M S C Pedras

Summary

Affiliation: University of Saskatchewan
Country: Canada

Publications

  1. Pedras M. The chemical ecology of crucifers and their fungal pathogens: boosting plant defenses and inhibiting pathogen invasion. Chem Rec. 2008;8:109-15 pubmed publisher
    ..Overall results of current work show the feasibility of using selective inhibitors of fungal detoxifying enzymes, i.e., paldoxins, to protect plants by boosting their chemical defenses. ..
  2. Pedras M, Minic Z, Jha M. Brassinin oxidase, a fungal detoxifying enzyme to overcome a plant defense -- purification, characterization and inhibition. FEBS J. 2008;275:3691-705 pubmed publisher
    ..This discovery suggests that camalexin could protect crucifers from attacks by L. maculans because camalexin is not metabolized by this pathogen and is a strong mycelial growth inhibitor. ..
  3. Pedras M, Yu Y. Structure and biological activity of maculansin A, a phytotoxin from the phytopathogenic fungus Leptosphaeria maculans. Phytochemistry. 2008;69:2966-71 pubmed publisher
    ..Considering that L. maculans seems to be expanding its host range to infect brown mustard as well, maculansins could assist in chemotaxonomic studies to group the diverse isolates...
  4. Pedras M, Chumala P, Jin W, Islam M, Hauck D. The phytopathogenic fungus Alternaria brassicicola: phytotoxin production and phytoalexin elicitation. Phytochemistry. 2009;70:394-402 pubmed publisher
    ..brassicicola. In addition, the structure elucidation of three hitherto unknown metabolites having a fusicoccane skeleton was carried out and the antifungal activity of several plant defenses against A. brassicicola was determined. ..
  5. Pedras M, Okinyo Owiti D, Thoms K, Adio A. The biosynthetic pathway of crucifer phytoalexins and phytoanticipins: de novo incorporation of deuterated tryptophans and quasi-natural compounds. Phytochemistry. 2009;70:1129-38 pubmed publisher
    ..A higher substrate specificity of some enzymes of the phytoalexin pathway might explain the relatively lower structural diversity among phytoalexins than among glucosinolates. ..
  6. Pedras M, Abdoli A. Methoxycamalexins and related compounds: Syntheses, antifungal activity and inhibition of brassinin oxidase. Bioorg Med Chem. 2018;: pubmed publisher
  7. Pedras M, To Q. Non-indolyl cruciferous phytoalexins: Nasturlexins and tridentatols, a striking convergent evolution of defenses in terrestrial plants and marine animals?. Phytochemistry. 2015;113:57-63 pubmed publisher
    ..The biosynthesis of these metabolites in both a terrestrial plant and a marine animal suggests a convergent evolution of unique metabolic pathways recruited for defense. ..
  8. Pedras M, To Q. Interrogation of biosynthetic pathways of the cruciferous phytoalexins nasturlexins with isotopically labelled compounds. Org Biomol Chem. 2018;16:3625-3638 pubmed publisher
    ..An application beyond these findings could lead to "designer crops" containing a wider range of chemical defenses that could make such crops more resistant to pests and diseases, a greatly advantageous trait. ..
  9. Pedras M, Alavi M, To Q. Expanding the nasturlexin family: Nasturlexins C and D and their sulfoxides are phytoalexins of the crucifers Barbarea vulgaris and B. verna. Phytochemistry. 2015;118:131-8 pubmed publisher
    ..This work indicates that B. vulgaris and B. verna have great potential as sources of defense pathways transferable to agriculturally important crops within the Brassica species. ..

More Information

Publications22

  1. Pedras M, Park M. Metabolite diversity in the plant pathogen Alternaria brassicicola: factors affecting production of brassicicolin A, depudecin, phomapyrone A and other metabolites. Mycologia. 2015;107:1138-50 pubmed publisher
    ..0 mM). Epigenetic modifiers, 5-azacitidin (5-AZA), suberoylanilide hydroxamic acid (SAHA) and suberoyl bis-hydroxamic acid (SBHA) do not affect the metabolite profiles of liquid cultures of this fungal pathogen. ..
  2. Pedras M, To Q, Schatte G. Divergent reactivity of an indole glucosinolate yields Lossen or Neber rearrangement products: the phytoalexin rapalexin A or a unique β-d-glucopyranose fused heterocycle. Chem Commun (Camb). 2016;52:2505-8 pubmed publisher
  3. Pedras M, Minic Z, Sarma Mamillapalle V. Substrate specificity and inhibition of brassinin hydrolases, detoxifying enzymes from the plant pathogens Leptosphaeria maculans and Alternaria brassicicola. FEBS J. 2009;276:7412-28 pubmed publisher
    ..The current information should facilitate the design of specific synthetic inhibitors of these enzymes for plant treatments against blackleg and black spot fungal infections. ..
  4. Pedras M, Abdoli A. Metabolism of the phytoalexins camalexins, their bioisosteres and analogues in the plant pathogenic fungus Alternaria brassicicola. Bioorg Med Chem. 2013;21:4541-9 pubmed publisher
    ..Based on these results, the potential intermediates that lead to formation of indole-3-thiocarboxamides are proposed. ..
  5. Pedras M, To Q. Unveiling the first indole-fused thiazepine: structure, synthesis and biosynthesis of cyclonasturlexin, a remarkable cruciferous phytoalexin. Chem Commun (Camb). 2016;52:5880-3 pubmed publisher
    ..Herein the chemical structure, synthesis, biosynthesis and antifungal activity of cyclonasturlexin, the most intriguing indolyl phytoalexin isolated to date, are reported. ..
  6. Pedras M, Chumala P. Phomapyrones from blackleg causing phytopathogenic fungi: isolation, structure determination, biosyntheses and biological activity. Phytochemistry. 2005;66:81-7 pubmed
    ..In addition, based on results of incorporations of 13C-labeled acetate and malonate, and deuterated methionine, a polyketide pathway is proposed for the biosyntheses of phomapyrones. ..
  7. Pedras M, Yaya E, Glawischnig E. The phytoalexins from cultivated and wild crucifers: chemistry and biology. Nat Prod Rep. 2011;28:1381-405 pubmed publisher
    ..A summary table containing all phytoalexins, their cultivated and wild cruciferous sources, their synthetic starting materials, biotransformation products and biological activities is provided. ..
  8. Pedras M, Hossain S, Snitynsky R. Detoxification of cruciferous phytoalexins in Botrytis cinerea: spontaneous dimerization of a camalexin metabolite. Phytochemistry. 2011;72:199-206 pubmed publisher
    ..A strongly antifungal bisindolylthiadiazole that B. cinerea could not detoxify was discovered, which resulted from spontaneous oxidative dimerization of 3-indolethiocarboxamide, a camalexin detoxification product. ..
  9. Pedras M, Zheng Q. Metabolic responses of Thellungiella halophila/salsuginea to biotic and abiotic stresses: metabolite profiles and quantitative analyses. Phytochemistry. 2010;71:581-9 pubmed publisher
  10. Pedras M, Park M. The biosynthesis of brassicicolin A in the phytopathogen Alternaria brassicicola. Phytochemistry. 2016;132:26-32 pubmed publisher
  11. Pedras M, Abdoli A. Biotransformation of rutabaga phytoalexins by the fungus Alternaria brassicicola: Unveiling the first hybrid metabolite derived from a phytoalexin and a fungal polyketide. Bioorg Med Chem. 2017;25:557-567 pubmed publisher
    ..Phytoalexins resistant to degradation by A. brassicicola are expected to provide the producing plants with higher disease resistance levels. ..
  12. Pedras M, To Q. Defense and signalling metabolites of the crucifer Erucastrum canariense: Synchronized abiotic induction of phytoalexins and galacto-oxylipins. Phytochemistry. 2017;139:18-24 pubmed publisher
    ..In addition, arabidopsides A and D were also identified in extracts of leaves of Nasturtium officinale R. Br. ..
  13. Pedras M, Abdoli A, Sarma Mamillapalle V. Inhibitors of the Detoxifying Enzyme of the Phytoalexin Brassinin Based on Quinoline and Isoquinoline Scaffolds. Molecules. 2017;22: pubmed publisher
    ..Overall, these results indicate that the quinoline scaffold is a good lead to design paldoxins (phytoalexin detoxification inhibitors) that inhibit the detoxification of brassinin by L. maculans. ..