B A Perkins

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint Diagnosis and management of diabetic neuropathy
    Bruce A Perkins
    Toronto General Hospital, University Health Network, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada
    Curr Diab Rep 2:495-500. 2002
  2. ncbi request reprint Diabetic neuropathy: a review emphasizing diagnostic methods
    Bruce A Perkins
    EN 11 209, TGH, University Health Network, University of Toronto, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4
    Clin Neurophysiol 114:1167-75. 2003
  3. pmc Structure-function relationship between corneal nerves and conventional small-fiber tests in type 1 diabetes
    Gavasker A Sivaskandarajah
    Corresponding author Bruce A Perkins
    Diabetes Care 36:2748-55. 2013
  4. pmc Serum levels of advanced glycation endproducts and other markers of protein damage in early diabetic nephropathy in type 1 diabetes
    Bruce A Perkins
    Division of Endocrinology, University of Toronto, Toronto, Canada
    PLoS ONE 7:e35655. 2012
  5. pmc Heart rate variability and sensorimotor polyneuropathy in type 1 diabetes
    Steven Orlov
    Department of Medicine, Division of Endocrinology and Metabolism, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 35:809-16. 2012
  6. pmc Detection of diabetic sensorimotor polyneuropathy by corneal confocal microscopy in type 1 diabetes: a concurrent validity study
    Ausma Ahmed
    Division of Endocrinology and Metabolism, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 35:821-8. 2012
  7. ncbi request reprint Multi-site testing with a point-of-care nerve conduction device can be used in an algorithm to diagnose diabetic sensorimotor polyneuropathy
    Bruce A Perkins
    Division of Endocrinology, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 31:522-4. 2008
  8. pmc Early nephropathy in type 1 diabetes: the importance of early renal function decline
    Bruce A Perkins
    Division of Endocrinology and Metabolism, University of Toronto, Toronto, Canada
    Curr Opin Nephrol Hypertens 18:233-40. 2009
  9. pmc In patients with type 1 diabetes and new-onset microalbuminuria the development of advanced chronic kidney disease may not require progression to proteinuria
    Bruce A Perkins
    Division of Endocrinology, University of Toronto, Toronto, Ontario, Canada
    Kidney Int 77:57-64. 2010
  10. pmc Prediction of incident diabetic neuropathy using the monofilament examination: a 4-year prospective study
    Bruce A Perkins
    Division of Endocrinology and Metabolism, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 33:1549-54. 2010

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Diagnosis and management of diabetic neuropathy
    Bruce A Perkins
    Toronto General Hospital, University Health Network, 200 Elizabeth Street, Toronto, Ontario M5G 2C4, Canada
    Curr Diab Rep 2:495-500. 2002
    ..The management of DSP is centered on optimal glycemic control, diligent foot care, and pain control as a means of preventing the progression of DSP and reducing the morbidity associated with foot complications...
  2. ncbi request reprint Diabetic neuropathy: a review emphasizing diagnostic methods
    Bruce A Perkins
    EN 11 209, TGH, University Health Network, University of Toronto, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4
    Clin Neurophysiol 114:1167-75. 2003
    ..Novel investigative techniques are highly promising, but their usefulness in the clinic setting remains limited at this time. This article presents an overview of diagnostic methods for DSP...
  3. pmc Structure-function relationship between corneal nerves and conventional small-fiber tests in type 1 diabetes
    Gavasker A Sivaskandarajah
    Corresponding author Bruce A Perkins
    Diabetes Care 36:2748-55. 2013
    ..CONCLUSIONS Small nerve fiber structural morphology assessed by IVCCM correlated well with functional measures of small nerve fiber injury. In particular, CNFL, CNFD, and CNBD demonstrated clear structure-function relationships. ..
  4. pmc Serum levels of advanced glycation endproducts and other markers of protein damage in early diabetic nephropathy in type 1 diabetes
    Bruce A Perkins
    Division of Endocrinology, University of Toronto, Toronto, Canada
    PLoS ONE 7:e35655. 2012
    ..To determine the role of markers of plasma protein damage by glycation, oxidation and nitration in microalbuminuria onset or subsequent decline of glomerular filtration rate (termed "early GFR decline") in patients with type 1 diabetes...
  5. pmc Heart rate variability and sensorimotor polyneuropathy in type 1 diabetes
    Steven Orlov
    Department of Medicine, Division of Endocrinology and Metabolism, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 35:809-16. 2012
    ..Reduced heart rate variability (HRV) is classically viewed as an early phenomenon in diabetic sensorimotor polyneuropathy (DSP). We aimed to determine the characteristics of HRV across the spectrum of clinical DSP in type 1 diabetes...
  6. pmc Detection of diabetic sensorimotor polyneuropathy by corneal confocal microscopy in type 1 diabetes: a concurrent validity study
    Ausma Ahmed
    Division of Endocrinology and Metabolism, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 35:821-8. 2012
    ..We aimed to determine the corneal confocal microscopy (CCM) parameter that best identifies diabetic sensorimotor polyneuropathy (DSP) in type 1 diabetes and to describe its performance characteristics...
  7. ncbi request reprint Multi-site testing with a point-of-care nerve conduction device can be used in an algorithm to diagnose diabetic sensorimotor polyneuropathy
    Bruce A Perkins
    Division of Endocrinology, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 31:522-4. 2008
    ..We aimed to establish whether multi-nerve testing with a point-of-care nerve conduction device could be used to diagnose diabetic sensorimotor polyneuropathy...
  8. pmc Early nephropathy in type 1 diabetes: the importance of early renal function decline
    Bruce A Perkins
    Division of Endocrinology and Metabolism, University of Toronto, Toronto, Canada
    Curr Opin Nephrol Hypertens 18:233-40. 2009
    ..However, recent observational studies refined the traditional model of early nephropathy in type 1 diabetes and may inform more effective therapies for the prevention of chronic kidney disease...
  9. pmc In patients with type 1 diabetes and new-onset microalbuminuria the development of advanced chronic kidney disease may not require progression to proteinuria
    Bruce A Perkins
    Division of Endocrinology, University of Toronto, Toronto, Ontario, Canada
    Kidney Int 77:57-64. 2010
    ....
  10. pmc Prediction of incident diabetic neuropathy using the monofilament examination: a 4-year prospective study
    Bruce A Perkins
    Division of Endocrinology and Metabolism, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 33:1549-54. 2010
    ..To determine the specific monofilament examination score that predicts the subsequent 4-year incidence of diabetic neuropathy with the highest degree of diagnostic accuracy...
  11. doi request reprint Short-term metabolic change is associated with improvement in measures of diabetic neuropathy: a 1-year placebo cohort analysis
    B A Perkins
    Division of Endocrinology and Metabolism, Department of Medicine, University of Toronto, 200 Elizabeth Street, Toronto, Ontario, Canada
    Diabet Med 27:1271-9. 2010
    ..We aimed to determine the variables associated with this paradoxical nerve function improvement...
  12. ncbi request reprint Validation of a novel point-of-care nerve conduction device for the detection of diabetic sensorimotor polyneuropathy
    Bruce A Perkins
    Toronto General Hospital, 200 Elizabeth St, Room EN 12 217, Toronto, Ontario, Canada M5G 2C4
    Diabetes Care 29:2023-7. 2006
    ....
  13. doi request reprint Variables associated with corneal confocal microscopy parameters in healthy volunteers: implications for diabetic neuropathy screening
    T Wu
    Division of Endocrinology and Metabolism, Department of Medicine, University of Toronto, Toronto, Canada
    Diabet Med 29:e297-303. 2012
    ....
  14. ncbi request reprint Glycemic control is related to the morphological severity of diabetic sensorimotor polyneuropathy
    B A Perkins
    Toronto General Hospital, University Health Network, University of Toronto, Canada
    Diabetes Care 24:748-52. 2001
    ..Based on the results of the present study, it might be hypothesized that improving glycemic control will lessen severity of DSP in terms of FD loss in subjects with diabetes...
  15. doi request reprint Ability of cystatin C to detect acute changes in glomerular filtration rate provoked by hyperglycaemia in uncomplicated Type 1 diabetes
    D Z I Cherney
    Division of Nephrology, University Health Network, Hospital for Sick Children, University of Toronto, ON, Canada
    Diabet Med 27:1358-65. 2010
    ..To test whether it can reflect acute changes, we examined the impact of clamped hyperglycaemia on GFR(CYSTATIN C) and GFR(INULIN) in subjects with Type 1 diabetes...
  16. ncbi request reprint Comparison of vibration perception thresholds obtained with the Neurothesiometer and the CASE IV and relationship to nerve conduction studies
    Vera Bril
    Toronto General Hospital, University of Toronto, University Health Network, 200 Elizabeth Street, Toronto, Ontario, Canada M5G 2C4
    Diabet Med 19:661-6. 2002
    ..Information comparing the VPT obtained with the Neurothesiometer with that with the Vibratron is available, but not for a similar comparison with the CASE IV (computer-assisted sensory examination device)...
  17. pmc Reliability and validity of the modified Toronto Clinical Neuropathy Score in diabetic sensorimotor polyneuropathy
    V Bril
    University Health Network, University of Toronto, Toronto, ON, Canada
    Diabet Med 26:240-6. 2009
    ..We aimed to assess the reproducibility of this modified tool, the mTCNS and to determine its validity relative to the precursor TCNS...
  18. doi request reprint Reproducibility of in vivo corneal confocal microscopy as a novel screening test for early diabetic sensorimotor polyneuropathy
    P Hertz
    Division of Endocrinology and Metabolism Division of Neurology, University of Toronto, Toronto, ON, Canada
    Diabet Med 28:1253-60. 2011
    ....
  19. ncbi request reprint Symmetry of nerve conduction studies in different stages of diabetic polyneuropathy
    Bruce A Perkins
    EN 11 209, Toronto General Hospital, University Health Network, University of Toronto, 200 Elizabeth St, Toronto, Ontario, Canada M5G 2C4
    Muscle Nerve 25:212-7. 2002
    ..Thus, unilateral evaluation of NCS in DSP is sufficient as a reference standard in clinical trials. We also conclude that great degrees of asymmetry in NCS results are reason to question inclusion of DSP patients in clinical trials...
  20. ncbi request reprint Validation of the Toronto Clinical Scoring System for diabetic polyneuropathy
    Vera Bril
    Toronto General Hospital, University Health Network, University of Toronto, Toronto, Canada
    Diabetes Care 25:2048-52. 2002
    ....
  21. ncbi request reprint Cooling detection thresholds in the assessment of diabetic sensory polyneuropathy: comparison of CASE IV and Medoc instruments
    Lorne H Zinman
    University Health Network, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 27:1674-9. 2004
    ..The present study sought to determine the agreement between two common testing devices and to determine whether these are concordant in their association with predictor variables for diabetic sensory polyneuropathy...
  22. pmc Exercise and glucose metabolism in persons with diabetes mellitus: perspectives on the role for continuous glucose monitoring
    Michael Riddell
    School of Kinesiology and Health Science, Muscle Research Centre, Faculty of Health, York University, Toronto, Ontario, Canada
    J Diabetes Sci Technol 3:914-23. 2009
    ....
  23. ncbi request reprint Efficacy of continuous real-time blood glucose monitoring during and after prolonged high-intensity cycling exercise: spinning with a continuous glucose monitoring system
    Katherine E Iscoe
    School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada
    Diabetes Technol Ther 8:627-35. 2006
    ..Continuous glucose monitoring systems have recently emerged as a potentially important tool in diabetes management, allowing individuals to track glucose levels continuously and learn how various behaviors influence glucose control...
  24. pmc Association of vitamin D with insulin resistance and beta-cell dysfunction in subjects at risk for type 2 diabetes
    Sheena Kayaniyil
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada
    Diabetes Care 33:1379-81. 2010
    ..To examine cross-sectional associations of serum vitamin D [25-hydroxyvitamin D, 25(OH)D] concentration with insulin resistance (IR) and beta-cell dysfunction in 712 subjects at risk for type 2 diabetes...
  25. ncbi request reprint Early vascular risk factor modification in type 1 diabetes
    Bruce A Perkins
    N Engl J Med 352:408-9. 2005
  26. ncbi request reprint Carpal tunnel syndrome in patients with diabetic polyneuropathy
    Bruce A Perkins
    Beth Israel Deaconness Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes Care 25:565-9. 2002
    ..The prevalence of clinical CTS and the most efficient electrodiagnostic discriminators of CTS from diffuse neuropathy are uncertain...
  27. ncbi request reprint Regression of microalbuminuria in type 1 diabetes
    Bruce A Perkins
    Section on Genetics and Epidemiology, Research Division, Joslin Diabetes Center, Boston, MA 02215, USA
    N Engl J Med 348:2285-93. 2003
    ..In the present study, we aimed to determine the frequency of a significant reduction in urinary albumin excretion and factors affecting such reduction in patients with type 1 diabetes and microalbuminuria...
  28. ncbi request reprint Objective evidence for the reversibility of nerve injury in diabetic neuropathic cachexia
    Jaspreet Grewal
    Diabetes Care 29:473-4. 2006
  29. ncbi request reprint Early nephropathy in type 1 diabetes: a new perspective on who will and who will not progress
    Bruce A Perkins
    Section on Genetics and Epidemiology, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Curr Diab Rep 5:455-63. 2005
    ..Therefore, early renal function decline, rather than microalbuminuria, may be considered as the early marker of the committed process underlying progressive diabetic nephropathy...
  30. ncbi request reprint Microalbuminuria and the risk for early progressive renal function decline in type 1 diabetes
    Bruce A Perkins
    Section on Genetics and Epidemiology, Research Division, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    J Am Soc Nephrol 18:1353-61. 2007
    ..Together with testing for microalbuminuria, clinical protocols using cystatin C to diagnose early renal function decline and track response to therapeutic interventions should be developed...
  31. ncbi request reprint Determinants of progression from microalbuminuria to proteinuria in patients who have type 1 diabetes and are treated with angiotensin-converting enzyme inhibitors
    Linda H Ficociello
    Research Division, Joslin Diabetes Center, Boston, Massachusetts 02215, USA
    Clin J Am Soc Nephrol 2:461-9. 2007
    ..The mechanisms that are responsible for the frequent failure of ACE-I to prevent progression of microalbuminuria to proteinuria in a clinical setting are not clear...