Christopher Power

Summary

Affiliation: University of Alberta
Country: Canada

Publications

  1. Power C, Johnson R. Current issues in clinical neurovirology: pathogenesis, diagnosis and treatment. Preface. Neurol Clin. 2008;26:xiii-xv pubmed publisher
  2. Limonta D, Jovel J, Kumar A, Airo A, Hou S, Saito L, et al. Human Fetal Astrocytes Infected with Zika Virus Exhibit Delayed Apoptosis and Resistance to Interferon: Implications for Persistence. Viruses. 2018;10: pubmed publisher
  3. Radomski A, Power C, Purdon S, Emery D, Blevins G, Warren K, et al. Decision-making under explicit risk is impaired in multiple sclerosis: relationships with ventricular width and disease disability. BMC Neurol. 2015;15:61 pubmed publisher
    ..Decision-making under explicit risk was reduced in MS patients, but only those with more pronounced disability. Independent of processing speed, decision-making under explicit risk correlates inversely with central atrophy in MS. ..
  4. Anderson D, Nathoo N, Lu J, Kowalewska Grochowska K, Power C. Sarcocystis myopathy in a patient with HIV-AIDS. J Neurovirol. 2018;24:376-378 pubmed publisher
    ..Here, we report a patient from sub-Saharan Africa with chronic Sarcocystis myopathy and well-controlled HIV-AIDS. ..
  5. Ramaswamy V, Walsh J, Sinclair D, Johnson E, Tang Wai R, Wheatley B, et al. Inflammasome induction in Rasmussen's encephalitis: cortical and associated white matter pathogenesis. J Neuroinflammation. 2013;10:152 pubmed publisher
    ..Inflammasome activation likely contributes to the disease process underlying RE and offers a mechanistic target for future therapeutic interventions. ..
  6. Walsh J, Reinke S, Mamik M, McKenzie B, Maingat F, Branton W, et al. Rapid inflammasome activation in microglia contributes to brain disease in HIV/AIDS. Retrovirology. 2014;11:35 pubmed publisher
    ..Inflammasome activation in the brain might represent a potential target for therapeutic interventions in HIV/AIDS. ..
  7. McKenzie B, Mamik M, Saito L, Boghozian R, Monaco M, Major E, et al. Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis. Proc Natl Acad Sci U S A. 2018;115:E6065-E6074 pubmed publisher
  8. Mamik M, Hui E, Branton W, McKenzie B, Chisholm J, Cohen E, et al. HIV-1 Viral Protein R Activates NLRP3 Inflammasome in Microglia: implications for HIV-1 Associated Neuroinflammation. J Neuroimmune Pharmacol. 2017;12:233-248 pubmed publisher
    ..Thus, Vpr-induced NLRP3 inflammasome activation, which contributed to neuroinflammation and was abrogated by caspase-1 inhibition. This study provides a new therapeutic perspective for HIV-associated neuropsychiatric disease. ..
  9. Na H, Acharjee S, Jones G, Vivithanaporn P, Noorbakhsh F, McFarlane N, et al. Interactions between human immunodeficiency virus (HIV)-1 Vpr expression and innate immunity influence neurovirulence. Retrovirology. 2011;8:44 pubmed publisher
    ..05). These observations underscored the potent neuropathogenic properties of Vpr but also indicated viral diversity modulates innate neuroimmunity and neurodegeneration. ..

More Information

Publications12

  1. Power C, Hui E, Vivithanaporn P, Acharjee S, Polyak M. Delineating HIV-associated neurocognitive disorders using transgenic models: the neuropathogenic actions of Vpr. J Neuroimmune Pharmacol. 2012;7:319-31 pubmed publisher
    ..The availability of different transgenic models to study HIV neuropathogenesis represents exciting and innovative approaches to understanding disease mechanisms and perhaps developing new therapeutic strategies in the future. ..
  2. Asahchop E, Meziane O, Mamik M, Chan W, Branton W, Resch L, et al. Reduced antiretroviral drug efficacy and concentration in HIV-infected microglia contributes to viral persistence in brain. Retrovirology. 2017;14:47 pubmed publisher
    ..These findings suggest that viral suppression in brain is feasible but new approaches to enhancing ART efficacy and concentrations in brain are required for sustained HIV-1 eradication from brain. ..
  3. Power C. Neurologic disease in feline immunodeficiency virus infection: disease mechanisms and therapeutic interventions for NeuroAIDS. J Neurovirol. 2018;24:220-228 pubmed publisher
    ..Thus, FIV infection of the nervous system provides a valuable comparative in vivo model for discovering and evaluating disease mechanisms as well as developing therapeutic strategies for NeuroAIDS in humans. ..