Klaus Peter Ossenkopp
Affiliation: University of Western Ontario
On Wah D, Kavaliers M, Bishnoi I, Ossenkopp K. Lipopolysaccharide (LPS) induced sickness in early adolescence alters the behavioral effects of the short-chain fatty acid, propionic acid, in late adolescence and adulthood: Examining anxiety and startle reactivity. Behav Brain Res. 2018;360:312-322 pubmed publisher
..Although no LPS and PPA interactions were found, the results of this study suggest that early adolescent immune activation can induce long-term behavioral changes that resemble the complex phenotypes of clinical disorders. ..
Kamen C, Zevy D, Ward J, Bishnoi I, Kavaliers M, Ossenkopp K. Systemic Treatment with the Enteric Bacterial Fermentation Product, Propionic Acid, Reduces Acoustic Startle Response Magnitude in Rats in a Dose-Dependent Fashion: Contribution to a Rodent Model of ASD. Neurotox Res. 2018;: pubmed publisher
..These findings add to the growing body of evidence supporting the validity of the PPA rodent model of ASD. ..
Cloutier C, Zevy D, Kavaliers M, Ossenkopp K. Conditioned disgust in rats (anticipatory nausea) to a context paired with the effects of the toxin LiCl: Influence of sex and the estrous cycle. Pharmacol Biochem Behav. 2018;173:51-57 pubmed publisher
Foley K, MacFabe D, Kavaliers M, Ossenkopp K. Sexually dimorphic effects of prenatal exposure to lipopolysaccharide, and prenatal and postnatal exposure to propionic acid, on acoustic startle response and prepulse inhibition in adolescent rats: relevance to autism spectrum disorders. Behav Brain Res. 2015;278:244-56 pubmed publisher
..The current study supports the hypotheses that immune activation and metabolic products of enteric bacteria may alter development and behavior in ways that resemble sensory abnormalities observed in ASD. ..
Cloutier C, Kavaliers M, Ossenkopp K. Lipopolysaccharide (LPS) induced sickness in adolescent female rats alters the acute-phase response and lithium chloride (LiCl)- induced impairment of conditioned place avoidance/aversion learning, following a homotypic LPS challenge in adulthood. Behav Brain Res. 2018;351:121-130 pubmed publisher
..The results of this study demonstrate the importance of considering the adolescent stage of development when evaluating the effects of environmental challenges on adult behavior. ..
Ossenkopp K, Foley K, Gibson J, Fudge M, Kavaliers M, Cain D, et al
. Systemic treatment with the enteric bacterial fermentation product, propionic acid, produces both conditioned taste avoidance and conditioned place avoidance in rats. Behav Brain Res. 2012;227:134-41 pubmed publisher
..During the extinction trials rats exhibited enhanced locomotor activity levels in the propionic acid associated chamber, likely due to the conditioned aversive nature of this chamber. ..