D S Park

Summary

Affiliation: University of Ottawa
Country: Canada

Publications

  1. pmc Cyclin-dependent kinases participate in death of neurons evoked by DNA-damaging agents
    D S Park
    Department of Pathology and Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Cell Biol 143:457-67. 1998
  2. ncbi request reprint Cell cycle regulators in neuronal death evoked by excitotoxic stress: implications for neurodegeneration and its treatment
    D S Park
    Neuroscience Research Institute, University of Ottawa, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada
    Neurobiol Aging 21:771-81. 2000
  3. ncbi request reprint Involvement of retinoblastoma family members and E2F/DP complexes in the death of neurons evoked by DNA damage
    D S Park
    Neuroscience Research Institute, University of Ottawa, Ottawa, Ontario, K1H 8M5, Canada
    J Neurosci 20:3104-14. 2000
  4. ncbi request reprint NAIP protects the nigrostriatal dopamine pathway in an intrastriatal 6-OHDA rat model of Parkinson's disease
    S J Crocker
    Neuroscience Research Institute, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario K1H 8M5, Canada
    Eur J Neurosci 14:391-400. 2001
  5. ncbi request reprint Induction and modulation of cerebellar granule neuron death by E2F-1
    M J O'Hare
    Neuroscience Research Institute, University of Ottawa, Ontario, Canada
    J Biol Chem 275:25358-64. 2000
  6. ncbi request reprint Inhibitors of trypsin-like serine proteases prevent DNA damage-induced neuronal death by acting upstream of the mitochondrial checkpoint and of p53 induction
    H J Rideout
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Neuroscience 107:339-52. 2001
  7. ncbi request reprint Caspase 3 deficiency rescues peripheral nervous system defect in retinoblastoma nullizygous mice
    M T Simpson
    Neuroscience Research Institute, University of Ottawa, Ottawa, Ontario, K1H 8M5, Canada
    J Neurosci 21:7089-98. 2001
  8. ncbi request reprint Involvement of caspase 3 in apoptotic death of cortical neurons evoked by DNA damage
    E Keramaris
    Neuroscience Research Institute, University of Ottawa, Ontario, Canada
    Mol Cell Neurosci 15:368-79. 2000
  9. ncbi request reprint The Rb-CDK4/6 signaling pathway is critical in neural precursor cell cycle regulation
    K L Ferguson
    Neuroscience Research Institute, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
    J Biol Chem 275:33593-600. 2000
  10. pmc c-Jun mediates axotomy-induced dopamine neuron death in vivo
    S J Crocker
    Neuroscience Research Institute, University of Ottawa, Ottawa, ON K1H 8M5, Canada
    Proc Natl Acad Sci U S A 98:13385-90. 2001

Collaborators

Detail Information

Publications17

  1. pmc Cyclin-dependent kinases participate in death of neurons evoked by DNA-damaging agents
    D S Park
    Department of Pathology and Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Cell Biol 143:457-67. 1998
    ..These results suggest that postmitotic neurons may utilize Cdk4 and 6, signals that normally control proliferation, to mediate death signaling resulting from DNA-damaging conditions...
  2. ncbi request reprint Cell cycle regulators in neuronal death evoked by excitotoxic stress: implications for neurodegeneration and its treatment
    D S Park
    Neuroscience Research Institute, University of Ottawa, 451 Smyth Rd, Ottawa, ON K1H 8M5, Canada
    Neurobiol Aging 21:771-81. 2000
    ..Taken together, these data support a role for cell cycle regulators in neuronal death evoked by excitotoxic stress and indicate a potential therapeutic target for treatment of excitotoxicity-related disorders...
  3. ncbi request reprint Involvement of retinoblastoma family members and E2F/DP complexes in the death of neurons evoked by DNA damage
    D S Park
    Neuroscience Research Institute, University of Ottawa, Ottawa, Ontario, K1H 8M5, Canada
    J Neurosci 20:3104-14. 2000
    ..Taken together, these results implicate the CDK-pRb/E2F/DP pathway as a required element in the neuronal death evoked by DNA damage...
  4. ncbi request reprint NAIP protects the nigrostriatal dopamine pathway in an intrastriatal 6-OHDA rat model of Parkinson's disease
    S J Crocker
    Neuroscience Research Institute, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario K1H 8M5, Canada
    Eur J Neurosci 14:391-400. 2001
    ..Taken together, these results suggest that therapeutic strategies based on NAIP may have potential value for the treatment of PD...
  5. ncbi request reprint Induction and modulation of cerebellar granule neuron death by E2F-1
    M J O'Hare
    Neuroscience Research Institute, University of Ottawa, Ontario, Canada
    J Biol Chem 275:25358-64. 2000
    ..These results indicate that E2F-1 expression is sufficient to promote neuronal apoptosis and that endogenous E2F-1 modulates the death of CGNs evoked by low K(+)...
  6. ncbi request reprint Inhibitors of trypsin-like serine proteases prevent DNA damage-induced neuronal death by acting upstream of the mitochondrial checkpoint and of p53 induction
    H J Rideout
    Department of Neurology, Columbia University, New York, NY 10032, USA
    Neuroscience 107:339-52. 2001
    ..We conclude that therapeutic strategies based on serine protease inhibition may be useful in preventing neuronal cell death...
  7. ncbi request reprint Caspase 3 deficiency rescues peripheral nervous system defect in retinoblastoma nullizygous mice
    M T Simpson
    Neuroscience Research Institute, University of Ottawa, Ottawa, Ontario, K1H 8M5, Canada
    J Neurosci 21:7089-98. 2001
    ..These findings suggest that PNS neurons are dependent on caspase 3 for the execution of apoptosis and that caspase 3 may serve as a key therapeutic target for neuroprotection after injury of this cell type...
  8. ncbi request reprint Involvement of caspase 3 in apoptotic death of cortical neurons evoked by DNA damage
    E Keramaris
    Neuroscience Research Institute, University of Ottawa, Ontario, Canada
    Mol Cell Neurosci 15:368-79. 2000
    ..This suggests that the requirement for caspase 3 in death of neurons evoked by DNA damage may differ depending upon the developmental state of the cell...
  9. ncbi request reprint The Rb-CDK4/6 signaling pathway is critical in neural precursor cell cycle regulation
    K L Ferguson
    Neuroscience Research Institute, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
    J Biol Chem 275:33593-600. 2000
    ..Furthermore, our data underscore the importance of the Rb regulatory pathway in neuronal development and cell cycle regulation, independent of CKI sequestration...
  10. pmc c-Jun mediates axotomy-induced dopamine neuron death in vivo
    S J Crocker
    Neuroscience Research Institute, University of Ottawa, Ottawa, ON K1H 8M5, Canada
    Proc Natl Acad Sci U S A 98:13385-90. 2001
    ..Ad.c-JunDN also delayed the degeneration of dopaminergic nigral axons in the striatum after MFB axotomy. Taken together, these findings suggest that activation of c-Jun mediates the loss of dopamine neurons after axotomy injury...
  11. pmc APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death
    A Fortin
    Ottawa Health Research Institute - Neuroscience, University of Ottawa, Ottawa, Ontario K1H-8M5, Canada
    J Cell Biol 155:207-16. 2001
    ..Together, these results demonstrate that Apaf1 is a key transcriptional target for p53 that plays a pivotal role in the regulation of apoptosis after neuronal injury...
  12. ncbi request reprint Induction of CPP32-like activity in PC12 cells by withdrawal of trophic support. Dissociation from apoptosis
    L Stefanis
    Department of Pathology, Taub Center for Alzheimer s Disease Research and Center for Neurobiology and Behavior, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 271:30663-71. 1996
    ....
  13. ncbi request reprint Cell cycle machinery and stroke
    J Rashidian
    Ottawa Health Research Institute, Neuroscience Group, Centre for Stroke Recovery, University of Ottawa, 451 Smyth Road, Ottawa, ON, Canada K1H 8M5
    Biochim Biophys Acta 1772:484-93. 2007
    ..Importantly, determining and blocking the signaling pathway(s) by which these molecules act to mediate ischemic neuronal death, in conjunction with other targets may provide a viable therapeutic strategy for stroke damage...
  14. ncbi request reprint Attenuation of MPTP-induced neurotoxicity and behavioural impairment in NSE-XIAP transgenic mice
    S J Crocker
    Neuroscience Research Institute, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada
    Neurobiol Dis 12:150-61. 2003
    ..Taken together, these findings suggest that strategies to enhance neuronal expression of XIAP may provide therapeutic benefit for the treatment of neurodegeneration in Parkinson's disease...
  15. doi request reprint Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics
    I Irrcher
    Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Canada
    Hum Mol Genet 19:3734-46. 2010
    ..Our findings define a mechanism by which the DJ-1-dependent mitochondrial defects contribute to the increased sensitivity to oxidative stress-induced cell death that has been previously reported...
  16. doi request reprint Pocket proteins pRb and p107 are required for cortical lamination independent of apoptosis
    D S Svoboda
    Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ont, Canada K1H 8M5
    Dev Biol 384:101-13. 2013
    ..These results define a novel role of pocket proteins in regulating cortical lamination through a cell autonomous mechanism independent of their role in apoptosis...
  17. ncbi request reprint Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons
    S P Cregan
    Neuroscience Research Institute, University of Ottawa, Ottawa, Ontario, K1H 8M5, Canada
    J Neurosci 19:7860-9. 1999
    ..These studies demonstrate that p53-induced cell death in postmitotic neurons involves a Bax-dependent caspase-3 activation, suggesting that these molecules are important determinants in neuronal cell death after injury...