Grant N Pierce

Summary

Affiliation: University of Manitoba
Country: Canada

Publications

  1. pmc The HYPERFlax trial for determining the anti-HYPERtensive effects of dietary flaxseed in newly diagnosed stage 1 hypertensive patients: study protocol for a randomized, double-blinded, controlled clinical trial
    Stephanie P B Caligiuri
    Canadian Centre for Agri food Research in Health and Medicine CCARM, St, Boniface Hospital Research Centre, 351 Tache Avenue, Winnipeg, MB R2H 2A6, Canada
    Trials 15:232. 2014
  2. pmc The alpha linolenic acid content of flaxseed is associated with an induction of adipose leptin expression
    Richelle S McCullough
    Canadian Centre for Agri Food Research in Health and Medicine, St Boniface Hospital Research Centre, 351 Tache Ave, Winnipeg, MB, R2H 2A6, Canada
    Lipids 46:1043-52. 2011
  3. doi request reprint Potent antihypertensive action of dietary flaxseed in hypertensive patients
    Delfin Rodriguez-Leyva
    St Boniface Hospital Research Centre, 351 Tache Ave, Winnipeg, Manitoba, Canada R2H 2A6
    Hypertension 62:1081-9. 2013
  4. ncbi request reprint Differential effects of trans and polyunsaturated fatty acids on ischemia/ reperfusion injury and its associated cardiovascular disease states
    Riya Ganguly
    St Boniface Hospital Research Centre, 351 Tache Avenue, Winnipeg, Manitoba, Canada R2H 2A6
    Curr Pharm Des 19:6858-63. 2013
  5. pmc The cardiac and haemostatic effects of dietary hempseed
    Delfin Rodriguez-Leyva
    Department of Physiology, University of Manitoba and Institute of Cardiovascular Sciences, St Boniface Hospital Research Centre, 351 Tache Avenue, Winnipeg, Manitoba, R2H 2A6, Canada
    Nutr Metab (Lond) 7:32. 2010
  6. doi request reprint Dietary vaccenic acid has antiatherogenic effects in LDLr-/- mice
    Chantal M C Bassett
    Canadian Centre for Agri Food Research in Health and Medicine, St Boniface Hospital Research Centre, and Department of Physiology, Faculty of Medicine and Pharmacy, University of Manitoba, Winnipeg R2H 2A6, Canada
    J Nutr 140:18-24. 2010
  7. doi request reprint A tea/vanadate decoction delivered orally over 14 months to diabetic rats induces long-term glycemic stability without organ toxicity
    Tod A Clark
    Department of Surgery, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada R3E OW3
    Metabolism 61:742-53. 2012
  8. doi request reprint Trans-fatty acids in the diet stimulate atherosclerosis
    Chantal M C Bassett
    Institute of Cardiovascular Sciences, St Boniface Hospital Research Centre, Winnipeg, Manitoba, Canada R2H 2A6
    Metabolism 58:1802-8. 2009
  9. doi request reprint Oxidized LDL affects smooth muscle cell growth through MAPK-mediated actions on nuclear protein import
    Mirna N Chahine
    Institute of Cardiovascular Sciences, St Boniface Hospital Research Centre, Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    J Mol Cell Cardiol 46:431-41. 2009
  10. doi request reprint Effects of dietary flaxseed on atherosclerotic plaque regression
    Andrew A Francis
    Canadian Centre for Agri food Research in Health and Medicine and the Institute of Cardiovascular Sciences, St Boniface Hospital Research Centre, Department of Physiology, Faculties of Medicine and Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Physiol Heart Circ Physiol 304:H1743-51. 2013

Collaborators

Detail Information

Publications66

  1. pmc The HYPERFlax trial for determining the anti-HYPERtensive effects of dietary flaxseed in newly diagnosed stage 1 hypertensive patients: study protocol for a randomized, double-blinded, controlled clinical trial
    Stephanie P B Caligiuri
    Canadian Centre for Agri food Research in Health and Medicine CCARM, St, Boniface Hospital Research Centre, 351 Tache Avenue, Winnipeg, MB R2H 2A6, Canada
    Trials 15:232. 2014
    ..Therefore, there is a need to assess if dietary flaxseed can effectively reduce blood pressure in the absence of peripheral arterial disease and anti-hypertensive medication in newly diagnosed hypertensive patients...
  2. pmc The alpha linolenic acid content of flaxseed is associated with an induction of adipose leptin expression
    Richelle S McCullough
    Canadian Centre for Agri Food Research in Health and Medicine, St Boniface Hospital Research Centre, 351 Tache Ave, Winnipeg, MB, R2H 2A6, Canada
    Lipids 46:1043-52. 2011
    ..The findings support the hypothesis that the beneficial cardiovascular effects associated with flaxseed consumption may be related to a change in leptin expression...
  3. doi request reprint Potent antihypertensive action of dietary flaxseed in hypertensive patients
    Delfin Rodriguez-Leyva
    St Boniface Hospital Research Centre, 351 Tache Ave, Winnipeg, Manitoba, Canada R2H 2A6
    Hypertension 62:1081-9. 2013
    ..Circulating α-linolenic acid levels correlated with SBP and DBP, and lignan levels correlated with changes in DBP. In summary, flaxseed induced one of the most potent antihypertensive effects achieved by a dietary intervention...
  4. ncbi request reprint Differential effects of trans and polyunsaturated fatty acids on ischemia/ reperfusion injury and its associated cardiovascular disease states
    Riya Ganguly
    St Boniface Hospital Research Centre, 351 Tache Avenue, Winnipeg, Manitoba, Canada R2H 2A6
    Curr Pharm Des 19:6858-63. 2013
    ..The identification of further targets of fatty acid interactions has great potential to provide valuable information for the modulation of cardiovascular disease. ..
  5. pmc The cardiac and haemostatic effects of dietary hempseed
    Delfin Rodriguez-Leyva
    Department of Physiology, University of Manitoba and Institute of Cardiovascular Sciences, St Boniface Hospital Research Centre, 351 Tache Avenue, Winnipeg, Manitoba, R2H 2A6, Canada
    Nutr Metab (Lond) 7:32. 2010
    ..The purpose of this article is to review the latest developments in this rapidly emerging research field with a focus on the cardiac and vascular effects of dietary hempseed...
  6. doi request reprint Dietary vaccenic acid has antiatherogenic effects in LDLr-/- mice
    Chantal M C Bassett
    Canadian Centre for Agri Food Research in Health and Medicine, St Boniface Hospital Research Centre, and Department of Physiology, Faculty of Medicine and Pharmacy, University of Manitoba, Winnipeg R2H 2A6, Canada
    J Nutr 140:18-24. 2010
    ..01). In summary, consuming a hydrogenated elaidic acid-rich diet stimulates atherosclerosis, whereas a vaccenic acid-rich butter protects against atherosclerosis in this animal model...
  7. doi request reprint A tea/vanadate decoction delivered orally over 14 months to diabetic rats induces long-term glycemic stability without organ toxicity
    Tod A Clark
    Department of Surgery, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada R3E OW3
    Metabolism 61:742-53. 2012
    ..Oral administration of a T/V decoction provides safe, long-acting hypoglycemic effects in type 1 diabetes mellitus rats. The typical glycemic signs of diabetes were absent for the last 5 months of the study...
  8. doi request reprint Trans-fatty acids in the diet stimulate atherosclerosis
    Chantal M C Bassett
    Institute of Cardiovascular Sciences, St Boniface Hospital Research Centre, Winnipeg, Manitoba, Canada R2H 2A6
    Metabolism 58:1802-8. 2009
    ..In summary, TFAs are atherogenic on their own; but they do not stimulate further effects beyond the strongly atherogenic effects of dietary cholesterol...
  9. doi request reprint Oxidized LDL affects smooth muscle cell growth through MAPK-mediated actions on nuclear protein import
    Mirna N Chahine
    Institute of Cardiovascular Sciences, St Boniface Hospital Research Centre, Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    J Mol Cell Cardiol 46:431-41. 2009
    ..The nucleus and NPI may represent a novel therapeutic target to control diseases like atherosclerosis that have changes in cell growth as a central feature...
  10. doi request reprint Effects of dietary flaxseed on atherosclerotic plaque regression
    Andrew A Francis
    Canadian Centre for Agri food Research in Health and Medicine and the Institute of Cardiovascular Sciences, St Boniface Hospital Research Centre, Department of Physiology, Faculties of Medicine and Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Physiol Heart Circ Physiol 304:H1743-51. 2013
    ....
  11. ncbi request reprint Reduced expression of the Na+/Ca2+ exchanger in adult cardiomyocytes via adenovirally delivered shRNA results in resistance to simulated ischemic injury
    Thane G Maddaford
    Department of Physiology, St Boniface Hospital Research Centre, 351 Tache Ave, Winnipeg, MB, Canada R2H 2A6
    Am J Physiol Heart Circ Physiol 298:H360-6. 2010
    ..Our data support the role for NCX in ischemic injury to the heart and demonstrate the usefulness of altering gene expression with an adenoviral-delivery system of shRNA in adult cardiomyocytes...
  12. ncbi request reprint Dietary flaxseed inhibits atherosclerosis in the LDL receptor-deficient mouse in part through antiproliferative and anti-inflammatory actions
    Chantal M C Dupasquier
    Canadian Center for Agri food Research in Health and Medicine, St Boniface Hospital Research Center, Winnipeg, Canada
    Am J Physiol Heart Circ Physiol 293:H2394-402. 2007
    ..Our results demonstrate that dietary flaxseed can inhibit atherosclerosis in the LDLrKO mouse through a reduction of circulating cholesterol levels and, at a cellular level, via antiproliferative and anti-inflammatory actions...
  13. ncbi request reprint A comparison of fish oil, flaxseed oil and hempseed oil supplementation on selected parameters of cardiovascular health in healthy volunteers
    Nalini Kaul
    Canadian Centre for Agri Food Research in Health and Medicine, St Boniface Hospital Research Centre, University of Manitoba, Winnipeg, Manitoba, Canada R2H 2A6
    J Am Coll Nutr 27:51-8. 2008
    ..To directly compare the effects of three dietary oils (fish, flaxseed and hempseed) given in concentrations expected to be self-administered in the general population on specific cardiovascular parameters in healthy volunteers...
  14. doi request reprint Effects of long-term consumption of a high-fructose diet on conventional cardiovascular risk factors in Sprague-Dawley rats
    Mohammad M Abdullah
    Departments of Human Nutritional Sciences, The University of Manitoba and St Boniface General Hospital Research Centre, Winnipeg, MB, Canada
    Mol Cell Biochem 327:247-56. 2009
    ..HF-feeding resulted in significant reductions in plasma levels of certain inflammatory biomarkers. HF intake over time may negatively impact cardiovascular health and liver function in rats...
  15. doi request reprint Oxidized LDL promotes the mitogenic actions of Chlamydia pneumoniae in vascular smooth muscle cells
    Mirna N Chahine
    Institute of Cardiovascular Sciences, St Boniface Hospital Research Centre, 351 Tache Ave, Winnipeg, Manitoba, Canada R2H 2A6
    Cardiovasc Res 92:476-83. 2011
    ..pneumoniae in vascular smooth muscle cells (VSMCs) and the involvement of mitogen-activated protein kinase (MAPK) pathways and heat shock protein 60 (HSP60) in these mechanisms...
  16. ncbi request reprint Bioavailability of alpha-linolenic acid in subjects after ingestion of three different forms of flaxseed
    J Alejandro Austria
    Cell Biology Laboratory, St Boniface Hospital Research Centre, Winnipeg, Manitoba, R2H 2A6, Canada
    J Am Coll Nutr 27:214-21. 2008
    ..However, before extensive work can be undertaken in clinical populations to determine its efficacy, basic information on ALA bioavailability from flaxseed and the physiological effects of its ingestion need to be examined...
  17. ncbi request reprint Ceramide regulation of nuclear protein import
    Randolph S Faustino
    Institute of Cardiovascular Sciences, St Boniface Hospital Research Centre, Department of Physiology, Faculties of Medicine and Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada
    J Lipid Res 49:654-62. 2008
    ..Together, these data demonstrate, for the first time, the sphingolipid regulation of nuclear import that defines and expands the adaptive capacity of the nucleocytoplasmic transport machinery...
  18. doi request reprint Distribution of omega-3 fatty acids in tissues of rabbits fed a flaxseed-supplemented diet
    Bradley P Ander
    Department of Physiology, Faculty of Medicine, Canadian Centre for Agri Food Research in Health and Medicine and Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre, University of Manitoba, Winnipeg, Canada
    Metabolism 59:620-7. 2010
    ..Consumption of dietary flaxseed appears to be an effective means to increase ALA content in body tissues, but the degree will depend upon the tissues examined...
  19. doi request reprint The α-linolenic acid content of flaxseed can prevent the atherogenic effects of dietary trans fat
    Chantal M C Bassett
    Canadian Centre for Agri Food Research in Health and Medicine, Department of Physiology, Faculties of Medicine and Pharmacy, University of Manitoba, Winnipeg, Canada
    Am J Physiol Heart Circ Physiol 301:H2220-6. 2011
    ..Dietary flaxseed protects against atherosclerotic development induced by TFA and cholesterol feeding through its content of ALA...
  20. ncbi request reprint Differential sensitivities of the NCX1.1 and NCX1.3 isoforms of the Na+-Ca2+ exchanger to alpha-linolenic acid
    Bradley P Ander
    Canadian Centre for Agri Food Research in Health and Medicine, Winnipeg, Manitoba, Canada
    Cardiovasc Res 73:395-403. 2007
    ..Thus, we tested the effects of ALA and other distinct fatty acids on the cardiac (NCX1.1) and vascular (NCX1.3) NCX isoforms...
  21. ncbi request reprint Restoration of cardiomyocyte function in streptozotocin-induced diabetic rats after treatment with vanadate in a tea decoction
    Tod A Clark
    Cell Biology Laboratory, Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre, 351 Tache Avenue, Winnipeg, Manitoba, R2H 2A6, Canada
    Curr Pharm Biotechnol 11:906-10. 2010
    ..It is concluded that a T/V glycemic therapy is capable of preventing the defect in IP₃/PLC signaling that occurs in diabetes and can restore normal cardiac contractile function...
  22. doi request reprint Experimental and clinical research findings on the cardiovascular benefits of consuming flaxseed
    Chantal M C Bassett
    Institute of Cardiovascular Sciences, St Boniface Hospital Research Centre and the Department of Physiology, Faculties of Medicine and Pharmacy, University of Manitoba, Winnipeg, MB, Canada
    Appl Physiol Nutr Metab 34:965-74. 2009
    ..Dietary flaxseed may also protect against ischemic heart disease by improving vascular relaxation responses and by inhibiting the incidence of ventricular fibrillation...
  23. doi request reprint Oxidized LDL enhances stretch-induced smooth muscle cell proliferation through alterations in nuclear protein import
    Mirna N Chahine
    Institute of Cardiovascular Sciences, St Boniface Hospital Research Centre, Department of Physiology, University of Manitoba, Winnipeg, Canada
    Can J Physiol Pharmacol 90:1559-68. 2012
    ..We conclude that oxLDL and mechanical stretch have a synergistic effect on VSMC proliferation. This synergistic effect is induced through a stimulation of nuclear protein import via HSP60 and an activation of the MAPK pathway...
  24. ncbi request reprint Homocysteine stimulates NADPH oxidase-mediated superoxide production leading to endothelial dysfunction in rats
    Vathsala E R Edirimanne
    Department of Animal Science, University of Manitoba, Canadian Centre for Agri Food Research in Medicine, St Boniface Hospital Research Centre, Winnipeg, MB R2H 2A6, Canada
    Can J Physiol Pharmacol 85:1236-47. 2007
    ..Taken together, these results suggest that Hcy-stimulated superoxide anion production in the vascular wall is mediated through the activation of NADPH oxidase, which leads to endothelial dysfunction during hyperhomocysteinemia...
  25. ncbi request reprint The effects of simultaneous administration of dietary conjugated linoleic acid and telmisartan on cardiovascular risks in rats
    Mohammad M Abdullah
    Department of Human Nutritional Sciences, The University of Manitoba and St Boniface General Hospital Research Centre, Winnipeg, MB, Canada
    Lipids 42:855-64. 2007
    ..This combination of nutraceuticals and pharmaceuticals may be a safe and cost-effective strategy in a number of high-risk subjects. Future studies will further document clinical benefits of such combination therapy...
  26. ncbi request reprint Mechanical stretching stimulates smooth muscle cell growth, nuclear protein import, and nuclear pore expression through mitogen-activated protein kinase activation
    Melanie N Richard
    Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre, Department of Physiology, Faculties of Medicine and Pharmacy, University of Manitoba, Winnipeg, Manitoba R2H 2A6, Canada
    J Biol Chem 282:23081-8. 2007
    ..We conclude that nuclear protein import and nuclear pore density can adapt to mechanical stimuli during the process of cell growth through a MAPK-mediated mechanism...
  27. ncbi request reprint RanGAP-mediated nuclear protein import in vascular smooth muscle cells is augmented by lysophosphatidylcholine
    Randolph S Faustino
    Cell Biology Laboratory, Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre, and Department of Physiology, Faculty of Medicine, University of Manitoba, 351 Tache Avenue, Winnipeg, Manitoba, Canada
    Mol Pharmacol 71:438-45. 2007
    ..This may play an important role in cancer and atherosclerosis and other disorders involving accelerated cell growth/proliferation...
  28. doi request reprint Chlamydophila pneumoniae infection induces alterations in vascular contractile responses
    Justin F Deniset
    Institute of Cardiovascular Sciences, St Boniface Hospital Research Centre, Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Pathol 180:1264-72. 2012
    ..These findings indicate that C. pneumoniae infection can directly alter the vascular contractile responses in porcine coronary arteries, providing additional evidence for the role of C. pneumoniae infection in cardiovascular disease...
  29. pmc The cardiovascular effects of flaxseed and its omega-3 fatty acid, alpha-linolenic acid
    Delfin Rodriguez-Leyva
    Institute of Cardiovascular Sciences, St Boniface Hospital Research Centre and Department of Physiology, University of Manitoba, Winnipeg, Manitoba
    Can J Cardiol 26:489-96. 2010
    ..The purpose of the present review was to identify the known cardiovascular effects of flaxseed and ALA and, just as importantly, what is presently unknown...
  30. pmc Chlamydophila pneumoniae infection leads to smooth muscle cell proliferation and thickening in the coronary artery without contributions from a host immune response
    Justin F Deniset
    Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre, 351 Tache Avenue, Winnipeg, Manitoba, Canada R2H 2A6
    Am J Pathol 176:1028-37. 2010
    ..These results demonstrate that C. pneumoniae infection can stimulate arterial thickening in a complex vessel environment without the presence of a host immune response and further supports the involvement of HSP60 in this action...
  31. ncbi request reprint Cells expressing unique Na+/Ca2+ exchange (NCX1) splice variants exhibit different susceptibilities to Ca2+ overload
    Cecilia Hurtado
    Division of Stroke and Vascular Disease, St Boniface Hospital Research Centre, Winnipeg, MB, Canada R2H 2A6
    Am J Physiol Heart Circ Physiol 290:H2155-62. 2006
    ..1 promotes Ca2+ overload in response to cardiac glycosides and ischemic challenges. These results highlight the importance of ionic regulation in controlling NCX1 activity under conditions that promote Ca2+ overload...
  32. doi request reprint Trans fat involvement in cardiovascular disease
    Riya Ganguly
    Institute of Cardiovascular Sciences, St Boniface Hospital Research Centre, Winnipeg, Manitoba, Canada
    Mol Nutr Food Res 56:1090-6. 2012
    ..In the following review, we discuss recent in vitro, animal and epidemiological research to better understand the effect of TFAs in the diet on cardiovascular disease, particularly atherosclerosis...
  33. doi request reprint The effect of dietary hempseed on atherogenesis and contractile function in aortae from hypercholesterolemic rabbits
    N T Gavel
    University of Manitoba, Canadian Centre for Agri Food Research in Health and Medicine, St Boniface Hospital Research Centre, and Department of Physiology, Faculties of Medicine and Pharmacy, Winnipeg, Manitoba, Canada
    Acta Physiol Hung 98:273-83. 2011
    ..The purpose of the present study is to determine if hempseed ingestion over an 8-week period may provide protection to rabbits against the deleterious effects associated with dietary cholesterol supplementation...
  34. ncbi request reprint Adenovirally delivered shRNA strongly inhibits Na+-Ca2+ exchanger expression but does not prevent contraction of neonatal cardiomyocytes
    Cecilia Hurtado
    Division of Stroke and Vascular Disease, St Boniface General Hospital Research Center, 351 Tache Avenue, Winnipeg, MB, Canada R2H 2A6
    J Mol Cell Cardiol 38:647-54. 2005
    ..Furthermore, this approach provides a valuable means for assessing the role of NCX1 and could be utilized to examine other cardiac proteins in physiological and pathological studies...
  35. ncbi request reprint Short-term bioaccumulation of vanadium when ingested with a tea decoction in streptozotocin-induced diabetic rats
    Andrea L Edel
    National Centre for Agri Food Research in Medicine, St Boniface General Hospital Research Centre, Winnipeg, Manitoba, Canada R2H 2A6
    Metabolism 55:263-70. 2006
    ..However, this effect is unlikely to be of a magnitude to explain the full capacity of TV to reduce the toxic side effects of vanadate...
  36. ncbi request reprint Extensive autolytic fragmentation of membranous versus cytosolic calpain following myocardial ischemia-reperfusion
    James S C Gilchrist
    Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre, University of Manitoba, 780 Bannatyne Avenue, Winnipeg, MB R3E 0W2, Canada
    Can J Physiol Pharmacol 88:584-94. 2010
    ..Our studies suggest calpain is preferentially activated at membranes following I-R, possibly contributing to impaired ion channel function implicated by others in I-R injury...
  37. ncbi request reprint Effective control of glycemic status and toxicity in Zucker diabetic fatty rats with an orally administered vanadate compound
    Tod A Clark
    The National Centre for Agri food Research in Medicine, St Boniface General Hospital Research Centre, Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    Can J Physiol Pharmacol 82:888-94. 2004
    ..Our results demonstrate that a novel oral therapy containing black tea and vanadate possesses a striking capacity to regulate glucose and attenuates complications in a rat model of type II diabetes...
  38. doi request reprint Low n-6:n-3 fatty acid ratio, with fish- or flaxseed oil, in a high fat diet improves plasma lipids and beneficially alters tissue fatty acid composition in mice
    Natalie D Riediger
    Dept of Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada
    Eur J Nutr 47:153-60. 2008
    ..Health benefits from low n-6:n-3 fatty acid (FA) ratio on cardiovascular risk have been shown. However, the impact of the source of n-3 FAs has not been fully investigated...
  39. doi request reprint Mitogen activated protein kinase at the nuclear pore complex
    Randolph S Faustino
    Institute of Cardiovascular Sciences, St Boniface Hospital Research Centre, and Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    J Cell Mol Med 15:928-37. 2011
    ..The NPC thus contains a spectrum of associated MAP kinases that suggests an intimate role for ERK and p38 in regulation of nuclear pore function...
  40. ncbi request reprint Dietary flaxseed protects against ventricular fibrillation induced by ischemia-reperfusion in normal and hypercholesterolemic Rabbits
    Bradley P Ander
    National Centre for Agri Food Research in Medicine, Department of Physiology, University of Manitoba, Winnipeg, Canada
    J Nutr 134:3250-6. 2004
    ..This study demonstrates that dietary flaxseed exerts antiarrhythmic effects during ischemia-reperfusion in rabbit hearts, possibly through shortening of the action potential...
  41. ncbi request reprint Codelivery of a tea extract prevents morbidity and mortality associated with oral vanadate therapy in streptozotocin-induced diabetic rats
    Tod A Clark
    The National Centre for Agrifood Research in Medicine, University of Mannitoba, Winnipeg, Canada
    Metabolism 53:1145-51. 2004
    ..In summary, because of its long-lasting effects, oral administration, and lack of side effects, vanadate/tea represents a potentially important alternative therapy for an insulin-deficient diabetic state...
  42. ncbi request reprint Low matrix metalloproteinase levels precede vascular lesion formation in the JCR:LA-cp rat
    David Wilson
    Institute of Cardiovascular Sciences, Winnipeg, Manitoba, Canada
    Mol Cell Biochem 249:151-5. 2003
    ..We conclude that reduced MMP levels could lead to increased ECM accumulation and thus contribute to early vascular lesion formation...
  43. ncbi request reprint Oxidized low-density lipoprotein retards the growth of proliferating cells by inhibiting nuclear translocation of cell cycle proteins
    Marjorie E Zettler
    Cell Biology Laboratory, Division of Stroke and Vascular Disease, St Boniface General Hospital Research Centre, Winnipeg, Manitoba, Canada
    Arterioscler Thromb Vasc Biol 24:727-32. 2004
    ....
  44. ncbi request reprint Defective phosphatidic acid-phospholipase C signaling in diabetic cardiomyopathy
    Paramjit S Tappia
    Institute of Cardiovascular Sciences, St Boniface Hospital Research Centre, Canada
    Biochem Biophys Res Commun 316:280-9. 2004
    ..Our results, therefore, identify an important defect in the PA-PLC signaling pathway in diabetic rat cardiomyocytes, which may have significant implications for heart dysfunction during diabetes...
  45. ncbi request reprint Regulation of stress-associated scaffold proteins JIP1 and JIP3 on the c-Jun NH2-terminal kinase in ischemia-reperfusion
    Bing Xu
    Centre for Research and Treatment of Atherosclerosis, University of Manitoba, Winnipeg, Canada
    Can J Physiol Pharmacol 88:1084-92. 2010
    ..These results suggest that JIP1 and JIP3 play important roles in the activation of JNK during simulated IR challenge in H9c2 cells...
  46. doi request reprint Supported liquid extraction in the quantitation of plasma enterolignans using isotope dilution GC/MS with application to flaxseed consumption in healthy adults
    Andrea L Edel
    Department of Physiology, Faculty of Medicine, Canadian Centre for Agri Food Research in Health and Medicine and Institute of Cardiovascular Sciences, St Boniface Hospital Research Centre, University of Manitoba, Winnipeg, Canada R2H 2A6
    J Chromatogr B Analyt Technol Biomed Life Sci 912:24-32. 2013
    ..Plasma total enterolignan levels significantly increased (P=0.002) at 4weeks relative to baseline. Average concentrations for END and ENL were 209nM and 304nM, respectively...
  47. ncbi request reprint Depressed phosphatidic acid-induced contractile activity of failing cardiomyocytes
    Paramjit S Tappia
    Institute of Cardiovascular Sciences, St Boniface Hospital Research Centre R3020, 351 Tache Avenue, Winnipeg, Manitoba, Canada R2H 2A6
    Biochem Biophys Res Commun 300:457-63. 2003
    ..Our results identify an important defect in the PA-PLC signaling pathway in failing cardiomyocytes, which may have significant implications for the depressed contractile function during CHF...
  48. ncbi request reprint Chlamydia pneumoniae stimulates proliferation of vascular smooth muscle cells through induction of endogenous heat shock protein 60
    Satoru Hirono
    Division of Stroke and Vascular Disease, St Boniface General Hospital Research Centre, and the Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
    Circ Res 93:710-6. 2003
    ..In addition to C pneumoniae, other infectious agents and atherogenic risk factors may also stimulate VSMC proliferation and contribute to the lesion formation through the induction of HSP60...
  49. ncbi request reprint Is infection a component of atherosclerosis?
    Grant N Pierce
    Division of Stroke and Vascular Disease, St Boniface Hospital Research Centre, Physiology Faculty of Medicine, University of Manitoba, Winnipeg, Canada
    J Muscle Res Cell Motil 25:617-8. 2004
  50. doi request reprint Alternative therapies for diabetes and its cardiac complications: role of vanadium
    Tod A Clark
    Department of Surgery, Faculty of Medicine, University of Manitoba, Winnipeg, MB, Canada
    Heart Fail Rev 19:123-32. 2014
    ....
  51. doi request reprint Therapeutic targeting of nuclear protein import in pathological cell conditions
    Mirna N Chahine
    Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre, Department of Physiology, Faculties of Medicine and Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada
    Pharmacol Rev 61:358-72. 2009
    ....
  52. ncbi request reprint Effect of flax addition on the flavor profile and acceptability of bagels
    Michel Aliani
    Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada
    J Food Sci 77:S62-70. 2012
    ..In conclusion, for bagels containing 6 g ALA in the form of milled flaxseed, cinnamon raisin appears to be a promising flavoring alternative for ALA fortification for use in clinical trials or as part of the daily diet...
  53. doi request reprint Possibilities for therapeutic interventions in disrupting Chlamydophila pneumoniae involvement in atherosclerosis
    Justin F Deniset
    Department of Physiology, Faculties of Medicine and Pharmacy, Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre, University of Manitoba, Winnipeg, Manitoba, Canada
    Fundam Clin Pharmacol 24:607-17. 2010
    ..Alternatively, selectively targeting host cell pathways and machinery required for Cpn's actions in vascular cells also represent potential treatment strategies for atherosclerosis...
  54. ncbi request reprint Flaxseed consumption reduces blood pressure in patients with hypertension by altering circulating oxylipins via an α-linolenic acid-induced inhibition of soluble epoxide hydrolase
    Stephanie P B Caligiuri
    From the Canadian Centre for Agri food Research in Health and Medicine S P B C, H M A, E D, G N P, Institute of Cardiovascular Sciences S P B C, A R, E D, G N P, Asper Clinical Research Institute R G, St Boniface Hospital Research Centre, Winnipeg, Manitoba, Canada and Departments of Physiology S P B C, A R, G N P, Human Nutritional Sciences H M A, and Internal Medicine A R, University of Manitoba, Winnipeg, Manitoba, Canada
    Hypertension 64:53-9. 2014
    ..94). In conclusion, α-linolenic acid in flaxseed may have inhibited soluble epoxide hydrolase, which altered oxylipin concentrations that contributed to the antihypertensive effects in patients with peripheral arterial disease...
  55. ncbi request reprint Effects of mitogen-activated protein kinases on nuclear protein import
    Randolph S Faustino
    Cell Biology Laboratory, Division of Stroke and Vascular Disease, St Boniface General Hospital Research Centre, and Department of Physiology, Faculties of Medicine and Pharmacy, University of Manitoba, Winnipeg, Canada
    Can J Physiol Pharmacol 84:469-75. 2006
    ..RanGAP represents the MAP kinase target whereby nuclear transport can be stimulated or inhibited...
  56. doi request reprint An international basic science and clinical research summer program for medical students
    Bram Ramjiawan
    St Boniface Hospital, Winnipeg, Manitoba, Canada
    Adv Physiol Educ 36:27-33. 2012
    ..An innovative international summer research course for medical students is necessary to cater to the needs of the medical students in the 21st century...
  57. ncbi request reprint Doping-control urinalysis of a ginseng extract, Cold-FX, in athletes
    Danny P Goel
    National Centre for Agri Food Research in Medicine, and Faculties of Medicine and Pharmacy, University of Manitoba, Winnipeg, MB, Canada
    Int J Sport Nutr Exerc Metab 14:473-80. 2004
    ....
  58. doi request reprint Involvement of caveolin in probucol-induced reduction in hERG plasma-membrane expression
    Jun Guo
    Department of Physiology, Queen s University, Kingston, ON, Canada
    Mol Pharmacol 79:806-13. 2011
    ..Our data provide evidence that targeting hERG-interacting protein caveolin represents a novel mechanism for drugs to decrease hERG expression and cause LQTS...
  59. ncbi request reprint Native and minimally oxidized low density lipoprotein depress smooth muscle matrix metalloproteinase levels
    David Wilson
    Institute of Cardiovascular Sciences, Winnipeg, Manitoba, Canada
    Mol Cell Biochem 249:141-9. 2003
    ..Our results demonstrate that an important atherogenic moiety, oxidized LDL, can reduce MMP activity and hence has the potential to increase the deposition of extracellular matrix proteins within SMC-rich vascular lesions...
  60. ncbi request reprint Salt in the wound: a possible role of Na+ gradient in chlamydial infection
    Pavel Dibrov
    Department of Microbiology, University of Manitoba, Winnipeg, Manitoba R3T 2N2, Canada
    J Mol Microbiol Biotechnol 8:1-6. 2004
    ..This introduces the intriguing possibility of the application of drugs targeting Na(+)-transporting enzymes to chlamydial infections, which are notoriously difficult to treat...
  61. ncbi request reprint Hyperhomocysteinemia induces hepatic cholesterol biosynthesis and lipid accumulation via activation of transcription factors
    Connie W H Woo
    Department of Physiology, St Boniface Hospital Research Centre, Faculty of Medicine, R4032, 351 Tache Ave, Winnipeg, Manitoba, Canada R2H 2A6
    Am J Physiol Endocrinol Metab 288:E1002-10. 2005
    ..In conclusion, the stimulatory effect of Hcy on hepatic cholesterol biosynthesis may represent an important mechanism for hepatic lipid accumulation and cardiovascular disorder associated with hyperhomocysteinemia...
  62. pmc Augmented cell cycle protein expression and kinase activity in atherosclerotic rabbit vessels
    Marjorie E Zettler
    Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre, and Department of Physiology, Faculties of Medicine and Pharmacy, University of Manitoba, Winnipeg, Manitoba
    Exp Clin Cardiol 15:e139-44. 2010
    ..Expression levels were similar during moderate and severe atherosclerosis, and were even detected in nonatherosclerotic vascular tissue bordering the plaque...
  63. ncbi request reprint Nucleoplasmic calcium regulation in rabbit aortic vascular smooth muscle cells
    Bernard Abrenica
    Department of Oral Biology, Division of Stroke and Vascular Disease, University of Manitoba, Winnipeg, MB R2H 2A6, Canada
    Can J Physiol Pharmacol 81:301-10. 2003
    ..These latter observations raise the possibility that VSMC nuclei represent an important sink of intracellular Ca2+ and may help explain vasodilatory actions of FK506 observed by others...
  64. ncbi request reprint Nucleolin is a calcium-binding protein
    James S C Gilchrist
    Department of Oral Biology and Physiology, Division of Stroke and Vascular Disease, University of Manitoba, Winnipeg, Manitoba, Canada
    J Cell Biochem 85:268-78. 2002
    ..Although the Ca2+-dependent functions of nucleolin are unknown, we discuss the possibility that like the structurally analogous HMG-1, its Ca2+-dependent actions may regulate chromatin structure, possibly during apoptosis...
  65. ncbi request reprint Effects of omega-3 polyunsaturated fatty acids on cardiac sarcolemmal Na(+)/H(+) exchange
    Danny P Goel
    Cell Biology Laboratory, Division of Stroke and Vascular Disease, St Boniface General Hospital Research Centre, Winnipeg, Manitoba R2H 2A6, Canada
    Am J Physiol Heart Circ Physiol 283:H1688-94. 2002
    ..This may explain, in part, their known cardioprotective effects and antiarrhythmic actions during ischemia-reperfusion...
  66. ncbi request reprint Lysophospholipids do not directly modulate Na(+)-H+ exchange
    Danny P Goel
    Cell Biology Laboratory, Division of Stroke and Vascular Disease, St Boniface General Hospital Research Centre, Winnipeg, Manitoba, Canada
    Mol Cell Biochem 251:3-7. 2003
    ..We conclude that any stimulatory effects of lysolipids on Na(+)-H+ exchange do not occur through a direct action on the exchanger or its membrane lipid environment and must occur through a second messenger pathway...