Marian A Packham

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi Probenecid inhibits platelet responses to aggregating agents in vitro and has a synergistic inhibitory effect with penicillin G
    M A Packham
    Department of Biochemistry, University of Toronto, Ontario, Canada
    Thromb Haemost 76:239-44. 1996
  2. ncbi Exogenous diacylglycerols synergize with PAF with human platelets, but inhibit PAF-induced responses of rabbit platelets
    M A Packham
    Department of Biochemistry, University of Toronto, Ontario, Canada
    J Lipid Mediat Cell Signal 15:69-87. 1996
  3. ncbi Platelet aggregation and adenosine diphosphate/adenosine triphosphate receptors: a historical perspective
    Marian A Packham
    Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada
    Semin Thromb Hemost 31:129-38. 2005
  4. ncbi Ethanol enhances the inhibitory effect of an oral GPIIb/IIIa antagonist on human platelet function
    Margaret L Rand
    Division of Haematology Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Lab Clin Med 140:391-7. 2002
  5. ncbi Calpain inhibition by calpeptin does not prevent APLT activity reduction in PS-exposing platelets, but calpeptin has independent pro-apoptotic effects
    Adam M Gwozdz
    Division of Haematology Oncology, The Hospital for Sick Children, Toronto, ON, Canada
    Thromb Haemost 103:1218-27. 2010
  6. ncbi Adenosine diphosphate(ADP) does not induce thromboxane A2 generation in human platelets
    Marco Cattaneo
    Blood 99:3868-9; author reply 3869-70. 2002
  7. ncbi Platelet function assays
    Margaret L Rand
    Division of Haematology Oncology, The Hospital for Sick Children, 555 University Ave, Toronto, Ont, Canada M5G 1X8
    Transfus Apher Sci 28:307-17. 2003

Collaborators

Detail Information

Publications7

  1. ncbi Probenecid inhibits platelet responses to aggregating agents in vitro and has a synergistic inhibitory effect with penicillin G
    M A Packham
    Department of Biochemistry, University of Toronto, Ontario, Canada
    Thromb Haemost 76:239-44. 1996
    ..The synergistic inhibitory effect of probenecid on platelet functions could further impair hemostasis if it has already been partially compromised by the administration of other drugs...
  2. ncbi Exogenous diacylglycerols synergize with PAF with human platelets, but inhibit PAF-induced responses of rabbit platelets
    M A Packham
    Department of Biochemistry, University of Toronto, Ontario, Canada
    J Lipid Mediat Cell Signal 15:69-87. 1996
    ....
  3. ncbi Platelet aggregation and adenosine diphosphate/adenosine triphosphate receptors: a historical perspective
    Marian A Packham
    Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada
    Semin Thromb Hemost 31:129-38. 2005
    ..ATP stimulates a rapid influx of calcium into platelets through the P2X (1) receptor, and it may synergize with ADP when these two nucleotides are released from platelets at a site of vessel injury...
  4. ncbi Ethanol enhances the inhibitory effect of an oral GPIIb/IIIa antagonist on human platelet function
    Margaret L Rand
    Division of Haematology Oncology, The Hospital for Sick Children, Toronto, Ontario, Canada
    J Lab Clin Med 140:391-7. 2002
    ....
  5. ncbi Calpain inhibition by calpeptin does not prevent APLT activity reduction in PS-exposing platelets, but calpeptin has independent pro-apoptotic effects
    Adam M Gwozdz
    Division of Haematology Oncology, The Hospital for Sick Children, Toronto, ON, Canada
    Thromb Haemost 103:1218-27. 2010
    ..These additional effects of calpeptin on platelet regulation of intracellular Ca(2+) levels and apoptotic-like events should be taken into account when it is used as an inhibitor of calpain...
  6. ncbi Adenosine diphosphate(ADP) does not induce thromboxane A2 generation in human platelets
    Marco Cattaneo
    Blood 99:3868-9; author reply 3869-70. 2002
  7. ncbi Platelet function assays
    Margaret L Rand
    Division of Haematology Oncology, The Hospital for Sick Children, 555 University Ave, Toronto, Ont, Canada M5G 1X8
    Transfus Apher Sci 28:307-17. 2003
    ....