David Proud

Summary

Affiliation: University of Calgary
Country: Canada

Publications

  1. ncbi Role of rhinovirus infections in asthma
    David Proud
    University of Calgary, Faculty of Medicine, HRIC 4AC60, 3280 Hospital Drive NW, Calgary, Alberta T2N 4Z6, Canada
    Asian Pac J Allergy Immunol 29:201-8. 2011
  2. pmc Cigarette smoke enhances human rhinovirus-induced CXCL8 production via HuR-mediated mRNA stabilization in human airway epithelial cells
    Magdalena H Hudy
    Department of Physiology and Pharmacology, HRIC 4AC60, University of Calgary Faculty of Medicine, 3280 Hospital Drive N, W, Calgary, AB T2N 4Z6, Canada
    Respir Res 14:88. 2013
  3. pmc Cigarette smoke modulates expression of human rhinovirus-induced airway epithelial host defense genes
    David Proud
    Airway Inflammation Research Group, Department of Physiology and Pharmacology, Snyder Institute for Chronic Diseases, University of Calgary Faculty of Medicine, Calgary, Alberta, Canada
    PLoS ONE 7:e40762. 2012
  4. doi Reproducibility of nasal allergen challenge in evaluating the efficacy of intranasal corticosteroid treatment
    D Proud
    Johns Hopkins Asthma and Allergy Center, Baltimore, MD, USA
    Clin Exp Allergy 40:738-44. 2010
  5. doi Gene expression profiles during in vivo human rhinovirus infection: insights into the host response
    David Proud
    Department of Physiology and Biophysics, Health Sciences 1626, University of Calgary Faculty of Medicine, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1 Canada
    Am J Respir Crit Care Med 178:962-8. 2008
  6. ncbi Human rhinovirus infection induces airway epithelial cell production of human beta-defensin 2 both in vitro and in vivo
    David Proud
    Respiratory Research Group and Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
    J Immunol 172:4637-45. 2004
  7. ncbi Upper airway viral infections
    David Proud
    Airway Inflammation Group and Institute of Infection, Immunity and Inflammation, University of Calgary, Alberta, Canada
    Pulm Pharmacol Ther 21:468-73. 2008
  8. ncbi Role of viral infections in asthma and chronic obstructive pulmonary disease
    David Proud
    Department of Physiology and Biophysics, University of Calgary, HSC 1627, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1 Canada
    Am J Respir Cell Mol Biol 35:513-8. 2006
  9. doi Epithelial cells and airway diseases
    David Proud
    Department of Physiology and Pharmacology, University of Calgary Faculty of Medicine, Calgary, AB, Canada
    Immunol Rev 242:186-204. 2011
  10. ncbi Nitric oxide and the common cold
    David Proud
    Respiratory Research Group and Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
    Curr Opin Allergy Clin Immunol 5:37-42. 2005

Collaborators

Detail Information

Publications36

  1. ncbi Role of rhinovirus infections in asthma
    David Proud
    University of Calgary, Faculty of Medicine, HRIC 4AC60, 3280 Hospital Drive NW, Calgary, Alberta T2N 4Z6, Canada
    Asian Pac J Allergy Immunol 29:201-8. 2011
    ..The current article reviews our current state of knowledge in these areas...
  2. pmc Cigarette smoke enhances human rhinovirus-induced CXCL8 production via HuR-mediated mRNA stabilization in human airway epithelial cells
    Magdalena H Hudy
    Department of Physiology and Pharmacology, HRIC 4AC60, University of Calgary Faculty of Medicine, 3280 Hospital Drive N, W, Calgary, AB T2N 4Z6, Canada
    Respir Res 14:88. 2013
    ..Here we further investigate the mechanisms by which HRV+CSE enhances CXCL8 expression...
  3. pmc Cigarette smoke modulates expression of human rhinovirus-induced airway epithelial host defense genes
    David Proud
    Airway Inflammation Research Group, Department of Physiology and Pharmacology, Snyder Institute for Chronic Diseases, University of Calgary Faculty of Medicine, Calgary, Alberta, Canada
    PLoS ONE 7:e40762. 2012
    ..These changes were not associated with altered expression of type I or type III interferons. Thus, CSE alters epithelial responses to HRV infection in a manner that may negatively impact antiviral and host defense outcomes...
  4. doi Reproducibility of nasal allergen challenge in evaluating the efficacy of intranasal corticosteroid treatment
    D Proud
    Johns Hopkins Asthma and Allergy Center, Baltimore, MD, USA
    Clin Exp Allergy 40:738-44. 2010
    ....
  5. doi Gene expression profiles during in vivo human rhinovirus infection: insights into the host response
    David Proud
    Department of Physiology and Biophysics, Health Sciences 1626, University of Calgary Faculty of Medicine, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1 Canada
    Am J Respir Crit Care Med 178:962-8. 2008
    ..Human rhinovirus infections cause colds and trigger exacerbations of lower airway diseases...
  6. ncbi Human rhinovirus infection induces airway epithelial cell production of human beta-defensin 2 both in vitro and in vivo
    David Proud
    Respiratory Research Group and Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
    J Immunol 172:4637-45. 2004
    ..This represents the first demonstration that HRV infection induces epithelial expression of HBD-2 both in vitro and in vivo, and supports the concept that HBD-2 may play a role in host defense to HRV infection...
  7. ncbi Upper airway viral infections
    David Proud
    Airway Inflammation Group and Institute of Infection, Immunity and Inflammation, University of Calgary, Alberta, Canada
    Pulm Pharmacol Ther 21:468-73. 2008
    ..We will also consider current and potential therapeutic approaches for the treatment of URI and their lower airway complications...
  8. ncbi Role of viral infections in asthma and chronic obstructive pulmonary disease
    David Proud
    Department of Physiology and Biophysics, University of Calgary, HSC 1627, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1 Canada
    Am J Respir Cell Mol Biol 35:513-8. 2006
    ..A better understanding of the mechanisms underlying viral modulation of these diseases, therefore, may lead to new therapeutic approaches...
  9. doi Epithelial cells and airway diseases
    David Proud
    Department of Physiology and Pharmacology, University of Calgary Faculty of Medicine, Calgary, AB, Canada
    Immunol Rev 242:186-204. 2011
    ..Finally, the concept that the epithelium is a major target for the actions of a number of classes of inhaled medications is discussed, as are the potential mechanisms by which selected drugs may alter epithelial function...
  10. ncbi Nitric oxide and the common cold
    David Proud
    Respiratory Research Group and Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
    Curr Opin Allergy Clin Immunol 5:37-42. 2005
    ..There is growing interest in host innate defence responses that may regulate the severity of viral responses. We will review recent evidence that nitric oxide is an important contributor to the host response during colds...
  11. doi Nitric oxide inhibits human rhinovirus-induced transcriptional activation of CXCL10 in airway epithelial cells
    Rommy Koetzler
    Airway Inflammation Group, Institute of Infection, Immunity and Inflammation, University of Calgary, Calgary, Alberta, Canada
    J Allergy Clin Immunol 123:201-208.e9. 2009
    ..Nitric oxide (NO) inhibits HRV replication in human airway epithelial cells and suppresses HRV-induced epithelial production of several cytokines and chemokines...
  12. doi Rhinovirus-induced MMP-9 expression is dependent on Fra-1, which is modulated by formoterol and dexamethasone
    Claire E Tacon
    Airway Inflammation Research Group, Snyder Institute for Chronic Diseases, Department of Medicine, University of Calgary, Calgary, Alberta T2N 4Z6, Canada
    J Immunol 188:4621-30. 2012
    ..Together, these results offer insights into the mechanisms by which long-acting β(2)-agonists and glucocorticoids might reduce HRV-related asthma exacerbations...
  13. doi Human rhinovirus infection enhances airway epithelial cell production of growth factors involved in airway remodeling
    Richard Leigh
    Airway Inflammation Research Group, Department of Medicine, Institute of Infection, Immunity and Inflammation, University of Calgary, Calgary, Alberta, Canada
    J Allergy Clin Immunol 121:1238-1245.e4. 2008
    ..We reasoned that HRV infections might be important in the pathogenesis of airway remodeling, thereby providing a mechanism by which these children are at risk of asthma...
  14. doi Human rhinovirus-induced epithelial production of CXCL10 is dependent upon IFN regulatory factor-1
    Raza S Zaheer
    Airway Inflammation Group, Institute of Infection, Immunity and Inflammation, and Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada
    Am J Respir Cell Mol Biol 43:413-21. 2010
    ..We conclude that HRV-16-induced CXCL10 production is dependent upon IRF-1, and that the MEK1 pathway-dependent suppression of CXCL10 expression is also mediated via effects on IRF-1...
  15. doi Human rhinovirus infection up-regulates MMP-9 production in airway epithelial cells via NF-{kappa}B
    Claire E Tacon
    Department of Medicine, Snyder Institute of Infection, Immunity, and Inflammation, University of Calgary, Alberta, Canada
    Am J Respir Cell Mol Biol 43:201-9. 2010
    ..This increase in MMP-9 may be a mechanism by which rhinovirus infections contribute to airway inflammation and, potentially, to airway remodeling...
  16. doi Nitric oxide inhibits IFN regulatory factor 1 and nuclear factor-kappaB pathways in rhinovirus-infected epithelial cells
    Rommy Koetzler
    Airway Inflammation Group, Institute of Infection, Immunity and Inflammation, University of Calgary, Calgary, Alberta, Canada
    J Allergy Clin Immunol 124:551-7. 2009
    ....
  17. doi Selective transcriptional down-regulation of human rhinovirus-induced production of CXCL10 from airway epithelial cells via the MEK1 pathway
    Raza S Zaheer
    Airway Inflammation Group, Institute of Infection, Immunity and Inflammation, University of Calgary, Calgary, Alberta, Canada
    J Immunol 182:4854-64. 2009
    ..We conclude that activation of MEK1 selectively down-regulates HRV-16-induced expression of CXCL10 via modulation of IRF-1 interactions with the gene promoter in human airway epithelial cells...
  18. doi Selective prostacyclin receptor agonism augments glucocorticoid-induced gene expression in human bronchial epithelial cells
    Sylvia M Wilson
    Department of Physiology and Pharmacology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
    J Immunol 183:6788-99. 2009
    ..This observation may have clinical relevance in the treatment of airway inflammatory diseases that are either refractory or respond suboptimally to glucocorticoids...
  19. ncbi Human airway epithelial cells produce IP-10 (CXCL10) in vitro and in vivo upon rhinovirus infection
    Jason C L Spurrell
    Respiratory Research Group and Department of Physiology and Biophysics, University of Calgary, Alberta
    Am J Physiol Lung Cell Mol Physiol 289:L85-95. 2005
    ..Levels of IP-10 correlated with symptom severity, viral titer, and numbers of lymphocytes in airway secretions. Thus IP-10 may play a role in the pathogenesis of HRV-induced colds and in HRV-induced exacerbations of COPD and asthma...
  20. doi Modulation of transcriptional responses by poly(I:C) and human rhinovirus: effect of long-acting β₂-adrenoceptor agonists
    Christopher F Rider
    Airways Inflammation Research Group, Snyder Institute for Chronic Diseases, Faculty of Medicine, University of Calgary, Calgary, 3330 Hospital Drive NW, AB, Canada T2N 4N1
    Eur J Pharmacol 708:60-7. 2013
    ....
  21. ncbi Interleukin-17A modulates human airway epithelial responses to human rhinovirus infection
    Shahina Wiehler
    Airway Inflammation Group, Institute for Infection, Immunity and Inflammation, University of Calgary, Calgary, Alberta, Canada
    Am J Physiol Lung Cell Mol Physiol 293:L505-15. 2007
    ....
  22. doi Rhinovirus has the unique ability to directly activate human T cells in vitro
    Ramses Ilarraza
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    J Allergy Clin Immunol 131:395-404. 2013
    ..These findings suggested that antigen presentation was important for T-cell activation...
  23. pmc Induction of B7-H1 and B7-DC expression on airway epithelial cells by the Toll-like receptor 3 agonist double-stranded RNA and human rhinovirus infection: In vivo and in vitro studies
    Lowella Heinecke
    Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
    J Allergy Clin Immunol 121:1155-60. 2008
    ..Viral infections are an important cause of disease exacerbations. We have found virus-induced expression of T cell-interacting ligands, B7 homolog costimulatory molecules, on airway epithelium...
  24. ncbi Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IkappaB kinase inhibitors
    Robert Newton
    Department of Cell Biology and Anatomy, Respiratory Research Group, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
    J Pharmacol Exp Ther 321:734-42. 2007
    ....
  25. ncbi Epithelial shedding is associated with nasal reactions to cold, dry air
    Alvaro A Cruz
    Johns Hopkins Asthma and Allergy Center, Johns Hopkins University, Baltimore, MD 21224 6801, USA
    J Allergy Clin Immunol 117:1351-8. 2006
    ..One hypothesis is that the respiratory mucosa of individuals with CDA sensitivity cannot compensate for the loss of water that occurs on exposure to the stimulus, leading to epithelial damage...
  26. doi Role of IL-17A and neutrophils in fibrosis in experimental hypersensitivity pneumonitis
    Simon A Hasan
    Airway Inflammation Research Group, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, Alberta, Canada
    J Allergy Clin Immunol 131:1663-73. 2013
    ..Furthermore, the main cell type(s) that produce IL-17A in experimental hypersensitivity pneumonitis have not yet been identified...
  27. ncbi Viral-associated exacerbations of asthma and COPD
    Suzanne L Traves
    Department of Physiology and Biophysics, University of Calgary, HSC1627, NW Calgary, Alberta T2N 4N1, Canada
    Curr Opin Pharmacol 7:252-8. 2007
    ..A more comprehensive understanding of the molecular basis of these processes could elucidate new therapeutic approaches to reduce the devastating impact that these exacerbations have on quality of life and healthcare costs...
  28. ncbi Role of nasal nitric oxide in the resolution of experimental rhinovirus infection
    Scherer P Sanders
    Divisions of Pulmonary and Critical Care Medicine, Department of Medicine, Asthma and Allergy Center, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
    J Allergy Clin Immunol 113:697-702. 2004
    ..Previous studies have shown that HRV infection in human subjects increased nasal epithelial expression of type 2 nitric oxide synthase (NOS2), an isoform of the enzyme that produces NO...
  29. doi The effects of the nasal antihistamines olopatadine and azelastine in nasal allergen provocation
    Patrik Pipkorn
    Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    Ann Allergy Asthma Immunol 101:82-9. 2008
    ..Olopatadine, an antihistamine used in allergic conjunctivitis, is under development as a nasal preparation for the treatment of allergic rhinitis...
  30. ncbi 4,5-Dihydro-1H-imidazol-2-yl)-[4-(4-isopropoxy-benzyl)-phenyl]-amine (RO1138452) is a selective, pseudo-irreversible orthosteric antagonist at the prostacyclin (IP)-receptor expressed by human airway epithelial cells: IP-receptor-mediated inhibition of CX
    Linda M Ayer
    Department of Pharmacology and Therapeutics, Airways Inflammation Group, Institute of Infection, Immunity and Inflammation, University of Calgary, 3330 Hospital Dr N W, Calgary, AB, Canada
    J Pharmacol Exp Ther 324:815-26. 2008
    ..Moreover, contrary to existing literature, RO1138452 behaved pseudoirreversibly, emphasizing the need, in drug discovery, to screen potential new medicines in the target tissue(s) of interest...
  31. ncbi The role of defensins in virus-induced asthma
    David Proud
    Department of Physiology and Biophysics, HSC 1627, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada dproud ucalgary ca
    Curr Allergy Asthma Rep 6:81-5. 2006
    ..They also have the capacity to modulate adaptive immunity and to contribute to airway remodeling. In this article, recent advances in these areas are reviewed in the context of the potential role of defensins in virus-induced asthma...
  32. doi Transcriptional and Epigenetic Modulation of Human Rhinovirus-Induced CXCL10 Production by Cigarette Smoke
    Magdalena H Hudy
    Airways Inflammation Research Group, Snyder Institute for Chronic Diseases, University of Calgary, Faculty of Medicine, Calgary, Alberta, Canada
    Am J Respir Cell Mol Biol 50:571-82. 2014
    ..Thus, we show that CSE can simultaneously modulate multiple pathways linked to innate immune responses to HRV infection. ..
  33. ncbi Chronic arthritis down-regulates peripheral mu-opioid receptor expression with concomitant loss of endomorphin 1 antinociception
    Zongming Li
    University of Calgary, Calgary, Alberta, Canada
    Arthritis Rheum 52:3210-9. 2005
    ..To determine whether peripheral administration of the endogenous mu-opioid peptide endomorphin 1 could reduce knee joint pain, using animal models of acute and chronic arthritis...
  34. doi Cigarette smoke modulates rhinovirus-induced airway epithelial cell chemokine production
    M H Hudy
    Airway Inflammation Group, Institute of Infection, Immunity and Inflammation and Dept of Physiology and Pharmacology, University of Calgary, Calgary, AB, Canada
    Eur Respir J 35:1256-63. 2010
    ..Thus, CSE differentially modulates HRV-16-induced chemokine production from human airway epithelial cells in a manner that might be expected to alter inflammatory cell profiles...
  35. ncbi Syk is downstream of intercellular adhesion molecule-1 and mediates human rhinovirus activation of p38 MAPK in airway epithelial cells
    Xiaomin Wang
    Division of Respirology, University Health Network, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    J Immunol 177:6859-70. 2006
    ..Taken together, these observations identify Syk as an important mediator of the airway epithelial cell inflammatory response by modulating p38 phosphorylation and IL-8 gene expression following ICAM-1 engagement by HRV...
  36. ncbi Syk associates with clathrin and mediates phosphatidylinositol 3-kinase activation during human rhinovirus internalization
    Christine Lau
    Division of Respirology, Multi Organ Transplantation Programme, University Health Network, Department of Medicine, University of Toronto, Ontario, Canada
    J Immunol 180:870-80. 2008
    ..Together, these data reveal Syk to be an important mediator of HRV endocytosis and HRV-induced PI3K activation...