ROSEMARY REDFIELD

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. ncbi request reprint Do bacteria have sex?
    R J Redfield
    Rosemary J Redfield is at the Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4
    Nat Rev Genet 2:634-9. 2001
  2. ncbi request reprint Is quorum sensing a side effect of diffusion sensing?
    Rosemary J Redfield
    Dept of Zoology, University of British Columbia, Vancouver, BC, Canada
    Trends Microbiol 10:365-70. 2002
  3. ncbi request reprint A novel CRP-dependent regulon controls expression of competence genes in Haemophilus influenzae
    Rosemary J Redfield
    Department of Zoology, University of British Columbia, Vancouver, Canada V6T 1Z4
    J Mol Biol 347:735-47. 2005
  4. pmc RNA secondary structure regulates the translation of sxy and competence development in Haemophilus influenzae
    Andrew D S Cameron
    Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada
    Nucleic Acids Res 36:10-20. 2008
  5. pmc Non-canonical CRP sites control competence regulons in Escherichia coli and many other gamma-proteobacteria
    Andrew D S Cameron
    Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada
    Nucleic Acids Res 34:6001-14. 2006
  6. pmc Sxy induces a CRP-S regulon in Escherichia coli
    Sunita Sinha
    Department of Zoology, University of British Columbia, Life Sciences Center, Vancouver, Canada
    J Bacteriol 191:5180-95. 2009
  7. doi request reprint CRP binding and transcription activation at CRP-S sites
    Andrew D S Cameron
    Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada
    J Mol Biol 383:313-23. 2008
  8. pmc The availability of purine nucleotides regulates natural competence by controlling translation of the competence activator Sxy
    Sunita Sinha
    Department of Zoology, University of British Columbia, Vancouver, V6T 3Z4, Canada
    Mol Microbiol 88:1106-19. 2013
  9. pmc Evolution of competence and DNA uptake specificity in the Pasteurellaceae
    Rosemary J Redfield
    Dept of Zoology, University of British Columbia, Vancouver, BC, Canada
    BMC Evol Biol 6:82. 2006
  10. ncbi request reprint Transformation of Haemophilus influenzae
    Grant Poje
    Department of Zoology, University of British Columbia, Vancouver, B C, Canada
    Methods Mol Med 71:57-70. 2003

Research Grants

  1. EVOLUTION OF DNA UPTAKE IN HAEMOPHILUS AND NEISSERIA
    ROSEMARY REDFIELD; Fiscal Year: 2003

Collaborators

Detail Information

Publications14

  1. ncbi request reprint Do bacteria have sex?
    R J Redfield
    Rosemary J Redfield is at the Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z4
    Nat Rev Genet 2:634-9. 2001
    ..However, this assumption has been perpetuated by generations of biology, microbiology and genetics textbooks without ever being critically examined...
  2. ncbi request reprint Is quorum sensing a side effect of diffusion sensing?
    Rosemary J Redfield
    Dept of Zoology, University of British Columbia, Vancouver, BC, Canada
    Trends Microbiol 10:365-70. 2002
    ..This diffusion sensing allows cells to regulate secretion of degradative enzymes and other effectors to minimize losses owing to extracellular diffusion and mixing...
  3. ncbi request reprint A novel CRP-dependent regulon controls expression of competence genes in Haemophilus influenzae
    Rosemary J Redfield
    Department of Zoology, University of British Columbia, Vancouver, Canada V6T 1Z4
    J Mol Biol 347:735-47. 2005
    ..Natural selection has united these 25 genes under a common regulatory mechanism. Elucidating this mechanism, and the functions of the genes, will provide a valuable window into the evolutionary function of natural competence...
  4. pmc RNA secondary structure regulates the translation of sxy and competence development in Haemophilus influenzae
    Andrew D S Cameron
    Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada
    Nucleic Acids Res 36:10-20. 2008
    ..Thus, mRNA secondary structure is responsive to conditions where DNA uptake will be favorable, and transcription of sxy is simultaneously enhanced if CRP activation signals that energy supplies are limited...
  5. pmc Non-canonical CRP sites control competence regulons in Escherichia coli and many other gamma-proteobacteria
    Andrew D S Cameron
    Department of Microbiology and Immunology, University of British Columbia, Vancouver, BC, Canada
    Nucleic Acids Res 34:6001-14. 2006
    ..This work suggests not only that the gamma-proteobacteria share a common DNA uptake mechanism, but also that, in the three best studied families, their competence regulons share both CRP-S specificity and Sxy dependence...
  6. pmc Sxy induces a CRP-S regulon in Escherichia coli
    Sunita Sinha
    Department of Zoology, University of British Columbia, Life Sciences Center, Vancouver, Canada
    J Bacteriol 191:5180-95. 2009
    ..coli Sxy regulon, induction was dramatically improved when it was coexpressed with its cognate CRP, suggesting that intimate interactions between Sxy and CRP are required for transcriptional activation at CRP-S sites...
  7. doi request reprint CRP binding and transcription activation at CRP-S sites
    Andrew D S Cameron
    Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada
    J Mol Biol 383:313-23. 2008
    ....
  8. pmc The availability of purine nucleotides regulates natural competence by controlling translation of the competence activator Sxy
    Sunita Sinha
    Department of Zoology, University of British Columbia, Vancouver, V6T 3Z4, Canada
    Mol Microbiol 88:1106-19. 2013
    ..Similar regulation occurs in the relatives of H. influenzae, Actinobacillus pneumoniae and A. suis, confirming the importance of processes enabling competent bacteria to exploit the abundant DNA in their environments...
  9. pmc Evolution of competence and DNA uptake specificity in the Pasteurellaceae
    Rosemary J Redfield
    Dept of Zoology, University of British Columbia, Vancouver, BC, Canada
    BMC Evol Biol 6:82. 2006
    ..We used the distribution of competence genes and DNA uptake specificity in H. influenzae's family, the Pasteurellaceae, to examine the ancestry of competence...
  10. ncbi request reprint Transformation of Haemophilus influenzae
    Grant Poje
    Department of Zoology, University of British Columbia, Vancouver, B C, Canada
    Methods Mol Med 71:57-70. 2003
  11. ncbi request reprint General methods for culturing Haemophilus influenzae
    Grant Poje
    Department of Zoology, University of British Columbia, Vancouver, B C, Canada
    Methods Mol Med 71:51-6. 2003
  12. doi request reprint Extensive variation in natural competence in Haemophilus influenzae
    Heather Maughan
    Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada
    Evolution 63:1852-66. 2009
    ..These results show that strains can differ considerably in the amount of DNA they take up and recombine, indicating that the benefit associated with competence is likely to vary in space and/or time...
  13. pmc Tracing the evolution of competence in Haemophilus influenzae
    Heather Maughan
    Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada
    PLoS ONE 4:e5854. 2009
    ..In some strains, changes in transformation have occurred that cannot be due to changes in DNA uptake, suggesting that selection can act on transformation independent of DNA uptake...
  14. pmc Natural transformation and DNA uptake signal sequences in Actinobacillus actinomycetemcomitans
    Ying Wang
    University of Southern California School of Dentistry, Los Angeles, California 90089, USA
    J Bacteriol 184:3442-9. 2002
    ..Finally, we have taken advantage of this system to develop a simple, highly efficient competence-based method for generating site-directed mutations in the wild-type fimbriated A. actinomycetemcomitans...

Research Grants4

  1. EVOLUTION OF DNA UPTAKE IN HAEMOPHILUS AND NEISSERIA
    ROSEMARY REDFIELD; Fiscal Year: 2003
    ..If a protein can be identified, it will be sequenced. Attempts will also be made to determine whether the USS are protected in nucleoids. ..