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Genomes and Genes | Robert RobertsSummaryAffiliation: University of Ottawa Heart Institute Country: Canada Publications
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Publications
Identifying genes for coronary artery disease: An idea whose time has comeRobert Roberts
University of Ottawa Heart Institute, Ontario
Can J Cardiol 23:7A-15A. 2007..To detect a minor allele frequency of 5% or greater with an odds ratio for risk of 1.3 or greater and 90% power, an estimated 14,000 (9000 affected and 5000 control) subjects are required...
Genes and coronary artery disease: where are we?Robert Roberts
John and Jennifer Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada Electronic address
J Am Coll Cardiol 60:1715-21. 2012..While risk variants are less potent predictors of CAD, compared with biomarkers, they have the advantage of not changing in one's lifetime and are unaffected by diet, sex, age, or medication...- Genetics of coronary artery disease in the 21st centuryRobert Roberts
John and Jennifer Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, Canada
Clin Cardiol 35:536-40. 2012..We are on the cusp of genetic screening, and new therapeutic targets are becoming available to manage both genetic and environmental risk factors for CAD... - The genetics of coronary artery diseaseRobert Roberts
University of Ottawa Heart Institute, Ottawa, Ontario, Canada
Curr Opin Cardiol 27:221-7. 2012..However, genetic risk, estimated to account for 40-60% of susceptibility to CAD, has until recently been unknown. Comprehensive prevention will require knowledge of both... - 9p21 and the genetic revolution for coronary artery diseaseRobert Roberts
Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
Clin Chem 58:104-12. 2012..It has long been recognized that 50% of the susceptibility for coronary artery disease (CAD) is due to predisposing genetic factors. Comprehensive prevention is likely to require knowledge of these genetic factors... - Genetic testing for early detection of individuals at risk of coronary heart disease and monitoring response to therapy: challenges and promisesH Robert Superko
Celera Corporation, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
Curr Atheroscler Rep 13:396-404. 2011..Additionally, genetic markers are fixed and need only be measured once in a patient's lifetime, can help guide therapy selection, and may be of utility in family counseling... - The genome-wide association study--a new era for common polygenic disordersRobert Roberts
The Ruddy Canadian Cardiovascular Genetics Centre, Ottawa, Ontario, Canada
J Cardiovasc Transl Res 3:173-82. 2010..This will require a new approach involving several disciplines, namely, bioinformatics, high-throughput cell expression, and animal models... - Personalized medicine: a reality within this decadeRobert Roberts
University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada
J Cardiovasc Transl Res 1:11-6. 2008..Thus, 9p21 is likely to provide the impetus and nidus for a major research effort over the next few years. It has the potential to not only provide for early genetic screening but also as a target for novel therapy... 
Genomics and cardiac arrhythmiasRobert Roberts
University of Ottawa Heart Institute, Ottawa, Ontario, Canada
J Am Coll Cardiol 47:9-21. 2006..The role of single nucleotide polymorphisms in predisposing to arrhythmias in acquired disorders such as hypertrophy is discussed...- Mechanisms of disease: Genetic mechanisms of atrial fibrillationRobert Roberts
University of Ottawa Heart Institute, ON, Canada
Nat Clin Pract Cardiovasc Med 3:276-82. 2006..In this review I provide an overview of the understanding of the relevant genetic mutations that have been identified so far, and briefly discuss what implications this information might have for practice... - Personalized genomic medicine: a future prerequisite for the prevention of coronary artery diseaseRobert Roberts
Division of Cardiology, Univeristy of Ottawa Heart Institute, Ottawa, Ontario, Canada
Am Heart Hosp J 4:222-7. 2006..Multislice CT will provide the high-throughput coronary arteriograms required for this research and for prevention in asymptomatic individuals with a family history of heart disease... - A customized genetic approach to the number one killer: coronary artery diseaseRobert Roberts
Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
Curr Opin Cardiol 23:629-33. 2008..Secondly, to elucidate the barriers precluding the identification of genes responsible for CAD. Thirdly, to indicate the new technology now available to overcome these barriers and summarize current progress... - Genetics of premature myocardial infarctionRobert Roberts
University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario, K1Y 4W7, Canada
Curr Atheroscler Rep 10:186-93. 2008..Identifying the 9p21 gene will elucidate novel mechanisms responsible for MI. Comprehensive prevention of MI based on individual genetic variants (personalized medicine) is expected in the next decade... - Will stem cells face the same premature demise as gene therapy?Robert Roberts
Universtiy of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario, Canada K1Y 4W7
Am Heart Hosp J 2:107-8. 2004 - Recent success in the discovery of coronary artery disease genesRobert Roberts
University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON K1Y 4W7, Canada
Can J Physiol Pharmacol 89:609-15. 2011..The most exciting and novel findings are that these loci do not act through known risk factors for CAD and that the loci are more likely to be in DNA regions that regulate transcription rather than being in coding regions for protein... - Improved prediction of cardiovascular disease based on a panel of single nucleotide polymorphisms identified through genome-wide association studiesRobert W Davies
Cardiovascular Research Methods Centre, University of Ottawa Heart Institute, Ontario, Canada
Circ Cardiovasc Genet 3:468-74. 2010..In this study, we sought to determine and compare the predictive capabilities of 9p21.3 alone and a panel of SNPs identified and replicated through GWAS for CAD... - A common allele on chromosome 9 associated with coronary heart diseaseRuth McPherson
Division of Cardiology, University of Ottawa Heart Institute, Ottawa K1Y4W7, Canada
Science 316:1488-91. 2007..Homozygotes for the risk allele make up 20 to 25% of Caucasians and have a approximately 30 to 40% increased risk of CHD... - Gene dosage of the common variant 9p21 predicts severity of coronary artery diseaseSonny Dandona
John and Jennifer Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario, Canada
J Am Coll Cardiol 56:479-86. 2010..The purpose of this study was to test the hypothesis that 9p21 gene dosage determines the severity of coronary artery disease (CAD)... - Functional analysis of the chromosome 9p21.3 coronary artery disease risk locusOlga Jarinova
University of Ottawa Heart Institute, Ottawa, Canada
Arterioscler Thromb Vasc Biol 29:1671-7. 2009..We have investigated the functional significance of conserved sequences within the 9p21.3 risk locus for coronary artery disease (CAD) and determined the relationship of 9p21.3 to expression of ANRIL and to whole genome gene expression... - The transcription factor GATA-2 does not associate with angiographic coronary artery disease in the Ottawa Heart Genomics and Cleveland Clinic GeneBank StudiesSonny Dandona
The John and Jennifer Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, Canada
Hum Genet 127:101-5. 2010..Neither of the genotyped SNPs associates with CAD in the OHGS1 or CC/OHGS2 populations. Our data suggest that GATA2 does not contribute to the development of angiographic CAD among sporadic cases... - A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complexRobert W Davies
Cardiovascular Research Methods Center, John and Jennifer Ruddy Canadian Cardiovascular Research Center, University of Ottawa Heart Institute, Ottawa, ON, Canada
Circ Cardiovasc Genet 5:217-25. 2012..However, known common CAD risk variants explain only 10% of the predicted genetic heritability of the disease, suggesting that important genetic signals remain to be discovered... - Genomics in coronary artery disease: past, present and futureSonny Dandona
The Ruddy Canadian Cardiovascular Genetics Centre, Ottawa, Ontario, Canada
Can J Cardiol 26:56A-59A. 2010.... - Genome-wide association studies of hypertension: have they been fruitful?Sajjad Rafiq
Department of Medicine and Clinical Epidemiology, McMaster University, Hamilton, Ontario, Canada
J Cardiovasc Transl Res 3:189-96. 2010..We will review these findings, and place these results in the context of the future potential of pharmocogenetics of hypertension... - Creating a genetic risk score for coronary artery diseaseSonny Dandona
University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario K1Y4W7, Canada
Curr Atheroscler Rep 11:175-81. 2009..3, has been confirmed, and other loci are awaiting replication studies. The relative importance of each locus from a global standpoint and the incremental information conferred by testing for genetic variants remain to be determined... - Interferon-γ Activates Expression of p15 and p16 Regardless of 9p21.3 Coronary Artery Disease Risk GenotypeNaif A M Almontashiri
Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada John and Jennifer Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada Center of Genetics and Inherited Diseases, Faculty of Applied Medical Sciences, Taibah University, Almadinah, Saudi Arabia
J Am Coll Cardiol 61:143-7. 2013..Because post-transcriptional mechanisms modulate levels of p16 (encoded by CDKN2A) and p15 (encoded by CDKN2B), we tested whether interferon-γ regulates the expression of these proteins and the effect of the 9p21 genotype... - Disruption at the PTCHD1 Locus on Xp22.11 in Autism spectrum disorder and intellectual disabilityAbdul Noor
Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
Sci Transl Med 2:49ra68. 2010..Thus, our systematic screen of PTCHD1 and its 5' flanking regions suggests that this locus is involved in ~1% of individuals with ASD and intellectual disability... - Genomic view of factors leading to plaque instabilitySonny Dandona
University of Ottawa Heart Institute, Ontario, Canada
Curr Cardiol Rep 11:282-7. 2009..As imaging modalities are refined and our ability to recruit large numbers of appropriate patients is facilitated by the formation of alliances, our ability to probe this conundrum via a genome-wide approach will improve... - PRKAG2 cardiac syndrome: familial ventricular preexcitation, conduction system disease, and cardiac hypertrophyMichael H Gollob
Division of Cardiology, University of Western Ontario, London Health Sciences Center, Ontario, Canada
Curr Opin Cardiol 17:229-34. 2002..The role of AMP-activated protein kinase in the regulation of the glucose metabolic pathway in muscle suggests that genetic defects in PRKAG2 may induce a previously undescribed cardiac glycogenosis syndrome... - Canadian-led capacity-building in biostatistics and methodology in cardiovascular and diabetes trials: the CANNeCTIN Biostatistics and Methodological Innovation Working GroupLehana Thabane
Department of Clinical Epidemiology and Biostatistics, McMaster University, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5, Canada
Trials 12:48. 2011..The ultimate goal is to enhance global health by contributing to efforts to reduce the burden of CVD and DM... - Myozenin 2 is a novel gene for human hypertrophic cardiomyopathyAdriana Osio
Center for Cardiovascular Genetic Research, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston, TX 77030, USA
Circ Res 100:766-8. 2007..It was absent in 2 normal family members and 517 controls. Both mutations affect highly conserved amino acids. We conclude MYOZ2 is a novel causal gene for human HCM... - Molecular cardiology and genetics in the 21st century--a primerRobert Roberts
Curr Probl Cardiol 31:637-701. 2006..Identification of genes responsible for coronary artery disease made possible by genome-wide single nucleotide polymorphism (SNP) mapping techniques paves the way for personalized medicine... - Genetics and arrhythmiasRobert Roberts
Baylor College of Medicine, 6550 Fannin, Houston, Texas 77027, USA
Annu Rev Med 54:257-67. 2003..Treatments based on knowledge of the molecular defect are being implemented for long QT syndrome and will probably provide paradigms for targeted treatment of acquired arrhythmias... - American College of Endocrinology position statement on inpatient diabetes and metabolic controlAlan J Garber
Endocr Pract 10:4-9. 2004 - American College of Endocrinology position statement on inpatient diabetes and metabolic controlAlan J Garber
Endocr Pract 10:77-82. 2004 - Aldosterone, through novel signaling proteins, is a fundamental molecular bridge between the genetic defect and the cardiac phenotype of hypertrophic cardiomyopathyNatalia Tsybouleva
Section of Cardiology, Department of Medicine, Baylor College of Medicine and The Methodist Hospital, Houston, Tex 77030, USA
Circulation 109:1284-91. 2004..The genetic basis of HCM is largely known; however, the molecular mediators of cardiac phenotypes are unknown... - Tissue Doppler imaging predicts the development of hypertrophic cardiomyopathy in subjects with subclinical diseaseSherif F Nagueh
Department of Medicine, Section of Cardiology, Baylor College of Medicine, Houston, Tex, USA
Circulation 108:395-8. 2003..By studying these subjects at a later date, we sought to determine whether TDI predicts the subsequent evolution of the HCM phenotype... - A statement on ethics from the HEART GroupHugo Ector
J Thorac Cardiovasc Surg 135:976-8. 2008 - Report of the American Heart Association Task Force on Strategic Research Direction: executive summaryRobert Roberts
Circulation 106:2630-2. 2002 - Determinants of cardiac electrophysiological properties in miceGregory O Appleton
Section of Cardiology, Department of Medicine, and The DeBakey Heart Center, Baylor College of Medicine, Houston, Texas 77030, USA
J Interv Card Electrophysiol 11:5-14. 2004..The influence of these factors should be considered when characterizing the electrical phenotype of transgenic mice in cardiovascular research... - Cardiac biomarkers for detection of myocardial infarction: perspectives from past to presentSidney B Rosalki
10 Wimpole News, London, United Kingdom
Clin Chem 50:2205-13. 2004.... - Alcohol use among American Indian high school youths from adolescence and young adulthood: a latent Markov modelChristina M Mitchell
American Indian and Alaska Native Programs, University of Colorado Denver, F800, P O Box 6508, Aurora, Colorado 80045 0508, USA
J Stud Alcohol Drugs 69:666-75. 2008..We explored patterns of alcohol use among American Indian youths as well as concurrent predictors and developmental outcomes 6 years later... - Genome-wide mapping of modifier chromosomal loci for human hypertrophic cardiomyopathyE Warwick Daw
Department of Epidemiology, MD Anderson Cancer Center, Houston, TX 77030, USA
Hum Mol Genet 16:2463-71. 2007.... - Positron molecular imaging, an in vivo glimpse of the genomeRob Beanlands
J Mol Cell Cardiol 43:11-4. 2007 - Statin therapy in acute coronary syndromeVincent E Friedewald
University of Texas Health Sciences Center at Houston, Houston, Texas, USA
Am J Cardiol 99:213-21. 2007 - Another chromosomal locus for mitral valve prolapse: close but no cigarRobert Roberts
Circulation 112:1924-6. 2005 - Current concepts of the pathogenesis and treatment of hypertrophic cardiomyopathyRobert Roberts
Baylor College of Medicine, Houston, Tex, USA
Circulation 112:293-6. 2005 - Genetic basis for hypertrophic cardiomyopathy: implications for diagnosis and treatmentRobert Roberts
Department of Medicine, Section of Cardiology, Baylor College of Medicine, Houston, TX 77030, USA
Am Heart Hosp J 1:128-34. 2003..Clinical trials are ongoing in human familial hypertrophic cardiomyopathy... - Transgenic mouse model of ventricular preexcitation and atrioventricular reentrant tachycardia induced by an AMP-activated protein kinase loss-of-function mutation responsible for Wolff-Parkinson-White syndromeJasvinder S Sidhu
Baylor College of Medicine, Houston, Tex, USA
Circulation 111:21-9. 2005..The human phenotype consists of ventricular preexcitation, conduction abnormalities, and cardiac hypertrophy... - [Molecular genetics of cardiomyopathies]Robert Roberts
Sección de Cardiología, Baylor College of Medicine, Houston, Texas, USA
Rev Esp Cardiol 55:292-302. 2002..Altogether the study of the molecular genetics of the cardiomyopathies should provide not only prognostic information but also new therapeutic alternatives...