Klaus Peter Ossenkopp

Summary

Affiliation: University of Western Ontario
Country: Canada

Publications

  1. ncbi Influence of photoperiod and sex on locomotor behavior of meadow voles (Microtus pennsylvanicus) in an automated light-dark 'anxiety' test
    Klaus Peter Ossenkopp
    Neuroscience Graduate Program, University of Western Ontario, London, Canada
    Psychoneuroendocrinology 30:869-79. 2005
  2. doi Acute corticosterone increases conditioned spontaneous orofacial behaviors but fails to influence dose related LiCl-induced conditioned "gaping" responses in a rodent model of anticipatory nausea
    Klaus Peter Ossenkopp
    Department of Psychology, University of Western Ontario, London, Ontario, Canada, N6A 5C2
    Eur J Pharmacol 660:358-62. 2011
  3. ncbi Vestibular lesions selectively abolish body rotation-induced, but not lithium-induced, conditioned taste aversions (oral rejection responses) in rats
    Klaus Peter Ossenkopp
    Department of Psychology, Neuroscience Program, University of Western Ontario, London, Canada
    Behav Neurosci 117:105-12. 2003
  4. doi Systemic treatment with the enteric bacterial fermentation product, propionic acid, produces both conditioned taste avoidance and conditioned place avoidance in rats
    Klaus Peter Ossenkopp
    The Kilee Patchell Evans Autism Research Group, Department of Psychology and Graduate Program in Neuroscience, University of Western Ontario, London, Canada
    Behav Brain Res 227:134-41. 2012
  5. ncbi Comparing immune activation (lipopolysaccharide) and toxin (lithium chloride)-induced gustatory conditioning: lipopolysaccharide produces conditioned taste avoidance but not aversion
    Shelley K Cross-Mellor
    Neuroscience Program and Department of Psychology, University of Western Ontario, Social Science Building, London, Ont, Canada N6A 5C2
    Behav Brain Res 148:11-9. 2004
  6. ncbi Neurobiological effects of intraventricular propionic acid in rats: possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders
    Derrick F MacFabe
    The Kilee Patchell Evans Autism Research Group, Department of Psychology, Division of Developmental Disabilities, University of Western Ontario, Social Science Centre, London, Canada
    Behav Brain Res 176:149-69. 2007
  7. doi Lipopolysaccharide inhibits the simultaneous establishment of LiCl-induced anticipatory nausea and intravascularly conditioned taste avoidance in the rat
    Caylen J Cloutier
    Department of Psychology, University of Western Ontario, London, Ontario, Canada N6A 5C2
    Behav Brain Res 232:278-86. 2012
  8. doi Intracerebroventricular injection of propionic acid, an enteric bacterial metabolic end-product, impairs social behavior in the rat: implications for an animal model of autism
    Sandy R Shultz
    The Kilee Patchell Evans Autism Research Group, Department of Psychology and Graduate Program in Neuroscience, University of Western Ontario, London, Ontario, Canada
    Neuropharmacology 54:901-11. 2008
  9. doi Lipopolysaccharide dose dependently impairs rapid toxin (LiCl)-induced gustatory conditioning: a taste reactivity examination of the conditioned taste aversion
    Shelley K Cross-Mellor
    Department of Psychology and Graduate Neuroscience Program, Social Science Centre, University of Western Ontario, London, Ont, Canada N6A 5C2
    Brain Behav Immun 23:204-16. 2009
  10. ncbi The effects of lipopolysaccharide and lithium chloride on the ingestion of a bitter-sweet taste: comparing intake and palatability
    Shelley K Cross-Mellor
    Graduate Program in Neuroscience, Department of Psychology, University of Western Ontario, London, Ont, Canada N6A 5C2
    Brain Behav Immun 19:564-73. 2005

Detail Information

Publications44

  1. ncbi Influence of photoperiod and sex on locomotor behavior of meadow voles (Microtus pennsylvanicus) in an automated light-dark 'anxiety' test
    Klaus Peter Ossenkopp
    Neuroscience Graduate Program, University of Western Ontario, London, Canada
    Psychoneuroendocrinology 30:869-79. 2005
    ..These findings suggest that meadow voles are an excellent animal model in which to examine the role of gonadal hormones, and their modulation of defence related neural systems, in the induction of anxiety...
  2. doi Acute corticosterone increases conditioned spontaneous orofacial behaviors but fails to influence dose related LiCl-induced conditioned "gaping" responses in a rodent model of anticipatory nausea
    Klaus Peter Ossenkopp
    Department of Psychology, University of Western Ontario, London, Ontario, Canada, N6A 5C2
    Eur J Pharmacol 660:358-62. 2011
    ..Thus, acute corticosterone did not alter the strength of conditioning of anticipatory nausea in rats...
  3. ncbi Vestibular lesions selectively abolish body rotation-induced, but not lithium-induced, conditioned taste aversions (oral rejection responses) in rats
    Klaus Peter Ossenkopp
    Department of Psychology, Neuroscience Program, University of Western Ontario, London, Canada
    Behav Neurosci 117:105-12. 2003
    ..The finding that normal vestibular function is necessary in obtaining rotation-induced conditioned taste aversions supports the face and construct validity of a rat model of motion sickness...
  4. doi Systemic treatment with the enteric bacterial fermentation product, propionic acid, produces both conditioned taste avoidance and conditioned place avoidance in rats
    Klaus Peter Ossenkopp
    The Kilee Patchell Evans Autism Research Group, Department of Psychology and Graduate Program in Neuroscience, University of Western Ontario, London, Canada
    Behav Brain Res 227:134-41. 2012
    ..During the extinction trials rats exhibited enhanced locomotor activity levels in the propionic acid associated chamber, likely due to the conditioned aversive nature of this chamber...
  5. ncbi Comparing immune activation (lipopolysaccharide) and toxin (lithium chloride)-induced gustatory conditioning: lipopolysaccharide produces conditioned taste avoidance but not aversion
    Shelley K Cross-Mellor
    Neuroscience Program and Department of Psychology, University of Western Ontario, Social Science Building, London, Ont, Canada N6A 5C2
    Behav Brain Res 148:11-9. 2004
    ..The present results demonstrate that LPS treatment produces conditioned avoidance but not aversion and suggest that LPS can selectively condition the appetitive aspects of feeding whereas the consummatory behaviors remain unaffected...
  6. ncbi Neurobiological effects of intraventricular propionic acid in rats: possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders
    Derrick F MacFabe
    The Kilee Patchell Evans Autism Research Group, Department of Psychology, Division of Developmental Disabilities, University of Western Ontario, Social Science Centre, London, Canada
    Behav Brain Res 176:149-69. 2007
    ..Thus, intraventricular administration of PPA in rats may provide a means to model some aspects of human ASD in rats...
  7. doi Lipopolysaccharide inhibits the simultaneous establishment of LiCl-induced anticipatory nausea and intravascularly conditioned taste avoidance in the rat
    Caylen J Cloutier
    Department of Psychology, University of Western Ontario, London, Ontario, Canada N6A 5C2
    Behav Brain Res 232:278-86. 2012
    ..The results of the current study provide additional evidence for the deleterious effects of LPS on learning and memory in aversive conditioning...
  8. doi Intracerebroventricular injection of propionic acid, an enteric bacterial metabolic end-product, impairs social behavior in the rat: implications for an animal model of autism
    Sandy R Shultz
    The Kilee Patchell Evans Autism Research Group, Department of Psychology and Graduate Program in Neuroscience, University of Western Ontario, London, Ontario, Canada
    Neuropharmacology 54:901-11. 2008
    ..These findings suggest that PPA can change both brain and behavior in the laboratory rat in a manner that is consistent with symptoms of human ASD...
  9. doi Lipopolysaccharide dose dependently impairs rapid toxin (LiCl)-induced gustatory conditioning: a taste reactivity examination of the conditioned taste aversion
    Shelley K Cross-Mellor
    Department of Psychology and Graduate Neuroscience Program, Social Science Centre, University of Western Ontario, London, Ont, Canada N6A 5C2
    Brain Behav Immun 23:204-16. 2009
    ..The present results suggest that LPS-induced immune system activation, significantly impairs the rapid acquisition of a conditioned taste aversion...
  10. ncbi The effects of lipopolysaccharide and lithium chloride on the ingestion of a bitter-sweet taste: comparing intake and palatability
    Shelley K Cross-Mellor
    Graduate Program in Neuroscience, Department of Psychology, University of Western Ontario, London, Ont, Canada N6A 5C2
    Brain Behav Immun 19:564-73. 2005
    ....
  11. ncbi Quinpirole-induced behavioral sensitization is enhanced by prior scheduled exposure to sucrose: A multi-variable examination of locomotor activity
    Kelly A Foley
    Neuroscience Graduate Program, Psychology Department, Social Science Centre Room 7418, University of Western Ontario, London, Ont, Canada N6A 5C2
    Behav Brain Res 167:49-56. 2006
    ..This may aid in further understanding the neural basis of eating disorders...
  12. ncbi Sex differences in the effects of muramyl dipeptide and lipopolysaccharide on locomotor activity and the development of behavioral tolerance in rats
    Christopher G Engeland
    Neuroscience Program, University of Western Ontario, London, Ontario, Canada N6A 5C2
    Pharmacol Biochem Behav 74:433-47. 2003
    ..These findings provide evidence for sex differences in the actions of MDP and LPS on various aspects of locomotor activity and in the development of behavioral tolerance to infection...
  13. doi Tamoxifen and raloxifene produce conditioned taste avoidance in female rats: a microstructural analysis of licking patterns
    Melissa A Fudge
    Neuroscience Graduate Program, Department of Psychology, The University of Western Ontario, London, Ontario, Canada N6A 5C2
    Life Sci 84:282-9. 2009
    ..This study determined if the selective estrogen receptor modulators tamoxifen and raloxifene, which effectively prevent and treat breast cancer, can induce a CTA and alter body weight in ovariectomized (OVX)-female rats...
  14. ncbi Activation of the immune system in rats with lipopolysaccharide reduces voluntary sucrose intake but not intraoral intake
    Shelley K Cross-Mellor
    Department of Psychology, University of Western Ontario, Social Science Building, London, Ontario, Canada N6A 5C2
    Pharmacol Biochem Behav 76:153-9. 2003
    ..The present results provide further evidence that activation of the immune system has adverse effects on the appetitive phase of ingestion, whereas the consummatory aspects are unaffected...
  15. ncbi Neonatal immune system activation with lipopolysaccharide enhances behavioural sensitization to the dopamine agonist, quinpirole, in adult female but not male rats
    Christine M Tenk
    Neuroscience Program and Department of Psychology, University of Western Ontario, London, Ont, Canada N6A 5C2
    Brain Behav Immun 21:935-45. 2007
    ..These findings have important implications for the sexually dimorphic development of addictions to both natural and artificial rewards...
  16. doi Impairment of lithium chloride-induced conditioned gaping responses (anticipatory nausea) following immune system stimulation with lipopolysaccharide (LPS) occurs in both LPS tolerant and LPS non-tolerant rats
    Melissa Y T Chan
    Department of Psychology, University of Western Ontario, London, Ontario, Canada N6A 5C2
    Brain Behav Immun 27:123-32. 2013
    ..These results show that LPS interferes with learning/memory in the anticipatory nausea paradigm in rats that are both LPS tolerant and LPS non-tolerant...
  17. ncbi Immune activation paired with intraoral sucrose conditions oral rejection
    Shelley K Cross-Mellor
    Neuroscience Program and Department of Psychology, Social Science Building, University of Western Ontario, London, ON, Canada N6A 5C2
    Neuroreport 15:2287-91. 2004
    ..Our results suggest activation of the immune system with LPS can condition consummatory aspects of ingestion when this conditioning involves intraoral fluid presentation...
  18. ncbi Rapid toxin-induced gustatory conditioning in rats: separate and combined effects of systemic injection or intraoral infusion of lithium chloride
    Shelley Cross-Mellor
    Neuroscience Program and Department of Psychology, University of Western Ontario, London, Ont, N6A 5C2, Canada
    Behav Brain Res 154:423-30. 2004
    ..A two process model by which animals may regulate toxicosis is discussed...
  19. ncbi Exposure to a context previously associated with nausea elicits conditioned gaping in rats: a model of anticipatory nausea
    Cheryl L Limebeer
    Department of Psychology, University of Western Ontario, London, ON, Canada
    Behav Brain Res 187:33-40. 2008
    ....
  20. doi Neonatal treatment with lipopolysaccharide differentially affects adult anxiety responses in the light-dark test and taste neophobia test in male and female rats
    Christine M Tenk
    Department of Psychology, Brescia University College, London, ON, Canada, N6G 1H2
    Int J Dev Neurosci 31:171-80. 2013
    ....
  21. doi Effects of the enteric bacterial metabolic product propionic acid on object-directed behavior, social behavior, cognition, and neuroinflammation in adolescent rats: Relevance to autism spectrum disorder
    Derrick F MacFabe
    The Kilee Patchell Evans Autism Research Group, Department of Psychology, Division of Developmental Disabilities, University of Western Ontario, London, Canada
    Behav Brain Res 217:47-54. 2011
    ....
  22. doi Simultaneous conditioning of "gaping" responses and taste avoidance in rats injected with LiCl and saccharin: examining the role of context and taste cues in the rodent model of anticipatory nausea
    Caylen J Cloutier
    Department of Psychology, University of Western Ontario, London, Ontario, Canada N6A 5C2
    Neurosci Lett 502:76-9. 2011
    ..These results indicate that systemic administration (intraperitoneal) of a LiCl+Saccharin solution is effective in simultaneously conditioning toxin elicited nausea to both internal (taste) and external (context) cues...
  23. ncbi Effects of the FAAH inhibitor, URB597, and anandamide on lithium-induced taste reactivity responses: a measure of nausea in the rat
    Shelley K Cross-Mellor
    Department of Psychology, University of Guelph, Guelph, ON, Canada
    Psychopharmacology (Berl) 190:135-43. 2007
    ..Because of the rapid breakdown and hydrolysis of endocannabinoids, such as anandamide, the therapeutic effects may be enhanced by prolonging their duration of action...
  24. ncbi The rate of behavioral tolerance development to repeated lipopolysaccharide treatments depends upon the time of injection during the light-dark cycle: a multivariable examination of locomotor activity
    Andrew E Franklin
    Neuroscience Graduate Program, Department of Psychology, University of Western Ontario, London, Ontario N6A 5C2, Canada
    Behav Brain Res 180:161-73. 2007
    ..The rate of tolerance development to LPS may be a critical factor to survival and the prevention of sepsis, as organisms are repeatedly exposed to pathogens across the life cycle...
  25. doi Intracerebroventricular injections of the enteric bacterial metabolic product propionic acid impair cognition and sensorimotor ability in the Long-Evans rat: further development of a rodent model of autism
    Sandy R Shultz
    The Kilee Patchell Evans Autism Research Group, Department of Psychology and Graduate Program in Neuroscience, University of Western Ontario, London, Canada
    Behav Brain Res 200:33-41. 2009
    ..Neuropathological analysis from PPA-treated rats revealed an innate neuroinflammatory response. These findings add to evidence that PPA can change the brain and behavior in the laboratory rat consistent with symptoms of human autism...
  26. doi Inhibition of LiCl-induced conditioning of anticipatory nausea in rats following immune system stimulation: comparing the immunogens lipopolysaccharide, muramyl dipeptide, and polyinosinic: polycytidylic acid
    Caylen J Cloutier
    Department of Psychology, University of Western Ontario, London, Ontario, Canada N6A5C2
    Physiol Behav 106:243-51. 2012
    ....
  27. doi Lipopolysaccharide (LPS) blocks the acquisition of LiCl-induced gaping in a rodent model of anticipatory nausea
    Melissa Y T Chan
    Department of Psychology and Graduate Neuroscience Program, University of Western Ontario, London, Ontario, N6A 5C2, Canada
    Neurosci Lett 450:301-5. 2009
    ..The present results suggest that activation of the immune system with LPS administration significantly impairs the acquisition of anticipatory nausea...
  28. pmc Tamoxifen produces conditioned taste avoidance in male rats: an analysis of microstructural licking patterns and taste reactivity
    Melissa A Fudge
    Department of Psychology, The University of Western Ontario, London, Ontario, Canada
    Horm Behav 56:322-31. 2009
    ....
  29. ncbi Lipopolysaccharide-induced hypoactivity and behavioral tolerance development are modulated by the light-dark cycle in male and female rats
    Andrew E Franklin
    Neuroscience Program, Department of Psychology, University of Western Ontario, London, Ontario, Canada N6A 5C2
    Psychopharmacology (Berl) 170:399-408. 2003
    ..Although the behavioral effects of systemic injection of lipopolysaccharide (LPS) have been extensively investigated, the modulation of these effects by natural environmental factors has received little attention...
  30. ncbi Allopregnanolone produces hyperphagia by reducing neophobia without altering food palatability
    Melissa A Fudge
    Neuroscience Program and Department of Psychology, Room 7418 Social Science Center, The University of Western Ontario, London, Ontario, Canada N6A 5C2
    Eur Neuropsychopharmacol 16:272-80. 2006
    ..Allopregnanolone-induced hyperphagia is not a result of altered sucrose palatability, but rather reflects a reduction in the neophobia elicited by a novel solution; an effect that further seems to be selective to safe, palatable foods...
  31. doi Sexually dimorphic effects of neonatal immune system activation with lipopolysaccharide on the behavioural response to a homotypic adult immune challenge
    Christine M Tenk
    Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada
    Int J Dev Neurosci 26:331-8. 2008
    ..These findings have potential clinical significance given that neonatal exposure to pathogens is a fairly common occurrence and Gram-negative bacteria are a common cause of neonatal bacterial infections...
  32. ncbi The effects of acute corticosterone on lithium chloride-induced conditioned place aversion and locomotor activity in rats
    Christine M Tenk
    Neuroscience Program and Department of Psychology, Social Science Centre, University of Western Ontario, 1100 Richmond Street, London, Ontario, Canada, N6A 5C2
    Life Sci 79:1069-80. 2006
    ....
  33. ncbi Dose response effects of lithium chloride on conditioned place aversions and locomotor activity in rats
    Christine M Tenk
    Neuroscience Program and Department of Psychology, Social Science Centre, University of Western Ontario, 1100 Richmond St, London, Ontario, Canada N6A 5C2
    Eur J Pharmacol 515:117-27. 2005
    ..These conditioned rearing response effects provide a valid measure of the conditioned avoidance response that provides evidence for dose-dependent LiCl-induced conditioned place aversions...
  34. doi Modeling the effects of low toxin levels in food on feeding: dose-dependent reduction of fluid intake by low levels of lithium chloride
    Amber N Good
    Graduate Program in Neuroscience, University of Western Ontario, 1151 Richmond Street, London, ON N6A 5C2, Canada
    Toxicol Lett 221:191-6. 2013
    ..The present findings support the hypothesis that rats use a behavioral tolerance mechanism to regulate their intake of foods containing low levels of toxins...
  35. ncbi The influence of photoperiod and sex on lipopolysaccharide-induced hypoactivity and behavioral tolerance development in meadow voles (Microtus pennsylvanicus)
    Christopher G Engeland
    Neuroscience Program, University of Western Ontario, Ontario, N6A 5C2 London, Canada
    Psychoneuroendocrinology 28:970-91. 2003
    ....
  36. ncbi Acute effects of corticosterone on LiCl-induced rapid gustatory conditioning in rats: a microstructural analysis of licking patterns
    William D T Kent
    Department of Psychology, Neuroscience Graduate Program, University of Western Ontario, London, ON, Canada N6A 5C2
    Behav Brain Res 136:143-50. 2002
    ..These findings indicate that Cort facilitates conditioning, possibly by modulation of LiCl-induced visceral afferent and/or central feedback mechanisms...
  37. doi Lipopolysaccharide produces dose-dependent reductions of the acoustic startle response without impairing prepulse inhibition in male rats
    Andrew J Lockey
    Neuroscience Graduate Program and Department of Psychology, The University of Western Ontario, 1151 Richmond Street, London, Ont, Canada N6A 5C2
    Brain Behav Immun 23:101-7. 2009
    ..In combination, the results suggest that the range of sickness behaviors following LPS-administration to adult rats includes decreased non-voluntary motor activity as reflected by reduced startle magnitude...
  38. doi Sexually dimorphic effects of prenatal exposure to lipopolysaccharide, and prenatal and postnatal exposure to propionic acid, on acoustic startle response and prepulse inhibition in adolescent rats: relevance to autism spectrum disorders
    Kelly A Foley
    Graduate Program in Neuroscience, Department of Psychology, University of Western Ontario, London, ON, Canada The Kilee Patchell Evans Autism Research Group, Department of Psychology, University of Western Ontario, London, ON, Canada
    Behav Brain Res 278:244-56. 2015
    ..The current study supports the hypotheses that immune activation and metabolic products of enteric bacteria may alter development and behavior in ways that resemble sensory abnormalities observed in ASD...
  39. doi Sexually dimorphic effects of prenatal exposure to propionic acid and lipopolysaccharide on social behavior in neonatal, adolescent, and adult rats: implications for autism spectrum disorders
    Kelly A Foley
    Graduate Program in Neuroscience, The University of Western Ontario, London, ON N6A 5B7, Canada Department of Psychology, The University of Western Ontario, London, ON N6A 5C2, Canada Electronic address
    Int J Dev Neurosci 39:68-78. 2014
    ..These findings raise the possibility that brief prenatal exposure to elevated levels of microbiome products, such as PPA or LPS, can subtly influence neonatal, adolescent and adult social behavior...
  40. pmc Pre- and neonatal exposure to lipopolysaccharide or the enteric metabolite, propionic acid, alters development and behavior in adolescent rats in a sexually dimorphic manner
    Kelly A Foley
    Graduate Program in Neuroscience, The University of Western Ontario, London, Ontario, Canada Department of Psychology, The University of Western Ontario, London, Ontario, Canada
    PLoS ONE 9:e87072. 2014
    ....
  41. doi Lipopolysaccharide reduces tactile startle response magnitude but not prepulse inhibition in rats: a dose-response examination
    Andrew J Lockey
    Neuroscience Graduate Program and Department of Psychology, The University of Western Ontario, London, Ontario, Canada
    Pharmacol Biochem Behav 93:47-53. 2009
    ..They also show that sensory processing, as measured by PPI, is not impaired with sickness...
  42. ncbi Oxytocin, social factors, and the expression of conditioned disgust (anticipatory nausea) in male rats
    Nathalie P Boulet
    aDepartment of Psychology bGraduate Program in Neuroscience, Western University, London, Ontario, Canada
    Behav Pharmacol 27:718-725. 2016
    ..These findings suggest that OT may play a role in the modulation and expression of socially mediated conditioned disgust in rats...
  43. ncbi Influence of the estrous cycle on tolerance development to LPS-induced sickness behaviors in rats
    Christopher G Engeland
    Department of Periodontics, College of Dentistry, University of Illinois at Chicago, 801 S Paulina Street, M C 859, Room 458, Chicago, IL 60612, USA
    Psychoneuroendocrinology 31:510-25. 2006
    ..Thus, the stages of the estrous cycle both at the time of initial exposure and of re-exposure appear critical in the formation of behavioral tolerance to LPS in rats...
  44. ncbi Pain perception and electromagnetic fields
    Cristina Del Seppia
    Institute of Clinical Physiology, National Council of Research, Pisa, Italy
    Neurosci Biobehav Rev 31:619-42. 2007
    ..We further consider some of the underlying cellular and biophysical mechanisms along with the clinical implications of these effects of various EMFs...