Research Topics
Genomes and Genes
| Joy RichmanSummaryAffiliation: University of British Columbia Location: Vancouver, Canada URL: http://www.dentistry.ubc.ca/research/researchers/Richman/ Summary: Professor, Pediatric Dentistry and Developmental Biology Publications
| Collaborators
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Detail Information
Publications
Reptilian tooth developmentJoy M Richman
Department of Oral Health Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC, Canada
Genesis 49:247-60. 2011..Finally, we review the location of label-retaining cells and suggest ways in which these putative dental epithelial stem cells contribute to continuous tooth replacement...- Expression and regulation of the decoy bone morphogenetic protein receptor BAMBI in the developing avian faceNorihisa Higashihori
Department of Oral Health Sciences, Life Sciences Institute, The University of British Columbia, Vancouver BC, Canada
Dev Dyn 237:1500-8. 2008..The data suggested that BAMBI could be used to regulate Bmp signaling during tissue interactions that are an integral part of facial morphogenesis... - Expression of the NET family member Zfp503 is regulated by hedgehog and BMP signaling in the limbEdwina McGlinn
Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia
Dev Dyn 237:1172-82. 2008..Finally, we demonstrate that posterior expression of Znf503 in the chick limb is responsive to bone morphogenetic protein (BMP) signaling, indicating that Zfp503/Znf503 may act at the nexus of multiple signaling pathways in development... 
Embryonic development of Python sebae - I: Staging criteria and macroscopic skeletal morphogenesis of the head and limbsJulia C Boughner
Department of Oral Health Sciences, Life Sciences Institute, University of British Columbia, Life Sciences Centre, 2350 Health Sciences Mall, Vancouver, BC, Canada V6T 1Z3
Zoology (Jena) 110:212-30. 2007..Thus, reptilian animal models will offer unique opportunities for understanding the early influences that contribute to perinatal bone shape...- Retinoid signaling determines germ cell fate in miceJosephine Bowles
Division of Genetics and Developmental Biology, Institute for Molecular Bioscience, University of Queensland, Brisbane, QLD 4072, Australia
Science 312:596-600. 2006..Thus, precise regulation of retinoid levels during fetal gonad development provides the molecular control mechanism that specifies germ cell fate... - Objective tests of symptom exaggeration in independent medical examinationsJack Richman
AssessMed, Toronto, Canada
J Occup Environ Med 48:303-11. 2006..This study used the Medical Symptom Validity Test (MSVT) to examine exaggeration of memory impairment in disability claimants... - Cell dissociation experiments reveal that positional information operates in the chicken frontonasal massMasayoshi Kawakami
Department of Oral and Maxillofacial Surgery, Nara Medical University, Japan
Genesis 44:105-14. 2006..Together, these data suggest that an important patterning mechanism in the face is the ability of mesenchymal cells to sort out according to position and that Msx2 may help repress chondrogenic potential in the lateral frontonasal mass... - Comparative ontogeny and phylogeny of the upper jaw skeleton in amniotesJoy M Richman
Cellular Mechanisms of Development Group and Department of Oral Health Sciences, Life Sciences Institute, University of British Columbia, Vancouver, B C, Canada
Dev Dyn 235:1230-43. 2006..Finally, we discuss how temporal and spatial regulation of preosseous condensations and ossification centers can lead to variation in the morphology of amniote upper jaw bones... - Control of retinoic acid synthesis and FGF expression in the nasal pit is required to pattern the craniofacial skeletonY Song
Department of Oral Health Sciences, Faculty of Dentistry, University of British Columbia, 2199 Wesbrook Mall, Vancouver, BC, Canada V6T 1Z3
Dev Biol 276:313-29. 2004..In addition, our data suggest a novel role for endogenous retinoids from the nasal pit in controlling the precise downregulation of FGF in the center of the frontonasal mass observed during normal vertebrate development... - FGF signals from the nasal pit are necessary for normal facial morphogenesisHeather L Szabo-Rogers
Department of Oral Health Sciences, Life Sciences Institute, The University of British Columbia, 2350 Health Sciences Mall, Vancouver BC, Canada
Dev Biol 318:289-302. 2008..Coordination of the proliferation in these regions leads ultimately to normal facial morphogenesis... - Initiation and patterning of the snake dentition are dependent on Sonic hedgehog signalingMarcela Buchtová
Department of Oral Health Sciences, University of British Columbia, Vancouver, BC, Canada
Dev Biol 319:132-45. 2008..In summary, we have found diverse roles for Shh in patterning the snake dentition but, have excluded the participation of this signal in replacement tooth formation... - Identification of putative dental epithelial stem cells in a lizard with life-long tooth replacementGregory R Handrigan
Department of Oral Health Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC V6T 1Z3, Canada
Development 137:3545-9. 2010..Furthermore, their location on the non-tooth-forming side of the dental lamina implies that dental stem cells are sequestered from signals that might otherwise induce them to differentiate... - A network of Wnt, hedgehog and BMP signaling pathways regulates tooth replacement in snakesGregory R Handrigan
Department of Oral Health Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC, Canada
Dev Biol 348:130-41. 2010.... - The function and regulation of TBX22 in avian frontonasal morphogenesisNorihisa Higashihori
Department of Oral Health Sciences, Life Sciences Institute, University of British Columbia, Vancouver, Canada
Dev Dyn 239:458-73. 2010..Our data suggest that genetic or environmental insults such as those affecting the BMP pathway could lead to a gain-of-function of TBX22 and predispose an individual to cleft lip... - Whole genome microarray analysis of chicken embryo facial prominencesMarcela Buchtová
Department of Oral Health Sciences, Life Sciences Institute, University of British Columbia, Vancouver, Canada
Dev Dyn 239:574-91. 2010..Microarrays trends were consistent with the QPCR data for the majority of genes (81%). On the basis of QPCR and microarray data, groups of genes that characterize each of the facial prominences can be determined... - The metalloendopeptidase gene Pitrm1 is regulated by hedgehog signaling in the developing mouse limb and is expressed in muscle progenitorsLiam Town
The University of Queensland, Institute for Molecular Bioscience, Queensland, Australia
Dev Dyn 238:3175-84. 2009..Additionally, Pitrm1 is expressed in Pax3-expressing myoblast progenitors in the limb, the dermomyotome, and developing muscles of the face and torso... - Autocrine and paracrine Shh signaling are necessary for tooth morphogenesis, but not tooth replacement in snakes and lizards (Squamata)Gregory R Handrigan
Department of Oral Health Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC, Canada
Dev Biol 337:171-86. 2010..Finally, in this study, we definitively refute a role for Shh signaling in successional dental lamina formation and conclude that other pathways regulate tooth replacement in squamates... - Expression of WNT signalling pathway genes during chicken craniofacial developmentPoongodi Geetha-Loganathan
Department of Oral Health Sciences, Life Sciences Institute, The University of British Columbia, Vancouver BC, Canada
Dev Dyn 238:1150-65. 2009..These data show that activation of the canonical WNT pathway is feasible in all regions of the face; however, the localization of ligands and antagonists confers specificity... - Novel skeletogenic patterning roles for the olfactory pitHeather L Szabo-Rogers
Department of Oral Health Sciences, Life Sciences Institute, The University of British Columbia, Vancouver BC, V6T 1Z3, Canada
Development 136:219-29. 2009..Thus, the nasal placode has two roles: as a signaling center for the lateral nasal skeleton and as a source of olfactory neurons and sensory epithelium... - Upper beak truncation in chicken embryos with the cleft primary palate mutation is due to an epithelial defect in the frontonasal massMary E MacDonald
Dalhousie University Medical School, Halifax, Nova Scotia, Canada
Dev Dyn 230:335-49. 2004..The cpp beak truncation, therefore, is due to an epithelial defect in the frontonasal mass that is coincident with a failure to down-regulate expression of Fgf8... - About face: signals and genes controlling jaw patterning and identity in vertebratesJoy M Richman
Department of Oral Health Sciences, University of British Columbia, 2199 Wesbrook Mall, Vancouver, BC, V6T 1Z3 Canada
Bioessays 25:554-68. 2003..We propose that signals such as retinoids and BMPs and downstream transcription factors such as Distal-less related genes specify jaw identity... - Head development. Craniofacial genetics makes headwayJ M Richman
Department of Clinical Dental Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, Canada
Curr Biol 5:345-8. 1995..Studies of neural crest migration in animal models, and of human syndromes in which craniofacial development is abnormal, are helping us to understand both prenatal and postnatal development of the head... - Epithelia are interchangeable between facial primordia of chick embryos and morphogenesis is controlled by the mesenchymeJ M Richman
Department of Anatomy and Developmental Biology, University College and Middlesex School of Medicine, London, England
Dev Biol 136:201-10. 1989..The form of the recombined graft is determined by the mesenchymal component... - Differential growth of facial primordia in chick embryos: responses of facial mesenchyme to basic fibroblast growth factor (bFGF) and serum in micromass cultureJ M Richman
Department of Anatomy and Developmental Biology, University College, Middlesex School of Medicine, London, UK
Development 109:341-8. 1990..abstract truncated at 250 words).. - A corneal perfusion device for estimating ocular bioavailability in vitroJ B Richman
Department of Pharmacokinetics, Allergan, Inc, Irvine, CA 92715
J Pharm Sci 79:153-7. 1990..The new model opens several potentially useful areas of research into ocular absorption.(ABSTRACT TRUNCATED AT 250 WORDS).. - Signals involved in patterning and morphogenesis of the embryonic faceJ M Richman
Dept of Anatomy and Developmental Biology, U C M S M, London, UK
Prog Clin Biol Res 373:117-31. 1991 - Retinoic acid treatment alters the distribution of retinoic acid receptor-beta transcripts in the embryonic chick faceA Rowe
Department of Biochemistry, University College and Middlesex School of Medicine, London, UK
Development 111:1007-16. 1991..In addition, they demonstrate that retinoic acid can induce changes in the pattern of expression of RAR-beta transcripts in vivo... - Epithelial-mesenchymal interactions in the outgrowth of limb buds and facial primordia in chick embryosJ M Richman
Department of Anatomy and Developmental Biology, University College, Middlesex School of Medicine, London, England
Dev Biol 154:299-308. 1992..The results suggest that signals employed in the epithelial-mesenchymal interactions in facial primordia are similar but not identical to those signals used in the limb bud... - The role of retinoids in normal and abnormal embryonic craniofacial morphogenesisJ M Richman
Department of Preventive Dental Science, University of Manitoba, Winnipeg, Canada
Crit Rev Oral Biol Med 4:93-109. 1992..Finally, the interaction of retinoids with other genes known to be expressed in the face as well as other factors required for facial growth is discussed... - Locally released retinoic acid leads to facial clefts in the chick embryo but does not alter the expression of receptors for fibroblast growth factorJ M Richman
Department of Clinical Dental Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, Canada
J Craniofac Genet Dev Biol 15:190-204. 1995..This data suggests that retinoic acid may be affecting other aspects of the FGF receptor-ligand interaction... - Craniofacial development: knockout mice take one on the chinJ Richman
Department of Clinical Dental Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, Canada
Curr Biol 6:364-7. 1996 - Chicken transcription factor AP-2: cloning, expression and its role in outgrowth of facial prominences and limb budsH Shen
Faculty of Dentistry, University of British Columbia, 2199 Wesbrook Mall, Vancouver, British Columbia, V6T 1Z3, Canada
Dev Biol 188:248-66. 1997..Application of an FGF-4 soaked bead to the apex of the limb bud maintained AP-2 expression. Thus AP-2 is involved in outgrowth and could be regulated by factors such as FGFs that are present in the ectoderm of both the face and limb... - Endogenous bone morphogenetic proteins regulate outgrowth and epithelial survival during avian lip fusionAmir M Ashique
Department of Oral Health Sciences, Faculty of Dentistry, The University of British Columbia, Vancouver, BC, Canada
Development 129:4647-60. 2002.... - Development of the spatial pattern of retinoic acid receptor-beta transcripts in embryonic chick facial primordiaA Rowe
Department of Anatomy and Developmental Biology, University College and Middlesex School of Medicine, UK
Development 114:805-13. 1992..The boundary between these two groups of cells persisted as the maxillary primordia developed.(ABSTRACT TRUNCATED AT 250 WORDS).. - Noggin and retinoic acid transform the identity of avian facial prominencesS H Lee
Department of Oral Health Science, Faculty of Dentistry, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
Nature 414:909-12. 2001..Thus the levels of Bmp and RA determine whether specific regions of the face form maxillary or frontonasal mass derivatives... - Epithelium is required for maintaining FGFR-2 expression levels in facial mesenchyme of the developing chick embryoE Matovinovic
Department of Oral Health Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, Canada
Dev Dyn 210:407-16. 1997..These results suggest that there are signals in the epithelium required for increasing FGFR-2 and collagen II gene transcription, and the expression of these genes are linked to outgrowth of facial prominences... - Expression of fibroblast growth factor receptors (FGFR1, FGFR2, FGFR3) in the developing head and faceT A Wilke
Department of Oral Health Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, Canada
Dev Dyn 210:41-52. 1997..Finally, we discuss the relationship between FGF receptor expression in the chicken and the phenotypes of FGF receptor mutations in humans... - Effect of fibroblast growth factors on outgrowth of facial mesenchymeJ M Richman
Faculty of Dentistry, University of Manitoba, Winnipeg, R3E 0W2, Canada
Dev Biol 189:135-47. 1997..Our results indicate that FGFs are part of an endogenous signaling pathway involved in distal outgrowth and chondrogenesis of the facial prominences... - Isolation and characterisation of the chick orthologue of the Opitz syndrome gene, Mid1, supports a conserved role in vertebrate developmentJoy M Richman
Department of Oral Health Sciences, University of British Columbia, Vancouver, Canada
Int J Dev Biol 46:441-8. 2002..These data indicate that Mid1 plays an evolutionarily conserved developmental function in vertebrates that may involve effects on cellular proliferation, tissue interactions and morphogenesis... - Signalling via type IA and type IB bone morphogenetic protein receptors (BMPR) regulates intramembranous bone formation, chondrogenesis and feather formation in the chicken embryoAmir M Ashique
Department of Oral Health Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, Canada
Int J Dev Biol 46:243-53. 2002..We conclude that the requirement for the type IB is greater than for the type IA receptor but, when active, both receptors play similar roles in regulating bone, cartilage and feather formation in the skull... - A new origin for the maxillary jawSang-Hwy Lee
Department of Oral, Maxillofacial Surgery and Oral Science Research Center, Medical Science and Engineering Research Center, BK 21 Project for Medical Science, College of Dentistry Yonsei University, Seoul, Korea
Dev Biol 276:207-24. 2004..These data also suggest that during evolution, recession of the first pharyngeal arch-derived palatoquadrate cartilage to a more proximal position gave way to the bony upper jaw of amniotes...