Robert Roberts

Summary

Affiliation: University of Ottawa Heart Institute
Country: Canada

Publications

  1. ncbi request reprint Genomics and cardiac arrhythmias
    Robert Roberts
    University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Am Coll Cardiol 47:9-21. 2006
  2. pmc Identifying genes for coronary artery disease: An idea whose time has come
    Robert Roberts
    University of Ottawa Heart Institute, Ontario
    Can J Cardiol 23:7A-15A. 2007
  3. ncbi request reprint Genetics of coronary artery disease
    Robert Roberts
    From the Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Circ Res 114:1890-903. 2014
  4. pmc Assessment of the 9p21.3 locus in severity of coronary artery disease in the presence and absence of type 2 diabetes
    Natalia V Rivera
    IRCCS Multimedica, via Fantoli 16 15, 20138, Milan, Italy
    BMC Med Genet 14:11. 2013
  5. pmc Genomics in cardiovascular disease
    Robert Roberts
    University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Am Coll Cardiol 61:2029-37. 2013
  6. doi request reprint Genes and coronary artery disease: where are we?
    Robert Roberts
    John and Jennifer Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Am Coll Cardiol 60:1715-21. 2012
  7. ncbi request reprint Genetics of coronary artery disease in the 21st century
    Robert Roberts
    John and Jennifer Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, Canada
    Clin Cardiol 35:536-40. 2012
  8. ncbi request reprint The genetics of coronary artery disease
    Robert Roberts
    University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Curr Opin Cardiol 27:221-7. 2012
  9. doi request reprint 9p21 and the genetic revolution for coronary artery disease
    Robert Roberts
    Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Clin Chem 58:104-12. 2012
  10. pmc Genetic testing for early detection of individuals at risk of coronary heart disease and monitoring response to therapy: challenges and promises
    H Robert Superko
    Celera Corporation, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
    Curr Atheroscler Rep 13:396-404. 2011

Detail Information

Publications55

  1. ncbi request reprint Genomics and cardiac arrhythmias
    Robert Roberts
    University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Am Coll Cardiol 47:9-21. 2006
    ..The role of single nucleotide polymorphisms in predisposing to arrhythmias in acquired disorders such as hypertrophy is discussed...
  2. pmc Identifying genes for coronary artery disease: An idea whose time has come
    Robert Roberts
    University of Ottawa Heart Institute, Ontario
    Can J Cardiol 23:7A-15A. 2007
    ..To detect a minor allele frequency of 5% or greater with an odds ratio for risk of 1.3 or greater and 90% power, an estimated 14,000 (9000 affected and 5000 control) subjects are required...
  3. ncbi request reprint Genetics of coronary artery disease
    Robert Roberts
    From the Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Circ Res 114:1890-903. 2014
    ..This therapy complements that of statin therapy, which inhibits the synthesis of cholesterol. The benefits of Mendelian randomization to assess safety and efficacy and their limitations are discussed along with future directions. ..
  4. pmc Assessment of the 9p21.3 locus in severity of coronary artery disease in the presence and absence of type 2 diabetes
    Natalia V Rivera
    IRCCS Multimedica, via Fantoli 16 15, 20138, Milan, Italy
    BMC Med Genet 14:11. 2013
    ..We investigated the association of 9p21.3 variants with severity of CAD (defined by the number of vessel diseased [VD]) in the presence and absence of T2D...
  5. pmc Genomics in cardiovascular disease
    Robert Roberts
    University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Am Coll Cardiol 61:2029-37. 2013
    ..The physician and health user will be challenged by the convergence of 2 major trends, whole genome sequencing, and the storage/retrieval and integration of the data...
  6. doi request reprint Genes and coronary artery disease: where are we?
    Robert Roberts
    John and Jennifer Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    J Am Coll Cardiol 60:1715-21. 2012
    ..While risk variants are less potent predictors of CAD, compared with biomarkers, they have the advantage of not changing in one's lifetime and are unaffected by diet, sex, age, or medication...
  7. ncbi request reprint Genetics of coronary artery disease in the 21st century
    Robert Roberts
    John and Jennifer Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, Canada
    Clin Cardiol 35:536-40. 2012
    ..We are on the cusp of genetic screening, and new therapeutic targets are becoming available to manage both genetic and environmental risk factors for CAD...
  8. ncbi request reprint The genetics of coronary artery disease
    Robert Roberts
    University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Curr Opin Cardiol 27:221-7. 2012
    ..However, genetic risk, estimated to account for 40-60% of susceptibility to CAD, has until recently been unknown. Comprehensive prevention will require knowledge of both...
  9. doi request reprint 9p21 and the genetic revolution for coronary artery disease
    Robert Roberts
    Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Clin Chem 58:104-12. 2012
    ..It has long been recognized that 50% of the susceptibility for coronary artery disease (CAD) is due to predisposing genetic factors. Comprehensive prevention is likely to require knowledge of these genetic factors...
  10. pmc Genetic testing for early detection of individuals at risk of coronary heart disease and monitoring response to therapy: challenges and promises
    H Robert Superko
    Celera Corporation, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
    Curr Atheroscler Rep 13:396-404. 2011
    ..Additionally, genetic markers are fixed and need only be measured once in a patient's lifetime, can help guide therapy selection, and may be of utility in family counseling...
  11. ncbi request reprint Mechanisms of disease: Genetic mechanisms of atrial fibrillation
    Robert Roberts
    University of Ottawa Heart Institute, ON, Canada
    Nat Clin Pract Cardiovasc Med 3:276-82. 2006
    ..In this review I provide an overview of the understanding of the relevant genetic mutations that have been identified so far, and briefly discuss what implications this information might have for practice...
  12. doi request reprint Personalized medicine: a reality within this decade
    Robert Roberts
    University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON, K1Y 4W7, Canada
    J Cardiovasc Transl Res 1:11-6. 2008
    ..Thus, 9p21 is likely to provide the impetus and nidus for a major research effort over the next few years. It has the potential to not only provide for early genetic screening but also as a target for novel therapy...
  13. ncbi request reprint Personalized genomic medicine: a future prerequisite for the prevention of coronary artery disease
    Robert Roberts
    Division of Cardiology, Univeristy of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Am Heart Hosp J 4:222-7. 2006
    ..Multislice CT will provide the high-throughput coronary arteriograms required for this research and for prevention in asymptomatic individuals with a family history of heart disease...
  14. doi request reprint A customized genetic approach to the number one killer: coronary artery disease
    Robert Roberts
    Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Curr Opin Cardiol 23:629-33. 2008
    ..Secondly, to elucidate the barriers precluding the identification of genes responsible for CAD. Thirdly, to indicate the new technology now available to overcome these barriers and summarize current progress...
  15. ncbi request reprint Recent success in the discovery of coronary artery disease genes
    Robert Roberts
    University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, ON K1Y 4W7, Canada
    Can J Physiol Pharmacol 89:609-15. 2011
    ..The most exciting and novel findings are that these loci do not act through known risk factors for CAD and that the loci are more likely to be in DNA regions that regulate transcription rather than being in coding regions for protein...
  16. ncbi request reprint Will stem cells face the same premature demise as gene therapy?
    Robert Roberts
    Universtiy of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario, Canada K1Y 4W7
    Am Heart Hosp J 2:107-8. 2004
  17. ncbi request reprint Genetics of premature myocardial infarction
    Robert Roberts
    University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario, K1Y 4W7, Canada
    Curr Atheroscler Rep 10:186-93. 2008
    ..Identifying the 9p21 gene will elucidate novel mechanisms responsible for MI. Comprehensive prevention of MI based on individual genetic variants (personalized medicine) is expected in the next decade...
  18. ncbi request reprint The genome-wide association study--a new era for common polygenic disorders
    Robert Roberts
    The Ruddy Canadian Cardiovascular Genetics Centre, Ottawa, Ontario, Canada
    J Cardiovasc Transl Res 3:173-82. 2010
    ..This will require a new approach involving several disciplines, namely, bioinformatics, high-throughput cell expression, and animal models...
  19. pmc Two chromosome 9p21 haplotype blocks distinguish between coronary artery disease and myocardial infarction risk
    Meng Fan
    John and Jennifer Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada
    Circ Cardiovasc Genet 6:372-80. 2013
    ..We performed haplotype analysis at the 9p21 locus to test whether haplotypes at distinct linkage disequilibrium blocks predict these phenotypes...
  20. pmc Improved prediction of cardiovascular disease based on a panel of single nucleotide polymorphisms identified through genome-wide association studies
    Robert W Davies
    Cardiovascular Research Methods Centre, University of Ottawa Heart Institute, Ontario, Canada
    Circ Cardiovasc Genet 3:468-74. 2010
    ..In this study, we sought to determine and compare the predictive capabilities of 9p21.3 alone and a panel of SNPs identified and replicated through GWAS for CAD...
  21. pmc A common allele on chromosome 9 associated with coronary heart disease
    Ruth McPherson
    Division of Cardiology, University of Ottawa Heart Institute, Ottawa K1Y4W7, Canada
    Science 316:1488-91. 2007
    ..Homozygotes for the risk allele make up 20 to 25% of Caucasians and have a approximately 30 to 40% increased risk of CHD...
  22. ncbi request reprint Gene dosage of the common variant 9p21 predicts severity of coronary artery disease
    Sonny Dandona
    John and Jennifer Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario, Canada
    J Am Coll Cardiol 56:479-86. 2010
    ..The purpose of this study was to test the hypothesis that 9p21 gene dosage determines the severity of coronary artery disease (CAD)...
  23. doi request reprint Functional analysis of the chromosome 9p21.3 coronary artery disease risk locus
    Olga Jarinova
    University of Ottawa Heart Institute, Ottawa, Canada
    Arterioscler Thromb Vasc Biol 29:1671-7. 2009
    ..We have investigated the functional significance of conserved sequences within the 9p21.3 risk locus for coronary artery disease (CAD) and determined the relationship of 9p21.3 to expression of ANRIL and to whole genome gene expression...
  24. doi request reprint Interferon-γ activates expression of p15 and p16 regardless of 9p21.3 coronary artery disease risk genotype
    Naif A M Almontashiri
    Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, Ontario, Canada
    J Am Coll Cardiol 61:143-7. 2013
    ..Because post-transcriptional mechanisms modulate levels of p16 (encoded by CDKN2A) and p15 (encoded by CDKN2B), we tested whether interferon-γ regulates the expression of these proteins and the effect of the 9p21 genotype...
  25. pmc The transcription factor GATA-2 does not associate with angiographic coronary artery disease in the Ottawa Heart Genomics and Cleveland Clinic GeneBank Studies
    Sonny Dandona
    The John and Jennifer Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, Canada
    Hum Genet 127:101-5. 2010
    ..Neither of the genotyped SNPs associates with CAD in the OHGS1 or CC/OHGS2 populations. Our data suggest that GATA2 does not contribute to the development of angiographic CAD among sporadic cases...
  26. pmc Comparative genome-wide association studies in mice and humans for trimethylamine N-oxide, a proatherogenic metabolite of choline and L-carnitine
    Jaana Hartiala
    From the Department of Preventive Medicine J H, H A and Institute for Genetic Medicine J H, H A, Keck School of Medicine of the University of Southern California, Los Angeles Department of Genetics B J B and Nutrition Research Institute B J B, University of North Carolina, Chapel Hill, Kannapolis Departments of Cardiovascular Medicine W H W T, Z W, S L H and Cellular and Molecular Medicine W H W T, Z W, S L H and Center for Cardiovascular Diagnostics and Prevention W H W T, Z W, S L H, Cleveland Clinic, OH John and Jennifer Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, Ontario, Canada A F R S, R R, R M and Departments of Medicine A J L, Human Genetics A J L, and Microbiology, Immunology, and Molecular Genetics A J L, David Geffen School of Medicine of UCLA
    Arterioscler Thromb Vasc Biol 34:1307-13. 2014
    ..The goal of this study was to identify the genetic factors associated with plasma TMAO levels...
  27. pmc A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex
    Robert W Davies
    Cardiovascular Research Methods Center, John and Jennifer Ruddy Canadian Cardiovascular Research Center, University of Ottawa Heart Institute, Ottawa, ON, Canada
    Circ Cardiovasc Genet 5:217-25. 2012
    ..However, known common CAD risk variants explain only 10% of the predicted genetic heritability of the disease, suggesting that important genetic signals remain to be discovered...
  28. ncbi request reprint Genome-wide association studies of hypertension: have they been fruitful?
    Sajjad Rafiq
    Department of Medicine and Clinical Epidemiology, McMaster University, Hamilton, Ontario, Canada
    J Cardiovasc Transl Res 3:189-96. 2010
    ..We will review these findings, and place these results in the context of the future potential of pharmocogenetics of hypertension...
  29. ncbi request reprint Genomics in coronary artery disease: past, present and future
    Sonny Dandona
    The Ruddy Canadian Cardiovascular Genetics Centre, Ottawa, Ontario, Canada
    Can J Cardiol 26:56A-59A. 2010
    ....
  30. ncbi request reprint Creating a genetic risk score for coronary artery disease
    Sonny Dandona
    University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario K1Y4W7, Canada
    Curr Atheroscler Rep 11:175-81. 2009
    ..3, has been confirmed, and other loci are awaiting replication studies. The relative importance of each locus from a global standpoint and the incremental information conferred by testing for genetic variants remain to be determined...
  31. pmc Disruption at the PTCHD1 Locus on Xp22.11 in Autism spectrum disorder and intellectual disability
    Abdul Noor
    Neurogenetics Section, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Sci Transl Med 2:49ra68. 2010
    ..Thus, our systematic screen of PTCHD1 and its 5' flanking regions suggests that this locus is involved in ~1% of individuals with ASD and intellectual disability...
  32. ncbi request reprint Genomic view of factors leading to plaque instability
    Sonny Dandona
    University of Ottawa Heart Institute, Ontario, Canada
    Curr Cardiol Rep 11:282-7. 2009
    ..As imaging modalities are refined and our ability to recruit large numbers of appropriate patients is facilitated by the formation of alliances, our ability to probe this conundrum via a genome-wide approach will improve...
  33. ncbi request reprint SPG7 variant escapes phosphorylation-regulated processing by AFG3L2, elevates mitochondrial ROS, and is associated with multiple clinical phenotypes
    Naif A M Almontashiri
    Ruddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ottawa, ON K1Y, Canada Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8M5, Canada Center for Genetics and Inherited Diseases, Department of Applied Medical Sciences, Taibah University, Almedinah, P O Box 41477, Saudi Arabia
    Cell Rep 7:834-47. 2014
    ..Our results thus reveal an unexpected link between the phosphorylation-dependent regulation of the mitochondria mAAA protease affecting ROS production and several clinical phenotypes. ..
  34. ncbi request reprint PRKAG2 cardiac syndrome: familial ventricular preexcitation, conduction system disease, and cardiac hypertrophy
    Michael H Gollob
    Division of Cardiology, University of Western Ontario, London Health Sciences Center, Ontario, Canada
    Curr Opin Cardiol 17:229-34. 2002
    ..The role of AMP-activated protein kinase in the regulation of the glucose metabolic pathway in muscle suggests that genetic defects in PRKAG2 may induce a previously undescribed cardiac glycogenosis syndrome...
  35. pmc Canadian-led capacity-building in biostatistics and methodology in cardiovascular and diabetes trials: the CANNeCTIN Biostatistics and Methodological Innovation Working Group
    Lehana Thabane
    Department of Clinical Epidemiology and Biostatistics, McMaster University, 1200 Main Street West, Hamilton, Ontario, L8N 3Z5, Canada
    Trials 12:48. 2011
    ..The ultimate goal is to enhance global health by contributing to efforts to reduce the burden of CVD and DM...
  36. pmc Myozenin 2 is a novel gene for human hypertrophic cardiomyopathy
    Adriana Osio
    Center for Cardiovascular Genetic Research, The Brown Foundation Institute of Molecular Medicine, University of Texas Health Sciences Center, Houston, TX 77030, USA
    Circ Res 100:766-8. 2007
    ..It was absent in 2 normal family members and 517 controls. Both mutations affect highly conserved amino acids. We conclude MYOZ2 is a novel causal gene for human HCM...
  37. ncbi request reprint Molecular cardiology and genetics in the 21st century--a primer
    Robert Roberts
    Curr Probl Cardiol 31:637-701. 2006
    ..Identification of genes responsible for coronary artery disease made possible by genome-wide single nucleotide polymorphism (SNP) mapping techniques paves the way for personalized medicine...
  38. ncbi request reprint Genetics and arrhythmias
    Robert Roberts
    Baylor College of Medicine, 6550 Fannin, Houston, Texas 77027, USA
    Annu Rev Med 54:257-67. 2003
    ..Treatments based on knowledge of the molecular defect are being implemented for long QT syndrome and will probably provide paradigms for targeted treatment of acquired arrhythmias...
  39. ncbi request reprint American College of Endocrinology position statement on inpatient diabetes and metabolic control
    Alan J Garber
    Endocr Pract 10:4-9. 2004
  40. pmc Aldosterone, through novel signaling proteins, is a fundamental molecular bridge between the genetic defect and the cardiac phenotype of hypertrophic cardiomyopathy
    Natalia Tsybouleva
    Section of Cardiology, Department of Medicine, Baylor College of Medicine and The Methodist Hospital, Houston, Tex 77030, USA
    Circulation 109:1284-91. 2004
    ..The genetic basis of HCM is largely known; however, the molecular mediators of cardiac phenotypes are unknown...
  41. ncbi request reprint American College of Endocrinology position statement on inpatient diabetes and metabolic control
    Alan J Garber
    Endocr Pract 10:77-82. 2004
  42. pmc Tissue Doppler imaging predicts the development of hypertrophic cardiomyopathy in subjects with subclinical disease
    Sherif F Nagueh
    Department of Medicine, Section of Cardiology, Baylor College of Medicine, Houston, Tex, USA
    Circulation 108:395-8. 2003
    ..By studying these subjects at a later date, we sought to determine whether TDI predicts the subsequent evolution of the HCM phenotype...
  43. ncbi request reprint Report of the American Heart Association Task Force on Strategic Research Direction: executive summary
    Robert Roberts
    Circulation 106:2630-2. 2002
  44. ncbi request reprint Determinants of cardiac electrophysiological properties in mice
    Gregory O Appleton
    Section of Cardiology, Department of Medicine, and The DeBakey Heart Center, Baylor College of Medicine, Houston, Texas 77030, USA
    J Interv Card Electrophysiol 11:5-14. 2004
    ..However, little is known regarding the impact of experimental conditions or model selection on the outcome of EP studies in mice...
  45. ncbi request reprint Cardiac biomarkers for detection of myocardial infarction: perspectives from past to present
    Sidney B Rosalki
    10 Wimpole News, London, United Kingdom
    Clin Chem 50:2205-13. 2004
    ....
  46. pmc Transgenic mouse model of ventricular preexcitation and atrioventricular reentrant tachycardia induced by an AMP-activated protein kinase loss-of-function mutation responsible for Wolff-Parkinson-White syndrome
    Jasvinder S Sidhu
    Baylor College of Medicine, Houston, Tex, USA
    Circulation 111:21-9. 2005
    ..The human phenotype consists of ventricular preexcitation, conduction abnormalities, and cardiac hypertrophy...
  47. pmc Genome-wide mapping of modifier chromosomal loci for human hypertrophic cardiomyopathy
    E Warwick Daw
    Department of Epidemiology, MD Anderson Cancer Center, Houston, TX 77030, USA
    Hum Mol Genet 16:2463-71. 2007
    ....
  48. pmc Alcohol use among American Indian high school youths from adolescence and young adulthood: a latent Markov model
    Christina M Mitchell
    American Indian and Alaska Native Programs, University of Colorado Denver, F800, P O Box 6508, Aurora, Colorado 80045 0508, USA
    J Stud Alcohol Drugs 69:666-75. 2008
    ..We explored patterns of alcohol use among American Indian youths as well as concurrent predictors and developmental outcomes 6 years later...
  49. ncbi request reprint Positron molecular imaging, an in vivo glimpse of the genome
    Rob Beanlands
    J Mol Cell Cardiol 43:11-4. 2007
  50. ncbi request reprint Statin therapy in acute coronary syndrome
    Vincent E Friedewald
    University of Texas Health Sciences Center at Houston, Houston, Texas, USA
    Am J Cardiol 99:213-21. 2007
  51. ncbi request reprint Another chromosomal locus for mitral valve prolapse: close but no cigar
    Robert Roberts
    Circulation 112:1924-6. 2005
  52. ncbi request reprint Current concepts of the pathogenesis and treatment of hypertrophic cardiomyopathy
    Robert Roberts
    Baylor College of Medicine, Houston, Tex, USA
    Circulation 112:293-6. 2005
  53. ncbi request reprint Genetic basis for hypertrophic cardiomyopathy: implications for diagnosis and treatment
    Robert Roberts
    Department of Medicine, Section of Cardiology, Baylor College of Medicine, Houston, TX 77030, USA
    Am Heart Hosp J 1:128-34. 2003
    ..Clinical trials are ongoing in human familial hypertrophic cardiomyopathy...
  54. ncbi request reprint [Molecular genetics of cardiomyopathies]
    Robert Roberts
    Sección de Cardiología, Baylor College of Medicine, Houston, Texas, USA
    Rev Esp Cardiol 55:292-302. 2002
    ..Altogether the study of the molecular genetics of the cardiomyopathies should provide not only prognostic information but also new therapeutic alternatives...