Michael Reedijk

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. doi request reprint A prospective study of tumor and technical factors associated with positive margins in breast-conservation therapy for nonpalpable malignancy
    Michael Reedijk
    Department of Surgical Oncology, Princess Margaret Hospital, University Health Network, 610 University Ave, Suite 3 130, Toronto, Ontario, Canada M5G 2M9
    Am J Surg 204:263-8. 2012
  2. doi request reprint Notch signaling and breast cancer
    Michael Reedijk
    Department of Surgical Oncology, University Health Network, Ontario, Canada
    Adv Exp Med Biol 727:241-57. 2012
  3. ncbi request reprint A case of axillary web syndrome with subcutaneous nodules following axillary surgery
    Michael Reedijk
    Department of Surgical Oncology, Princess Margaret Hospital, University Health Network and the University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Breast 15:411-3. 2006
  4. pmc Expression profiling of familial breast cancers demonstrates higher expression of FGFR2 in BRCA2-associated tumors
    Anita L Bane
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada
    Breast Cancer Res Treat 117:183-91. 2009
  5. doi request reprint Plasminogen activator uPA is a direct transcriptional target of the JAG1-Notch receptor signaling pathway in breast cancer
    Mamiko Shimizu
    Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, Ontario, Canada
    Cancer Res 71:277-86. 2011
  6. pmc High throughput kinase inhibitor screens reveal TRB3 and MAPK-ERK/TGFβ pathways as fundamental Notch regulators in breast cancer
    Julia Izrailit
    Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, ON, Canada M5G 2M9
    Proc Natl Acad Sci U S A 110:1714-9. 2013
  7. doi request reprint Metformin in early breast cancer: a prospective window of opportunity neoadjuvant study
    Saroj Niraula
    Division of Medical Oncology and Hematology, Department of Medicine, Mount Sinai Hospital and Princess Margaret Hospital, University of Toronto, 1284 600 University Avenue, Toronto, ON M5G 1X5, Canada
    Breast Cancer Res Treat 135:821-30. 2012
  8. doi request reprint Sentinel nodes in breast cancer: relevance of axillary level II nodes and optimal number of nodes that need to be removed
    Jean François Boileau
    Department of Surgical Oncology, Princess Margaret Hospital, University Health Network and University of Toronto, Toronto, Ontario, Canada
    Ann Surg Oncol 15:1710-6. 2008
  9. doi request reprint Developmental pathways in breast cancer and breast tumor-initiating cells: therapeutic implications
    Julia Izrailit
    Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, 620 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Cancer Lett 317:115-26. 2012
  10. pmc Expansion and characterization of human melanoma tumor-infiltrating lymphocytes (TILs)
    Linh T Nguyen
    Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, Canada
    PLoS ONE 5:e13940. 2010

Collaborators

Detail Information

Publications16

  1. doi request reprint A prospective study of tumor and technical factors associated with positive margins in breast-conservation therapy for nonpalpable malignancy
    Michael Reedijk
    Department of Surgical Oncology, Princess Margaret Hospital, University Health Network, 610 University Ave, Suite 3 130, Toronto, Ontario, Canada M5G 2M9
    Am J Surg 204:263-8. 2012
    ..The purpose of this study was to identify factors that predict an increased risk of a positive surgical margin after breast-conserving therapy for nonpalpable carcinoma of the breast...
  2. doi request reprint Notch signaling and breast cancer
    Michael Reedijk
    Department of Surgical Oncology, University Health Network, Ontario, Canada
    Adv Exp Med Biol 727:241-57. 2012
    ..Perturbation of these activities is a hallmark of carcinogenesis and evidence continues to accumulate that aberrant Notch activity influences breast cancer progression through these processes...
  3. ncbi request reprint A case of axillary web syndrome with subcutaneous nodules following axillary surgery
    Michael Reedijk
    Department of Surgical Oncology, Princess Margaret Hospital, University Health Network and the University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Breast 15:411-3. 2006
    ..Few reports have been published describing this entity, which results in pain and a limitation of shoulder abduction. Here, we report a case of AWS that was accompanied with sub-cutaneous nodules mimicking recurrence of breast cancer...
  4. pmc Expression profiling of familial breast cancers demonstrates higher expression of FGFR2 in BRCA2-associated tumors
    Anita L Bane
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada
    Breast Cancer Res Treat 117:183-91. 2009
    ..To elucidate novel genes involved in these two spectra of breast tumorigenesis we performed global gene expression analysis on breast tumors from germline BRCA1 and BRCA2 mutation carriers...
  5. doi request reprint Plasminogen activator uPA is a direct transcriptional target of the JAG1-Notch receptor signaling pathway in breast cancer
    Mamiko Shimizu
    Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, Ontario, Canada
    Cancer Res 71:277-86. 2011
    ..These data suggest that JAG1-induced Notch activation results in breast cancer progression through upregulation of the plasminogen activator system, directly linking these 2 important pathways of poor prognosis...
  6. pmc High throughput kinase inhibitor screens reveal TRB3 and MAPK-ERK/TGFβ pathways as fundamental Notch regulators in breast cancer
    Julia Izrailit
    Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, ON, Canada M5G 2M9
    Proc Natl Acad Sci U S A 110:1714-9. 2013
    ..These data demonstrate a dominant role for TRB3 and MAPK-ERK/TGFβ pathways as Notch regulators in breast cancer, establishing TRB3 as a potential therapeutic target...
  7. doi request reprint Metformin in early breast cancer: a prospective window of opportunity neoadjuvant study
    Saroj Niraula
    Division of Medical Oncology and Hematology, Department of Medicine, Mount Sinai Hospital and Princess Margaret Hospital, University of Toronto, 1284 600 University Avenue, Toronto, ON M5G 1X5, Canada
    Breast Cancer Res Treat 135:821-30. 2012
    ....
  8. doi request reprint Sentinel nodes in breast cancer: relevance of axillary level II nodes and optimal number of nodes that need to be removed
    Jean François Boileau
    Department of Surgical Oncology, Princess Margaret Hospital, University Health Network and University of Toronto, Toronto, Ontario, Canada
    Ann Surg Oncol 15:1710-6. 2008
    ..Our objective was to verify the staging accuracy of harvesting only the first 4 SLNSs and to determine the relevance of SLNSs that reside in level II of the axilla...
  9. doi request reprint Developmental pathways in breast cancer and breast tumor-initiating cells: therapeutic implications
    Julia Izrailit
    Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, 620 University Avenue, Toronto, Ontario, Canada M5G 2M9
    Cancer Lett 317:115-26. 2012
    ..Herein, we review the role of developmental pathways in stem cell biology and provide an up-to-date survey of pre-clinical and clinical trials of novel strategies to target them...
  10. pmc Expansion and characterization of human melanoma tumor-infiltrating lymphocytes (TILs)
    Linh T Nguyen
    Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, University Health Network, Toronto, Canada
    PLoS ONE 5:e13940. 2010
    ..These protocols still have room for improvement and furthermore are currently only performed at a limited number of institutions. The goal of this work was to develop TILs as a therapeutic product at our institution...
  11. pmc Mammary ductoscopy in the evaluation and treatment of pathologic nipple discharge: a Canadian experience
    Jory S Simpson
    Department of Surgical Oncology, Princess Margaret Hospital, Toronto, Ont
    Can J Surg 52:E245-8. 2009
    ..Mammary ductoscopy allows direct visualization of ductal epithelium using a fibreoptic microendoscope. As the first centre in Canada to apply ductoscopy to surgical practice, we report our experience with this technology...
  12. doi request reprint Cyclin D1 is a direct target of JAG1-mediated Notch signaling in breast cancer
    Brenda Cohen
    Campbell Family Institute for Breast Cancer Research, Ontario Cancer Institute, Toronto, Canada
    Breast Cancer Res Treat 123:113-24. 2010
    ..Furthermore, we show that cyclin D1 and JAG1 expression correlate in TN breast cancer expression datasets. These data suggest a model whereby JAG1 promotes cyclin D1-mediated proliferation of TN breast cancers...
  13. doi request reprint Notch signaling pathway as a therapeutic target in breast cancer
    Hamed Al-Hussaini
    University of Toronto, Princess Margaret Hospital, 610 University Avenue, Suite 5 222, Toronto, Ontario, M5G 2M9
    Mol Cancer Ther 10:9-15. 2011
    ..Several clinical trials are currently underway to determine if targeting the Notch pathway with drugs such as the γ-secretase inhibitors may be an effective therapeutic strategy that improves outcomes in this disease...
  14. ncbi request reprint JAG1 expression is associated with a basal phenotype and recurrence in lymph node-negative breast cancer
    Michael Reedijk
    Department of Surgical Oncology, University of Toronto, Toronto, ON, Canada, M5G 2M9
    Breast Cancer Res Treat 111:439-48. 2008
    ..As JAG1 is a target of several oncogenic signaling pathways, and is a ligand for Notch, these data provide novel insights into signaling that may contribute to progression of early stage breast cancer...
  15. ncbi request reprint High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival
    Michael Reedijk
    Program in Developmental Biology, The Hospital for Sick Children, Toronto, Ontario, Canada
    Cancer Res 65:8530-7. 2005
    ....
  16. ncbi request reprint High-level JAG1 mRNA and protein predict poor outcome in breast cancer
    Brendan C Dickson
    Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada
    Mod Pathol 20:685-93. 2007
    ....