Affiliation: University of Alberta
Power C, Johnson R. Current issues in clinical neurovirology: pathogenesis, diagnosis and treatment. Preface. Neurol Clin. 2008;26:xiii-xv pubmed publisher
Limonta D, Jovel J, Kumar A, Airo A, Hou S, Saito L, et al
. Human Fetal Astrocytes Infected with Zika Virus Exhibit Delayed Apoptosis and Resistance to Interferon: Implications for Persistence. Viruses. 2018;10: pubmed publisher
Radomski A, Power C, Purdon S, Emery D, Blevins G, Warren K, et al
. Decision-making under explicit risk is impaired in multiple sclerosis: relationships with ventricular width and disease disability. BMC Neurol. 2015;15:61 pubmed publisher
..Decision-making under explicit risk was reduced in MS patients, but only those with more pronounced disability. Independent of processing speed, decision-making under explicit risk correlates inversely with central atrophy in MS. ..
Anderson D, Nathoo N, Lu J, Kowalewska Grochowska K, Power C. Sarcocystis myopathy in a patient with HIV-AIDS. J Neurovirol. 2018;24:376-378 pubmed publisher
..Here, we report a patient from sub-Saharan Africa with chronic Sarcocystis myopathy and well-controlled HIV-AIDS. ..
Ramaswamy V, Walsh J, Sinclair D, Johnson E, Tang Wai R, Wheatley B, et al
. Inflammasome induction in Rasmussen's encephalitis: cortical and associated white matter pathogenesis. J Neuroinflammation. 2013;10:152 pubmed publisher
..Inflammasome activation likely contributes to the disease process underlying RE and offers a mechanistic target for future therapeutic interventions. ..
Walsh J, Reinke S, Mamik M, McKenzie B, Maingat F, Branton W, et al
. Rapid inflammasome activation in microglia contributes to brain disease in HIV/AIDS. Retrovirology. 2014;11:35 pubmed publisher
..Inflammasome activation in the brain might represent a potential target for therapeutic interventions in HIV/AIDS. ..
McKenzie B, Mamik M, Saito L, Boghozian R, Monaco M, Major E, et al
. Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis. Proc Natl Acad Sci U S A. 2018;115:E6065-E6074 pubmed publisher
Mamik M, Hui E, Branton W, McKenzie B, Chisholm J, Cohen E, et al
. HIV-1 Viral Protein R Activates NLRP3 Inflammasome in Microglia: implications for HIV-1 Associated Neuroinflammation. J Neuroimmune Pharmacol. 2017;12:233-248 pubmed publisher
..Thus, Vpr-induced NLRP3 inflammasome activation, which contributed to neuroinflammation and was abrogated by caspase-1 inhibition. This study provides a new therapeutic perspective for HIV-associated neuropsychiatric disease. ..
Na H, Acharjee S, Jones G, Vivithanaporn P, Noorbakhsh F, McFarlane N, et al
. Interactions between human immunodeficiency virus (HIV)-1 Vpr expression and innate immunity influence neurovirulence. Retrovirology. 2011;8:44 pubmed publisher
..05). These observations underscored the potent neuropathogenic properties of Vpr but also indicated viral diversity modulates innate neuroimmunity and neurodegeneration. ..