G Reid

Summary

Affiliation: University of Western Ontario
Country: Canada

Publications

  1. pmc Deep sequencing of the vaginal microbiota of women with HIV
    Ruben Hummelen
    Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, London, Canada
    PLoS ONE 5:e12078. 2010
  2. pmc Vaginal microbiome and epithelial gene array in post-menopausal women with moderate to severe dryness
    Ruben Hummelen
    Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, London, Canada
    PLoS ONE 6:e26602. 2011
  3. pmc Vaginal microbiota and the use of probiotics
    Sarah Cribby
    Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, 268 Grosvenor Street, London, ON, Canada N6A4V2
    Interdiscip Perspect Infect Dis 2008:256490. 2008
  4. pmc Lactobacillus rhamnosus GR-1 enhances NF-kappaB activation in Escherichia coli-stimulated urinary bladder cells through TLR4
    Mattias Karlsson
    School of Science and Technology, Life Science, Orebro University, Sweden
    BMC Microbiol 12:15. 2012
  5. ncbi Probiotic and prebiotic applications for vaginal health
    Gregor Reid
    The University of Western Ontario, Department of Microbiology and Immunology, London, ON, Canada
    J AOAC Int 95:31-4. 2012
  6. ncbi Selecting, testing and understanding probiotic microorganisms
    Gregor Reid
    Canadian R and D Centre for Probiotics, Lawson Health Research Institute, London, Canada
    FEMS Immunol Med Microbiol 46:149-57. 2006
  7. pmc Probiotics. Some evidence of their effectiveness
    Gregor Reid
    Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, London, Ont
    Can Fam Physician 51:1487-93. 2005
  8. doi Opinion paper: Quo vadis - EFSA?
    G Reid
    Lawson Health Research Institute, Canadian Research and Development Centre for Probiotics, London N6A 4V2 Ontario, Canada
    Benef Microbes 2:177-81. 2011
  9. doi Probiotic Lactobacilli for urogenital health in women
    Gregor Reid
    Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, London, Ontario, Canada
    J Clin Gastroenterol 42:S234-6. 2008
  10. pmc The potential role for probiotic yogurt for people living with HIV/AIDS
    Gregor Reid
    Lawson Health Research Institute, Department of Microbiology, The University of Western Ontario, London, Ontario, Canada
    Gut Microbes 1:411-4. 2010

Collaborators

Detail Information

Publications105 found, 100 shown here

  1. pmc Deep sequencing of the vaginal microbiota of women with HIV
    Ruben Hummelen
    Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, London, Canada
    PLoS ONE 5:e12078. 2010
    ..It is poorly understood which bacterial communities constitute BV or the normal vaginal microbiota among this population and how the microbiota associated with BV responds to antibiotic treatment...
  2. pmc Vaginal microbiome and epithelial gene array in post-menopausal women with moderate to severe dryness
    Ruben Hummelen
    Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, London, Canada
    PLoS ONE 6:e26602. 2011
    ....
  3. pmc Vaginal microbiota and the use of probiotics
    Sarah Cribby
    Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, 268 Grosvenor Street, London, ON, Canada N6A4V2
    Interdiscip Perspect Infect Dis 2008:256490. 2008
    ....
  4. pmc Lactobacillus rhamnosus GR-1 enhances NF-kappaB activation in Escherichia coli-stimulated urinary bladder cells through TLR4
    Mattias Karlsson
    School of Science and Technology, Life Science, Orebro University, Sweden
    BMC Microbiol 12:15. 2012
    ....
  5. ncbi Probiotic and prebiotic applications for vaginal health
    Gregor Reid
    The University of Western Ontario, Department of Microbiology and Immunology, London, ON, Canada
    J AOAC Int 95:31-4. 2012
    ..In the future, probiotics and prebiotics will represent an important adjunct to pharmaceutical and other approaches used to care for feminine health...
  6. ncbi Selecting, testing and understanding probiotic microorganisms
    Gregor Reid
    Canadian R and D Centre for Probiotics, Lawson Health Research Institute, London, Canada
    FEMS Immunol Med Microbiol 46:149-57. 2006
    ..This minireview provides an update on critical studies, particularly since 2002, that are helping to explain the mechanisms of action of probiotic organisms...
  7. pmc Probiotics. Some evidence of their effectiveness
    Gregor Reid
    Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, London, Ont
    Can Fam Physician 51:1487-93. 2005
    ..To define the term probiotics, to indicate how to identify products that have been proven beneficial, and to assess the quality of evidence regarding probiotics...
  8. doi Opinion paper: Quo vadis - EFSA?
    G Reid
    Lawson Health Research Institute, Canadian Research and Development Centre for Probiotics, London N6A 4V2 Ontario, Canada
    Benef Microbes 2:177-81. 2011
    ..The recent rejection of a simple and quite bland claim related to vaginal health emphasises the travesty of this bureaucracy. Herein, the science fights back and counters the critique of EFSA...
  9. doi Probiotic Lactobacilli for urogenital health in women
    Gregor Reid
    Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, London, Ontario, Canada
    J Clin Gastroenterol 42:S234-6. 2008
    ..The mechanisms involved have not been completely resolved, but seem to include modulation of host immunity, reduction in pathogen ascension from the rectum, and interference with colonization and survival of pathogens...
  10. pmc The potential role for probiotic yogurt for people living with HIV/AIDS
    Gregor Reid
    Lawson Health Research Institute, Department of Microbiology, The University of Western Ontario, London, Ontario, Canada
    Gut Microbes 1:411-4. 2010
    ..Such outcomes have a scientific rationale, many social implications, and perhaps most importantly raise the question, why have developed countries not tried harder to bring nutrition-based probiotics to people in need?..
  11. pmc Responders and non-responders to probiotic interventions: how can we improve the odds?
    Gregor Reid
    Lawson Health Research Institute Probiotics, London, Ontario, Canada
    Gut Microbes 1:200-4. 2010
    ..By following these recommendations and selecting an appropriate primary outcome, it is hoped that clinical data will emerge in the future that expands our knowledge of which probiotics benefits which subjects and by what mechanism...
  12. doi Microbiota restoration: natural and supplemented recovery of human microbial communities
    Gregor Reid
    Human Microbiology and Probiotics, F2 116, Lawson Health Research Institute, 268 Grosvenor Street, London, Ontario N6A 4V2, Canada
    Nat Rev Microbiol 9:27-38. 2011
    ....
  13. ncbi Probiotic Lactobacillus dose required to restore and maintain a normal vaginal flora
    G Reid
    H414, Lawson Health Research Institute, University of Western Ontario, London, ON, Canada
    FEMS Immunol Med Microbiol 32:37-41. 2001
    ..This study confirms the potential efficacy of orally administered lactobacilli as a non-chemotherapeutic means to restore and maintain a normal urogenital flora, and shows that over 10(8) viable organisms per day is the required dose...
  14. doi Targeting the vaginal microbiota with probiotics as a means to counteract infections
    Gregor Reid
    Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, 268 Grosvenor St, London ON N6A 4V2, Canada
    Curr Opin Clin Nutr Metab Care 12:583-7. 2009
    ..The purpose of this review is to examine our current understanding of the vaginal microbiota and assess how probiotic bacteria might reduce infectivity...
  15. ncbi The importance of guidelines in the development and application of probiotics
    Gregor Reid
    Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, 268 Grosvenor Street, London, Ontario N6A 4V2, Canada
    Curr Pharm Des 11:11-6. 2005
    ....
  16. ncbi The potential for probiotics to prevent bacterial vaginosis and preterm labor
    Gregor Reid
    Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada
    Am J Obstet Gynecol 189:1202-8. 2003
    ....
  17. ncbi Probiotics for mother and child
    Gregor Reid
    Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, Department of Microbiology and Immunology, University of Western Ontario, London, Canada
    J Clin Gastroenterol 38:S94-101. 2004
    ..It is now up to science to deliver the remedies, and to society to make sure that only proven products reach the marketplace and the people in most need...
  18. ncbi Nucleic acid-based diagnosis of bacterial vaginosis and improved management using probiotic lactobacilli
    Gregor Reid
    Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, 268 Grosvenor Street, London, Ontario, Canada N6A 4V2
    J Med Food 7:223-8. 2004
    ..rhamnosus GR-1 and L. fermentum RC-14...
  19. ncbi The role of cranberry and probiotics in intestinal and urogenital tract health
    Gregor Reid
    Lawson Research Institute, University of Western Ontario, London, Canada
    Crit Rev Food Sci Nutr 42:293-300. 2002
    ..For such alternative approaches to be successful, scientific rigor must be backed by public education and physician acceptance. Given the emergence of virulent and multidrug-resistant pathogens, time is not on our side...
  20. ncbi Probiotics to prevent urinary tract infections: the rationale and evidence
    Gregor Reid
    Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, 268 Grosvenor Street, N6A 4V2, London, Ontario, Canada
    World J Urol 24:28-32. 2006
    ....
  21. ncbi Alternatives to antibiotic use: probiotics for the gut
    Gregor Reid
    Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, London, Ontario
    Anim Biotechnol 13:97-112. 2002
  22. ncbi Use of Lactobacillus to prevent infection by pathogenic bacteria
    Gregor Reid
    Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, and Department of Microbiology and Immunology at the University of Western Ontario, 268 Grosvenor Street, London, Ontario, N6A 4V2, Canada
    Microbes Infect 4:319-24. 2002
    ..Such critically important studies will require the medical science community to show a willingness to turn away from pharmaceutical remedies as the only solution to health and disease...
  23. pmc Potential uses of probiotics in clinical practice
    Gregor Reid
    Canadian Research and Development Centre for Probiotics, The Lawson Health Research Institute, London, Ontario N6A 4V2, Canada
    Clin Microbiol Rev 16:658-72. 2003
    ..Based upon the evidence to date, future advances with single- and multiple-strain therapies are on the horizon for the management of a number of debilitating and even fatal conditions...
  24. ncbi New scientific paradigms for probiotics and prebiotics
    Gregor Reid
    Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, 268 Grosvenor Street, London, Ontario, N6A 4V2, Canada
    J Clin Gastroenterol 37:105-18. 2003
    ....
  25. doi How science will help shape future clinical applications of probiotics
    Gregor Reid
    Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada
    Clin Infect Dis 46:S62-6; discussion S144-51. 2008
    ..In time and with rigorous documentation, some probiotics will likely find an important place in medical practice...
  26. pmc Probiotic products in Canada with clinical evidence: what can gastroenterologists recommend?
    G Reid
    Department of Microbiology, University of Western Ontario, London, Canada
    Can J Gastroenterol 22:169-75. 2008
    ..In due course, more clinically documented probiotics will emerge, some with therapeutic effects based on a better understanding of disease processes...
  27. ncbi When microbe meets human
    Gregor Reid
    Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, London, Ontario, Canada
    Clin Infect Dis 39:827-30. 2004
    ....
  28. pmc Urogenital infections in women: can probiotics help?
    G Reid
    Department of Microbiology and Immunology, University of Western Ontario and Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, London, Ontario, Canada
    Postgrad Med J 79:428-32. 2003
    ..The role of the intestinal, vaginal, and urethral flora and probiotics in urogenital health will be the focus of this review...
  29. ncbi Safe and efficacious probiotics: what are they?
    Gregor Reid
    Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute and Departments of Microbiology and Immunology and Surgery, The University of Western Ontario, London, Ontario N6A 4V2, Canada
    Trends Microbiol 14:348-52. 2006
    ..In this Opinion article, recommendations are made based upon the current understanding of scientific, clinical and regulatory issues, with a special focus on safety...
  30. ncbi Probiotics for urogenital health
    Gregor Reid
    University of Western Ontario, 268 Grosvenor Street, London, Ontario, N6A 4V2, Canada
    Nutr Clin Care 5:3-8. 2002
    ....
  31. ncbi Probiotics for the developing world
    Gregor Reid
    Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, London, Ontario, Canada
    J Clin Gastroenterol 39:485-8. 2005
    ....
  32. ncbi Oral use of Lactobacillus rhamnosus GR-1 and L. fermentum RC-14 significantly alters vaginal flora: randomized, placebo-controlled trial in 64 healthy women
    Gregor Reid
    Lawson Health Research Institute, Canadian Research and Development Center for Probiotics, 268 Grosvenor Street, London, ON, Canada N6A 4V2
    FEMS Immunol Med Microbiol 35:131-4. 2003
    ..The combination of probiotic L. rhamnosus GR-1 and L. fermentum RC-14 is not only safe for daily use in healthy women, but it can reduce colonization of the vagina by potential pathogenic bacteria and yeast...
  33. ncbi Probiotic agents to protect the urogenital tract against infection
    G Reid
    Lawson Research Institute and the Department of Microbiology and Immunology, The University of Western Ontario, Canada
    Am J Clin Nutr 73:437S-443S. 2001
    ....
  34. ncbi Vaginal microbial diversity among postmenopausal women with and without hormone replacement therapy
    Christine Heinemann
    Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, University of Western Ontario, London, Canada
    Can J Microbiol 51:777-81. 2005
    ..In women not using HRTs, use of probiotics may be the only way to restore a nonpathogen-dominated flora...
  35. ncbi Could probiotics be an option for treating and preventing urogenital infections?
    G Reid
    Lawson Health Research Institute and Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada
    Medscape Womens Health 6:9. 2001
    ..Although few strains have been selected and targeted for urogenital applications, and none are currently available on the market, evidence shows that probiotic therapy has the potential to make an impact on women's health...
  36. ncbi Oral probiotics can resolve urogenital infections
    G Reid
    Lawson Research Institute, London, Ont, Canada
    FEMS Immunol Med Microbiol 30:49-52. 2001
    ..In six cases of asymptomatic BV or intermediate BV (based upon Nugent scoring) was resolved within 1 week of therapy...
  37. ncbi Ofloxacin for the treatment of urinary tract infections and biofilms in spinal cord injury
    G Reid
    Lawson Research Institute, London, Ont, Canada
    Int J Antimicrob Agents 13:305-7. 2000
    ..24%) (P=0.005) and day 7 (67 vs. 35%) (P=0.014). The study showed that ofloxacin was better than TMPSMX and alternatives at relieving clinical infection and eradicating bladder cell biofilms...
  38. ncbi Evaluation of the bacterial vaginal flora of 20 postmenopausal women by direct (Nugent score) and molecular (polymerase chain reaction and denaturing gradient gel electrophoresis) techniques
    Jeremy P Burton
    Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, London, Ontario, Canada
    J Infect Dis 186:1770-80. 2002
    ..This study indicates that asymptomatic BV appears to be much more common than is currently perceived; these findings may have implications for the health of postmenopausal women...
  39. ncbi Can bacterial interference prevent infection?
    G Reid
    Lawson Health Research Institute, University of Western Ontario, 268 Grosvenor Street, London, Ontario, Canada N6A 4V2
    Trends Microbiol 9:424-8. 2001
    ..The potential for new therapeutic regimens using probiotics is significant and worthy of further study...
  40. ncbi Lactobacillus by-products inhibit the growth and virulence of uropathogenic Escherichia coli
    P A Cadieux
    Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, London, Canada
    J Physiol Pharmacol 60:13-8. 2009
    ..Our findings indicate that compounds secreted by lactobacilli likely protect the urogenital tract from UPEC colonization and infection by inhibiting growth, inducing stress and downregulating proteins critical for host attachment...
  41. ncbi Potential preventive strategies and therapies in urinary tract infection
    G Reid
    Lawson Research Institute, London, Ontario, Canada
    World J Urol 17:359-63. 1999
    ..The next decade should see the introduction of new methods for reduction of the high incidence of UTI and better management of recurring urogenital infections...
  42. pmc Improved understanding of the bacterial vaginal microbiota of women before and after probiotic instillation
    Jeremy P Burton
    Canadian Research and Development Centre for Probiotics, The Lawson Health Research Institute, London, Ontario, Canada
    Appl Environ Microbiol 69:97-101. 2003
    ..This study demonstrates that non-culture-based techniques, such as PCR-DGGE, are useful adjuncts for studies of the vaginal microbiota...
  43. ncbi Novel insight into the vaginal microflora in postmenopausal women under hormone replacement therapy as analyzed by PCR-denaturing gradient gel electrophoresis
    Estelle Devillard
    Canadian Research and Development Centre for Probiotics, The Lawson Health Research Institute, University of Western Ontario, 268 Grosvenor Street, London, Ont, Canada N6A 4V2
    Eur J Obstet Gynecol Reprod Biol 117:76-81. 2004
    ..A study was conducted to use new molecular technologies to identify the vaginal bacterial species of postmenopausal women under oral estrogen therapy (Premarin-conjugated equine estrogen, CEE)...
  44. ncbi Cranberry juice consumption may reduce biofilms on uroepithelial cells: pilot study in spinal cord injured patients
    G Reid
    Lawson Health Research Institute, London, Ontario, Canada
    Spinal Cord 39:26-30. 2001
    ..SPONSORSHIP: This study was funded by Ocean Spray Cranberries, Lakeville, MA, USA...
  45. ncbi Biofilms in infectious disease and on medical devices
    G Reid
    Department of Microbiology and Immunology, The University of Western Ontario, and Lawson Research Institute, London, Canada
    Int J Antimicrob Agents 11:223-6; discussion 237-9. 1999
    ..For the treating physician, many antibiotics are unable to eradicate dense biofilms, and therefore much work is required to devise ways to prevent their occurrence and clear them from the host...
  46. ncbi Effect of Lactobacillus challenge on Gardnerella vaginalis biofilms
    Sheri Saunders
    Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, F2 116, 268 Grosvenor Street, London, Ontario N6A 4V2, Canada
    Colloids Surf B Biointerfaces 55:138-42. 2007
    ..reuteri RC-14. These studies help to provide insight into the clinical situation in which probiotic and indigenous vaginal lactobacilli can interfere with Gardnerella's presence and reduce the risk of bacterial vaginosis...
  47. ncbi Lactobacillus vaginal microbiota of women attending a reproductive health care service in Benin city, Nigeria
    Kingsley C Anukam
    Canadian Research and Development Centre for Probiotic, Lawson Health Research Institute, London, Ontario, Canada
    Sex Transm Dis 33:59-62. 2006
    ....
  48. ncbi Detection of Bifidobacterium species and Gardnerella vaginalis in the vagina using PCR and denaturing gradient gel electrophoresis (DGGE)
    J P Burton
    The Lawson Health Research Institute, St Joseph s Hospital, London, Ontario, Canada
    Int J Gynaecol Obstet 81:61-3. 2003
  49. ncbi Digoxigenin-labelled peptide nucleic acid to detect lactobacilli PCR amplicons immobilized on membranes from denaturing gradient gel electrophoresis
    J P Burton
    Canadian Research and Development Center for Probiotics, The Lawson Health Research Institute, Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada
    Lett Appl Microbiol 36:145-9. 2003
    ....
  50. ncbi Research priorities for urological care following spinal cord injury: recommendations of an expert panel
    K C Hayes
    The Ontario Neurotrauma Foundation International Expert Panel, Ontario, Canada
    Can J Urol 14:3416-23. 2007
    ....
  51. doi Probiotics and nutrients for the first 1000 days of life in the developing world
    M K Enos
    Canadian Research and Development Centre for Probiotics, F2 116, The Lawson Health Research Institute, 268 Grosvenor Street, London, ON N6A 4V2, Canada
    Benef Microbes 4:3-16. 2013
    ....
  52. ncbi Uropathogenic Escherichia coli adhere to urinary catheters without using fimbriae
    G Reid
    Department of Microbiology and Immunology, University of Western Ontario, London, Canada
    FEMS Immunol Med Microbiol 16:159-62. 1996
    ....
  53. ncbi Identification and plasmid profiles of Lactobacillus species from the vagina of 100 healthy women
    G Reid
    Department of Microbiology and Immunology, University of Western Ontario, London, Canada
    FEMS Immunol Med Microbiol 15:23-6. 1996
    ..Of the strains tested, few were resistant to the spermicidal agent nonoxynol-9. The data identify species within which strains may possess properties associated with maintenance of a healthy vaginal ecology...
  54. ncbi Effect of nutrient composition on the in vitro growth of urogenital lactobacilli and uropathogens
    G Reid
    Department of Microbiology and Immunology, University of Western Ontario, London, Canada
    Can J Microbiol 44:866-71. 1998
    ..These in vitro results provide a basis for testing nutritional supplements to alter the urogenital flora in an attempt to enhance restoration and maintenance of a normal disease-free state...
  55. ncbi Gut flora in health and disease: potential role of probiotics
    M Heselmans
    Lawson Health and Research Institute, University of Western Ontario, London, Ontario, Canada
    Curr Issues Intest Microbiol 6:1-7. 2005
    ..Besides, more clinical studies are required to convince authorities and the public of the value of microbial therapies...
  56. ncbi Oral fluoroquinolone therapy results in drug adsorption on ureteral stents and prevention of biofilm formation
    G Reid
    Division of Urology, Lawson Health Research Institute, 268 Grosvenor Street, Ont, N6A 4V2, London, Canada
    Int J Antimicrob Agents 17:317-9; discussion 319-20. 2001
    ..If biomaterial properties can be enhanced to increase further the adsorptive concentration of drug, the risk of infections and recalcitrant biofilm formation could be significantly reduced in a highly susceptible patient population...
  57. ncbi The potential role of probiotics in pediatric urology
    Gregor Reid
    Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute and Department of Microbiology, University of Western Ontario, London, Canada
    J Urol 168:1512-7. 2002
    ..quot; This review was done to evaluate the potential role that probiotic therapy may have in pediatric urology...
  58. pmc Organisms associated with bacterial vaginosis in Nigerian women as determined by PCR-DGGE and 16S rRNA gene sequence
    Kingsley C Anukam
    Canadian Research and Development Centre for Probiotic, Lawson Health Research Institute, 268 Grosvenor Street, London, Ontario, Canada
    Afr Health Sci 7:68-72. 2007
    ..The diagnostic methods currently adopted in the evaluation of patient samples for BV are arguably Amsel criteria, and Nugent score that require microscopy and expert interpretation. These two methods are still subjective...
  59. ncbi In vitro evaluation of the viability of vaginal cells (VK2/E6E7) and probiotic Lactobacillus species in lemon juice
    Kingsley C Anukam
    Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, 268 Grosvenor Street, London, Ontario N6A4V2, Canada
    Sex Health 6:67-74. 2009
    ..Few in vitro studies have been done on the effect of lemon juice on vaginal cells and lactobacilli that constitute the major microbiota in healthy women...
  60. ncbi Rat PSP94 inhibits the growth and viability of the rat adenocarcinoma cell line PAIII in vitro
    Peter A Cadieux
    Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada
    Cancer Invest 24:246-55. 2006
    ..Rat PSP was shown to inhibit the growth and survival of PAIII cells in a dose-dependent manner with > 90 percent reductions in both observed. TUNEL and Annexin-V assays confirmed PAIII cell death to be via apoptosis...
  61. pmc Evaluation of reuterin production in urogenital probiotic Lactobacillus reuteri RC-14
    Peter Cadieux
    Lawson Health Research Institute, University of Western Ontario, 268 Grosvenor Street, London, Ontario N6A 4V2, Canada
    Appl Environ Microbiol 74:4645-9. 2008
    ..These findings support that the probiotic effects of L. reuteri RC-14, repeatedly demonstrated during numerous studies of the intestine and vagina, are independent of reuterin production...
  62. doi Effect of bacterial vaginosis, Lactobacillus and Premarin estrogen replacement therapy on vaginal gene expression changes
    Adam Dahn
    Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada
    Microbes Infect 10:620-7. 2008
    ..83-fold for IL-1alpha, -8.33 for IL-1beta and -3.63 for IL-6. This is the first study to use gene arrays to correlate changes in host expression response to estrogen replacement therapy and BV...
  63. pmc Microbiome profiling by illumina sequencing of combinatorial sequence-tagged PCR products
    Gregory B Gloor
    Department of Biochemistry, University of Western Ontario, London, Ontario, Canada
    PLoS ONE 5:e15406. 2010
    ....
  64. pmc Complexity of vaginal microflora as analyzed by PCR denaturing gradient gel electrophoresis in a patient with recurrent bacterial vaginosis
    Estelle Devillard
    Canadian Research and Development Centre for Probiotics, The Lawson Health Research Institute, London, Ontario, Canada
    Infect Dis Obstet Gynecol 13:25-31. 2005
    ..We aimed to test our hypothesis that symptoms and signs of BV do not necessarily indicate colonization by this organism, and often will not respond to standard metronidazole or clindamycin treatment...
  65. pmc Anti-inflammatory effects of probiotic yogurt in inflammatory bowel disease patients
    M Lorea Baroja
    Canadian Research and Development Centre for Probiotics, The Lawson Health Research Institute, London, Ontario, Canada
    Clin Exp Immunol 149:470-9. 2007
    ..Probiotic yogurt intake was associated with significant anti-inflammatory effects that paralleled the expansion of peripheral pool of putative T(reg) cells in IBD patients and with few effects in controls...
  66. ncbi Biomaterials in Urology II: future usage and management
    G Reid
    Department of Microbiology and Immunology, The University of Western Ontario, London, Canada
    J Endourol 13:1-7. 1999
    ..By necessity, some of these citations are speculative, but supporting documentation for their inclusion is presented...
  67. ncbi Advances in ureteral stent technology
    J D Denstedt
    Division of Urology, The University of Western Ontario, St Joseph s Health Care London, 268 Grosvenor Street, London, Ontario, Canada
    World J Urol 18:237-42. 2000
    ..Just so, encrustation limits the long-term use of urinary materials, and a better understanding of factors involved in encrustation are needed to reduce the problem...
  68. pmc Detection of Atopobium vaginae in postmenopausal women by cultivation-independent methods warrants further investigation
    Jeremy P Burton
    The Lawson Health Research Institute, Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada
    J Clin Microbiol 42:1829-31. 2004
    ..Sequences from Atopobium vaginae were the most commonly detected. In a survey of 35 other postmenopausal women, this organism was detected in 44% with BV but not in any subjects deemed healthy...
  69. pmc Abnormal immunological profile and vaginal microbiota in women prone to urinary tract infections
    Pirkka V Kirjavainen
    Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, The University of Western Ontario, London, Ontario, Canada
    Clin Vaccine Immunol 16:29-36. 2009
    ..Further studies of antigen-presenting-cell function and T-cell activation in recurrent UTI are called for...
  70. ncbi Probiotics and the urologist
    Andrew W Bruce
    University of Toronto, Lawson Health Research Institute, London, Ontario, Canada
    Can J Urol 10:1785-9. 2003
    ..plantarum 299 show significantly reduced infection rates in patients undergoing major surgical procedures. In short, specific probiotic strains hold much promise for use in the urology setting...
  71. pmc The rationale for probiotics in female urogenital healthcare
    Gregor Reid
    Department of Microbiology and Immunology, and Surgery, The University of Western Ontario, London, Ontario, Canada
    MedGenMed 6:49. 2004
    ..The concept of probiotic therapy is familiar to many consumers and although it has historically lacked credibility in the medical community, perceptions are changing...
  72. ncbi In-vitro activity of triclosan-eluting ureteral stents against common bacterial uropathogens
    Ben H Chew
    Division of Urology, Department of Surgery, University of Western Ontario, London, Ontario, Canada
    J Endourol 20:949-58. 2006
    ..The bactericidal and bacteriostatic effect of a triclosan-eluting ureteral stent was tested against clinical isolates of common bacterial uropathogens in an in-vitro setting...
  73. ncbi Asymptomatic bacteriuria in spinal cord patients and the elderly
    G Reid
    Department of Microbiology and Immunology, University of Western Ontario, Canada
    Urol Clin North Am 26:789-95. 1999
    ....
  74. doi Reduced expression of basal and probiotic-inducible G-CSF in intestinal mononuclear cells is associated with inflammatory bowel disease
    Andrew J Martins
    Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada
    Inflamm Bowel Dis 15:515-25. 2009
    ..Previously, we have shown that probiotic Lactobacillus rhamnosus GR-1 induces G-CSF production from bone marrow-derived macrophages. Whether this probiotic also induces G-CSF in intestinal mononuclear cells is unknown...
  75. ncbi Triclosan loaded ureteral stents decrease proteus mirabilis 296 infection in a rabbit urinary tract infection model
    Peter A Cadieux
    Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, Canada
    J Urol 175:2331-5. 2006
    ..Using a rabbit model of UTI we examined the effects of triclosan impregnated stent segments on the growth and survival of Proteus mirabilis, a uropathogen commonly associated with device related UTI and encrustation...
  76. ncbi Inhibition of expression of a staphylococcal superantigen-like protein by a soluble factor from Lactobacillus reuteri
    Jennifer M Laughton
    The Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, 268 Grosvenor St, London, Ontario, Canada N6A 4V2
    Microbiology 152:1155-67. 2006
    ..These results suggest that L. reuteri RC-14 has the potential to alter the virulence of Staph. aureus via secretion of cell-cell signalling molecules...
  77. pmc Persistence of Lactobacillus fermentum RC-14 and Lactobacillus rhamnosus GR-1 but not L. rhamnosus GG in the human vagina as demonstrated by randomly amplified polymorphic DNA
    Gillian E Gardiner
    Lawson Health Research Institute, London, Ontario N6A 4V2, Canada
    Clin Diagn Lab Immunol 9:92-6. 2002
    ..rhamnosus GG. This highlights the importance of proper selection of strains for urogenital probiotic applications...
  78. pmc Rapid identification of probiotic lactobacillus biosurfactant proteins by ProteinChip tandem mass spectrometry tryptic peptide sequencing
    Gregor Reid
    Lawson Health Research Institute, St Joseph s Health Care, 268 Grosvenor St, London, Ontario N6A 4V2, Canada
    Appl Environ Microbiol 68:977-80. 2002
    ..On-chip tryptic digestion of the captured collagen binding proteins resulted in rapid sequence identification of five novel tryptic peptide sequences via collision-induced dissociation tandem mass spectrometry...
  79. ncbi Lactobacillus fermentum RC-14 inhibits Staphylococcus aureus infection of surgical implants in rats
    Bing Siang Gan
    Hand and Upper Limb Centre, Lawson Health Research Institute, Department of Surgery, University of Western Ontario, London, Canada
    J Infect Dis 185:1369-72. 2002
    ..aureus. L. fermentum RC-14 and its secreted biosurfactant both significantly inhibited S. aureus infection and bacteria adherence to surgical implants...
  80. pmc Taking probiotics during pregnancy. Are they useful therapy for mothers and newborns?
    Gregor Reid
    Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute
    Can Fam Physician 51:1477-9. 2005
    ..Most probiotics available in Canada, however, are of dubious quality, and, for many claimed indications, there is no proof of effectiveness yet...
  81. doi African traditional fermented foods and probiotics
    Kingsley C Anukam
    Department of Microbiology and Immunology, University of Western Ontario and Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, London, Ontario, Canada
    J Med Food 12:1177-84. 2009
    ..Given the recent upsurge in probiotic research, recommendations are made on studies that could be performed with African fermented foods and their strains, with a view to improving the health of people in sub-Saharan Africa...
  82. doi Development and pilot evaluation of a novel probiotic mixture for the management of seasonal allergic rhinitis
    Tara Koyama
    Canadian Research and Development Centre for Probiotics, Lawson Health Research Institute, 268 Grosvenor Street, London, ON N6A 4V2, Canada
    Can J Microbiol 56:730-8. 2010
    ..The study highlights the challenges in designing efficient immunomodulatory probiotic therapies based upon in vitro findings...
  83. ncbi G-CSF-mediated inhibition of JNK is a key mechanism for Lactobacillus rhamnosus-induced suppression of TNF production in macrophages
    Sung O Kim
    Department of Microbiology and Immunology, University of Western Ontario, London, Ontario, N6G 2V4, Canada
    Cell Microbiol 8:1958-71. 2006
    ..This demonstrates a novel role of G-CSF in L. rhamnosus-triggered anti-inflammatory effects and its mechanism in the suppression of TNF production in macrophages...
  84. doi Effect of Lactobacillus rhamnosus GR-1 supernatant and fetal sex on lipopolysaccharide-induced cytokine and prostaglandin-regulating enzymes in human placental trophoblast cells: implications for treatment of bacterial vaginosis and prevention of preterm
    Maryam Yeganegi
    Department of Physiology, University of Toronto, Toronto, ON, Canada
    Am J Obstet Gynecol 200:532.e1-8. 2009
    ..The objective of the study was to determine the effect of fetal sex on the output of cytokines and prostaglandin-regulating enzymes in lipopolysaccharide (LPS) and probiotic lactobacilli-treated placental trophoblast cells...
  85. ncbi Probiotics in surgical wound infections: current status
    Jeffrey C Howard
    Hand and Upper Limb Centre, Cell and Molecular Biology Laboratory, Lawson Health Research Institute, London, Ont
    Clin Invest Med 27:274-81. 2004
    ..Some have been found to play a role in disease remediation. However, mainstream medicine and science remain divided about the validity of health claims made about them...
  86. ncbi Swarming of Proteus mirabilis over ureteral stents: a comparative assessment
    James D Watterson
    Division of Urology, University of Western Ontario, London, Ontario, Canada
    J Endourol 17:523-7. 2003
    ....
  87. ncbi Urinary tract biomaterials
    Darren T Beiko
    Department of Urology, Queen s University, Kingston, University of Western Ontario, London, Ontario, Canada
    J Urol 171:2438-44. 2004
    ..Perspectives on future materials for use in the urinary tract are also provided...
  88. ncbi Lactobacillus strains and vaginal ecology
    Peter Cadieux
    JAMA 287:1940-1. 2002
  89. ncbi Augmentation of antimicrobial metronidazole therapy of bacterial vaginosis with oral probiotic Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14: randomized, double-blind, placebo controlled trial
    Kingsley Anukam
    Department of Pharmaceutical Microbiology, Faculty of Pharmacy, University of Benin, Nigeria
    Microbes Infect 8:1450-4. 2006
    ..In summary, this study showed efficacious use of lactobacilli and antibiotic in the eradication of BV in black African women...
  90. ncbi Selected topics in probiotics and prebiotics: meeting report for the 2004 international scientific association for probiotics and prebiotics
    Mary Ellen Sanders
    Dairy and Food Culture Technologies, 7119 S Glencoe Ct, Centennial, CO 80122 2526, USA
    Curr Issues Intest Microbiol 6:55-68. 2005
    ..Brief conclusions from these discussion groups are summarized in this paper...
  91. pmc Analysis of vaginal lactobacilli from healthy and infected Brazilian women
    Rafael C R Martinez
    Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Brazil
    Appl Environ Microbiol 74:4539-42. 2008
    ..Only Lactobacillus crispatus was detected accordingly by both methods, and H(2)O(2)-producing lactobacilli were not associated with protection against VVC...
  92. ncbi Predictors of urinary tract infection after menopause: a prospective study
    Gregor Reid
    Am J Med 118:930-1; author reply 931. 2005
  93. ncbi Clinical study comparing probiotic Lactobacillus GR-1 and RC-14 with metronidazole vaginal gel to treat symptomatic bacterial vaginosis
    Kingsley C Anukam
    Department of Pharmaceutical Microbiology, Faculty of Pharmacy, University of Benin, Nigeria
    Microbes Infect 8:2772-6. 2006
    ....
  94. ncbi Receptivity for probiotic products among premenopausal female students in an African university
    Kingsley C Anukam
    Department of Pharmaceutical Microbiology, Faculty of Pharmacy, University of Benin, Nigeria
    Sex Transm Dis 31:460-4. 2004
    ..The objective of this study was to examine the receptivity for probiotic products among premenopausal female students in an African university...
  95. pmc Beware of "natural" products
    Gregor Reid
    Can Fam Physician 50:1081. 2004
  96. ncbi Activity of HIV entry and fusion inhibitors expressed by the human vaginal colonizing probiotic Lactobacillus reuteri RC-14
    Janice J Liu
    Washington National Primate Research Center, University of Washington, Seattle, WA 98195, USA
    Cell Microbiol 9:120-30. 2007
    ..This is the first study to show that a well-documented and proven human vaginal probiotic strain can express potent functional viral inhibitors, which may potentially lower the sexual transmission of HIV...
  97. doi Yogurt containing probiotic Lactobacillus rhamnosus GR-1 and L. reuteri RC-14 helps resolve moderate diarrhea and increases CD4 count in HIV/AIDS patients
    Kingsley C Anukam
    Department of Pharmaceutical Microbiology, Faculty of Pharmacy, University of Benin, Benin City, Edo State, Nigeria
    J Clin Gastroenterol 42:239-43. 2008
    ....
  98. ncbi Discussion on toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis
    Gregor Reid
    Gastroenterology 127:366-7; author reply 367. 2004
  99. ncbi Safety of lactobacillus strains as probiotic agents
    Gregor Reid
    Clin Infect Dis 35:349-50. 2002
  100. ncbi Time for probiotics
    Gregor Reid
    Lancet Infect Dis 2:459. 2002