Research Topics
| George RodriguesSummaryAffiliation: University of Western Ontario Country: Canada Publications
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Detail Information
Publications
Prediction of radiation pneumonitis by dose - volume histogram parameters in lung cancer--a systematic reviewGeorge Rodrigues
Department of Radiation Oncology, London Regional Cancer Centre, London, Ontario, Canada
Radiother Oncol 71:127-38. 2004..Several recommendations for reporting and conduct of future research into the association between DVH metrics and RP risk are provided...
Propensity-score matched pair comparison of whole brain with simultaneous in-field boost radiotherapy and stereotactic radiosurgeryGeorge Rodrigues
London Health Sciences Centre, London, Canada Western University, London, Canada Electronic address
Radiother Oncol 106:206-9. 2013..To compare lesional stereotactic radiosurgery to whole brain (WBRT) radiotherapy with simultaneous in-field boost for brain metastases in terms of overall survival...
A statistical comparison of prognostic index systems for brain metastases after stereotactic radiosurgery or fractionated stereotactic radiation therapyG Rodrigues
Department of Radiation Oncology, London Regional Cancer Program, London Health Sciences Centre, London, Ontario, Canada
Clin Oncol (R Coll Radiol) 25:227-35. 2013..The purpose of this investigation was to compare nine published brain metastases prognostic indices using traditional and novel statistical comparison metrics...
Categorizing segmentation quality using a quantitative quality assurance algorithmGeorge Rodrigues
Department of Radiation Oncology, University of Western Ontario and Lawson Health Research Institute, Canada
J Med Imaging Radiat Oncol 56:668-78. 2012..We describe a novel quantitative methodology for the quality assurance (QA) of contour compliance referenced against a community set of contouring experts...
A pooled analysis of arc-based image-guided simultaneous integrated boost radiation therapy for oligometastatic brain metastasesGeorge Rodrigues
Department of Oncology, University of Western Ontario and Lawson Health Research Institute, London, ON, Canada
Radiother Oncol 102:180-6. 2012..To report pooled overall survival and time to radiological intracranial progression results related to arc-based image-guided radiotherapy for dose-escalation of oligometastatic disease of the brain...
Age and comorbidity considerations related to radiotherapy and chemotherapy administrationGeorge Rodrigues
Department of Radiation Oncology, London Health Sciences Centre, London, ON, Canada
Semin Radiat Oncol 22:277-83. 2012..Knowledge gaps, future research, and clinical recommendation in this increasingly important field are highlighted as well...
International practice survey on palliative lung radiotherapy: third international consensus workshop on palliative radiotherapy and symptom controlGeorge Rodrigues
Department of Radiation Oncology, University of Western Ontario, London Ontario, Canada
Clin Lung Cancer 13:225-35. 2012..The purpose of this work was to disseminate international practice survey results created in conjunction with the Third International Lung Cancer Consensus Workshop...
A phase II multi-institutional study assessing simultaneous in-field boost helical tomotherapy for 1-3 brain metastasesGeorge Rodrigues
Division of Radiation Oncology, Department of Oncology, University of Western Ontario and London Regional Cancer Program, London Health Sciences Centre, London, ON N6A4L6, Canada
Radiat Oncol 7:42. 2012..A phase I trial has been now completed at our institution with a total of 60 enrolled patients and 48 evaluable patients. The phase II dose has been determined to be the final phase I cohort dose of 60 Gy/10 fractions...
Consensus statement on palliative lung radiotherapy: third international consensus workshop on palliative radiotherapy and symptom controlGeorge Rodrigues
Department of Radiation Oncology, University of Western Ontario, London, ON, Canada
Clin Lung Cancer 13:1-5. 2012..Despite an expanding literature, continued prospective randomized investigations to better define the role of XRT, EBB, and CC in the context of thoracic palliation of patients with lung cancer is needed...
Novel application of helical tomotherapy in whole skull palliative radiotherapyGeorge Rodrigues
Departments of Radiation Oncology and Physics and Engineering, London Regional Cancer Program, London, Ontario, Canada
Med Dosim 33:282-5. 2008..Prospective clinical evaluation with relevant end points (quality of life, symptom relief) are required to confirm the potential benefits of highly conformal therapies applied to palliative situations such as this case...
A comparison of prostate IMRT and helical tomotherapy class solutionsGeorge Rodrigues
Department of Radiation Oncology, London Health Sciences, London, Ont, Canada
Radiother Oncol 80:374-7. 2006..HT prostate planning generally provided treatment plans with excellent target homogeneity and favorable critical structure sparing when compared to conventional IMRT...
Impact of ultrahigh baseline PSA levels on biochemical and clinical outcomes in two Radiation Therapy Oncology Group prostate clinical trialsGeorge Rodrigues
Department of Oncology, University of Western Ontario, London, Ontario, Canada
Int J Radiat Oncol Biol Phys 80:445-52. 2011..To assess ultrahigh (UH; prostate-specific antigen [PSA] levels ≥50 ng/ml) patient outcomes by comparison to other high-risk patient outcomes and to identify outcome predictors...
Phase I trial of simultaneous in-field boost with helical tomotherapy for patients with one to three brain metastasesGeorge Rodrigues
Department of Oncology, University of Western Ontario and London Regional Cancer Program, London Health Sciences Centre, London, ON, Canada
Int J Radiat Oncol Biol Phys 80:1128-33. 2011..The present study's objective was to determine the maximally tolerated dose of a simultaneous in-field boost integrated with whole brain radiotherapy for palliative treatment of patients with one to three brain metastases using HT...
Psychometric properties of a prostate cancer radiation late toxicity questionnaireGeorge Rodrigues
Department of Oncology, University of Western Ontario, London, Ontario, Canada
Health Qual Life Outcomes 5:29. 2007..To construct a short prostate cancer radiation late toxicity (PCRT) questionnaire with health-related quality-of-life (HRQoL) domains...
Planning evaluation of radiotherapy for complex lung cancer cases using helical tomotherapyTomas Kron
London Regional Cancer Centre, Departments of Radiation Oncology and Physics and Engineering, London Ontario N6A 4L6, Canada
Phys Med Biol 49:3675-90. 2004..Work is underway to investigate the possibility of breath-hold techniques for tomotherapy delivery to facilitate this aim...
Analysis of a novel protocol of combined induction chemotherapy and concurrent chemoradiation in unresected non-small-cell lung cancer: a ten-year experience with vinblastine, Cisplatin, and radiation therapyEugenie Waters
University of Western Ontario, Canada
Clin Lung Cancer 11:243-50. 2010..This analysis was conducted to better understand the outcomes in VCRT-treated patients...
Comparative planning evaluation of intensity-modulated radiotherapy techniques for complex lung cancer casesSlav Yartsev
Department of Physics and Engineering, London Regional Cancer Program, London Health Sciences Centre, London, Ontario, Canada
Radiother Oncol 78:169-76. 2006..The aim of the present study was to compare different modalities of radiation delivery based on a balanced scoring scheme for target coverage and normal tissue avoidance...
A Phase II trial of arc-based hypofractionated intensity-modulated radiotherapy in localized prostate cancerMichael Lock
Department of Oncology, University of Western Ontario and London Regional Cancer Program, London Health Sciences Centre, London, ON, Canada
Int J Radiat Oncol Biol Phys 80:1306-15. 2011....
An evaluation of an automated 4D-CT contour propagation tool to define an internal gross tumour volume for lung cancer radiotherapyStewart Gaede
Physics and Engineering Department, London Regional Cancer Program, 790 Commissioners Road East, London, Ontario, Canada
Radiother Oncol 101:322-8. 2011..To evaluate an automated 4D-CT contouring propagation tool by its impact on the inter- and intra-physician variability in lung tumour delineation...
Technology assessment of automated atlas based segmentation in prostate bed contouringJeremiah Hwee
Department of Epidemiology and Biostatistics, University of Western Ontario, London, Ontario, Canada
Radiat Oncol 6:110. 2011..Prostate bed (PB) contouring is time consuming and associated with inter-observer variability. We evaluated an automated atlas-based segmentation (AABS) engine in its potential to reduce contouring time and inter-observer variability...
Cross validation of the prostate cancer radiotherapy late toxicity (PCRT) questionnaire with the expanded prostate cancer index composite (EPIC) instrumentGeorge Rodrigues
Department of Radiation Oncology, London Regional Cancer Program, London Health Sciences, Ontario, Canada
Can J Urol 18:5802-10. 2011..The study objective was to cross-validate the PCRT domains versus the expanded prostate cancer index composite (EPIC) questionnaire urinary (U), bowel (B), hormonal (H), and S subscales...
A prospective evaluation of helical tomotherapyGlenn Bauman
London Regional Cancer Program, London, Ontario, Canada
Int J Radiat Oncol Biol Phys 68:632-41. 2007..To report results from two clinical trials evaluating helical tomotherapy (HT)...
Intensity modulated radiotherapy of non-small-cell lung cancer incorporating SPECT ventilation imagingIram Munawar
Department of Physics and Astronomy, University of Western Ontario, London, Ontario N6A 3K7, Canada
Med Phys 37:1863-72. 2010....
A multiphase validation of atlas-based automatic and semiautomatic segmentation strategies for prostate MRISpencer Martin
Department of Medical Biophysics, University of Western Ontario, London, Ontario, Canada
Int J Radiat Oncol Biol Phys 85:95-100. 2013..To perform a rigorous technological assessment and statistical validation of a software technology for anatomic delineations of the prostate on MRI datasets...
Circulating tumour cells in prostate cancer patients receiving salvage radiotherapyLori E Lowes
Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
Clin Transl Oncol 14:150-6. 2012....
Comparing two strategies of dynamic intensity modulated radiation therapy (dIMRT) with 3-dimensional conformal radiation therapy (3DCRT) in the hypofractionated treatment of high-risk prostate cancerJasper Yuen
Department of Radiation Oncology, London Regional Cancer Program, London, Ontario, Canada
Radiat Oncol 3:1. 2008..To compare two strategies of dynamic intensity modulated radiation therapy (dIMRT) with 3-dimensional conformal radiation therapy (3DCRT) in the setting of hypofractionated high-risk prostate cancer treatment...
Stereotactic body radiotherapy versus surgery for medically operable Stage I non-small-cell lung cancer: a Markov model-based decision analysisAlexander V Louie
Department of Oncology, University of Western Ontario, London, ON, Canada
Int J Radiat Oncol Biol Phys 81:964-73. 2011..To compare the quality-adjusted life expectancy and overall survival in patients with Stage I non-small-cell lung cancer (NSCLC) treated with either stereotactic body radiation therapy (SBRT) or surgery...
Intensity-modulated arc therapy for treatment of high-risk endometrial malignanciesEugene Wong
Department of Oncology, University of Western Ontario, and London Regional Cancer Centre, 790 Commissioners Road East, London, Ontario N6A 4L6, Canada
Int J Radiat Oncol Biol Phys 61:830-41. 2005..In the context of multimodality therapy, nodal and tumor bed irradiation was delivered while respecting tolerance doses for critical structures...
Predicting Radiation Pneumonitis After Chemoradiation Therapy for Lung Cancer: An International Individual Patient Data Meta-analysisDavid A Palma
Department of Radiation Oncology, London Regional Cancer Program, London, Canada Electronic address
Int J Radiat Oncol Biol Phys 85:444-50. 2013..We performed an individual patient data meta-analysis to determine factors predictive of clinically significant pneumonitis...
Inter- and intrafraction uncertainty in prostate bed image-guided radiotherapyKitty Huang
Department of Radiation Oncology, London Health Sciences Centre, London, Canada
Int J Radiat Oncol Biol Phys 84:402-7. 2012....
Management and prognosis in synchronous solitary resected brain metastasis from non-small-cell lung cancerAlexander V Louie
Department of Radiation Oncology, London Regional Cancer Program, London, Ontario, Canada
Clin Lung Cancer 10:174-9. 2009..The objective of this research is to analyze prognostic factors that predict for outcome in this unique patient population...
Withholding stereotactic radiotherapy in elderly patients with stage I non-small cell lung cancer and co-existing COPD is not justified: outcomes of a Markov model analysisAlexander V Louie
Department of Radiation Oncology, London Regional Cancer Program, London, Canada
Radiother Oncol 99:161-5. 2011..To model outcomes of SBRT versus best supportive care (BSC) in elderly COPD patients with stage I NSCLC...
Chemoradiation-induced superior vena cava syndrome: a case reportMathieu Castonguay
Department of Pathology, The University of Western Ontario, London, Canada
Can Respir J 15:444-6. 2008..The literature regarding the etiology, diagnosis and treatment of this rare entity is discussed...
Assessment and improvement of radiation oncology trainee contouring ability utilizing consensus-based penalty metricsAbhirami Hallock
Department of Oncology, University of Western Ontario and London Health Sciences Centre, London, Ontario, Canada
J Med Imaging Radiat Oncol 56:679-88. 2012..The objective of this study was to develop and assess the feasibility of utilizing consensus-based penalty metrics for the purpose of critical structure and organ at risk (OAR) contouring quality assurance and improvement...
Systematic review of dose-volume parameters in the prediction of esophagitis in thoracic radiotherapyJim Rose
Department of Radiation Oncology, Kingston Regional Cancer Centre, ON, Canada
Radiother Oncol 91:282-7. 2009....
Prognostic variables in adult Wilms tumourJonathan I Izawa
Department of Surgery, London Health Sciences Centre, London, Ont
Can J Surg 51:252-6. 2008..To identify outcomes and prognostic variables that predict survival outcomes in adult Wilms tumour patients...
Inter-observer and intra-observer reliability for lung cancer target volume delineation in the 4D-CT eraAlexander V Louie
Department of Radiation Oncology, London Regional Cancer Program, London, Ont, Canada
Radiother Oncol 95:166-71. 2010..To investigate inter-observer and intra-observer target volume delineation (TVD) error in 4D-CT imaging of thoracic tumours...
Three-dimensional image-based planning for cervix brachytherapy with bilateral hip prostheses: a solution using MVCT with helical tomotherapyRenee M Korol
Department of Medical Physics, Odette Cancer Centre, Toronto, Ontario, Canada
Brachytherapy 9:278-81. 2010..We present a method of three-dimensional image-based planning for cervix high-dose-rate (HDR) brachytherapy for patients with bilateral metal hip prostheses using megavoltage computed tomography (MVCT) imaging...
Prostate contouring uncertainty in megavoltage computed tomography images acquired with a helical tomotherapy unit during image-guided radiation therapyWilliam Y Song
Radiation Treatment Program, London Regional Cancer Program, London Health Sciences Centre, London, Ontario, Canada
Int J Radiat Oncol Biol Phys 65:595-607. 2006..32 cm from KVCT to MVCT. CONCLUSIONS: Although MVCT was inferior to KVCT for prostate delineation, the application of MVCT in prostate radiotherapy remains useful...
Open clinical uro-oncology trials in CanadaMary J Mackenzie
London Health Sciences Centre, London, Ontario, Canada
Can J Urol 15:4223-8. 2008
Hyperpolarized (3)He pulmonary functional magnetic resonance imaging prior to radiation therapyLindsay Mathew
Department of Medical Biophysics, The University of Western Ontario, London, Ontario N6A 5K8, Canada
Med Phys 39:4284-90. 2012....
Future directions in palliative thoracic radiotherapyGeorge Rodrigues
Department of Radiation Oncology, London Health Sciences Centre, London, Ontario, Canada
Curr Opin Support Palliat Care 6:91-6. 2012..The purpose of this review is to describe our present knowledge with regards to palliative thoracic radiotherapeutic maneuvers and to identify potential areas for future research inquiry consistent with current knowledge gaps...
Evaluation of tomotherapy MVCT image enhancement program for tumor volume delineationSpencer Martin
Department of Physics, London Regional Cancer Program, London Health Sciences Centre, London, Ontario, Canada
J Appl Clin Med Phys 12:3505. 2011..Enhanced MVCT provides advantages in reduction of variance among physicians in delineation of the GTV. Agreement on contouring by the same physician on both original and enhanced MVCT was equally high...
Application of helical tomotherapy in genitourinary malignanciesGeorge Rodrigues
Department of Radiation Oncology, London Regional Cancer Program, London Health Sciences, London, Ontario, Canada
Can J Urol 17:5453-8. 2010..The purpose of this report is to describe our experience with the clinical implementation of HT for genitourinary malignancies...
Changing management of localized prostate cancer: a comparison survey of Ontario radiation oncologistsJarad Martin
Division of Radiation Oncology, Princess Margaret Hospital, Toronto, Ontario, Canada
Can J Urol 13:26-33. 2006..CONCLUSIONS: There have been significant changes in the way that prostate cancer is managed with radiotherapy in Ontario between 2002 and 2005. Dose escalation and more complex treatment planning is widely evident...
Pelvic chemoradiotherapy after chemotherapy for metastatic bladder cancerKavitha Passaperuma
Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
Can J Urol 13:3009-15. 2006..This intervention should be considered for further study in prospective controlled clinical trials...
Hyperpolarized (3)He magnetic resonance imaging: comparison with four-dimensional x-ray computed tomography imaging in lung cancerLindsay Mathew
Imaging Research Laboratories, Robarts Research Institute, 100 Perth Drive, London, ON N6A 5K8, Canada
Acad Radiol 19:1546-53. 2012..The aim of this study was to evaluate the quantitative spatial relationship between 4DCT and hyperpolarized (3)He MRI ventilation maps...
Evaluation of image-guidance strategies with helical tomotherapy for localised prostate cancerTimothy P C Yeung
London Regional Cancer Program, London Health Sciences Centre, London, Ontario, Canada
J Med Imaging Radiat Oncol 55:220-8. 2011..Anatomical characteristics were investigated for their potential to help select the suitable IG protocols for individual patients...
Open clinical uro-oncology trials in CanadaEric Winquist
London Health Sciences Centre, London, Ontario, Canada
Can J Urol 15:4034-42. 2008
Open clinical uro-oncology trials in CanadaEric Winquist
London Health Sciences Centre, London, Ontario, Canada
Can J Urol 15:4284-90. 2008
Toxicity and health-related quality-of-life assessment in prostate radiotherapyGeorge Rodrigues
Department of Radiation Oncology, London Regional Cancer Program, London, Ontario, Canada
Can J Urol 14:3608-15. 2007..Herein, common toxicity scales and HRQoL instruments that attempt to describe the deleterious effects of prostate radiation therapy are reviewed...
Controversies in prostate cancer staging implementation at a tertiary cancer centerTracy Sexton
Department of Radiation Oncology, London Regional Cancer Program, London Health Sciences Center, London, Ontario, Canada
Can J Urol 13:3327-34. 2006..CONCLUSIONS: Despite guidelines and educational interventions, computer registry staging accuracy remains an issue. On-going audit procedures are proposed to identify and correct both published and institutional staging guidelines...
Curative treatment of Stage I non-small-cell lung cancer in patients with severe COPD: stereotactic radiotherapy outcomes and systematic reviewDavid Palma
VU University Medical Center, Amsterdam, Netherlands
Int J Radiat Oncol Biol Phys 82:1149-56. 2012....
Outcome analysis of prostate cancer patients with pre-treatment PSA greater than 50 ng/mlEricka Wiebe
Department of Radiation Oncology, London Regional Cancer Program, London, Ontario, Canada
Can J Urol 15:4078-83. 2008..0 ng/ml at time of diagnosis, and no clinical or radiological evidence of metastatic disease...
Open clinical uro-oncology trials in CanadaGeorge Rodrigues
London Health Sciences Center, London, Ontario, Canada
Can J Urol 15:4130-7. 2008
Recursive partitioning analysis for the prediction of stereotactic radiosurgery brain metastases lesion controlGeorge Rodrigues
Department of Radiation Oncology, London Regional Cancer Program, London Health Sciences Centre, London, Ontario, Canada
Oncologist 18:330-5. 2013..The SRS lesion analysis may help to stratify future clinical trials and better define patient care options and prognosis...
Systematic review of baseline low-dose CT lung cancer screeningGary Yau
Department of Radiation Oncology, London Regional Cancer Program, London, Ontario, Canada
Lung Cancer 58:161-70. 2007..Therefore, LDCT for lung cancer screening should be considered as investigative and needs to be confirmed by well-designed randomized controlled trials prior to community and institutional implementation...
Open clinical uro-oncology trials in CanadaGeorge Rodrigues
London Health Sciences Centre, London, Ontario, Canada
Can J Urol 14:3779-86. 2007
Open clinical uro-oncology trials in CanadaEric Winquist
London Health Sciences Centre, London, Ontario, Canada
Can J Urol 14:3716-22. 2007
Ontario radiation oncology residents' needs in the first postgraduate year-residents' perspective surveyEwa Szumacher
Department of Radiation Oncology, Toronto Regional Cancer Centre, Toronto, Ontario, Canada
Int J Radiat Oncol Biol Phys 69:512-7. 2007..To assess radiation oncology residents' needs and satisfaction in their first postgraduate year (PGY-1) in the province of Ontario...
Open clinical uro-oncology trials in CanadaMary MacKenzie
London Health Sciences Centre, London, Ontario, Canada
Can J Urol 14:3662-7. 2007
Open clinical uro-oncology trials in CanadaEric Winquist
London Health Sciences Centre, London, Ontario, Canada
Can J Urol 15:3942-9. 2008
Contemporary management of prostate cancer: a practice survey of Ontario genitourinary radiation oncologistsGeorge Rodrigues
Department of Radiation Oncology, London Regional Cancer Centre, London, Ont. N6A 4L6, Canada
Radiother Oncol 69:63-72. 2003..Current clinical practice in localized prostate cancer reflects the evolving information in the published medical literature...
Toothache as a presenting symptom of metastatic renal cell cancerAbhirami Hallock
Department of Radiation Oncology, London Regional Cancer Program, London, ON
Can Urol Assoc J 3:E42-4. 2009..The presentation, differential diagnosis and literature review of this uncommon presentation of metastatic kidney cancer are discussed in this report...
Pre-treatment risk stratification of prostate cancer patients: A critical reviewGeorge Rodrigues
Department of Radiation Oncology, London Health Sciences Centre, London, ON
Can Urol Assoc J 6:121-7. 2012....
Malignant pheochromocytoma associated with germline mutation of the SDHB geneZishan Allibhai
Division of Radiation Oncology, London Regional Cancer Centre and University of Western Ontario, London, Ontario, Canada
J Urol 172:1409-10. 2004
Prostate volume contouring: a 3D analysis of segmentation using 3DTRUS, CT, and MRWendy L Smith
Department of Medical Physics, Tom Baker Cancer Centre, and Departments of Oncology and Physics and Astronomy, University of Calgary, Calgary, Alberta, Canada
Int J Radiat Oncol Biol Phys 67:1238-47. 2007..Randomized images were contoured twice by each observer. We analyzed length and volume measurements and performed a 3D analysis of intra- and intermodality variation...
Serial megavoltage CT imaging during external beam radiotherapy for non-small-cell lung cancer: in regard to Kupelian et al. (Int J Radiat Oncol Biol Phys 2005;630:1024-1028)A Rashid Dar
Int J Radiat Oncol Biol Phys 64:328; author reply 328-9. 2006
In regard to Fiorino et al.: Rectal dose-volume constraints in high-dose radiotherapy of localized prostate cancer (Int J Radiat Oncol Biol Phys 2003;57:953-962)Glenn Bauman
Int J Radiat Oncol Biol Phys 59:912-4; author reply 914-5. 2004
