Jüri Reimand

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. pmc Systematic analysis of somatic mutations in phosphorylation signaling predicts novel cancer drivers
    Jüri Reimand
    The Donnelly Centre, University of Toronto, Toronto, Canada
    Mol Syst Biol 9:637. 2013
  2. doi request reprint Domain-mediated protein interaction prediction: From genome to network
    Jüri Reimand
    The Donnelly Centre, University of Toronto, 160 College Street, Toronto, Ontario, Canada
    FEBS Lett 586:2751-63. 2012
  3. pmc m:Explorer: multinomial regression models reveal positive and negative regulators of longevity in yeast quiescence
    Jüri Reimand
    EMBL European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, UK
    Genome Biol 13:R55. 2012
  4. pmc Comprehensive reanalysis of transcription factor knockout expression data in Saccharomyces cerevisiae reveals many new targets
    Jüri Reimand
    EMBL European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, UK
    Nucleic Acids Res 38:4768-77. 2010
  5. pmc Evolutionary constraint and disease associations of post-translational modification sites in human genomes
    Jüri Reimand
    The Donnelly Centre, University of Toronto, Canada
    PLoS Genet 11:e1004919. 2015
  6. pmc The mutational landscape of phosphorylation signaling in cancer
    Jüri Reimand
    The Donnelly Centre, University of Toronto, Canada
    Sci Rep 3:2651. 2013
  7. pmc HyperModules: identifying clinically and phenotypically significant network modules with disease mutations for biomarker discovery
    Alvin Leung
    The Donnelly Centre, University of Toronto, 160 College Street, M5S 3E1 Toronto, Ontario, Canada
    Bioinformatics 30:2230-2. 2014
  8. pmc Subgroup-specific structural variation across 1,000 medulloblastoma genomes
    Paul A Northcott
    Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada
    Nature 488:49-56. 2012

Collaborators

Detail Information

Publications8

  1. pmc Systematic analysis of somatic mutations in phosphorylation signaling predicts novel cancer drivers
    Jüri Reimand
    The Donnelly Centre, University of Toronto, Toronto, Canada
    Mol Syst Biol 9:637. 2013
    ..This study demonstrates new ways of interpreting cancer genomes and presents new leads for cancer research...
  2. doi request reprint Domain-mediated protein interaction prediction: From genome to network
    Jüri Reimand
    The Donnelly Centre, University of Toronto, 160 College Street, Toronto, Ontario, Canada
    FEBS Lett 586:2751-63. 2012
    ....
  3. pmc m:Explorer: multinomial regression models reveal positive and negative regulators of longevity in yeast quiescence
    Jüri Reimand
    EMBL European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, UK
    Genome Biol 13:R55. 2012
    ..m:Explorer (http://biit.cs.ut.ee/mexplorer/) is instrumental in interrogating eukaryotic regulatory systems using heterogeneous data...
  4. pmc Comprehensive reanalysis of transcription factor knockout expression data in Saccharomyces cerevisiae reveals many new targets
    Jüri Reimand
    EMBL European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, UK
    Nucleic Acids Res 38:4768-77. 2010
    ..compendium. The dataset is available from ArrayExpress (accession: E-MTAB-109) and it will be invaluable to any scientist interested in the yeast transcriptional regulatory system...
  5. pmc Evolutionary constraint and disease associations of post-translational modification sites in human genomes
    Jüri Reimand
    The Donnelly Centre, University of Toronto, Canada
    PLoS Genet 11:e1004919. 2015
    ..Further, as PTMs are molecular switches that are modulated by drugs, we study mutated binding sites of PTM enzymes in disease genes and define a drug-disease network containing 413 novel predicted disease-gene links. ..
  6. pmc The mutational landscape of phosphorylation signaling in cancer
    Jüri Reimand
    The Donnelly Centre, University of Toronto, Canada
    Sci Rep 3:2651. 2013
    ..This analysis shows that incorporation of information about protein signaling sites will improve computational pipelines for variant function prediction. ..
  7. pmc HyperModules: identifying clinically and phenotypically significant network modules with disease mutations for biomarker discovery
    Alvin Leung
    The Donnelly Centre, University of Toronto, 160 College Street, M5S 3E1 Toronto, Ontario, Canada
    Bioinformatics 30:2230-2. 2014
    ..HyperModules is a network search algorithm that finds frequently mutated gene modules with significant clinical or phenotypic signatures from biomolecular interaction networks...
  8. pmc Subgroup-specific structural variation across 1,000 medulloblastoma genomes
    Paul A Northcott
    Developmental and Stem Cell Biology Program, The Hospital for Sick Children, Toronto, Ontario M5G 1L7, Canada
    Nature 488:49-56. 2012
    ..Numerous targetable SCNAs, including recurrent events targeting TGF-β signalling in Group 3, and NF-κB signalling in Group 4, suggest future avenues for rational, targeted therapy...