Brian O'Sullivan

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi request reprint The benefits and pitfalls of ipsilateral radiotherapy in carcinoma of the tonsillar region
    B O'Sullivan
    Department of Radiation Oncology, Wharton Head and Neck Centre, The Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 51:332-43. 2001
  2. doi request reprint Magnetic resonance imaging of nasopharyngeal carcinoma
    Eugene Yu
    Head and Neck Imaging and Neuroradiology, Department of Medical Imaging, University of Toronto, Princess Margaret Hospital, 610 University Avenue, Toronto, Ontario, Canada
    Expert Rev Anticancer Ther 10:365-75. 2010
  3. pmc Progressive tumefactive fibroinflammatory lesion of the infratemporal fossa treated by radiation therapy
    Frank J P Hoebers
    Radiation Medicine Program, Princess Margaret Hospital, University Health Network and Radiation Oncology, University of Toronto, Ontario
    Rare Tumors 4:e12. 2012
  4. pmc Oral cancer: Current role of radiotherapy and chemotherapy
    Shao Hui Huang
    Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    Med Oral Patol Oral Cir Bucal 18:e233-40. 2013
  5. doi request reprint Deintensification candidate subgroups in human papillomavirus-related oropharyngeal cancer according to minimal risk of distant metastasis
    Brian O'Sullivan
    Room 5 624, Princess Margaret Hospital, 610 University Ave, Toronto, Ontario, Canada M5G 2M9
    J Clin Oncol 31:543-50. 2013
  6. doi request reprint Outcomes of HPV-related oropharyngeal cancer patients treated by radiotherapy alone using altered fractionation
    Brian O'Sullivan
    Department of Radiation Oncology, Princess Margaret Hospital, Toronto, Canada
    Radiother Oncol 103:49-56. 2012
  7. ncbi request reprint Nasopharynx cancer: therapeutic value of chemoradiotherapy
    Brian O'Sullivan
    Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 69:S118-21. 2007
  8. ncbi request reprint Techniques to modulate radiotherapy toxicity and outcome in soft tissue sarcoma
    Brian O'Sullivan
    Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, 610 University Avenue, Toronto, ON M5G 2M9, Canada
    Curr Treat Options Oncol 4:453-64. 2003
  9. ncbi request reprint New TNM staging criteria for head and neck tumors
    Brian O'Sullivan
    Wharton Head and Neck Center, Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Canada
    Semin Surg Oncol 21:30-42. 2003
  10. ncbi request reprint Staging and prognostic factor evaluation in soft tissue sarcoma
    Brian O'Sullivan
    Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, 610 University Avenue, Toronto, Ontario, M5G 2M9, Canada
    Surg Oncol Clin N Am 12:333-53. 2003

Detail Information

Publications104 found, 100 shown here

  1. ncbi request reprint The benefits and pitfalls of ipsilateral radiotherapy in carcinoma of the tonsillar region
    B O'Sullivan
    Department of Radiation Oncology, Wharton Head and Neck Centre, The Princess Margaret Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 51:332-43. 2001
    ..The primary purpose of this study is to evaluate the risk of failure in the opposite neck in cases selected for unilateral radiotherapy over a 21-year period...
  2. doi request reprint Magnetic resonance imaging of nasopharyngeal carcinoma
    Eugene Yu
    Head and Neck Imaging and Neuroradiology, Department of Medical Imaging, University of Toronto, Princess Margaret Hospital, 610 University Avenue, Toronto, Ontario, Canada
    Expert Rev Anticancer Ther 10:365-75. 2010
    ..MRI is currently considered the best modality to assess for NPC. The aim of this review is to provide a pictorial MRI review of NPC according to the recently released 7th edition of the International Union Against Cancer staging system...
  3. pmc Progressive tumefactive fibroinflammatory lesion of the infratemporal fossa treated by radiation therapy
    Frank J P Hoebers
    Radiation Medicine Program, Princess Margaret Hospital, University Health Network and Radiation Oncology, University of Toronto, Ontario
    Rare Tumors 4:e12. 2012
    ..The dilemma of treatment of benign disease with radiation with potential long-term complications is discussed and a review of the literature on TFIL is presented...
  4. pmc Oral cancer: Current role of radiotherapy and chemotherapy
    Shao Hui Huang
    Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    Med Oral Patol Oral Cir Bucal 18:e233-40. 2013
    ..Biological agents targeting the epithelial growth factor receptor (EGFR) have emerged as a potential modality in combination with radiotherapy or chemoradiotherapy and are currently under evaluation in clinical trials...
  5. doi request reprint Deintensification candidate subgroups in human papillomavirus-related oropharyngeal cancer according to minimal risk of distant metastasis
    Brian O'Sullivan
    Room 5 624, Princess Margaret Hospital, 610 University Ave, Toronto, Ontario, Canada M5G 2M9
    J Clin Oncol 31:543-50. 2013
    ..To define human papillomavirus (HPV) -positive oropharyngeal cancers (OPC) suitable for treatment deintensification according to low risk of distant metastasis (DM)...
  6. doi request reprint Outcomes of HPV-related oropharyngeal cancer patients treated by radiotherapy alone using altered fractionation
    Brian O'Sullivan
    Department of Radiation Oncology, Princess Margaret Hospital, Toronto, Canada
    Radiother Oncol 103:49-56. 2012
    ..To report outcome of HPV-related [HPV(+)] oropharyngeal cancer (OPC) managed predominantly by altered-fractionation radiotherapy-alone (RT-alone)...
  7. ncbi request reprint Nasopharynx cancer: therapeutic value of chemoradiotherapy
    Brian O'Sullivan
    Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 69:S118-21. 2007
    ..The discussion concludes with some commentary concerning newer strategies for the management of NPC to address the problem of distant metastases...
  8. ncbi request reprint Techniques to modulate radiotherapy toxicity and outcome in soft tissue sarcoma
    Brian O'Sullivan
    Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, 610 University Avenue, Toronto, ON M5G 2M9, Canada
    Curr Treat Options Oncol 4:453-64. 2003
    ....
  9. ncbi request reprint New TNM staging criteria for head and neck tumors
    Brian O'Sullivan
    Wharton Head and Neck Center, Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Canada
    Semin Surg Oncol 21:30-42. 2003
    ..It also provides some guidance regarding optimal source data to facilitate classification in the registry setting. In addition, the need for additional changes in the future is recognized...
  10. ncbi request reprint Staging and prognostic factor evaluation in soft tissue sarcoma
    Brian O'Sullivan
    Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, 610 University Avenue, Toronto, Ontario, M5G 2M9, Canada
    Surg Oncol Clin N Am 12:333-53. 2003
    ..The ongoing pursuit of prognostic issues should also recognize the dynamic nature of prognosis course in a patient's disease...
  11. ncbi request reprint Late radiation-related fibrosis: pathogenesis, manifestations, and current management
    Brian O'Sullivan
    Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    Semin Radiat Oncol 13:274-89. 2003
    ..To this end, it is also important to develop a means of registering its occurrence for outcome analysis and to refer these patients to colleagues familiar with optimal management and enrollment in clinical trials...
  12. ncbi request reprint Recent advances in radiotherapy for soft-tissue sarcoma
    Brian O'Sullivan
    Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, 610 University Avenue, Toronto, Ontario, M5G 2M9, Canada
    Curr Oncol Rep 5:274-81. 2003
    ..Finally, the potential for image-guided radiotherapy, enhanced targeting, and better radiotherapy delivery in the contemporary era is addressed...
  13. ncbi request reprint Preoperative versus postoperative radiotherapy in soft-tissue sarcoma of the limbs: a randomised trial
    Brian O'Sullivan
    Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Ontario, Canada
    Lancet 359:2235-41. 2002
    ..We aimed to determine whether the timing of external-beam radiotherapy affected the number of wound healing complications in soft-tissue sarcoma in the limbs of adults...
  14. ncbi request reprint Preoperative radiotherapy for adult head and neck soft tissue sarcoma: assessment of wound complication rates and cancer outcome in a prospective series
    Brian O'Sullivan
    Department of Radiation Oncology, The Princess Margaret Hospital, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    World J Surg 27:875-83. 2003
    ..This is especially important when tumor may be adjacent to critical head and neck structures which may be protected from the high-dose RT area...
  15. ncbi request reprint Wound healing morbidity in STS patients treated with preoperative radiotherapy in relation to in vitro skin fibroblast radiosensitivity, proliferative capacity and TGF-beta activity
    John M Akudugu
    Division of Applied Molecular Oncology, Ontario Cancer Institute Princess Margaret Hospital, Toronto, Ont, Canada
    Radiother Oncol 78:17-26. 2006
    ....
  16. doi request reprint Natural course of distant metastases following radiotherapy or chemoradiotherapy in HPV-related oropharyngeal cancer
    Shao Hui Huang
    Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Canada
    Oral Oncol 49:79-85. 2013
    ..To describe the natural course of distant metastases (DMs) following radiotherapy (RT) or chemoradiotherapy (CRT) in HPV(+) oropharyngeal carcinoma (OPC)...
  17. doi request reprint A dose escalation study of hyperfractionated accelerated radiation delivered with integrated neck surgery (HARDWINS) for the management of advanced head and neck cancer
    John Waldron
    Department of Radiation Oncology, Princess Margaret Hospital and the University of Toronto, Canada
    Radiother Oncol 87:173-80. 2008
    ..To determine toxicity and outcome of radiation dose escalation with hyperfractionated accelerated radiation delivered with neck surgery (HARDWINS) for head and neck cancer...
  18. doi request reprint Temporal nodal regression and regional control after primary radiation therapy for N2-N3 head-and-neck cancer stratified by HPV status
    Shao Hui Huang
    Department of Radiation Oncology, Princess Margaret Cancer Centre University of Toronto, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 87:1078-85. 2013
    ....
  19. ncbi request reprint Prognostic significance of the Epstein-Barr virus, p53, Bcl-2, and survivin in nasopharyngeal cancer
    Kenneth W Yip
    Department of Medical Biophysics, University of Toronto, and Division of Applied Molecular Oncology, Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, Canada
    Clin Cancer Res 12:5726-32. 2006
    ..The latent presence of EBV affects the function of p53, Bcl-2, and survivin. We thus investigated the relationship between EBV status, p53, Bcl-2, and survivin in biopsy specimens from patients with primary NPC...
  20. doi request reprint Patterns of care in elderly head-and-neck cancer radiation oncology patients: a single-center cohort study
    Shao Hui Huang
    Princess Margaret Hospital, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 79:46-51. 2011
    ..To compare the patterns of care for elderly head-and-neck cancer patients with those of younger patients...
  21. doi request reprint Phase 2 study of preoperative image-guided intensity-modulated radiation therapy to reduce wound and combined modality morbidities in lower extremity soft tissue sarcoma
    Brian O'Sullivan
    Department of Radiation Oncology, Princess Margaret Hospital, Toronto, Ontario, Canada
    Cancer 119:1878-84. 2013
    ....
  22. ncbi request reprint Combination bcl-2 antisense and radiation therapy for nasopharyngeal cancer
    Kenneth W Yip
    Division of Applied Molecular Oncology, Ontario Cancer Institute, Princess Margaret Hospital, Toronto, Canada
    Clin Cancer Res 11:8131-44. 2005
    ..This current study evaluates the efficacy of combining systemically delivered Bcl-2 phosphorothioate antisense (Bcl-2 ASO) and radiation for nasopharyngeal cancer therapy...
  23. doi request reprint Potentially prognostic miRNAs in HPV-associated oropharyngeal carcinoma
    Angela B Y Hui
    Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada
    Clin Cancer Res 19:2154-62. 2013
    ..Seven FFPE specimens of histologically normal tonsils were used as controls...
  24. ncbi request reprint Multiple dysregulated pathways in nasopharyngeal carcinoma revealed by gene expression profiling
    Wei Shi
    Division of Applied Molecular Oncology, Ontario Cancer Institute, Toronto, Canada
    Int J Cancer 119:2467-75. 2006
    ..The role of survivin in resisting apoptosis in NPC was confirmed by RNA interference. Our data provide novel insights into the development and progression of NPC, and suggest survivin as a novel therapeutic target for NPC...
  25. ncbi request reprint Results of radiotherapy for primary subglottic squamous cell carcinoma
    Sonya Paisley
    Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 52:1245-50. 2002
    ..To retrospectively evaluate the outcome after radical radiotherapy (RT) and surgical salvage and assess the risk of late toxicity for patients with primary subglottic squamous cell carcinoma treated at our center...
  26. doi request reprint Postoperative intensity-modulated radiotherapy following surgery for oral cavity squamous cell carcinoma: patterns of failure
    Andrew K Chan
    Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Canada
    Oral Oncol 49:255-60. 2013
    ..To review outcomes and analyze the patterns of locoregional recurrence of oral cavity squamous cell carcinoma (OCSCC) treated with surgery and postoperative intensity-modulated radiation therapy (IMRT)...
  27. doi request reprint Atypical clinical behavior of p16-confirmed HPV-related oropharyngeal squamous cell carcinoma treated with radical radiotherapy
    Shao Hui Huang
    Department of Radiation Oncology, Princess Margaret Hospital University of Toronto, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 82:276-83. 2012
    ..To report atypical clinical behavior observed in human papillomavirus (HPV)-related oropharyngeal carcinoma (OPC) treated with radiotherapy...
  28. ncbi request reprint Clonogenic survival and cytokinesis-blocked binucleation of skin fibroblasts and normal tissue complications in soft tissue sarcoma patients treated with preoperative radiotherapy
    John M Akudugu
    Division of Experimental Therapeutics, Ontario Cancer Institute Princess Margaret Hospital and Department of Medical Biophysics, University of Toronto, Toronto, Canada
    Radiother Oncol 72:103-12. 2004
    ..To evaluate the clonogenic and cytokinesis-blocked assays in skin fibroblast cultures for their utility as tools for predicting normal tissue responses in soft tissue sarcoma (STS) patients treated with preoperative radiotherapy...
  29. ncbi request reprint The indications for and the prognostic significance of amputation as the primary surgical procedure for localized soft tissue sarcoma of the extremity
    Michelle A Ghert
    University Musculoskeletal Oncology Unit, Mount Sinai Hospital, 600 University Avenue, Suite 476E, Toronto, Ontario, M5G 1X5, Canada
    Ann Surg Oncol 12:10-7. 2005
    ..We categorized the main indications for primary amputation in our patient population and compared their oncological outcome with the outcome of patients who underwent limb-sparing surgery...
  30. ncbi request reprint Cognitive functioning after radiotherapy or chemoradiotherapy for head-and-neck cancer
    Hui K Gan
    Department of Medical Oncology, Princess Margaret Hospital, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 81:126-34. 2011
    ..To perform a comprehensive cognitive function (CF) assessment in patients who were relapse free after curative intent radiotherapy (RT) or chemoradiotherapy for squamous cell carcinoma of the head and neck...
  31. doi request reprint Cone-beam CT assessment of interfraction and intrafraction setup error of two head-and-neck cancer thermoplastic masks
    Michael Velec
    Radiation Medicine Program, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 76:949-55. 2010
    ..To prospectively compare setup error in standard thermoplastic masks and skin-sparing masks (SSMs) modified with low neck cutouts for head-and-neck intensity-modulated radiation therapy (IMRT) patients...
  32. ncbi request reprint Potential efficacy of p16 gene therapy for EBV-positive nasopharyngeal carcinoma
    Anna Aihua Li
    Ontario Cancer Institute, University Health Network, Ontario, Canada
    Int J Cancer 110:452-8. 2004
    ..p16 gene therapy for NPC, mediated through multimodal mechanisms of cytotoxicity. Future evaluations will examine strategies to increase in vivo tumor transduction with a view towards future clinical applications...
  33. doi request reprint Patterns of failure and histopathologic outcome predictors following definitive radiotherapy and planned neck dissection with residual disease
    Shao Hui Huang
    Department of Radiation Oncology, Princess Margaret Hospital University of Toronto, Canada
    Head Neck 34:913-22. 2012
    ..Our aim was to report patterns of failure and histopathological predictors in patients with head and neck cancer treated by planned neck dissection...
  34. doi request reprint Significance of dysregulated metadherin and microRNA-375 in head and neck cancer
    Angela B Y Hui
    Department of Pathology, Princess Margaret Hospital Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, Canada, M5G 2M9
    Clin Cancer Res 17:7539-50. 2011
    ..Hence, further understanding of HNC biology, and in particular, the genes/pathways driving metastasis is essential to improve outcome...
  35. doi request reprint Hyperfractionated, accelerated radiotherapy for locally advanced head and neck cancer: quality of life in a prospective phase I/II trial
    Jolie Ringash
    Department of Radiation Oncology, The Princess Margaret Hospital, Toronto, Canada
    Radiother Oncol 87:181-7. 2008
    ..Quality of life (QOL) was measured prospectively in a dose escalation study of twice daily hyperfractionated, accelerated radiotherapy for locally advanced head and neck cancer (HNC)...
  36. doi request reprint Measuring interfractional and intrafractional motion with cone beam computed tomography and an optical localization system for lower extremity soft tissue sarcoma patients treated with preoperative intensity-modulated radiation therapy
    Colleen I Dickie
    Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 78:1437-44. 2010
    ..To evaluate inter- and intrafractional motion and rotational error for lower extremity soft tissue sarcoma patients by using cone beam computed tomography (CBCT) and an optical localization system...
  37. doi request reprint Radiosensitivity translates into excellent local control in extremity myxoid liposarcoma: a comparison with other soft tissue sarcomas
    Peter W M Chung
    Radiation Oncology, Princess Margaret Hospital, Toronto, Ontario, Canada
    Cancer 115:3254-61. 2009
    ..The authors report the results of multidisciplinary treatment of extremity myxoid liposarcoma compared with a contemporary cohort of other STS subtypes with an emphasis on the role of radiotherapy (RT) in improving local control...
  38. ncbi request reprint Truths and myths about radiotherapy for verrucous carcinoma of larynx
    Shao Hui Huang
    Radiation Medicine Program, Princess Margaret Hospital, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 73:1110-5. 2009
    ..To address these concerns, we report our experience...
  39. ncbi request reprint Volume-based radiotherapy targeting in soft tissue sarcoma
    Iain Ward
    Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Canada
    Cancer Treat Res 120:17-42. 2004
  40. ncbi request reprint The influence of anatomic location on outcome in patients with soft tissue sarcoma of the extremity
    Craig H Gerrand
    University Musculoskeletal Oncology Unit, Department of Surgery, Mount Sinai Hospital, The University of Toronto, Toronto, Ontario, Canada
    Cancer 97:485-92. 2003
    ..The objective of this study was to compare the presentation, management, and outcome of patients with soft tissue sarcomas of the upper extremity and the lower extremity...
  41. ncbi request reprint The surgical and functional outcome of limb-salvage surgery with vascular reconstruction for soft tissue sarcoma of the extremity
    Michelle A Ghert
    University Musculoskeletal Oncology Unit, Mount Sinai Hospital, University of Toronto, 600 University Avenue, Suite 476E, Toronto, Ontario M6B 1H9, Canada
    Ann Surg Oncol 12:1102-10. 2005
    ....
  42. ncbi request reprint Bone invasion in extremity soft-tissue sarcoma: impact on disease outcomes
    Peter C Ferguson
    University Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, Ontario, Canada
    Cancer 106:2692-700. 2006
    ..The purpose of the current study was to evaluate histologic bone invasion as a predictor of oncologic outcome in extremity soft-tissue sarcoma (STS) patients presenting to a specialty sarcoma center between 1986 and 2001...
  43. doi request reprint Retrospective study of palliative radiotherapy in newly diagnosed head and neck carcinoma
    Christiaan M Stevens
    Department of Radiation Oncology, Princess Margaret Hospital, University Health Network, and University of Toronto, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 81:958-63. 2011
    ..To examine the patterns of care, outcomes, and prognostic factors for patients with head-and-neck cancer (HNC) treated with palliative radiotherapy (RT)...
  44. doi request reprint Bone fractures following external beam radiotherapy and limb-preservation surgery for lower extremity soft tissue sarcoma: relationship to irradiated bone length, volume, tumor location and dose
    Colleen I Dickie
    Princess Margaret Hospital, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 75:1119-24. 2009
    ....
  45. doi request reprint Adverse effect of older age on the recurrence of soft tissue sarcoma of the extremities and trunk
    David J Biau
    Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    J Clin Oncol 29:4029-35. 2011
    ..To examine the effect of age on the recurrence of soft tissue sarcoma in the extremities and trunk...
  46. ncbi request reprint Compromised local control due to treatment interruptions and late treatment breaks in early glottic cancer: Population-based outcomes study supporting need for intensified treatment schedules
    Patti A Groome
    Division of Cancer Care and Epidemiology, Queen s Cancer Research Institute, Queen s University, Kingston, ON, Canada
    Int J Radiat Oncol Biol Phys 64:1002-12. 2006
    ..This population-based study describes the treatment of early glottic cancer in Ontario, Canada and assesses whether treatment variations were associated with treatment effectiveness...
  47. ncbi request reprint High-risk extracranial chondrosarcoma: long-term results of surgery and radiation therapy
    Jayant Sastri Goda
    Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada
    Cancer 117:2513-9. 2011
    ..A study was undertaken to evaluate results of surgery and radiotherapy (RT) for high-risk extracranial chondrosarcomas...
  48. ncbi request reprint Efficacy of targeted FasL in nasopharyngeal carcinoma
    Jian Hua Li
    Ontario Cancer Institute, University of Toronto, Toronto, Ontario MS 1A1, Canada
    Mol Ther 8:964-73. 2003
    ..These results demonstrate the efficacy of our EBV-specific targeting strategy, which allows the potentially safe and effective utilization of a highly potent membrane-based apoptotic gene...
  49. ncbi request reprint Epineural dissection is a safe technique that facilitates limb salvage surgery
    Paul W Clarkson
    University Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, Ontario, Canada
    Clin Orthop Relat Res 438:92-6. 2005
    ....
  50. ncbi request reprint Limitation of conventional two dimensional radiation therapy planning in nasopharyngeal carcinoma
    John Waldron
    Department of Radiation Oncology, The Princess Margaret Hospital, University of Toronto, 610 University Avenue, Toronto, Ont M5G 2M9, Canada
    Radiother Oncol 68:153-61. 2003
    ..To assess the adequacy of coverage of gross tumor volume (GTV) with traditional two dimensional (2D) radiation therapy (RT) planning in patients with nasopharyngeal cancer (NPC)...
  51. doi request reprint Esthesioneuroblastoma: The Princess Margaret Hospital experience
    Gideon Bachar
    Department of Otolaryngology Head and Neck Surgery, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    Head Neck 30:1607-14. 2008
    ..Esthesioneuroblastoma is rare. The aim of the study was to review our experience and to evaluate the staging system and treatment that best correlates with the patient outcome...
  52. doi request reprint Comparative prognostic value of HPV16 E6 mRNA compared with in situ hybridization for human oropharyngeal squamous carcinoma
    Wei Shi
    Department of Radiation Oncology, Princess Margaret Hospital Ontario Cancer Institute, 610 University Ave, Toronto, Ontario, Canada, M5G 2M9
    J Clin Oncol 27:6213-21. 2009
    ..We compared a quantitative real-time polymerase chain reaction (qRT-PCR) assay for HPV16 mRNA to a DNA in situ hybridization (ISH) method, and evaluated their significance for overall (OS) and disease-free (DFS) survival...
  53. doi request reprint Positive surgical margins in soft tissue sarcoma treated with preoperative radiation: is a postoperative boost necessary?
    Ali Al Yami
    Orthopaedic Surgery, University Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 77:1191-7. 2010
    ....
  54. ncbi request reprint Evaluating function and health related quality of life in patients treated for extremity soft tissue sarcoma
    Daphne Schreiber
    Division of Outcomes and Population Health, Toronto Western Research Institute, Toronto, Ontario, Canada
    Qual Life Res 15:1439-46. 2006
    ..To evaluate how functional disability impacts on health related quality of life (HRQOL) of patients with extremity soft tissue sarcoma (STS) at 1 year post-surgery...
  55. pmc MicroRNA-193b enhances tumor progression via down regulation of neurofibromin 1
    Michelle Lenarduzzi
    Ontario Cancer Institute, University Health Network, Toronto, Canada
    PLoS ONE 8:e53765. 2013
    ....
  56. doi request reprint Long-term outcome of the treatment of high-risk tenosynovial giant cell tumor/pigmented villonodular synovitis with radiotherapy and surgery
    Anthony M Griffin
    Department of Orthopedic Surgery, University Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, Ontario, Canada
    Cancer 118:4901-9. 2012
    ..The authors of this report examined their experience in treating patients with advanced/multiply recurrent TGCT with a combination of surgery and external-beam radiotherapy...
  57. ncbi request reprint Postradiotherapy quality of life for head-and-neck cancer patients is independent of xerostomia
    Jolie Ringash
    Department of Radiation Oncology, Princess Margaret Hospital and University of Toronto, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 61:1403-7. 2005
    ..To determine the relationship between quality of life (QOL) and xerostomia over time for patients undergoing radiotherapy (RT) for head-and-neck cancer in a prospective clinical trial...
  58. doi request reprint Squamous cell carcinoma of the buccal mucosa: outcomes of treatment in the modern era
    Gideon Bachar
    Department of Otolaryngology Head and Neck Surgery Surgical Oncology, Toronto, Ontario, Canada
    Laryngoscope 122:1552-7. 2012
    ....
  59. ncbi request reprint Radiotherapy alone in patients with advanced nasopharyngeal cancer: comparison with an intergroup study. Is combined modality treatment really necessary?
    Edward Chow
    Department of Radiation Oncology, University of Toronto, Toronto, Ontario, Canada
    Radiother Oncol 63:269-74. 2002
    ..To examine the outcome of radiotherapy (RT) alone in patients with advanced nasopharyngeal cancer (NPC) and to compare the results with those reported by the Intergroup study 0099 (IGS) comparing RT to combined modality therapy (CMT)...
  60. doi request reprint The relationship between local recurrence and radiotherapy treatment volume for soft tissue sarcomas treated with external beam radiotherapy and function preservation surgery
    Colleen I Dickie
    Radiation Medicine Program, Princess Margaret Hospital, Toronto, Canada
    Int J Radiat Oncol Biol Phys 82:1528-34. 2012
    ..To examine the geometric relationship between local recurrence (LR) and external beam radiotherapy (RT) volumes for soft-tissue sarcoma (STS) patients treated with function-preserving surgery and RT...
  61. doi request reprint MiR-218 suppresses nasopharyngeal cancer progression through downregulation of survivin and the SLIT2-ROBO1 pathway
    Nehad M Alajez
    Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada
    Cancer Res 71:2381-91. 2011
    ..008, HR=6.0). Our findings define an integrative tumor suppressor function for miR-218 in NPC and further suggest that restoring miR-218 expression in NPC might be useful for its clinical management...
  62. doi request reprint Prognostic factors in malignancy of the minor salivary glands
    Kwok Seng Loh
    Department of Otolaryngology Head and Neck Surgery, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    Head Neck 31:58-63. 2009
    ..The purpose of this study was to identify prognostic factors associated with minor salivary gland malignancies...
  63. doi request reprint Significance of Plk1 regulation by miR-100 in human nasopharyngeal cancer
    Wei Shi
    Division of Applied Molecular Oncology, Ontario Cancer Institute, Toronto, ON, Canada
    Int J Cancer 126:2036-48. 2010
    ..Targeting Plk1 will cause mitotic catastrophe, with significant cytotoxicity both in vitro and in vivo, underscoring the important therapeutic opportunity of Plk1 in NPC...
  64. pmc Studies of the in vivo radiosensitivity of human skin fibroblasts
    Richard P Hill
    Division of Applied Molecular Oncology, Ontario Cancer Institute Princess Margaret Hospital, University Ave, Toronto, Ont, Canada M5G 2M9
    Radiother Oncol 84:75-83. 2007
    ....
  65. doi request reprint The clinical and functional outcome for patients with radiation-induced soft tissue sarcoma
    Soha Riad
    Mount Sinai Hospital, Toronto, Ontario, Canada
    Cancer 118:2682-92. 2012
    ..The authors of this report compared the clinical and functional outcomes of adults who had extremity RI-STS with the outcomes of adults with sporadic STS...
  66. doi request reprint Therapeutic efficacy of seliciclib in combination with ionizing radiation for human nasopharyngeal carcinoma
    Angela B Y Hui
    Division of Applied Molecular Oncology, Ontario Cancer Institute, University Health Network, University of Toronto, Canada
    Clin Cancer Res 15:3716-24. 2009
    ..Because most nasopharyngeal carcinoma patients harbor EBV, we proceeded to evaluate the cytotoxic effects of seliciclib in EBV-positive nasopharyngeal carcinoma models...
  67. doi request reprint Towards further understanding of prognostic factors for head and neck cancer patients: the example of hypopharyngeal cancer
    Stephen F Hall
    Department of Otolaryngology, The Cancer Care and Epidemiology Division of Queen s Cancer Research Institute, Queen s University, Kingston, Ontario, Canada
    Laryngoscope 119:696-702. 2009
    ..The objectives of this study were to demonstrate that prognostic factors and their impact can vary depending on study design and to examine the relationships between select prognostic factors...
  68. doi request reprint Radiotherapy or surgery for head and neck squamous cell cancer: establishing the baseline for hypopharyngeal carcinoma?
    Stephen F Hall
    Department of Otolaryngology, Cancer Care and Epidemiology Division, Queen s Cancer Research Institute, Queen s University, Kingston, Ontario, Canada
    Cancer 115:5711-22. 2009
    ..There was no evidence beyond observational studies and no consensus on the which treatment is most effective for this patient group...
  69. doi request reprint Comprehensive MicroRNA profiling for head and neck squamous cell carcinomas
    Angela B Y Hui
    Division of Applied Molecular Oncology, Ontario Cancer Institute, University of Toronto, Toronto, Ontario, Canada
    Clin Cancer Res 16:1129-39. 2010
    ..The objective of this study is to investigate the significance of microRNAs (miRNA) in patients with locally advanced head and neck squamous cell carcinoma (HNSCC)...
  70. doi request reprint Local recurrence of localized soft tissue sarcoma: a new look at old predictors
    David J Biau
    University Musculoskeletal Oncology Unit, Mount Sinai Hospital, Toronto, Ontario, Canada
    Cancer 118:5867-77. 2012
    ..The objective of this study was to examine the effect of known predictors of local recurrence of soft tissue sarcoma in a competing risk setting...
  71. ncbi request reprint Lack of influence of intravenous contrast on head and neck IMRT dose distributions
    Daniel Letourneau
    Radiation Medicine Program, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    Acta Oncol 47:90-4. 2008
    ..Here, the effect of physiologic and non-physiologic extremes of i.v. contrast densities on intensity modulated radiotherapy (IMRT) plans for patients with head and neck cancer was investigated...
  72. doi request reprint Soft tissue sarcoma presenting with metastatic disease: outcome with primary surgical resection
    Peter C Ferguson
    University Musculoskeletal Oncology Unit, Division of Orthopedic Surgery, Mount Sinai Hospital, Toronto, Ontario, Canada
    Cancer 117:372-9. 2011
    ....
  73. ncbi request reprint Adenoid cystic carcinoma of the larynx: a 40-year experience
    Roger V Moukarbel
    Department of Otolaryngology Head and Neck Surgery, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    Head Neck 30:919-24. 2008
    ..Laryngeal adenoid cystic carcinoma (ACC) is a rare disease. We reviewed our experience at the Princess Margaret Hospital (PMH) with its treatment...
  74. ncbi request reprint Fractures following radiotherapy and limb-salvage surgery for lower extremity soft-tissue sarcomas. A comparison of high-dose and low-dose radiotherapy
    Ginger E Holt
    Department of Radiation Oncology, Princess Margaret Hospital, Toronto, Ontario, Canada
    J Bone Joint Surg Am 87:315-9. 2005
    ..The purpose of the present retrospective study was to determine the correlation between radiation therapy and the risk of postradiation fracture following combined therapy for the treatment of soft-tissue sarcomas of the lower extremity...
  75. ncbi request reprint Point-of-care outcome assessment in the cancer clinic: audit of data quality
    Karen Wong
    Department of Radiation Oncology, The Princess Margaret Hospital and The University of Toronto, Toronto, Ontario, Canada M5G 2M9
    Radiother Oncol 95:339-43. 2010
    ..To assess the completeness and accuracy of stage and outcome data in the Anthology of Outcomes (AOs), a prospective point-of-care physician-collected electronic data system for patients at the Princess Margaret Hospital...
  76. doi request reprint Mucosal melanomas of the head and neck: experience of the Princess Margaret Hospital
    Gideon Bachar
    Department of Otolaryngology, Head and Neck Surgery, Princess Margaret Hospital, Toronto, Canada
    Head Neck 30:1325-31. 2008
    ..The aim of this study was to identify the prognostic variables in mucosal melanoma of the head and neck...
  77. doi request reprint TNM-based stage groupings in head and neck cancer: application in cancer of the hypopharynx
    Stephen F Hall
    Department of Otolaryngology, Queen s University, Kingston, Ontario, Canada
    Head Neck 31:1-8. 2009
    ....
  78. pmc Potentially novel candidate biomarkers for head and neck squamous cell carcinoma identified using an integrated cell line-based discovery strategy
    Lusia Sepiashvili
    Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada
    Mol Cell Proteomics 11:1404-15. 2012
    ..Furthermore, as demonstrated using ELISAs, circulating levels of PLAU and IGFBP7 were significantly higher in the plasma of HNSCC patients compared with healthy individuals...
  79. doi request reprint Clinical outcome of children and adults with localized Ewing sarcoma: impact of chemotherapy dose and timing of local therapy
    Abha A Gupta
    Department of Hematology Oncology, Hospital for Sick Children, Toronto, Ontario, Canada
    Cancer 116:3189-94. 2010
    ..This study investigated whether differences in therapeutic strategy undertaken in pediatric and adult specialty sarcoma centers correlated with clinical outcome...
  80. ncbi request reprint Evaluation of clinical utility of BTC-2000 for measuring soft tissue fibrosis
    Aileen M Davis
    Research Toronto Rehabilitation Institute, 550 University Avenue, Toronto, Ontario M5G 2A2, Canada
    Int J Radiat Oncol Biol Phys 60:286-94. 2004
    ....
  81. doi request reprint Long-term outcome analysis after surgical salvage for recurrent tonsil carcinoma following radical radiotherapy
    Gideon Y Bachar
    Department of Otolaryngology Head and Neck Surgery, Princess Margaret Hospital, University of Toronto, Toronto, ON M5G2M9, Canada
    Eur Arch Otorhinolaryngol 267:295-301. 2010
    ..Despite the poor prognosis, 20% of patients will be alive at 5 years and therefore salvage surgery should be considered when possible...
  82. doi request reprint Prediction of pathologic fracture risk of the femur after combined modality treatment of soft tissue sarcoma of the thigh
    Yair Gortzak
    University Musculoskeletal Oncology Unit, Division of Orthopaedic Surgery, Department of Surgery, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada
    Cancer 116:1553-9. 2010
    ..The objective of the current study was to formulate a scoring system to enable decision making for prophylactic stabilization of the femur after surgical resection of a soft tissue sarcoma (STS) of the thigh...
  83. ncbi request reprint Long-term results of two prospective trials of preoperative external beam radiotherapy for localized intermediate- or high-grade retroperitoneal soft tissue sarcoma
    Timothy M Pawlik
    Department of Surgical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA, and Department of Surgery, The University of Toronto, Princess Margaret Hospital, Canada
    Ann Surg Oncol 13:508-17. 2006
    ..We evaluated the long-term outcome of patients with operable RPS who were treated with protocol-based preoperative radiotherapy followed by complete surgical resection...
  84. doi request reprint Predictive value of tumor thickness for cervical lymph-node involvement in squamous cell carcinoma of the oral cavity: a meta-analysis of reported studies
    Shao Hui Huang
    Radiation Medicine Program, Princess Margaret Hospital, Toronto, Ontario, Canada
    Cancer 115:1489-97. 2009
    ..To address this question, the authors conducted a meta-analysis...
  85. doi request reprint The natural history of patients with squamous cell carcinoma of the hypopharynx
    Stephen F Hall
    Department of Otolaryngology, The Division of Cancer Care and Epidemiology, Queen s University, Kingston, Ontario, Canada
    Laryngoscope 118:1362-71. 2008
    ....
  86. ncbi request reprint A device and procedure for immobilization of patients receiving limb-preserving radiotherapy for soft tissue sarcoma
    Colleen I Dickie
    Department of Radiation Medicine, Princess Margaret Hospital, Toronto, ON, Canada
    Med Dosim 34:243-9. 2009
    ..Patient setup time was reduced for conformal techniques and IMRT of thigh tumors. Positioning uncertainty was improved, permitting a reduction of the planning target volume margin by 2 to 4 mm...
  87. ncbi request reprint A Phase III placebo-controlled trial of oral pilocarpine in patients undergoing radiotherapy for head-and-neck cancer
    Padraig Warde
    Department of Radiation Oncology, Princess Margaret Hospital, University Health Network, 610 University Avenue, 5th Floor, Toronto, Ontario M5G 2M9, Canada
    Int J Radiat Oncol Biol Phys 54:9-13. 2002
    ..To test the hypothesis that the use of oral pilocarpine during and after radiotherapy (RT) for head-and-neck cancer would reduce the symptoms of post-RT xerostomia...
  88. ncbi request reprint Spinal cord planning risk volumes for intensity-modulated radiation therapy of head-and-neck cancer
    Stephen L Breen
    Radiation Medicine Program, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 64:321-5. 2006
    ....
  89. ncbi request reprint Histologic assessment of peritumoral edema in soft tissue sarcoma
    Lawrence M White
    Department of Medical Imaging, Mt Sinai Hospital and Princess Margaret Hospital, University of Toronto, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 61:1439-45. 2005
    ..To evaluate whether satellite tumor cells can be identified histologically in the tissues surrounding a soft tissue sarcoma and whether their presence correlates with increased T(2)-weighted signal intensity on MRI...
  90. doi request reprint Uroporphyrinogen decarboxylase is a radiosensitizing target for head and neck cancer
    Emma Ito
    Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada M5G 2M9
    Sci Transl Med 3:67ra7. 2011
    ..Thus, our study has revealed UROD as a potent tumor-selective sensitizer for both radiation and chemotherapy, with potential relevance to many human malignancies...
  91. ncbi request reprint Opportunities for improving the therapeutic ratio for patients with sarcoma
    Jay S Wunder
    University Musculoskeletal Oncology Unit and Program in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Canada
    Lancet Oncol 8:513-24. 2007
    ..Research in stem-cell biology and nanotechnology holds promise for additional novel treatment options in the future...
  92. ncbi request reprint Interpreting differences in quality of life: the FACT-H&N in laryngeal cancer patients
    Jolie Ringash
    Department of Radiation Oncology, Princess Margaret Hospital, University Health Network, Toronto, ON, Canada
    Qual Life Res 13:725-33. 2004
    ..Quality of life (QOL) scores can be difficult to interpret, because small statistically significant differences can be clinically unimportant. Our goal was to estimate the magnitude of difference in QOL that is noticeable to patients...
  93. doi request reprint Nasopharyngeal carcinoma: the next challenges
    Albiruni R A Razak
    Division of Medical Oncology and Haematology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada
    Eur J Cancer 46:1967-78. 2010
    ....
  94. ncbi request reprint Intraobserver and interobserver variability in GTV delineation on FDG-PET-CT images of head and neck cancers
    Stephen L Breen
    Radiation Medicine Program, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 68:763-70. 2007
    ..To determine if the addition of fluorodeoxyglucose positron emission tomography (FDG-PET) data changes primary site gross tumor volumes (GTVs) in head and neck cancers...
  95. ncbi request reprint A comparison of published head and neck stage groupings in laryngeal cancer using data from two countries
    Patti A Groome
    The Radiation Oncology Research Unit at Queen s University, Kingston General Hospital, Apps Level 4, Kingston, Ontario, Canada
    J Clin Epidemiol 55:533-44. 2002
    ..When tested, this scheme did not perform best. Our results suggest that the usefulness of the TNM system could be enhanced by optimizing the design of stage groupings through empirical investigation...
  96. ncbi request reprint East-West Symposium on nasopharyngeal cancer
    Fei Fei Liu
    Department of Radiation Oncology, Princess Margaret Hospital, University Health Network, Toronto, Canada
    Int J Radiat Oncol Biol Phys 67:703-8. 2007
    ..To achieve greater understanding of the epidemiology, pathogenesis, molecular oncology, diagnostic, and therapeutic aspects of nasopharyngeal cancer (NPC), an international meeting was held in June 2005, Toronto, Canada...
  97. ncbi request reprint Measuring postirradiation subcutaneous soft-tissue fibrosis: state-of-the-art and future directions
    Aileen M Davis
    Toronto Rehabilitation Institute, University of Toronto, Toronto, Canada
    Semin Radiat Oncol 13:203-13. 2003
    ..Finally, a framework for evaluating fibrosis and the consequences of fibrosis is presented...
  98. ncbi request reprint Pretreatment proliferation parameters do not add predictive power to clinical factors in cervical cancer treated with definitive radiation therapy
    Richard W Tsang
    Department of Radiation Oncology, Princess Margaret Hospital Ontario Cancer Institute, University Health Network, Toronto, Ontario, M5G 2M9 Canada
    Clin Cancer Res 9:4387-95. 2003
    ..We report an update of a prospective study focusing on whether pretreatment proliferation parameters are associated with clinical outcome, relative to other established clinical factors...
  99. ncbi request reprint Prognostic factors in cancer
    Mary Gospodarowicz
    Department of Radiation Oncology, University of Toronto, Princess Margaret Hospital, University Health Network, ON, Canada
    Semin Surg Oncol 21:13-8. 2003
    ..The acceptance of a generic prognostic factor classification would facilitate communication and education about this most important subject in oncology...
  100. ncbi request reprint Cervical cancer regression measured using weekly magnetic resonance imaging during fractionated radiotherapy: radiobiologic modeling and correlation with tumor hypoxia
    Karen Lim
    Radiation Medicine Program, Princess Margaret Hospital Ontario Cancer Institute, University Health Network, Toronto, ON, Canada
    Int J Radiat Oncol Biol Phys 70:126-33. 2008
    ....
  101. ncbi request reprint Consolidative abdominopelvic radiotherapy after surgery and carboplatin/paclitaxel chemotherapy for epithelial ovarian cancer
    Robert Dinniwell
    Department of Radiation Oncology, Princess Margaret Hospital and University of Toronto, Toronto, Ontario, Canada
    Int J Radiat Oncol Biol Phys 62:104-10. 2005
    ..To assess the feasibility and morbidity of sequential cytoreductive surgery, carboplatin/paclitaxel chemotherapy, and consolidative abdominopelvic radiotherapy (APRT) in ovarian cancer...