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Genomes and Genes | David ProudSummaryAffiliation: University of Calgary Country: Canada Publications
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Publications
Role of rhinovirus infections in asthmaDavid Proud
University of Calgary, Faculty of Medicine, HRIC 4AC60, 3280 Hospital Drive NW, Calgary, Alberta T2N 4Z6, Canada
Asian Pac J Allergy Immunol 29:201-8. 2011..The current article reviews our current state of knowledge in these areas...
Cigarette smoke modulates expression of human rhinovirus-induced airway epithelial host defense genesDavid Proud
Airway Inflammation Research Group, Department of Physiology and Pharmacology, Snyder Institute for Chronic Diseases, University of Calgary Faculty of Medicine, Calgary, Alberta, Canada
PLoS ONE 7:e40762. 2012..These changes were not associated with altered expression of type I or type III interferons. Thus, CSE alters epithelial responses to HRV infection in a manner that may negatively impact antiviral and host defense outcomes...
Epithelial cells and airway diseasesDavid Proud
Department of Physiology and Pharmacology, University of Calgary Faculty of Medicine, Calgary, AB, Canada
Immunol Rev 242:186-204. 2011..Finally, the concept that the epithelium is a major target for the actions of a number of classes of inhaled medications is discussed, as are the potential mechanisms by which selected drugs may alter epithelial function...- Reproducibility of nasal allergen challenge in evaluating the efficacy of intranasal corticosteroid treatmentD Proud
Johns Hopkins Asthma and Allergy Center, Baltimore, MD, USA
Clin Exp Allergy 40:738-44. 2010.... - Gene expression profiles during in vivo human rhinovirus infection: insights into the host responseDavid Proud
Department of Physiology and Biophysics, Health Sciences 1626, University of Calgary Faculty of Medicine, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1 Canada
Am J Respir Crit Care Med 178:962-8. 2008..Human rhinovirus infections cause colds and trigger exacerbations of lower airway diseases... - Human rhinovirus infection induces airway epithelial cell production of human beta-defensin 2 both in vitro and in vivoDavid Proud
Respiratory Research Group and Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
J Immunol 172:4637-45. 2004..This represents the first demonstration that HRV infection induces epithelial expression of HBD-2 both in vitro and in vivo, and supports the concept that HBD-2 may play a role in host defense to HRV infection... - Upper airway viral infectionsDavid Proud
Airway Inflammation Group and Institute of Infection, Immunity and Inflammation, University of Calgary, Alberta, Canada
Pulm Pharmacol Ther 21:468-73. 2008..We will also consider current and potential therapeutic approaches for the treatment of URI and their lower airway complications... - Role of viral infections in asthma and chronic obstructive pulmonary diseaseDavid Proud
Department of Physiology and Biophysics, University of Calgary, HSC 1627, 3330 Hospital Drive NW, Calgary, AB, T2N 4N1 Canada
Am J Respir Cell Mol Biol 35:513-8. 2006..A better understanding of the mechanisms underlying viral modulation of these diseases, therefore, may lead to new therapeutic approaches... - Nitric oxide and the common coldDavid Proud
Respiratory Research Group and Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada
Curr Opin Allergy Clin Immunol 5:37-42. 2005..There is growing interest in host innate defence responses that may regulate the severity of viral responses. We will review recent evidence that nitric oxide is an important contributor to the host response during colds... - Nitric oxide inhibits human rhinovirus-induced transcriptional activation of CXCL10 in airway epithelial cellsRommy Koetzler
Airway Inflammation Group, Institute of Infection, Immunity and Inflammation, University of Calgary, Calgary, Alberta, Canada
J Allergy Clin Immunol 123:201-208.e9. 2009..Nitric oxide (NO) inhibits HRV replication in human airway epithelial cells and suppresses HRV-induced epithelial production of several cytokines and chemokines... - Rhinovirus-induced MMP-9 expression is dependent on Fra-1, which is modulated by formoterol and dexamethasoneClaire E Tacon
Airway Inflammation Research Group, Snyder Institute for Chronic Diseases, Department of Medicine, University of Calgary, Calgary, Alberta T2N 4Z6, Canada
J Immunol 188:4621-30. 2012..Together, these results offer insights into the mechanisms by which long-acting β(2)-agonists and glucocorticoids might reduce HRV-related asthma exacerbations... - Human rhinovirus infection enhances airway epithelial cell production of growth factors involved in airway remodelingRichard Leigh
Airway Inflammation Research Group, Department of Medicine, Institute of Infection, Immunity and Inflammation, University of Calgary, Calgary, Alberta, Canada
J Allergy Clin Immunol 121:1238-1245.e4. 2008..We reasoned that HRV infections might be important in the pathogenesis of airway remodeling, thereby providing a mechanism by which these children are at risk of asthma... - Human rhinovirus-induced epithelial production of CXCL10 is dependent upon IFN regulatory factor-1Raza S Zaheer
Airway Inflammation Group, Institute of Infection, Immunity and Inflammation, and Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada
Am J Respir Cell Mol Biol 43:413-21. 2010..We conclude that HRV-16-induced CXCL10 production is dependent upon IRF-1, and that the MEK1 pathway-dependent suppression of CXCL10 expression is also mediated via effects on IRF-1... - Human rhinovirus infection up-regulates MMP-9 production in airway epithelial cells via NF-{kappa}BClaire E Tacon
Department of Medicine, Snyder Institute of Infection, Immunity, and Inflammation, University of Calgary, Alberta, Canada
Am J Respir Cell Mol Biol 43:201-9. 2010..This increase in MMP-9 may be a mechanism by which rhinovirus infections contribute to airway inflammation and, potentially, to airway remodeling... - Nitric oxide inhibits IFN regulatory factor 1 and nuclear factor-kappaB pathways in rhinovirus-infected epithelial cellsRommy Koetzler
Airway Inflammation Group, Institute of Infection, Immunity and Inflammation, University of Calgary, Calgary, Alberta, Canada
J Allergy Clin Immunol 124:551-7. 2009.... - Selective prostacyclin receptor agonism augments glucocorticoid-induced gene expression in human bronchial epithelial cellsSylvia M Wilson
Department of Physiology and Pharmacology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada
J Immunol 183:6788-99. 2009..This observation may have clinical relevance in the treatment of airway inflammatory diseases that are either refractory or respond suboptimally to glucocorticoids... - Selective transcriptional down-regulation of human rhinovirus-induced production of CXCL10 from airway epithelial cells via the MEK1 pathwayRaza S Zaheer
Airway Inflammation Group, Institute of Infection, Immunity and Inflammation, University of Calgary, Calgary, Alberta, Canada
J Immunol 182:4854-64. 2009..We conclude that activation of MEK1 selectively down-regulates HRV-16-induced expression of CXCL10 via modulation of IRF-1 interactions with the gene promoter in human airway epithelial cells... - Human airway epithelial cells produce IP-10 (CXCL10) in vitro and in vivo upon rhinovirus infectionJason C L Spurrell
Respiratory Research Group and Department of Physiology and Biophysics, University of Calgary, Alberta
Am J Physiol Lung Cell Mol Physiol 289:L85-95. 2005..Levels of IP-10 correlated with symptom severity, viral titer, and numbers of lymphocytes in airway secretions. Thus IP-10 may play a role in the pathogenesis of HRV-induced colds and in HRV-induced exacerbations of COPD and asthma... - Interleukin-17A modulates human airway epithelial responses to human rhinovirus infectionShahina Wiehler
Airway Inflammation Group, Institute for Infection, Immunity and Inflammation, University of Calgary, Calgary, Alberta, Canada
Am J Physiol Lung Cell Mol Physiol 293:L505-15. 2007.... - Repression of inflammatory gene expression in human pulmonary epithelial cells by small-molecule IkappaB kinase inhibitorsRobert Newton
Department of Cell Biology and Anatomy, Respiratory Research Group, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
J Pharmacol Exp Ther 321:734-42. 2007.... - Induction of B7-H1 and B7-DC expression on airway epithelial cells by the Toll-like receptor 3 agonist double-stranded RNA and human rhinovirus infection: In vivo and in vitro studiesLowella Heinecke
Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
J Allergy Clin Immunol 121:1155-60. 2008..Viral infections are an important cause of disease exacerbations. We have found virus-induced expression of T cell-interacting ligands, B7 homolog costimulatory molecules, on airway epithelium... - Epithelial shedding is associated with nasal reactions to cold, dry airAlvaro A Cruz
Johns Hopkins Asthma and Allergy Center, Johns Hopkins University, Baltimore, MD 21224-6801, USA
J Allergy Clin Immunol 117:1351-8. 2006..CLINICAL IMPLICATIONS: A defect in mucosal water homeostasis may need to be considered in individuals who get excessive nasal symptoms when exposed to cold and dry, windy environment... - Viral-associated exacerbations of asthma and COPDSuzanne L Traves
Department of Physiology and Biophysics, University of Calgary, HSC1627, NW Calgary, Alberta T2N 4N1, Canada
Curr Opin Pharmacol 7:252-8. 2007..A more comprehensive understanding of the molecular basis of these processes could elucidate new therapeutic approaches to reduce the devastating impact that these exacerbations have on quality of life and healthcare costs... - Role of nasal nitric oxide in the resolution of experimental rhinovirus infectionScherer P Sanders
Divisions of Pulmonary and Critical Care Medicine, Department of Medicine, Asthma and Allergy Center, Johns Hopkins University School of Medicine, 5501 Hopkins Bayview Circle, Baltimore, MD 21224, USA
J Allergy Clin Immunol 113:697-702. 2004..CONCLUSIONS: We conclude that increased production of NO occurs as part of the host response to HRV infection and speculate that NO plays a beneficial role in viral clearance... - The effects of the nasal antihistamines olopatadine and azelastine in nasal allergen provocationPatrik Pipkorn
Division of Allergy and Clinical Immunology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
Ann Allergy Asthma Immunol 101:82-9. 2008..Olopatadine, an antihistamine used in allergic conjunctivitis, is under development as a nasal preparation for the treatment of allergic rhinitis... - The role of defensins in virus-induced asthmaDavid Proud
Department of Physiology and Biophysics, HSC 1627, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada. dproud @ucalgary.ca
Curr Allergy Asthma Rep 6:81-5. 2006..They also have the capacity to modulate adaptive immunity and to contribute to airway remodeling. In this article, recent advances in these areas are reviewed in the context of the potential role of defensins in virus-induced asthma... - 4,5-Dihydro-1H-imidazol-2-yl)-[4-(4-isopropoxy-benzyl)-phenyl]-amine (RO1138452) is a selective, pseudo-irreversible orthosteric antagonist at the prostacyclin (IP)-receptor expressed by human airway epithelial cells: IP-receptor-mediated inhibition of CXLinda M Ayer
Department of Pharmacology and Therapeutics, Airways Inflammation Group, Institute of Infection, Immunity and Inflammation, University of Calgary, 3330 Hospital Dr N W, Calgary, AB, Canada
J Pharmacol Exp Ther 324:815-26. 2008..Moreover, contrary to existing literature, RO1138452 behaved pseudoirreversibly, emphasizing the need, in drug discovery, to screen potential new medicines in the target tissue(s) of interest... - Chronic arthritis down-regulates peripheral mu-opioid receptor expression with concomitant loss of endomorphin 1 antinociceptionZongming Li
University of Calgary, Calgary, Alberta, Canada
Arthritis Rheum 52:3210-9. 2005..To determine whether peripheral administration of the endogenous mu-opioid peptide endomorphin 1 could reduce knee joint pain, using animal models of acute and chronic arthritis... - Cigarette smoke modulates rhinovirus-induced airway epithelial cell chemokine productionM H Hudy
Airway Inflammation Group, Institute of Infection, Immunity and Inflammation and Dept of Physiology and Pharmacology, University of Calgary, Calgary, AB, Canada
Eur Respir J 35:1256-63. 2010..Thus, CSE differentially modulates HRV-16-induced chemokine production from human airway epithelial cells in a manner that might be expected to alter inflammatory cell profiles... - Syk is downstream of intercellular adhesion molecule-1 and mediates human rhinovirus activation of p38 MAPK in airway epithelial cellsXiaomin Wang
Division of Respirology, University Health Network, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
J Immunol 177:6859-70. 2006..Taken together, these observations identify Syk as an important mediator of the airway epithelial cell inflammatory response by modulating p38 phosphorylation and IL-8 gene expression following ICAM-1 engagement by HRV... - Syk associates with clathrin and mediates phosphatidylinositol 3-kinase activation during human rhinovirus internalizationChristine Lau
Division of Respirology, Multi Organ Transplantation Programme, University Health Network, Department of Medicine, University of Toronto, Ontario, Canada
J Immunol 180:870-80. 2008..Together, these data reveal Syk to be an important mediator of HRV endocytosis and HRV-induced PI3K activation...