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Genomes and Genes | Grant N PierceSummaryAffiliation: University of Manitoba Country: Canada Publications
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Publications
The α-linolenic acid content of flaxseed can prevent the atherogenic effects of dietary trans fatChantal M C Bassett
Canadian Centre for Agri Food Research in Health and Medicine, Department of Physiology, Faculties of Medicine and Pharmacy, University of Manitoba, Winnipeg, Canada
Am J Physiol Heart Circ Physiol 301:H2220-6. 2011..Dietary flaxseed protects against atherosclerotic development induced by TFA and cholesterol feeding through its content of ALA...
The cardiac and haemostatic effects of dietary hempseedDelfin Rodriguez-Leyva
Department of Physiology, University of Manitoba and Institute of Cardiovascular Sciences, St Boniface Hospital Research Centre, 351 Tache Avenue, Winnipeg, Manitoba, R2H 2A6, Canada
Nutr Metab (Lond) 7:32. 2010..The purpose of this article is to review the latest developments in this rapidly emerging research field with a focus on the cardiac and vascular effects of dietary hempseed...- Dietary vaccenic acid has antiatherogenic effects in LDLr-/- miceChantal M C Bassett
Canadian Centre for Agri Food Research in Health and Medicine, St Boniface Hospital Research Centre, and Department of Physiology, Faculty of Medicine and Pharmacy, University of Manitoba, Winnipeg R2H 2A6, Canada
J Nutr 140:18-24. 2010..01). In summary, consuming a hydrogenated elaidic acid-rich diet stimulates atherosclerosis, whereas a vaccenic acid-rich butter protects against atherosclerosis in this animal model... - Trans-fatty acids in the diet stimulate atherosclerosisChantal M C Bassett
Institute of Cardiovascular Sciences, St Boniface Hospital Research Centre, Winnipeg, Manitoba, Canada R2H 2A6
Metabolism 58:1802-8. 2009..In summary, TFAs are atherogenic on their own; but they do not stimulate further effects beyond the strongly atherogenic effects of dietary cholesterol... - Effects of long-term consumption of a high-fructose diet on conventional cardiovascular risk factors in Sprague-Dawley ratsMohammad M Abdullah
Departments of Human Nutritional Sciences, The University of Manitoba and St Boniface General Hospital Research Centre, Winnipeg, MB, Canada
Mol Cell Biochem 327:247-56. 2009..HF-feeding resulted in significant reductions in plasma levels of certain inflammatory biomarkers. HF intake over time may negatively impact cardiovascular health and liver function in rats... 
Bioavailability of alpha-linolenic acid in subjects after ingestion of three different forms of flaxseedJ Alejandro Austria
Cell Biology Laboratory, St Boniface Hospital Research Centre, Winnipeg, Manitoba, R2H 2A6, Canada
J Am Coll Nutr 27:214-21. 2008..However, before extensive work can be undertaken in clinical populations to determine its efficacy, basic information on ALA bioavailability from flaxseed and the physiological effects of its ingestion need to be examined...- Oxidized LDL affects smooth muscle cell growth through MAPK-mediated actions on nuclear protein importMirna N Chahine
Institute of Cardiovascular Sciences, St Boniface Hospital Research Centre, Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
J Mol Cell Cardiol 46:431-41. 2009..The nucleus and NPI may represent a novel therapeutic target to control diseases like atherosclerosis that have changes in cell growth as a central feature... - Distribution of omega-3 fatty acids in tissues of rabbits fed a flaxseed-supplemented dietBradley P Ander
Department of Physiology, Faculty of Medicine, Canadian Centre for Agri Food Research in Health and Medicine and Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre, University of Manitoba, Winnipeg, Canada
Metabolism 59:620-7. 2010..Consumption of dietary flaxseed appears to be an effective means to increase ALA content in body tissues, but the degree will depend upon the tissues examined... - Restoration of cardiomyocyte function in streptozotocin-induced diabetic rats after treatment with vanadate in a tea decoctionTod A Clark
Cell Biology Laboratory, Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre, 351 Tache Avenue, Winnipeg, Manitoba, R2H 2A6, Canada
Curr Pharm Biotechnol 11:906-10. 2010..It is concluded that a T/V glycemic therapy is capable of preventing the defect in IP₃/PLC signaling that occurs in diabetes and can restore normal cardiac contractile function... - Experimental and clinical research findings on the cardiovascular benefits of consuming flaxseedChantal M C Bassett
Institute of Cardiovascular Sciences, St Boniface Hospital Research Centre and the Department of Physiology, Faculties of Medicine and Pharmacy, University of Manitoba, Winnipeg, MB, Canada
Appl Physiol Nutr Metab 34:965-74. 2009..Dietary flaxseed may also protect against ischemic heart disease by improving vascular relaxation responses and by inhibiting the incidence of ventricular fibrillation... - The cardiovascular effects of flaxseed and its omega-3 fatty acid, alpha-linolenic acidDelfin Rodriguez-Leyva
Institute of Cardiovascular Sciences, St Boniface Hospital Research Centre and Department of Physiology, University of Manitoba, Winnipeg, Manitoba
Can J Cardiol 26:489-96. 2010..The purpose of the present review was to identify the known cardiovascular effects of flaxseed and ALA and, just as importantly, what is presently unknown... - A comparison of fish oil, flaxseed oil and hempseed oil supplementation on selected parameters of cardiovascular health in healthy volunteersNalini Kaul
Canadian Centre for Agri Food Research in Health and Medicine, St Boniface Hospital Research Centre, University of Manitoba, Winnipeg, Manitoba, Canada R2H 2A6
J Am Coll Nutr 27:51-8. 2008..To directly compare the effects of three dietary oils (fish, flaxseed and hempseed) given in concentrations expected to be self-administered in the general population on specific cardiovascular parameters in healthy volunteers... - The alpha linolenic acid content of flaxseed is associated with an induction of adipose leptin expressionRichelle S McCullough
Canadian Centre for Agri Food Research in Health and Medicine, St Boniface Hospital Research Centre, 351 Tache Ave, Winnipeg, MB, R2H 2A6, Canada
Lipids 46:1043-52. 2011..The findings support the hypothesis that the beneficial cardiovascular effects associated with flaxseed consumption may be related to a change in leptin expression... - Short-term bioaccumulation of vanadium when ingested with a tea decoction in streptozotocin-induced diabetic ratsAndrea L Edel
National Centre for Agri-Food Research in Medicine, St Boniface General Hospital Research Centre, Winnipeg, Manitoba, Canada R2H 2A6
Metabolism 55:263-70. 2006..However, this effect is unlikely to be of a magnitude to explain the full capacity of TV to reduce the toxic side effects of vanadate... - Chlamydophila pneumoniae infection leads to smooth muscle cell proliferation and thickening in the coronary artery without contributions from a host immune responseJustin F Deniset
Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre, 351 Tache Avenue, Winnipeg, Manitoba, Canada R2H 2A6
Am J Pathol 176:1028-37. 2010..These results demonstrate that C. pneumoniae infection can stimulate arterial thickening in a complex vessel environment without the presence of a host immune response and further supports the involvement of HSP60 in this action... - Effective control of glycemic status and toxicity in Zucker diabetic fatty rats with an orally administered vanadate compoundTod A Clark
The National Centre for Agri-food Research in Medicine, St. Boniface General Hospital Research Centre, Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
Can J Physiol Pharmacol 82:888-94. 2004..Our results demonstrate that a novel oral therapy containing black tea and vanadate possesses a striking capacity to regulate glucose and attenuates complications in a rat model of type II diabetes... - The effect of dietary hempseed on atherogenesis and contractile function in aortae from hypercholesterolemic rabbitsN T Gavel
University of Manitoba, Canadian Centre for Agri Food Research in Health and Medicine, St Boniface Hospital Research Centre, and Department of Physiology, Faculties of Medicine and Pharmacy, Winnipeg, Manitoba, Canada
Acta Physiol Hung 98:273-83. 2011..The purpose of the present study is to determine if hempseed ingestion over an 8-week period may provide protection to rabbits against the deleterious effects associated with dietary cholesterol supplementation... - The effects of simultaneous administration of dietary conjugated linoleic acid and telmisartan on cardiovascular risks in ratsMohammad M Abdullah
Department of Human Nutritional Sciences, The University of Manitoba and St Boniface General Hospital Research Centre, Winnipeg, MB, Canada
Lipids 42:855-64. 2007..This combination of nutraceuticals and pharmaceuticals may be a safe and cost-effective strategy in a number of high-risk subjects. Future studies will further document clinical benefits of such combination therapy... - Homocysteine stimulates NADPH oxidase-mediated superoxide production leading to endothelial dysfunction in ratsVathsala E R Edirimanne
Department of Animal Science, University of Manitoba, Canadian Centre for Agri Food Research in Medicine, St Boniface Hospital Research Centre, Winnipeg, MB R2H 2A6, Canada
Can J Physiol Pharmacol 85:1236-47. 2007..Taken together, these results suggest that Hcy-stimulated superoxide anion production in the vascular wall is mediated through the activation of NADPH oxidase, which leads to endothelial dysfunction during hyperhomocysteinemia... - Mitogen activated protein kinase at the nuclear pore complexRandolph S Faustino
Institute of Cardiovascular Sciences, St Boniface Hospital Research Centre, and Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada
J Cell Mol Med 15:928-37. 2011..The NPC thus contains a spectrum of associated MAP kinases that suggests an intimate role for ERK and p38 in regulation of nuclear pore function... - Ceramide regulation of nuclear protein importRandolph S Faustino
Institute of Cardiovascular Sciences, St Boniface Hospital Research Centre, Department of Physiology, Faculties of Medicine and Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada
J Lipid Res 49:654-62. 2008..Together, these data demonstrate, for the first time, the sphingolipid regulation of nuclear import that defines and expands the adaptive capacity of the nucleocytoplasmic transport machinery... - Dietary flaxseed inhibits atherosclerosis in the LDL receptor-deficient mouse in part through antiproliferative and anti-inflammatory actionsChantal M C Dupasquier
Canadian Center for Agri food Research in Health and Medicine, St Boniface Hospital Research Center, Winnipeg, Canada
Am J Physiol Heart Circ Physiol 293:H2394-402. 2007..Our results demonstrate that dietary flaxseed can inhibit atherosclerosis in the LDLrKO mouse through a reduction of circulating cholesterol levels and, at a cellular level, via antiproliferative and anti-inflammatory actions... - Oxidized LDL promotes the mitogenic actions of Chlamydia pneumoniae in vascular smooth muscle cellsMirna N Chahine
Institute of Cardiovascular Sciences, St Boniface Hospital Research Centre, 351 Tache Ave, Winnipeg, Manitoba, Canada R2H 2A6
Cardiovasc Res 92:476-83. 2011..pneumoniae in vascular smooth muscle cells (VSMCs) and the involvement of mitogen-activated protein kinase (MAPK) pathways and heat shock protein 60 (HSP60) in these mechanisms... - Extensive autolytic fragmentation of membranous versus cytosolic calpain following myocardial ischemia-reperfusionJames S C Gilchrist
Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre, University of Manitoba, 780 Bannatyne Avenue, Winnipeg, MB R3E 0W2, Canada
Can J Physiol Pharmacol 88:584-94. 2010..Our studies suggest calpain is preferentially activated at membranes following I-R, possibly contributing to impaired ion channel function implicated by others in I-R injury... - Depressed phosphatidic acid-induced contractile activity of failing cardiomyocytesParamjit S Tappia
Institute of Cardiovascular Sciences, St Boniface Hospital Research Centre R3020, 351 Tache Avenue, Winnipeg, Manitoba, Canada R2H 2A6
Biochem Biophys Res Commun 300:457-63. 2003..Our results identify an important defect in the PA-PLC signaling pathway in failing cardiomyocytes, which may have significant implications for the depressed contractile function during CHF... - Low n-6:n-3 fatty acid ratio, with fish- or flaxseed oil, in a high fat diet improves plasma lipids and beneficially alters tissue fatty acid composition in miceNatalie D Riediger
Dept of Human Nutritional Sciences, University of Manitoba, Winnipeg, MB, Canada
Eur J Nutr 47:153-60. 2008..Health benefits from low n-6:n-3 fatty acid (FA) ratio on cardiovascular risk have been shown. However, the impact of the source of n-3 FAs has not been fully investigated... - Possibilities for therapeutic interventions in disrupting Chlamydophila pneumoniae involvement in atherosclerosisJustin F Deniset
Department of Physiology, Faculties of Medicine and Pharmacy, Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre, University of Manitoba, Winnipeg, Manitoba, Canada
Fundam Clin Pharmacol 24:607-17. 2010..Alternatively, selectively targeting host cell pathways and machinery required for Cpn's actions in vascular cells also represent potential treatment strategies for atherosclerosis... - Regulation of stress-associated scaffold proteins JIP1 and JIP3 on the c-Jun NH2-terminal kinase in ischemia-reperfusionBing Xu
Centre for Research and Treatment of Atherosclerosis, University of Manitoba, Winnipeg, Canada
Can J Physiol Pharmacol 88:1084-92. 2010..These results suggest that JIP1 and JIP3 play important roles in the activation of JNK during simulated IR challenge in H9c2 cells... - Reduced expression of the Na+/Ca2+ exchanger in adult cardiomyocytes via adenovirally delivered shRNA results in resistance to simulated ischemic injuryThane G Maddaford
Department of Physiology, St Boniface Hospital Research Centre, 351 Tache Ave, Winnipeg, MB, Canada R2H 2A6
Am J Physiol Heart Circ Physiol 298:H360-6. 2010..Our data support the role for NCX in ischemic injury to the heart and demonstrate the usefulness of altering gene expression with an adenoviral-delivery system of shRNA in adult cardiomyocytes... - Doping-control urinalysis of a ginseng extract, Cold-FX, in athletesDanny P Goel
National Centre for Agri-Food Research in Medicine, and Faculties of Medicine and Pharmacy, University of Manitoba, Winnipeg, MB, Canada
Int J Sport Nutr Exerc Metab 14:473-80. 2004.... - Chlamydophila pneumoniae infection induces alterations in vascular contractile responsesJustin F Deniset
Institute of Cardiovascular Sciences, St Boniface Hospital Research Centre, Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada
Am J Pathol 180:1264-72. 2012..These findings indicate that C. pneumoniae infection can directly alter the vascular contractile responses in porcine coronary arteries, providing additional evidence for the role of C. pneumoniae infection in cardiovascular disease... - Therapeutic targeting of nuclear protein import in pathological cell conditionsMirna N Chahine
Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre, Department of Physiology, Faculties of Medicine and Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada
Pharmacol Rev 61:358-72. 2009.... - Codelivery of a tea extract prevents morbidity and mortality associated with oral vanadate therapy in streptozotocin-induced diabetic ratsTod A Clark
The National Centre for Agrifood Research in Medicine, University of Mannitoba, Winnipeg, Canada
Metabolism 53:1145-51. 2004..In summary, because of its long-lasting effects, oral administration, and lack of side effects, vanadate/tea represents a potentially important alternative therapy for an insulin-deficient diabetic state... - Is infection a component of atherosclerosis?Grant N Pierce
Division of Stroke and Vascular Disease, St Boniface Hospital Research Centre, Physiology Faculty of Medicine, University of Manitoba, Winnipeg, Canada
J Muscle Res Cell Motil 25:617-8. 2004 - Hyperhomocysteinemia induces hepatic cholesterol biosynthesis and lipid accumulation via activation of transcription factorsConnie W H Woo
Department of Physiology, St. Boniface Hospital Research Centre, Faculty of Medicine, R4032, 351 Tache Ave, Winnipeg, Manitoba, Canada R2H 2A6
Am J Physiol Endocrinol Metab 288:E1002-10. 2005..In conclusion, the stimulatory effect of Hcy on hepatic cholesterol biosynthesis may represent an important mechanism for hepatic lipid accumulation and cardiovascular disorder associated with hyperhomocysteinemia... - Augmented cell cycle protein expression and kinase activity in atherosclerotic rabbit vesselsMarjorie E Zettler
Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre, and Department of Physiology, Faculties of Medicine and Pharmacy, University of Manitoba, Winnipeg, Manitoba
Exp Clin Cardiol 15:e139-44. 2010..Expression levels were similar during moderate and severe atherosclerosis, and were even detected in nonatherosclerotic vascular tissue bordering the plaque... - Adenovirally delivered shRNA strongly inhibits Na+-Ca2+ exchanger expression but does not prevent contraction of neonatal cardiomyocytesCecilia Hurtado
Division of Stroke and Vascular Disease, St Boniface General Hospital Research Center, 351 Tache Avenue, Winnipeg, MB, Canada R2H 2A6
J Mol Cell Cardiol 38:647-54. 2005..Furthermore, this approach provides a valuable means for assessing the role of NCX1 and could be utilized to examine other cardiac proteins in physiological and pathological studies... - Differential sensitivities of the NCX1.1 and NCX1.3 isoforms of the Na+-Ca2+ exchanger to alpha-linolenic acidBradley P Ander
Canadian Centre for Agri Food Research in Health and Medicine, Winnipeg, Manitoba, Canada
Cardiovasc Res 73:395-403. 2007..Thus, we tested the effects of ALA and other distinct fatty acids on the cardiac (NCX1.1) and vascular (NCX1.3) NCX isoforms... - Lysophospholipids do not directly modulate Na(+)-H+ exchangeDanny P Goel
Cell Biology Laboratory, Division of Stroke and Vascular Disease, St. Boniface General Hospital Research Centre, Winnipeg, Manitoba, Canada
Mol Cell Biochem 251:3-7. 2003..We conclude that any stimulatory effects of lysolipids on Na(+)-H+ exchange do not occur through a direct action on the exchanger or its membrane lipid environment and must occur through a second messenger pathway... - Nucleoplasmic calcium regulation in rabbit aortic vascular smooth muscle cellsBernard Abrenica
Department of Oral Biology, Division of Stroke and Vascular Disease, University of Manitoba, Winnipeg, MB R2H 2A6, Canada
Can J Physiol Pharmacol 81:301-10. 2003..These latter observations raise the possibility that VSMC nuclei represent an important sink of intracellular Ca2+ and may help explain vasodilatory actions of FK506 observed by others... - Effects of omega-3 polyunsaturated fatty acids on cardiac sarcolemmal Na(+)/H(+) exchangeDanny P Goel
Cell Biology Laboratory, Division of Stroke and Vascular Disease, St. Boniface General Hospital Research Centre, Winnipeg, Manitoba R2H 2A6, Canada
Am J Physiol Heart Circ Physiol 283:H1688-94. 2002..This may explain, in part, their known cardioprotective effects and antiarrhythmic actions during ischemia-reperfusion... - Nucleolin is a calcium-binding proteinJames S C Gilchrist
Department of Oral Biology and Physiology, Division of Stroke and Vascular Disease, University of Manitoba, Winnipeg, Manitoba, Canada
J Cell Biochem 85:268-78. 2002..Although the Ca2+-dependent functions of nucleolin are unknown, we discuss the possibility that like the structurally analogous HMG-1, its Ca2+-dependent actions may regulate chromatin structure, possibly during apoptosis... - Cells expressing unique Na+/Ca2+ exchange (NCX1) splice variants exhibit different susceptibilities to Ca2+ overloadCecilia Hurtado
Division of Stroke and Vascular Disease, St Boniface Hospital Research Centre, Winnipeg, MB, Canada R2H 2A6
Am J Physiol Heart Circ Physiol 290:H2155-62. 2006..1 promotes Ca2+ overload in response to cardiac glycosides and ischemic challenges. These results highlight the importance of ionic regulation in controlling NCX1 activity under conditions that promote Ca2+ overload...