G A Quamme

Summary

Affiliation: University of British Columbia
Country: Canada

Publications

  1. ncbi Epithelial magnesium transport and regulation by the kidney
    G A Quamme
    Department of Medicine, University of British Columbia, Vancouver, BC Canada
    Front Biosci 5:D694-711. 2000
  2. ncbi Identification and characterization of a novel mammalian Mg2+ transporter with channel-like properties
    Angela Goytain
    Department of Medicine University of British Columbia Vancouver, BC, Canada
    BMC Genomics 6:48. 2005
  3. ncbi Molecular identification of ancient and modern mammalian magnesium transporters
    Gary A Quamme
    Dept of Medicine, Vancouver Hospital and HSC, Koerner Pavilion, 2211 Wesbrook Mall, Vancouver, BC, Canada V6T 1Z3
    Am J Physiol Cell Physiol 298:C407-29. 2010
  4. ncbi Recent developments in intestinal magnesium absorption
    Gary A Quamme
    Department of Medicine, University of British Columbia, Vancouver, BC, Canada
    Curr Opin Gastroenterol 24:230-5. 2008
  5. ncbi ATP inhibits Mg(2+) uptake in MDCT cells via P2X purinoceptors
    L J Dai
    Department of Medicine, University of British Columbia, Vancouver Hospital and Health Sciences Centre, Vancouver, British Columbia, Canada V6T 1Z3
    Am J Physiol Renal Physiol 281:F833-40. 2001
  6. ncbi Functional characterization of ACDP2 (ancient conserved domain protein), a divalent metal transporter
    Angela Goytain
    Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Physiol Genomics 22:382-9. 2005
  7. ncbi 1,25(OH)(2)D(3) stimulates Mg2+ uptake into MDCT cells: modulation by extracellular Ca2+ and Mg2+
    G Ritchie
    Department of Medicine, University Hospital, University of British Columbia, Vancouver, British Columbia V6T 1Z3
    Am J Physiol Renal Physiol 280:F868-78. 2001
  8. ncbi Magnesium transport in the renal distal convoluted tubule
    L J Dai
    Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Physiol Rev 81:51-84. 2001
  9. ncbi Cellular mechanisms of chlorothiazide and cellular potassium depletion on Mg2+ uptake in mouse distal convoluted tubule cells
    L J Dai
    Department of Medicine, University of British Columbia, Vancouver, Canada
    Kidney Int 51:1008-17. 1997
  10. ncbi Acid-base changes alter Mg2+ uptake in mouse distal convoluted tubule cells
    L J Dai
    Department of Medicine, University of British Columbia, Vancouver Hospital, Canada
    Am J Physiol 272:F759-66. 1997

Collaborators

  • P A Friedman
  • G N Hendy
  • D E Cole
  • Angela Goytain
  • L J Dai
  • Rochelle M Hines
  • G Ritchie
  • H S Kang
  • D Kerstan
  • Shang-Jin Kim
  • Rujun Kang
  • Alaa El-Husseini
  • Jin-Shang Kim
  • Sang-Yeol Park
  • In-Shik Kim
  • Yong-Geun Kwak
  • Hyung-Sub Kang
  • Sung-Zoo Kim
  • Nam-Soo Kim
  • Chang-Woo Jeong
  • L Canaff
  • B Bapty
  • L Raymond

Detail Information

Publications20

  1. ncbi Epithelial magnesium transport and regulation by the kidney
    G A Quamme
    Department of Medicine, University of British Columbia, Vancouver, BC Canada
    Front Biosci 5:D694-711. 2000
    ..Research in the 90's have greatly contributed to our understanding of renal magnesium handling...
  2. ncbi Identification and characterization of a novel mammalian Mg2+ transporter with channel-like properties
    Angela Goytain
    Department of Medicine University of British Columbia Vancouver, BC, Canada
    BMC Genomics 6:48. 2005
    ..We have shown that epithelial magnesium conservation is controlled, in part, by differential gene expression leading to regulation of Mg2+ transport. We used this knowledge to identify a novel gene that is regulated by magnesium...
  3. ncbi Molecular identification of ancient and modern mammalian magnesium transporters
    Gary A Quamme
    Dept of Medicine, Vancouver Hospital and HSC, Koerner Pavilion, 2211 Wesbrook Mall, Vancouver, BC, Canada V6T 1Z3
    Am J Physiol Cell Physiol 298:C407-29. 2010
    ..It is anticipated that future research will identify other novel Mg(2+) transporters and reveal other diseases...
  4. ncbi Recent developments in intestinal magnesium absorption
    Gary A Quamme
    Department of Medicine, University of British Columbia, Vancouver, BC, Canada
    Curr Opin Gastroenterol 24:230-5. 2008
    ..The predominant Mg transporters include TRPM6 and TRPM7, members of the transient receptor potential melastatin family of cation channels. Mutations of TRPM6 result in a primary disorder termed hypomagnesemia with secondary hypocalcemia...
  5. ncbi ATP inhibits Mg(2+) uptake in MDCT cells via P2X purinoceptors
    L J Dai
    Department of Medicine, University of British Columbia, Vancouver Hospital and Health Sciences Centre, Vancouver, British Columbia, Canada V6T 1Z3
    Am J Physiol Renal Physiol 281:F833-40. 2001
    ..We conclude from this information that ATP inhibited Mg(2+) uptake in MDCT cells through P2X purinoceptors expressed in this distal convoluted tubule cell line...
  6. ncbi Functional characterization of ACDP2 (ancient conserved domain protein), a divalent metal transporter
    Angela Goytain
    Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Physiol Genomics 22:382-9. 2005
    ..These studies suggest that ACDP2 may provide a regulated transporter for Mg2+ and other divalent cations in epithelial cells...
  7. ncbi 1,25(OH)(2)D(3) stimulates Mg2+ uptake into MDCT cells: modulation by extracellular Ca2+ and Mg2+
    G Ritchie
    Department of Medicine, University Hospital, University of British Columbia, Vancouver, British Columbia V6T 1Z3
    Am J Physiol Renal Physiol 280:F868-78. 2001
    ..These data indicate that 1,25(OH)(2)D(3) has important effects on the control of magnesium entry in MDCT cells and these responses can be modulated by extracellular divalent cations...
  8. ncbi Magnesium transport in the renal distal convoluted tubule
    L J Dai
    Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Physiol Rev 81:51-84. 2001
    ..Although it is clear that many influences affect Mg(2+) transport within the DCT, the transport processes have not been identified...
  9. ncbi Cellular mechanisms of chlorothiazide and cellular potassium depletion on Mg2+ uptake in mouse distal convoluted tubule cells
    L J Dai
    Department of Medicine, University of British Columbia, Vancouver, Canada
    Kidney Int 51:1008-17. 1997
    ..We postulate that chronic chlorothiazide use may lead to hypokalemia that in turn diminishes Mg2+ transport in the distal tubule resulting in urinary magnesium-wasting...
  10. ncbi Acid-base changes alter Mg2+ uptake in mouse distal convoluted tubule cells
    L J Dai
    Department of Medicine, University of British Columbia, Vancouver Hospital, Canada
    Am J Physiol 272:F759-66. 1997
    ..0, -55 +/- 3%. Accordingly, MDCT cells become refractory to the stimulating effects of hyperpolarization at alkaline pH values. These studies show that protons may directly affect Mg2+ transport in MDCT cells...
  11. ncbi Functional characterization of human SLC41A1, a Mg2+ transporter with similarity to prokaryotic MgtE Mg2+ transporters
    Angela Goytain
    Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Physiol Genomics 21:337-42. 2005
    ..These studies suggest that SLC41A1 is a regulated Mg2+ transporter that might be involved in magnesium homeostasis in epithelial cells...
  12. ncbi Functional characterization of NIPA2, a selective Mg2+ transporter
    Angela Goytain
    Department of Medicine, Vancouver Hospital, Koerner Pavilion, 2211 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 1Z37
    Am J Physiol Cell Physiol 295:C944-53. 2008
    ..We conclude that NIPA2 plays a role in magnesium metabolism and regulation of renal magnesium conservation...
  13. ncbi Identification and characterization of a novel family of membrane magnesium transporters, MMgT1 and MMgT2
    Angela Goytain
    Department of Medicine, University of British Columbia, Vancouver, Canada
    Am J Physiol Cell Physiol 294:C495-502. 2008
    ..These experiments suggest that MMgT proteins may provide regulated pathways for Mg(2+) transport in the Golgi and post-Golgi organelles of epithelium-derived cells...
  14. ncbi Huntingtin-interacting proteins, HIP14 and HIP14L, mediate dual functions, palmitoyl acyltransferase and Mg2+ transport
    Angela Goytain
    Department of Medicine, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Biol Chem 283:33365-74. 2008
    ..We conclude that the huntingtin interacting protein genes, HIP14 and HIP14L, encode Mg2+ transport proteins that are regulated by their innate palmitoyl acyltransferases thus fulfilling the characteristics of "chanzymes."..
  15. ncbi Functional characterization of the mouse [corrected] solute carrier, SLC41A2
    Angela Goytain
    Department of Medicine, University of British Columbia, Vancouver, BC, Canada
    Biochem Biophys Res Commun 330:701-5. 2005
    ..These studies suggest that SLC41A2 is a Mg2+ transporter that might be involved in magnesium homeostasis in epithelial cells...
  16. ncbi NIPA1(SPG6), the basis for autosomal dominant form of hereditary spastic paraplegia, encodes a functional Mg2+ transporter
    Angela Goytain
    Department of Medicine and Department of Psychiatry, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Biol Chem 282:8060-8. 2007
    ..We conclude that NIPA1 normally encodes a Mg2+ transporter and the loss-of function of NIPA1(SPG6) due to abnormal trafficking of the mutated protein provides the basis of the HSP phenotype...
  17. ncbi Golgi-specific DHHC zinc finger protein GODZ mediates membrane Ca2+ transport
    Rochelle M Hines
    Department of Psychiatry, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada
    J Biol Chem 285:4621-8. 2010
    ..We conclude that GODZ encodes a Ca(2+) transport protein in addition to its ability to palmitoylate protein substrates...
  18. ncbi Adenosine modulates Mg(2+) uptake in distal convoluted tubule cells via A(1) and A(2) purinoceptors
    H S Kang
    Department of Medicine, University of British Columbia, Vancouver Hospital and Health Sciences Centre, Vancouver, British Columbia, Canada V6T 1Z3
    Am J Physiol Renal Physiol 281:F1141-7. 2001
    ..We conclude that adenosine has dual effects on Mg(2+) uptake in MDCT cells through separate A(1) and A(2) purinoceptor pathways...
  19. ncbi Na+/Ca2+ exchanger in epithelial cells of the porcine cortical thick ascending limb
    L J Dai
    Department of Medicine, University of British Columbia, Vancouver Hospital, Canada
    Am J Physiol 270:F411-8. 1996
    ..The results provide both functional and molecular evidence for a Na+/Ca2+ exchanger in thick ascending limb cells of the porcine kidney...
  20. ncbi Immunosuppressants inhibit hormone-stimulated Mg2+ uptake in mouse distal convoluted tubule cells
    Shang-Jin Kim
    College of Veterinary Medicine, Chonbuk National University, Jeonju 561-756, Republic of Korea
    Biochem Biophys Res Commun 341:742-8. 2006
    ....