrude H Sergievsky Center, Columbia University, 630 W 168th St, New York, NY 10032, USA
    Arch Neurol 63:1591-8. 2006
    ..To identify novel candidate regions for late-onset Alzheimer disease (LOAD) and to confirm linkage in previously identified chromosomal regions...
  22. ncbi request reprint Characterization of the kindred of Alois Alzheimer's patient with plaque-only dementia
    Hans H Klünemann
    Universitätsklinik für Psychiatrie, Universitätsstr 84, D 93053 Regensburg, Germany
    Alzheimer Dis Assoc Disord 20:291-4. 2006
    ..The analyses of known dominant dementia genes (APP, PS1, PS2, PRNP, and BRI) failed to reveal mutations in the proband. Further examination of this family might yield new insights into the genetics of Alzheimer disease...
  23. ncbi request reprint Clinical findings in a large family with a parkin ex3delta40 mutation
    Renato P Munhoz
    Movement Disorders Centre, Toronto Western Hospital, and Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada
    Arch Neurol 61:701-4. 2004
    ..To describe a large consanguineous family in which inheritance of a 438- to 477-base pair deletion in exon 3 (Ex3Delta40) in the parkin gene resulted in parkinsonism (age range at onset, 24-32 years)...
  24. pmc The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease
    Ekaterina Rogaeva
    Centre for Research in Neurodegenerative Diseases, Department of Medicine, Department, University of Toronto, Toronto, Ontario, Canada
    Nat Genet 39:168-77. 2007
    ..These data suggest that inherited or acquired changes in SORL1 expression or function are mechanistically involved in causing Alzheimer disease...
  25. ncbi request reprint Deciphering the role of heterozygous mutations in genes associated with parkinsonism
    Christine Klein
    Department of Neurology, University of Lubeck, Lubeck, Germany
    Lancet Neurol 6:652-62. 2007
    ..We discuss the roles of heterozygous LRRK2 mutations and heterozygous parkin and PINK1 mutations in the development of parkinsonism, and propose an integrated aetiological model for this complex disease...
  26. ncbi request reprint Genetic variability in CHMP2B and frontotemporal dementia
    Parastoo Momeni
    Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892, USA
    Neurodegener Dis 3:129-33. 2006
    ..The putative pathogenicity of CHMP2B mutations for dementia is discussed...
  27. doi request reprint Microbleed topography, leukoaraiosis, and cognition in probable Alzheimer disease from the Sunnybrook dementia study
    Jacqueline A Pettersen
    Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, A421 2075 Bayview Ave, Toronto, ON M4N 3M5, Canada
    Arch Neurol 65:790-5. 2008
    ..Microbleeds are hemosiderin deposits around small vessels and are well visualized with T2*-weighted gradient-recalled echo (GRE) imaging...
  28. ncbi request reprint Brain levels of CDK5 activator p25 are not increased in Alzheimer's or other neurodegenerative diseases with neurofibrillary tangles
    Anurag Tandon
    Departments of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Neurochem 86:572-81. 2003
    ..Our data suggest that high Abeta levels in brain do not activate p35 proteolysis, and p25 is unlikely to be a causative agent for NFT formation in AD or other tauopathies...
  29. ncbi request reprint Absence of association between Alzheimer disease and the regulatory region polymorphism of the PS2 gene in an Italian population
    Manuela Di Natale
    Centro Regionale di Neurogenetica AS 6, Viale A Perugini, 88046, Lamezia Terme CZ, Italy
    Neurosci Lett 343:210-2. 2003
    ....
  30. ncbi request reprint Childhood onset in familial prion disease with a novel mutation in the PRNP gene
    Ekaterina Rogaeva
    Centre for Research in Neurodegenerative Diseases, Department of Medicine, Toronto, Ontario, Canada
    Arch Neurol 63:1016-21. 2006
    ..Up to 15% of cases of prion diseases are due to the autosomal dominant inheritance of coding PRNP mutations...
  31. pmc Association studies between the plasmin genes and late-onset Alzheimer's disease
    Nobuto Shibata
    Centre for Research in Neurodegenerative Diseases, Department of Medicine, University of Toronto and Toronto Western Hospital Research Institute, Toronto, Ontario, Canada
    Neurobiol Aging 28:1041-3. 2007
    ..Thus, the current survey does not support the notion that common polymorphisms in the plasmin genes influence the development of AD...
  32. ncbi request reprint Conversion to dementia among two groups with cognitive impairment. A preliminary report
    Cheryl A Luis
    Wien Center for Alzheimer s Disease and Memory Disorders, Mount Sinai Medical Center, Miami, Fla 33140, USA
    Dement Geriatr Cogn Disord 18:307-13. 2004
    ..To determine the conversion rates to dementia in patients diagnosed with mild cognitive impairment (MCI) thought to be caused by incipient Alzheimer's disease (MCI-AD) or with MCI with features of vascular disease (MCI-Vas)...
  33. ncbi request reprint Genetic association study of PINK1 coding polymorphisms in Parkinson's disease
    Justus L Groen
    Centre for Research in Neurodegenerative Diseases, Department of Medicine, University of Toronto, 6 Queen s Park Crescent West, Toronto, Ont, Canada M5S 3H2
    Neurosci Lett 372:226-9. 2004
    ..19). Nevertheless, it remains to be evaluated whether PINK1 variations contribute to the risk of common late onset sporadic PD...
  34. ncbi request reprint Novel PS1 mutation in a Bavarian kindred with familial Alzheimer disease
    Hans H Klünemann
    Universitätsklinik für Psychiatrie, Regensburg, Germany
    Alzheimer Dis Assoc Disord 18:256-8. 2004
    ..Intriguingly, there is the possibility that there is an 18th century founder effect and that this family is related to original kindreds with familial Alzheimer disease described in the early 20th century...
  35. ncbi request reprint A novel mutation in the SPG3A gene (atlastin) in hereditary spastic paraplegia
    Masaru Matsui
    J Neurol 254:972-4. 2007
  36. ncbi request reprint Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations
    Agnes Petit
    Centre for Research in Neurodegenerative Diseases, Department of Medicine Neurology, University of Toronto, Toronto, Ontario M5S 3H2, Canada
    J Biol Chem 280:34025-32. 2005
    ..Loss of this protective function may therefore underlie the degeneration of nigral dopaminergic neurons in patients with PINK1 mutations...
  37. ncbi request reprint Association studies of cholesterol metabolism genes (CH25H, ABCA1 and CH24H) in Alzheimer's disease
    Nobuto Shibata
    Centre for Research in Neurodegenerative Diseases, Tanz Neuroscience Building, University of Toronto, 6 Queen s Park Crescent West, Toronto, Ont, Canada M5S 3H2
    Neurosci Lett 391:142-6. 2006
    ..Similarly, no association was found in the Caribbean Hispanic families for CH25H. However, we did observe a possible interaction between ABCA1 and APOE in the Hispanics...
  38. ncbi request reprint Clinical and genetic study of a Brazilian family with spastic paraplegia (SPG6 locus)
    Renato P Munhoz
    Movement Disorders Unit, Neurology Service, Hospital de Clinicas, Federal University of Parana, Curitiba, PR, Brazil
    Mov Disord 21:279-81. 2006
    ..All patients presented with gait difficulty in their twenties, progressing to frank spastic paraplegia during the next decade. Our report further supports evidence that mutations in SPG6 cause ADHSP...
  39. ncbi request reprint Novel SPG6 mutation p.A100T in a Japanese family with autosomal dominant form of hereditary spastic paraplegia
    Satoshi Kaneko
    Department of Neurology, Kitano Hospital, The Tazuke Kofukai Medical Institute, Osaka, Japan
    Mov Disord 21:1531-3. 2006
    ..A100T in SPG6 resulted in an autosomal dominant form of hereditary spastic paraplegia (ADHSP). Clinical investigation showed a pure form of HSP. Our study demonstrates further allelic heterogeneity of SPG6...
  40. ncbi request reprint Lack of association between Alzheimer's disease and the promoter region polymorphisms of the nicastrin gene
    Antonio Orlacchio
    Laboratorio di Neurogenetica, IRCCS Santa Lucia, Rome, Italy
    Neurosci Lett 363:49-53. 2004
    ..Our investigation suggests that the two promoter SNPs are unrelated to the development of AD, however, further investigation at the promoter region of NCSTN may be necessary to address its potential implication of gene expression in AD...
  41. ncbi request reprint TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity
    Fusheng Chen
    Department of Medicine, and Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada M5S 3H2
    Nature 440:1208-12. 2006
    ..Here we report that TMP21, a member of the p24 cargo protein family, is a component of presenilin complexes and differentially regulates gamma-secretase cleavage without affecting epsilon-secretase activity...
  42. ncbi request reprint Analysis of the glucocerebrosidase gene in Parkinson's disease
    Christine Sato
    Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 20:367-70. 2005
    ..Our results demonstrate a marginally significant association of GBA mutations with PD and suggest that variations in the GBA gene may constitute a rare susceptibility factor for PD (P = 0.048)...
  43. ncbi request reprint Benign hereditary chorea: clinical, genetic, and pathological findings
    Galit Kleiner-Fisman
    Division of Neurology, Toronto Western Hospital, Ontario, Canada
    Ann Neurol 54:244-7. 2003
    ..1, and T/ebp) on chromosome 14 which is predicted to have drastic consequences on the maturation processes of TITF-1...
  44. doi request reprint Gaucher and Parkinson diseases: unexpectedly related
    Ekaterina Rogaeva
    Neurology 70:2272-3. 2008
  45. ncbi request reprint Homozygous and heterozygous PINK1 mutations: considerations for diagnosis and care of Parkinson's disease patients
    Cindy Zadikoff
    Movement Disorders Centre, Toronto Western Hospital, Toronto, Ontario, Canada
    Mov Disord 21:875-9. 2006
    ..We describe two unrelated cases with PINK1 mutations (homozygous nonsense and heterozygous missense) that highlight issues regarding the role of heterozygous mutations and the utility of genetic screening in patient care...
  46. ncbi request reprint The G2019S LRRK2 mutation in Brazilian patients with Parkinson's disease: phenotype in monozygotic twins
    Renato P Munhoz
    Movement Disorders Unit, Neurology Service, Hospital de Clinicas, Federal University of Parana, Curitiba, PR, Brazil
    Mov Disord 23:290-4. 2008
    ..The clinical presentation of twins was strikingly similar including an identical PD onset at age 60. This observation may suggest that genetic factors predominantly determine age-at-onset...
  47. ncbi request reprint Statins differentially affect amyloid precursor protein metabolism in presymptomatic PS1 and non-PS1 subjects
    Douglas A Hinerfeld
    Arch Neurol 64:1672-3. 2007
  48. ncbi request reprint Analysis of the PINK1 gene in a large cohort of cases with Parkinson disease
    Ekaterina Rogaeva
    Centre for Research in Neurodegenerative Diseases and Division of Neurology, Department of Medicine, Toronto Western Hospital, University of Toronto, Ontario, Canada
    Arch Neurol 61:1898-904. 2004
    ..Mutations in the PTEN-induced kinase (PINK1) gene located within the PARK6 locus on chromosome 1p35-p36 have recently been identified in patients with recessive early-onset Parkinson disease...
  49. ncbi request reprint Genetic studies of GRN and IFT74 in amyotrophic lateral sclerosis
    Shangxi Xiao
    Centre for Research in Neurodegenerative Diseases, Tanz Neuroscience Building, University of Toronto, 6 Queen s Park Crescent West, Toronto, Ontario, Canada M5S 3H2
    Neurobiol Aging 29:1279-82. 2008
    ..The results revealed that the common variations in IFT74 and GRN neither constitute strong ALS risk factors nor modify the age-at-onset. However, the possibility of a modest risk effect remains to be assessed in large datasets...
  50. ncbi request reprint Early-onset Parkinson's disease caused by a compound heterozygous DJ-1 mutation
    Stephen Hague
    Molecular Genetics Section, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA
    Ann Neurol 54:271-4. 2003
    ..This subject was diagnosed with probable PD at age 24 years with asymmetric onset and an excellent response to levodopa therapy. Our observations suggest that sequence alterations in DJ-1 are a rare cause of early-onset PD...
  51. ncbi request reprint Characterization of a cyclooxygenase-2-765G-->C promoter polymorphism in human neural cells
    Jian Guo Cui
    Neuroscience Center, Louisiana State University School of Medicine, New Orleans, Louisiana, USA
    Neuroreport 16:575-9. 2005
    ....
  52. pmc The association between genetic variants in SORL1 and Alzheimer disease in an urban, multiethnic, community-based cohort
    Joseph H Lee
    Taub Institute on Alzheimer s Disease and the Aging Brain, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Arch Neurol 64:501-6. 2007
    ..To investigate the association between Alzheimer disease (AD) and variant alleles in SORL1 using a series of single nucleotide polymorphisms (SNPs) in an urban, multiethnic, community-based population...