Jason S Rockel

Summary

Affiliation: University of Western Ontario
Country: Canada

Publications

  1. pmc P2X7 receptors on osteoblasts couple to production of lysophosphatidic acid: a signaling axis promoting osteogenesis
    Nattapon Panupinthu
    Canadian Institutes of Health Research Group in Skeletal Development and Remodeling, London, ON, Canada
    J Cell Biol 181:859-71. 2008
  2. doi request reprint P2X₇-mediated calcium influx triggers a sustained, PI3K-dependent increase in metabolic acid production by osteoblast-like cells
    Matthew W Grol
    Dept of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, Univ of Western Ontario, London, ON, Canada
    Am J Physiol Endocrinol Metab 302:E561-75. 2012
  3. pmc Activation of transcription factors by extracellular nucleotides in immune and related cell types
    Souzan Armstrong
    CIHR Group in Skeletal Development and Remodeling, Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON, Canada, N6A 5C1
    Purinergic Signal 3:59-69. 2007
  4. pmc Regulation of Sox9 activity by crosstalk with nuclear factor-kappaB and retinoic acid receptors
    Jason S Rockel
    Canadian Institutes of Health Research Group in Skeletal Development and Remodeling, Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Canada
    Arthritis Res Ther 10:R3. 2008
  5. pmc Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by TNFalpha-induced MEK/ERK signalling
    Jason S Rockel
    Canadian Institutes of Health Research Group in Skeletal Development and Remodeling, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario N6A5C1, Canada
    Arthritis Res Ther 11:R8. 2009
  6. doi request reprint Cyclic AMP regulates extracellular matrix gene expression and metabolism in cultured primary rat chondrocytes
    Jason S Rockel
    Canadian Institutes of Health Research Group in Skeletal Development and Remodeling, Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada
    Matrix Biol 28:354-64. 2009
  7. doi request reprint Specification of chondrocytes and cartilage tissues from embryonic stem cells
    April M Craft
    McEwen Centre for Regenerative Medicine, University Health Network, Toronto, ON, M5G 1L7, Canada
    Development 140:2597-610. 2013
  8. pmc The induction of CCN2 by TGFbeta1 involves Ets-1
    Jonathan P van Beek
    CIHR Group in Skeletal Development and Remodeling, Schulich School of Medicine and Dentistry, Dental Sciences Building, The University of Western Ontario, London, ON N6A 5C1, Canada
    Arthritis Res Ther 8:R36. 2006

Collaborators

Detail Information

Publications8

  1. pmc P2X7 receptors on osteoblasts couple to production of lysophosphatidic acid: a signaling axis promoting osteogenesis
    Nattapon Panupinthu
    Canadian Institutes of Health Research Group in Skeletal Development and Remodeling, London, ON, Canada
    J Cell Biol 181:859-71. 2008
    ..We conclude that P2X7 receptors enhance osteoblast function through a cell-autonomous mechanism. Furthermore, a novel signaling axis links P2X7 receptors to production of LPA and COX metabolites, which in turn stimulate osteogenesis...
  2. doi request reprint P2X₇-mediated calcium influx triggers a sustained, PI3K-dependent increase in metabolic acid production by osteoblast-like cells
    Matthew W Grol
    Dept of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, Univ of Western Ontario, London, ON, Canada
    Am J Physiol Endocrinol Metab 302:E561-75. 2012
    ..This increase in proton efflux is sustained and dependent on glucose and phosphatidylinositol 3-kinase activity...
  3. pmc Activation of transcription factors by extracellular nucleotides in immune and related cell types
    Souzan Armstrong
    CIHR Group in Skeletal Development and Remodeling, Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON, Canada, N6A 5C1
    Purinergic Signal 3:59-69. 2007
    ..Furthermore, we propose areas for future work in this new and expanding field...
  4. pmc Regulation of Sox9 activity by crosstalk with nuclear factor-kappaB and retinoic acid receptors
    Jason S Rockel
    Canadian Institutes of Health Research Group in Skeletal Development and Remodeling, Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Canada
    Arthritis Res Ther 10:R3. 2008
    ..Separately, both TNF-alpha and atRA suppress cartilage matrix gene expression. We investigated how TNF-alpha and atRA alter the expression of cartilage matrix genes...
  5. pmc Egr-1 inhibits the expression of extracellular matrix genes in chondrocytes by TNFalpha-induced MEK/ERK signalling
    Jason S Rockel
    Canadian Institutes of Health Research Group in Skeletal Development and Remodeling, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario N6A5C1, Canada
    Arthritis Res Ther 11:R8. 2009
    ..TNFalpha activates mitogen-activated kinase kinase (MEK)/extracellular regulated kinase (ERK) in chondrocytes; however, the overall functional relevance of MEK/ERK to TNFalpha-regulated gene expression in chondrocytes is unknown...
  6. doi request reprint Cyclic AMP regulates extracellular matrix gene expression and metabolism in cultured primary rat chondrocytes
    Jason S Rockel
    Canadian Institutes of Health Research Group in Skeletal Development and Remodeling, Department of Anatomy and Cell Biology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada
    Matrix Biol 28:354-64. 2009
    ..Collectively, these results suggest that agents that elevate cAMP signaling may impair chondrocyte function in conditions such as arthritis...
  7. doi request reprint Specification of chondrocytes and cartilage tissues from embryonic stem cells
    April M Craft
    McEwen Centre for Regenerative Medicine, University Health Network, Toronto, ON, M5G 1L7, Canada
    Development 140:2597-610. 2013
    ....
  8. pmc The induction of CCN2 by TGFbeta1 involves Ets-1
    Jonathan P van Beek
    CIHR Group in Skeletal Development and Remodeling, Schulich School of Medicine and Dentistry, Dental Sciences Building, The University of Western Ontario, London, ON N6A 5C1, Canada
    Arthritis Res Ther 8:R36. 2006
    ..Antagonizing Ets-1 might be of benefit in attenuating CCN2 expression in fibrosis, arthritis and cancer, and may be useful in modulating the outcome of these disorders...