Rithwik Ramachandran

Summary

Affiliation: University of Calgary
Country: Canada

Publications

  1. pmc TRPM8 activation attenuates inflammatory responses in mouse models of colitis
    Rithwik Ramachandran
    Department of Physiology and Pharmacology, Inflammation Research Network, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB, Canada T2N 4N1
    Proc Natl Acad Sci U S A 110:7476-81. 2013
  2. ncbi Developing PAR1 antagonists: minding the endothelial gap
    Rithwik Ramachandran
    Department of Physiology and Pharmacology, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N4N1, Canada
    Discov Med 13:425-31. 2012
  3. doi Targeting proteinase-activated receptors: therapeutic potential and challenges
    Rithwik Ramachandran
    Department of Physiology and Pharmacology, Faculty of Medicine, University of Calgary, Alberta T2N 4N1, Canada
    Nat Rev Drug Discov 11:69-86. 2012
  4. pmc Neutrophil elastase acts as a biased agonist for proteinase-activated receptor-2 (PAR2)
    Rithwik Ramachandran
    Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    J Biol Chem 286:24638-48. 2011
  5. ncbi Implantation serine proteinase 2 is a monomeric enzyme with mixed serine proteolytic activity and can silence signalling via proteinase activated receptors
    Navneet Sharma
    a Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    Biochem Cell Biol 91:487-97. 2013
  6. doi Derivatized 2-furoyl-LIGRLO-amide, a versatile and selective probe for proteinase-activated receptor 2: binding and visualization
    Morley D Hollenberg
    Department of Pharmacology and Therapeutics, University of Calgary Faculty of Medicine, 3330 Hospital Drive NW, Calgary, AB T2N4N1, Canada
    J Pharmacol Exp Ther 326:453-62. 2008
  7. ncbi Proteinase-activated receptors (PARs): differential signalling by kallikrein-related peptidases KLK8 and KLK14
    Rithwik Ramachandran
    Department of Physiology and Pharmacology, University of Calgary, Faculty of Medicine, AB, Canada
    Biol Chem 393:421-7. 2012
  8. doi Insulin modulates protease-activated receptor 2 signaling: implications for the innate immune response
    Eric Hyun
    Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada
    J Immunol 184:2702-9. 2010
  9. pmc Agonist-biased signaling via proteinase activated receptor-2: differential activation of calcium and mitogen-activated protein kinase pathways
    Rithwik Ramachandran
    Department of Pharmacology and Therapeutics and Medicine, University of Calgary, Calgary, AB T2N4C2, Canada
    Mol Pharmacol 76:791-801. 2009
  10. pmc Implantation serine proteinase 1 exhibits mixed substrate specificity that silences signaling via proteinase-activated receptors
    Navneet Sharma
    Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Canada
    PLoS ONE 6:e27888. 2011

Collaborators

Detail Information

Publications16

  1. pmc TRPM8 activation attenuates inflammatory responses in mouse models of colitis
    Rithwik Ramachandran
    Department of Physiology and Pharmacology, Inflammation Research Network, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB, Canada T2N 4N1
    Proc Natl Acad Sci U S A 110:7476-81. 2013
    ..Our data document an anti-inflammatory role for TRPM8 activation, in part due to an inhibiton of neuropeptide release, pointing to a novel therapeutic target for colitis and other inflammatory diseases...
  2. ncbi Developing PAR1 antagonists: minding the endothelial gap
    Rithwik Ramachandran
    Department of Physiology and Pharmacology, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N4N1, Canada
    Discov Med 13:425-31. 2012
    ..This review provides an overview of the proteinase activated receptor family and focuses on the role of PAR1 in regulating the endothelial barrier integrity and its implication on developing PAR antagonists for anti-platelet therapy...
  3. doi Targeting proteinase-activated receptors: therapeutic potential and challenges
    Rithwik Ramachandran
    Department of Physiology and Pharmacology, Faculty of Medicine, University of Calgary, Alberta T2N 4N1, Canada
    Nat Rev Drug Discov 11:69-86. 2012
    ..In this Review we summarize the mechanisms by which PARs modulate cell function and the roles they can have in physiology and diseases. Furthermore, we provide an overview of possible strategies for developing PAR antagonists...
  4. pmc Neutrophil elastase acts as a biased agonist for proteinase-activated receptor-2 (PAR2)
    Rithwik Ramachandran
    Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    J Biol Chem 286:24638-48. 2011
    ..Our data illustrate a new mode of PAR regulation that involves biased PAR(2) signaling by neutrophil elastase and a disarming/silencing effect of cathepsin-G and proteinase-3...
  5. ncbi Implantation serine proteinase 2 is a monomeric enzyme with mixed serine proteolytic activity and can silence signalling via proteinase activated receptors
    Navneet Sharma
    a Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada
    Biochem Cell Biol 91:487-97. 2013
    ..The disarming and silencing of PARs by ISP2 may play a role in successful embryo implantation. ..
  6. doi Derivatized 2-furoyl-LIGRLO-amide, a versatile and selective probe for proteinase-activated receptor 2: binding and visualization
    Morley D Hollenberg
    Department of Pharmacology and Therapeutics, University of Calgary Faculty of Medicine, 3330 Hospital Drive NW, Calgary, AB T2N4N1, Canada
    J Pharmacol Exp Ther 326:453-62. 2008
    ..We conclude that ornithine-derivatized 2fLI peptides are conveniently synthesized PAR2 probes that will be of value for future studies of receptor binding and visualization...
  7. ncbi Proteinase-activated receptors (PARs): differential signalling by kallikrein-related peptidases KLK8 and KLK14
    Rithwik Ramachandran
    Department of Physiology and Pharmacology, University of Calgary, Faculty of Medicine, AB, Canada
    Biol Chem 393:421-7. 2012
    ..Thus, KLK8 and KLK14 can signal differentially via the PARs to affect tissue function...
  8. doi Insulin modulates protease-activated receptor 2 signaling: implications for the innate immune response
    Eric Hyun
    Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada
    J Immunol 184:2702-9. 2010
    ..Our data point to an anti-inflammatory action of insulin that targets the acute innate inflammatory response triggered by PAR(2)...
  9. pmc Agonist-biased signaling via proteinase activated receptor-2: differential activation of calcium and mitogen-activated protein kinase pathways
    Rithwik Ramachandran
    Department of Pharmacology and Therapeutics and Medicine, University of Calgary, Calgary, AB T2N4C2, Canada
    Mol Pharmacol 76:791-801. 2009
    ..Thus, PAR(2) can signal to multiple pathways that are differentially triggered by distinct proteinase-revealed TLs or by synthetic signal-selective activating peptides...
  10. pmc Implantation serine proteinase 1 exhibits mixed substrate specificity that silences signaling via proteinase-activated receptors
    Navneet Sharma
    Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Canada
    PLoS ONE 6:e27888. 2011
    ..We observed that ISP1 silenced enzyme-triggered PAR signaling by receptor-disarming. This PAR-disarming action of ISP1 may be important for embryo development and implantation...
  11. doi Proteinases as hormones: targets and mechanisms for proteolytic signaling
    Kristina K Hansen
    Proteinases and Inflammation Network, University of Calgary Faculty of Medicine, Calgary T2N 4N1, AB, Canada
    Biol Chem 389:971-82. 2008
    ..Further, proteinases can be considered as physiologically relevant 'hormone-like' messengers that can convey signals locally or systemically either via PARs or by other mechanisms...
  12. ncbi MicroRNA profiling reveals new aspects of HIV neurodegeneration: caspase-6 regulates astrocyte survival
    Farshid Noorbakhsh
    Department of Medicine Neurology, University of Alberta, Edmonton, AB, Canada
    FASEB J 24:1799-812. 2010
    ..Overall, these data point to previously unrecognized alterations in miRNA profile in the brain during HIV infection, which contribute to cell death through dysregulation of cell death machinery...
  13. ncbi Mechanisms behind the anti-inflammatory actions of insulin
    Eric Hyun
    Department of Physiology and Pharmacology, University of Calgary, Canada
    Crit Rev Immunol 31:307-40. 2011
    ..Further, we discuss how the anti-inflammatory action of insulin bears on our current understanding of the pathophysiology and complications of both type 1 and type 2 diabetes...
  14. doi Kallikreins and proteinase-mediated signaling: proteinase-activated receptors (PARs) and the pathophysiology of inflammatory diseases and cancer
    Morley D Hollenberg
    Proteinases and Inflammation Network, Department of Pharmacology and Therapeutics, University of Calgary Faculty of Medicine, Calgary T2N 4N1, AB, Canada
    Biol Chem 389:643-51. 2008
    ....
  15. pmc Proteinase-activated receptors 1 and 2 and the regulation of porcine coronary artery contractility: a role for distinct tyrosine kinase pathways
    Mahmoud El-Daly
    Libin Cardiovascular Institute of Alberta and the Snyder Institute for Chronic Diseases, Calgary, AB, Canada Department of Physiology and Pharmacology, The University of Calgary Faculty of Medicine, Calgary, AB, Canada
    Br J Pharmacol 171:2413-25. 2014
    ....
  16. ncbi Proteinase-activated receptor-2 activating peptides: distinct canine coronary artery receptor systems
    Mahmoud Saifeddine
    Department of Pharmacology and Therapeutics, University of Calgary Faculty of Medicine, 3330 Hospital Drive N W, Calgary, Alberta, Canada
    Am J Physiol Heart Circ Physiol 293:H3279-89. 2007
    ....