Jonathan P Rast


Affiliation: University of Toronto
Country: Canada


  1. request reprint
    Rast J, Messier Solek C. Marine invertebrate genome sequences and our evolving understanding of animal immunity. Biol Bull. 2008;214:274-83 pubmed
    ..In this review we summarize these findings with particular attention toward immunity in Strongylocentrotus purpuratus, the purple sea urchin, and outline the changing perspective on the evolution of deuterostome immunity...
  2. Schrankel C, Solek C, Buckley K, Anderson M, Rast J. A conserved alternative form of the purple sea urchin HEB/E2-2/E2A transcription factor mediates a switch in E-protein regulatory state in differentiating immune cells. Dev Biol. 2016;416:149-161 pubmed publisher
    ..Collectively, these findings reorient our understanding of the evolution of this transcription factor family and highlight fundamental properties of E-protein biology. ..
  3. Rast J, Smith L, Loza Coll M, Hibino T, Litman G. Genomic insights into the immune system of the sea urchin. Science. 2006;314:952-6 pubmed
    ..The findings serve to underscore the dynamic utilization of receptors and the complexity of immune recognition that may be basal for deuterostomes and predicts features of the ancestral bilaterian form...