Kailash Prasad

Summary

Affiliation: University of Saskatchewan
Country: Canada

Publications

  1. ncbi C-reactive protein increases oxygen radical generation by neutrophils
    Kailash Prasad
    Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, S7N 5E5, Canada
    J Cardiovasc Pharmacol Ther 9:203-9. 2004
  2. ncbi Hypocholesterolemic and antiatherosclerotic effect of flax lignan complex isolated from flaxseed
    Kailash Prasad
    Department of Physiology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, Saskatchewan, Canada S7N 5E5
    Atherosclerosis 179:269-75. 2005
  3. ncbi Suppression of oxidative stress as a mechanism of reduction of hypercholesterolemic atherosclerosis by aspirin
    Kailash Prasad
    Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon, Canada
    J Cardiovasc Pharmacol Ther 8:61-9. 2003
  4. ncbi Relaxant effect of oxygen free radicals on rabbit tracheal smooth muscle
    Kailash Prasad
    Department of Physiology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, Saskatchewan S7N 5E5, USA
    Pulm Pharmacol Ther 15:375-84. 2002
  5. ncbi Is there an answer?
    K Prasad
    Department of Physiology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, Saskatchewan, Canada S7N 5E5
    IUBMB Life 56:633-5. 2004
  6. ncbi Reduction of serum cholesterol and hypercholesterolemic atherosclerosis in rabbits by secoisolariciresinol diglucoside isolated from flaxseed
    K Prasad
    Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Circulation 99:1355-62. 1999
  7. ncbi Superoxide dismutase and catalase in protection of cardiopulmonary bypass-induced cardiac dysfunction and cellular injury
    K Prasad
    Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon
    Can J Cardiol 12:1083-91. 1996
  8. doi A study on regression of hypercholesterolemic atherosclerosis in rabbits by flax lignan complex
    Kailash Prasad
    Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    J Cardiovasc Pharmacol Ther 12:304-13. 2007
  9. ncbi Flax lignan complex slows down the progression of atherosclerosis in hyperlipidemic rabbits
    Kailash Prasad
    Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    J Cardiovasc Pharmacol Ther 14:38-48. 2009
  10. ncbi Suppression of hypercholesterolemic atherosclerosis by pentoxifylline and its mechanism
    Kailash Prasad
    Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Atherosclerosis 192:313-22. 2007

Collaborators

  • Paul Lee
  • Fawzy Elbarbry
  • Ahmed Attia
  • Nilanjana Maulik
  • Erick D McNair
  • Ahmed Ragheb
  • Suresh Varma Penumathsa
  • Ahmed Shoker
  • Mabood Qureshi
  • A Mabood Qureshi
  • Calvin R Wells
  • Jacobus Devilliers
  • Colin Pearce
  • Rashpal Basran
  • Jason Orvold
  • Srikanth Koneru
  • Lijun Zhan
  • Suzan M G A El-Ghar
  • Carlo Stuglin
  • U Pattanaik
  • Venogopal P Menon
  • Mohamed S Ahmed
  • Adel Mohamed
  • Saji John
  • Mahesh Thirunavukkarasu
  • Hasnain Khsandwala
  • Inam ul Haq
  • R T Card
  • B Bharadwaj
  • M A MacFadyen
  • L A Hnatuk

Detail Information

Publications36

  1. ncbi C-reactive protein increases oxygen radical generation by neutrophils
    Kailash Prasad
    Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, S7N 5E5, Canada
    J Cardiovasc Pharmacol Ther 9:203-9. 2004
    ..These results suggest that CRP increases the generation of oxygen radicals from the WBCs. CRP-induced atherosclerosis may be mediated through generation of oxygen radicals by neutrophils...
  2. ncbi Hypocholesterolemic and antiatherosclerotic effect of flax lignan complex isolated from flaxseed
    Kailash Prasad
    Department of Physiology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, Saskatchewan, Canada S7N 5E5
    Atherosclerosis 179:269-75. 2005
    ..Lignan complex may, therefore, be beneficial in preventing atherosclerosis, and reducing risk factors for coronary artery disease and stroke...
  3. ncbi Suppression of oxidative stress as a mechanism of reduction of hypercholesterolemic atherosclerosis by aspirin
    Kailash Prasad
    Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon, Canada
    J Cardiovasc Pharmacol Ther 8:61-9. 2003
    ..The purpose of the investigation was to determine if aspirin attenuates the development of hypercholesterolemic atherosclerosis, and if this attenuation is associated with a decrease in the oxidative stress...
  4. ncbi Relaxant effect of oxygen free radicals on rabbit tracheal smooth muscle
    Kailash Prasad
    Department of Physiology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, Saskatchewan S7N 5E5, USA
    Pulm Pharmacol Ther 15:375-84. 2002
    ..These results suggest that OFRs relax rabbit tracheal smooth muscle. The relaxation appears to be mediated through the synthesis and release of prostaglandins from the epithelium and smooth muscles...
  5. ncbi Is there an answer?
    K Prasad
    Department of Physiology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, Saskatchewan, Canada S7N 5E5
    IUBMB Life 56:633-5. 2004
  6. ncbi Reduction of serum cholesterol and hypercholesterolemic atherosclerosis in rabbits by secoisolariciresinol diglucoside isolated from flaxseed
    K Prasad
    Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Circulation 99:1355-62. 1999
    ..The objective of this study was to determine the effect of SDG on various blood lipid and aortic tissue oxidative stress parameters and on the development of atherosclerosis in rabbits fed a high-cholesterol diet...
  7. ncbi Superoxide dismutase and catalase in protection of cardiopulmonary bypass-induced cardiac dysfunction and cellular injury
    K Prasad
    Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon
    Can J Cardiol 12:1083-91. 1996
    ..Various possible sources for increased levels of oxygen free radicals (OFRs) exist during CPB and OFRs depress cardiac function. Postpump (following CPB) cardiac dysfunction may be due to increased levels of OFRs...
  8. doi A study on regression of hypercholesterolemic atherosclerosis in rabbits by flax lignan complex
    Kailash Prasad
    Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    J Cardiovasc Pharmacol Ther 12:304-13. 2007
    ..These effects of FLC are not associated with reductions in serum lipids and oxidative stress...
  9. ncbi Flax lignan complex slows down the progression of atherosclerosis in hyperlipidemic rabbits
    Kailash Prasad
    Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    J Cardiovasc Pharmacol Ther 14:38-48. 2009
    ..In conclusion, flax lignan complex was effective in slowing down the progression of atherosclerosis by 31%, and this effect was associated with a reduction in oxidative stress...
  10. ncbi Suppression of hypercholesterolemic atherosclerosis by pentoxifylline and its mechanism
    Kailash Prasad
    Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Atherosclerosis 192:313-22. 2007
    ....
  11. ncbi Effects of flaxseed oil on serum lipids and atherosclerosis in hypercholesterolemic rabbits
    Paul Lee
    Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    J Cardiovasc Pharmacol Ther 8:227-35. 2003
    ....
  12. doi Vitamin E does not regress hypercholesterolemic atherosclerosis
    Kailash Prasad
    Department of Physiology, University of Saskatchewan, Saskatoon, Canada
    J Cardiovasc Pharmacol Ther 14:231-41. 2009
    ..The objectives of this study were to determine if (1) vitamin E regresses hypercholesterolemic atherosclerosis; and (2) regression is associated with reductions in serum lipids and aortic oxidative stress...
  13. doi Vitamin E slows the progression of hypercholesterolemia-induced oxidative stress in heart, liver and kidney
    Kailash Prasad
    Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada
    Mol Cell Biochem 368:181-7. 2012
    ....
  14. ncbi Natural products in regression and slowing of progression of atherosclerosis
    Kailash Prasad
    Department of Physiology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK, S7N 5E5, Canada
    Curr Pharm Biotechnol 11:794-800. 2010
    ..SDG slows the progression and regresses established atherosclerosis. FLC does not regress but slows the progression of established atherosclerosis...
  15. ncbi Regression of hypercholesterolemic atherosclerosis in rabbits by secoisolariciresinol diglucoside isolated from flaxseed
    Kailash Prasad
    Department of Physiology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, Saskatchewan, Canada
    Atherosclerosis 197:34-42. 2008
    ....
  16. ncbi Modulation of high sensitivity C-reactive protein by soluble receptor for advanced glycation end products
    Erick D McNair
    Department of Pathology, College of Medicine, University of Saskatchewan and Royal University Hospital, Saskatoon, SK, Canada
    Mol Cell Biochem 341:135-8. 2010
    ..The data suggest that sRAGE modulates the synthesis of hs-CRP through TNF-alpha...
  17. ncbi Vitamin E and regression of hypercholesterolemia-induced oxidative stress in kidney
    Kailash Prasad
    Department of Physiology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK, S7N 5E5, Canada
    Mol Cell Biochem 385:17-21. 2014
    ..E following high-cholesterol diet normalized the CL activity/AR. In conclusion, HC increases OS in the kidney; reduction of serum cholesterol by regular diet regresses the renal OS but Vit.E does not regress HC-induced OS in kidney...
  18. doi Flaxseed and cardiovascular health
    Kailash Prasad
    Department of Physiology, University of Saskatchewan, Saskatoon, Canada
    J Cardiovasc Pharmacol 54:369-77. 2009
    ..Flaxseed oil suppresses oxygen radical production by white blood cells, prolongs bleeding time, and in higher doses suppresses serum levels of inflammatory mediators and does not lower serum lipids...
  19. ncbi Oxidative stress in renal transplant patients who develop cardiovascular disease
    Suzan M G A El-Ghar
    Department of Pathology, College of Medicine, University of Saskatchewan, Royal University Hospital, Saskatoon, Saskatchewan, Canada
    J Cardiovasc Pharmacol Ther 11:203-10. 2006
    ..Glutathione levels in red blood cells were similar in all 3 groups. Renal transplant recipients without cardiovascular disease have high levels of oxidative stress and may develop cardiovascular disease with time...
  20. ncbi Effect of chronic administration of lignan complex isolated from flaxseed on the hemopoietic system
    Kailash Prasad
    Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon, Canada
    Mol Cell Biochem 270:139-45. 2005
    ..It is concluded that chronic use of lignan complex had no adverse effects on the hemopoietic system...
  21. doi Effects of vitamin E on serum enzymes and electrolytes in hypercholesterolemia
    Kailash Prasad
    Department of Physiology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon SK S7N 5E5, Canada
    Mol Cell Biochem 335:67-74. 2010
    ..Hypercholesterolemia for short and long term does not have adverse effects on liver or kidney function, and serum electrolytes. Vitamin E during hypercholesterolemia does not affect serum electrolytes or liver and kidney function...
  22. ncbi Effect of flaxseed consumption on blood pressure, serum lipids, hemopoietic system and liver and kidney enzymes in healthy humans
    Carlo Stuglin
    Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    J Cardiovasc Pharmacol Ther 10:23-7. 2005
    ....
  23. ncbi Secoisolariciresinol diglucoside from flaxseed delays the development of type 2 diabetes in Zucker rat
    K Prasad
    Department of Physiology, College of Medicine, University of Saskatchewan, 107 Wiggins Rd, Saskatoon, SK Canada, S7N 5ES
    J Lab Clin Med 138:32-9. 2001
    ..These results suggest that type 2 diabetes is associated with an increase in oxidative stress and that SDG is effective in retarding the development of diabetes...
  24. ncbi Reactive oxygen species and endotoxic shock: effect of dimethylthiourea
    U Pattanaik
    Toxicology Center, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, SK S7N 5ES, Canada
    J Cardiovasc Pharmacol Ther 6:273-85. 2001
    ....
  25. ncbi Elevated levels of plasma homocysteine in hypertensive patients with diabetes mellitus
    Mabood Qureshi
    Department of Pathology, Royal University Hospital, College of Medicine, University of Saskatchewan, Saskatoon, Canada
    J Cardiovasc Pharmacol Ther 8:261-6. 2003
    ..We investigated the plasma levels of homocysteine, factors involved in homocysteine metabolism (serum folic acid and vitamin B12) and lipid peroxidation product in the serum of diabetic patients with hypertension...
  26. pmc Attenuated combined action of cyclosporine a and hyperlipidemia on atherogenesis in rabbits by thymoquinone
    Ahmed Ragheb
    Department of Medicine, Royal University Hospital, University of Saskatchewan, Saskatoon, SK, Canada
    Evid Based Complement Alternat Med 2011:620319. 2011
    ..We concluded that (i) CsA aggravates hyperlipidemia-induced atherosclerosis and (ii) TQ attenuates the oxidative stress and atherogenesis induced by the combined effect of CsA and hyperlipidemia...
  27. doi Effect of chronic administration of vitamin E on the hemopoietic system in hypercholesterolemia
    Kailash Prasad
    Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada
    Mol Cell Biochem 343:67-73. 2010
    ..In conclusion, hypercholesterolemia of short duration has adverse effects on certain elements of the hemopoietic system. Vitamin E does not affect the hemopoietic system during hypercholesterolemia...
  28. ncbi Vitamin E does not regress hypercholesterolemia-induced oxidative stress in heart
    Kailash Prasad
    Department of Physiology, College of Medicine, University of Saskatchewan, 105 Wiggins Road, Saskatoon, SK, S7N 5E5, Canada
    Mol Cell Biochem 391:211-6. 2014
    ..Vitamin E reduces oxidative stress in the heart tissue in spite of a decrease in CL activity (increase in antioxidant reserve). ..
  29. doi Do statins have a role in reduction/prevention of post-PCI restenosis?
    Kailash Prasad
    Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon, SK, Canada
    Cardiovasc Ther 31:12-26. 2013
    ..The future directions for the use of statins in reduction of post-PCI restenosis and myonecrosis have been discussed...
  30. ncbi Tocotrienols and cardiovascular health
    Kailash Prasad
    Department of Physiology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon SK S7N 5E5, Canada
    Curr Pharm Des 17:2147-54. 2011
    ..In conclusion, experimental data suggest that tocotrienols have a potential for cardiovascular health, but long-term randomized clinical trials are needed to establish their efficacy in primary and secondary prevention of CAD...
  31. ncbi C-reactive protein (CRP)-lowering agents
    Kailash Prasad
    Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
    Cardiovasc Drug Rev 24:33-50. 2006
    ....
  32. ncbi High 2,3-DPG blood cardioplegia and myocardial preservation during cardiopulmonary bypass
    R T Card
    Department of Physiology, College of Medicine, University of Saskatchewan, Saskatoon, Canada
    Angiology 39:123-31. 1988
    ..The LVWI was significantly greater and the TSVR smaller in the HDPG group as compared with those in the SB group.(ABSTRACT TRUNCATED AT 250 WORDS)..
  33. pmc Attenuation of the development of hypercholesterolemic atherosclerosis by thymoquinone
    Ahmed Ragheb
    Department of Medicine, Royal University Hospital, University of Saskatchewan, Saskatoon, Saskatchewan
    Int J Angiol 17:186-92. 2008
    ..It is concluded that TQ attenuates hypercholesterolemic atherosclerosis and this effect is associated with a decrease in serum lipids and oxidative stress...
  34. doi Soluble receptors for advanced glycation end products (sRAGE) as a predictor of restenosis following percutaneous coronary intervention
    Erick D McNair
    Department of Pathology, College of Medicine, University of Saskatchewan, and Royal University Hospital, Saskatoon, Saskatchewan, Canada
    Clin Cardiol 33:678-85. 2010
    ..Balloon-injury-induced atherosclerosis is associated with increased expression of AGEs and RAGE. The soluble receptor for AGE (sRAGE), which acts as a decoy for RAGE ligands (AGEs), prevents atherosclerosis in this model...
  35. pmc Secoisolariciresinol diglucoside induces neovascularization-mediated cardioprotection against ischemia-reperfusion injury in hypercholesterolemic myocardium
    Suresh Varma Penumathsa
    Molecular Cardiology and Angiogenesis Laboratory, Department of Surgery, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030 1110, USA
    J Mol Cell Cardiol 44:170-9. 2008
    ..In conclusion, our study demonstrates for the first time that SDG treatment reduces ventricular remodeling by neovascularization of the infarcted HC myocardium...
  36. ncbi Secoisolariciresinol diglucoside: relevance to angiogenesis and cardioprotection against ischemia-reperfusion injury
    Suresh Varma Penumathsa
    Molecular Cardiology and Angiogenesis Laboratory, Department of Surgery, University of Connecticut Health Center, Farmington, CT 06030 1110, USA
    J Pharmacol Exp Ther 320:951-9. 2007
    ..In conclusion, these results suggest that SDG has potent angiogenic and antiapoptotic properties that may contribute to its cardioprotective effect in ischemic models...