John H Peever

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. doi request reprint Neuroscience: A Distributed Neural Network Controls REM Sleep
    John Peever
    Departments of Cell and Systems Biology and Physiology, University of Toronto, Toronto, ON, M5S 3G5, Canada Electronic address
    Curr Biol 26:R34-5. 2016
  2. doi request reprint Human Behavior: Sleep in Hunter-Gatherer Societies
    John Peever
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S 3G5, Canada Department of Physiology, University of Toronto, Toronto, Ontario M5S 3G5, Canada Electronic address
    Curr Biol 25:R1133-5. 2015
  3. doi request reprint Breakdown in REM sleep circuitry underlies REM sleep behavior disorder
    John Peever
    Systems Neurobiology Laboratory, Departments of Cell and Systems Biology and Physiology, University of Toronto, Ontario, Canada Electronic address
    Trends Neurosci 37:279-88. 2014
  4. doi request reprint Control of motoneuron function and muscle tone during REM sleep, REM sleep behavior disorder and cataplexy/narcolepsy
    J Peever
    Department of Cell and Systems Biology and Physiology, University of Toronto, Toronto, Ontario, Canada
    Arch Ital Biol 149:454-66. 2011
  5. doi request reprint Identification of the transmitter and receptor mechanisms responsible for REM sleep paralysis
    Patricia L Brooks
    Department of Cell and Systems Biology, Systems Neurobiology Laboratory, University of Toronto, Toronto, Ontario M5S 3G5, Canada
    J Neurosci 32:9785-95. 2012
  6. doi request reprint Glycinergic and GABA(A)-mediated inhibition of somatic motoneurons does not mediate rapid eye movement sleep motor atonia
    Patricia L Brooks
    Department of Cell and Systems Biology, Systems Neurobiology Laboratory, University of Toronto, Toronto, Ontario, Canada M5S 3G5
    J Neurosci 28:3535-45. 2008
  7. doi request reprint GABAergic and glycinergic control of upper airway motoneurons in rapid eye movement sleep
    Patricia L Brooks
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada
    Adv Exp Med Biol 669:259-62. 2010
  8. doi request reprint Dopamine triggers skeletal muscle tone by activating D1-like receptors on somatic motoneurons
    Peter B Schwarz
    Systems Neurobiology Laboratory, Department of Cell and Systems Biology, University of Toronto, 25 Harbord St, Toronto, ON M5S 3G5, Canada
    J Neurophysiol 106:1299-309. 2011
  9. doi request reprint Noradrenergic control of trigeminal motoneurons in sleep: relevance to sleep apnea
    Peter B Schwarz
    Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada
    Adv Exp Med Biol 669:281-4. 2010
  10. pmc Noradrenaline triggers muscle tone by amplifying glutamate-driven excitation of somatic motoneurones in anaesthetized rats
    Peter B Schwarz
    Department Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario, M5S 3G5, Canada
    J Physiol 586:5787-802. 2008

Collaborators

Detail Information

Publications16

  1. doi request reprint Neuroscience: A Distributed Neural Network Controls REM Sleep
    John Peever
    Departments of Cell and Systems Biology and Physiology, University of Toronto, Toronto, ON, M5S 3G5, Canada Electronic address
    Curr Biol 26:R34-5. 2016
    ..How does the brain control dreams? New science shows that a small node of cells in the medulla - the most primitive part of the brain - may function to control REM sleep, the brain state that underlies dreaming. ..
  2. doi request reprint Human Behavior: Sleep in Hunter-Gatherer Societies
    John Peever
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S 3G5, Canada Department of Physiology, University of Toronto, Toronto, Ontario M5S 3G5, Canada Electronic address
    Curr Biol 25:R1133-5. 2015
    ....
  3. doi request reprint Breakdown in REM sleep circuitry underlies REM sleep behavior disorder
    John Peever
    Systems Neurobiology Laboratory, Departments of Cell and Systems Biology and Physiology, University of Toronto, Ontario, Canada Electronic address
    Trends Neurosci 37:279-88. 2014
    ..This finding is important because it opens new avenues for treating RBD and understanding its link to neurodegenerative disorders. ..
  4. doi request reprint Control of motoneuron function and muscle tone during REM sleep, REM sleep behavior disorder and cataplexy/narcolepsy
    J Peever
    Department of Cell and Systems Biology and Physiology, University of Toronto, Toronto, Ontario, Canada
    Arch Ital Biol 149:454-66. 2011
    ..Together, this research indicates that multiple transmitters systems are responsible for regulating postural muscle tone during REM sleep, RBD and cataplexy...
  5. doi request reprint Identification of the transmitter and receptor mechanisms responsible for REM sleep paralysis
    Patricia L Brooks
    Department of Cell and Systems Biology, Systems Neurobiology Laboratory, University of Toronto, Toronto, Ontario M5S 3G5, Canada
    J Neurosci 32:9785-95. 2012
    ..These results demonstrate that multiple receptor mechanisms trigger REM sleep paralysis. Breakdown in normal REM inhibition may underlie common sleep motor pathologies such as REM sleep behavior disorder...
  6. doi request reprint Glycinergic and GABA(A)-mediated inhibition of somatic motoneurons does not mediate rapid eye movement sleep motor atonia
    Patricia L Brooks
    Department of Cell and Systems Biology, Systems Neurobiology Laboratory, University of Toronto, Toronto, Ontario, Canada M5S 3G5
    J Neurosci 28:3535-45. 2008
    ..Our data refute the prevailing hypothesis that REM atonia is caused by glycinergic inhibition. The inhibitory mechanism mediating REM atonia therefore requires reevaluation...
  7. doi request reprint GABAergic and glycinergic control of upper airway motoneurons in rapid eye movement sleep
    Patricia L Brooks
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada
    Adv Exp Med Biol 669:259-62. 2010
    ..The results reported herein indicate that GABA(B) receptors, acting in concert with GABA(A) and glycine receptors, play a role in mediating REM sleep atonia...
  8. doi request reprint Dopamine triggers skeletal muscle tone by activating D1-like receptors on somatic motoneurons
    Peter B Schwarz
    Systems Neurobiology Laboratory, Department of Cell and Systems Biology, University of Toronto, 25 Harbord St, Toronto, ON M5S 3G5, Canada
    J Neurophysiol 106:1299-309. 2011
    ..Our results provide the first demonstration that dopamine can directly control movement by manipulating somatic motoneuron behavior and skeletal muscle tone...
  9. doi request reprint Noradrenergic control of trigeminal motoneurons in sleep: relevance to sleep apnea
    Peter B Schwarz
    Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada
    Adv Exp Med Biol 669:281-4. 2010
    ..We report that noradrenaline cannot trigger motoneuron excitability on its own, instead acting to facilitate glutamatergic motor excitation...
  10. pmc Noradrenaline triggers muscle tone by amplifying glutamate-driven excitation of somatic motoneurones in anaesthetized rats
    Peter B Schwarz
    Department Cell and Systems Biology, University of Toronto, 25 Harbord Street, Toronto, Ontario, M5S 3G5, Canada
    J Physiol 586:5787-802. 2008
    ....
  11. doi request reprint A noradrenergic mechanism functions to couple motor behavior with arousal state
    Christian R Burgess
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, M5S 3G5, Canada
    Curr Biol 23:1719-25. 2013
    ..Here, we used hypocretin knockout mice to identify the neurochemical cause of cataplexy and to determine the biochemical mechanisms that normally function to couple arousal and motor systems...
  12. doi request reprint Impaired GABA and glycine transmission triggers cardinal features of rapid eye movement sleep behavior disorder in mice
    Patricia L Brooks
    Systems Neurobiology Laboratory, Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario M5S 3G5, Canada
    J Neurosci 31:7111-21. 2011
    ..We propose that these mice are a useful resource for investigating in vivo disease mechanisms and developing potential therapeutics for RBD...
  13. pmc Dopaminergic regulation of sleep and cataplexy in a murine model of narcolepsy
    Christian R Burgess
    Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada
    Sleep 33:1295-304. 2010
    ..To determine if the dopaminergic system modulates cataplexy, sleep attacks and sleep-wake behavior in narcoleptic mice...
  14. ncbi request reprint Biochemical control of airway motor neurons during rapid eye movement sleep
    Patricia L Brooks
    University of Toronto, Department of Cell and Systems Biology
    Adv Exp Med Biol 605:437-41. 2008
  15. pmc Noradrenergic modulation of masseter muscle activity during natural rapid eye movement sleep requires glutamatergic signalling at the trigeminal motor nucleus
    Peter B Schwarz
    Systems Neurobiology Laboratory, Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada
    J Physiol 592:3597-609. 2014
    ..We conclude that the presence of an endogenous glutamatergic drive is necessary for noradrenaline to trigger muscle activity at the level of the motoneuron in an animal behaving naturally. ..
  16. ncbi request reprint Bilateral coordination of inspiratory neurones in the rat
    Linlin Shen
    Department of Physiology, University of Toronto, Toronto, Ontario, M5S 1A8, Canada
    Pflugers Arch 443:829-35. 2002
    ....