David M Olson

Summary

Affiliation: University of Alberta
Country: Canada

Publications

  1. ncbi request reprint Growth hormone (GH) receptor knockout mice reveal actions of GH in lung development
    Jason A Beyea
    Department of Physiology, Medical Sciences Building, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
    Proteomics 6:341-8. 2006
  2. ncbi request reprint Role of the prostaglandins in labour and prostaglandin receptor inhibitors in the prevention of preterm labour
    David M Olson
    Perinatal Research Centre, Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Alberta, Canada
    Front Biosci 12:1329-43. 2007
  3. pmc Maternal circulating leukocytes display early chemotactic responsiveness during late gestation
    Nardhy Gomez-Lopez
    Department of Obstetrics and Gynecology, Pediatrics and Physiology, University of Alberta, Edmonton T6G 2S2, Canada
    BMC Pregnancy Childbirth 13:S8. 2013
  4. doi request reprint Effects of PGF2α on the expression of uterine activation proteins in pregnant human myometrial cells from upper and lower segment
    Chen Xu
    Department of Physiology and The Key Laboratory of Molecular Neurobiology of the Ministry of Education, Second Military Medical University, Shanghai, China 200433, USA
    J Clin Endocrinol Metab 98:2975-83. 2013
  5. pmc Expression of ATP-sensitive potassium channels in human pregnant myometrium
    Chen Xu
    Department of Physiology, Second Military Medical University, Shanghai 200433, China
    Reprod Biol Endocrinol 9:35. 2011
  6. pmc All Our Babies Cohort Study: recruitment of a cohort to predict women at risk of preterm birth through the examination of gene expression profiles and the environment
    Sara K Gracie
    Department of Paediatrics, University of Calgary, Calgary, Alberta, Canada
    BMC Pregnancy Childbirth 10:87. 2010
  7. ncbi request reprint The promise of prostaglandins: have they fulfilled their potential as therapeutic targets for the delay of preterm birth?
    David M Olson
    Department of Obstetrics and Gynecology, Perinatal Research Centre, University of Alberta, Edmonton, Alberta, Canada
    J Soc Gynecol Investig 12:466-78. 2005
  8. ncbi request reprint The role of prostaglandins in the initiation of parturition
    David M Olson
    Department of Obstetrics and Gynaecology, CIHR Group in Perinatal Health and Disease, Perinatal Research Centre, University of Alberta, Edmonton, Canada
    Best Pract Res Clin Obstet Gynaecol 17:717-30. 2003
  9. ncbi request reprint Myometrial activation and preterm labour: evidence supporting a role for the prostaglandin F receptor--a review
    D M Olson
    The Perinatal Research Centre, The CIHR Group in Perinatal Health and Disease, Department of Obstetrics and Gynaecology, The University of Alberta, Edmonton, Canada
    Placenta 24:S47-54. 2003
  10. ncbi request reprint Emerging tocolytics: challenges in designing and testing drugs to delay preterm delivery and prolong pregnancy
    David M Olson
    University of Alberta, AHFMR Interdisciplinary Team in Preterm Birth and Healthy Outcomes, Department of Obstetrics and Gynecology, 220 HMRC, Edmonton, T6G 2S2, Alberta, Canada
    Expert Opin Emerg Drugs 13:695-707. 2008

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Growth hormone (GH) receptor knockout mice reveal actions of GH in lung development
    Jason A Beyea
    Department of Physiology, Medical Sciences Building, University of Alberta, Edmonton, Alberta T6G 2H7, Canada
    Proteomics 6:341-8. 2006
    ..These roles may reflect endocrine actions of pituitary GH and/or local autocrine/paracrine actions of GH produced within the lung...
  2. ncbi request reprint Role of the prostaglandins in labour and prostaglandin receptor inhibitors in the prevention of preterm labour
    David M Olson
    Perinatal Research Centre, Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Alberta, Canada
    Front Biosci 12:1329-43. 2007
    ..31, delays preterm birth in mice and sheep with no observable maternal or fetal side effects. Hence antagonizing PG action offers new hope for delaying preterm birth...
  3. pmc Maternal circulating leukocytes display early chemotactic responsiveness during late gestation
    Nardhy Gomez-Lopez
    Department of Obstetrics and Gynecology, Pediatrics and Physiology, University of Alberta, Edmonton T6G 2S2, Canada
    BMC Pregnancy Childbirth 13:S8. 2013
    ....
  4. doi request reprint Effects of PGF2α on the expression of uterine activation proteins in pregnant human myometrial cells from upper and lower segment
    Chen Xu
    Department of Physiology and The Key Laboratory of Molecular Neurobiology of the Ministry of Education, Second Military Medical University, Shanghai, China 200433, USA
    J Clin Endocrinol Metab 98:2975-83. 2013
    ..The switch from pregnancy to delivery involves changes in expression of uterine activation proteins (UAPs). Prostaglandin (PG) F2α has multiple and complex roles in the birth process in addition to its vital contractile role...
  5. pmc Expression of ATP-sensitive potassium channels in human pregnant myometrium
    Chen Xu
    Department of Physiology, Second Military Medical University, Shanghai 200433, China
    Reprod Biol Endocrinol 9:35. 2011
    ..The objectives of this study were to investigate the protein expression of KATP channel in human myometrium and determine the levels of KATP channel in lower and upper segmental myometrium before and after onset of labour...
  6. pmc All Our Babies Cohort Study: recruitment of a cohort to predict women at risk of preterm birth through the examination of gene expression profiles and the environment
    Sara K Gracie
    Department of Paediatrics, University of Calgary, Calgary, Alberta, Canada
    BMC Pregnancy Childbirth 10:87. 2010
    ..Specifically this study will examine the predictive potential of maternal leukocytes for predicting preterm birth in non-labouring women through the examination of gene expression profiles and gene-environment interactions...
  7. ncbi request reprint The promise of prostaglandins: have they fulfilled their potential as therapeutic targets for the delay of preterm birth?
    David M Olson
    Department of Obstetrics and Gynecology, Perinatal Research Centre, University of Alberta, Edmonton, Alberta, Canada
    J Soc Gynecol Investig 12:466-78. 2005
    ..This was the "promise of PGs."..
  8. ncbi request reprint The role of prostaglandins in the initiation of parturition
    David M Olson
    Department of Obstetrics and Gynaecology, CIHR Group in Perinatal Health and Disease, Perinatal Research Centre, University of Alberta, Edmonton, Canada
    Best Pract Res Clin Obstet Gynaecol 17:717-30. 2003
    ..The PGF(2alpha) receptor, FP, is emerging as a central component of uterine sensitivity and may prove to be involved with preterm birth and a reasonable target for tocolysis...
  9. ncbi request reprint Myometrial activation and preterm labour: evidence supporting a role for the prostaglandin F receptor--a review
    D M Olson
    The Perinatal Research Centre, The CIHR Group in Perinatal Health and Disease, Department of Obstetrics and Gynaecology, The University of Alberta, Edmonton, Canada
    Placenta 24:S47-54. 2003
    ..Finally new data showing that administration of a specific FP antagonist delays preterm birth in sheep will be presented...
  10. ncbi request reprint Emerging tocolytics: challenges in designing and testing drugs to delay preterm delivery and prolong pregnancy
    David M Olson
    University of Alberta, AHFMR Interdisciplinary Team in Preterm Birth and Healthy Outcomes, Department of Obstetrics and Gynecology, 220 HMRC, Edmonton, T6G 2S2, Alberta, Canada
    Expert Opin Emerg Drugs 13:695-707. 2008
    ....
  11. doi request reprint Inflammatory processes in preterm and term parturition
    Inge Christiaens
    Perinatal Research Centre, Departments of Obstetrics and Gynecology, Pediatrics, Physiology, and Medical Microbiology and Immunology, University of Alberta, Edmonton, Canada
    J Reprod Immunol 79:50-7. 2008
    ..In turn, cortisol may drive PG synthesis. Together these feed-forward mechanisms activate the uterus, trigger the production of uterine contractile stimulants and lead to labour and delivery...
  12. ncbi request reprint Prostaglandin F2alpha and its receptor as activators of human decidua
    Shintaro Makino
    Perinatal Research Centre, Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Canada
    Semin Reprod Med 25:60-8. 2007
    ..These collective actions prepare the decidua for its role in parturition...
  13. ncbi request reprint The interleukin 1beta-induced expression of human prostaglandin F2alpha receptor messenger RNA in human myometrial-derived ULTR cells requires the transcription factor, NFkappaB
    Dean B Zaragoza
    Department of Obstetrics and Gynecology, University of Alberta, Canada
    Biol Reprod 75:697-704. 2006
    ....
  14. ncbi request reprint Prostaglandin endoperoxide H synthase inhibitors and other tocolytics in preterm labour
    Bryan F Mitchell
    Department of Obstetrics and Gynaecology, Perinatal Research Centre, CIHR Group in Perinatal Health and Disease, University of Alberta, 220 HMRC, Edmonton, Alberta, Canada T6G2S2
    Prostaglandins Leukot Essent Fatty Acids 70:167-87. 2004
    ..Mixed inhibitors and isoform-specific inhibitors of PGHS have been developed, and their roles in delaying preterm labour are examined and compared to other tocolytics...
  15. ncbi request reprint Growth hormone (GH) action in the developing lung: changes in lung proteins after adenoviral GH overexpression
    Jason A Beyea
    Department of Physiology and Perinatal Research Centre, University of Alberta, Edmonton, Alberta, Canada
    Dev Dyn 234:404-12. 2005
    ....
  16. ncbi request reprint Expression of myometrial activation and stimulation genes in a mouse model of preterm labor: myometrial activation, stimulation, and preterm labor
    J L Cook
    Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Canada
    Endocrinology 141:1718-28. 2000
    ..The PGHS-2 messenger RNA expression pattern suggests that it is a CAP...
  17. ncbi request reprint Hyperoxia decreases matrix metalloproteinase-9 and increases tissue inhibitor of matrix metalloproteinase-1 protein in the newborn rat lung: association with arrested alveolarization
    Gayle E Hosford
    Departmen of Physiology, Perinatal Research Centre, The University of Alberta, Edmonton, Alberta, Canada
    Pediatr Res 56:26-34. 2004
    ..We conclude that hyperoxia decreases MMP-9 mRNA, protein, and activity and elevates TIMP-1 protein, and these changes have the potential to contribute to the arrest of normal lung development...
  18. pmc Development and validation of primary human myometrial cell culture models to study pregnancy and labour
    Andrea A Mosher
    Department of Physiology and Pharmacology, University of Calgary, Calgary, Alberta, Canada
    BMC Pregnancy Childbirth 13:S7. 2013
    ..Labour has been described as an inflammatory process; therefore, the ability of these cells to respond to an inflammatory stimulus was also investigated...
  19. doi request reprint Invasion of the leukocytes into the fetal-maternal interface during pregnancy
    Nardhy Gomez-Lopez
    Department of Obstetrics and Gynecology, Universityof Alberta, Edmonton, Alberta, Canada
    J Leukoc Biol 88:625-33. 2010
    ..In this review, we discuss leukocyte infiltration and recruitment and the potential roles of each subpopulation of leukocytes in relation to pregnancy and the problems of preterm birth, pre-eclampsia, and intrauterine growth restriction...
  20. doi request reprint Increased expression of enzymes for sphingosine 1-phosphate turnover and signaling in human decidua during late pregnancy
    Yuka Yamamoto
    Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Alberta, Canada
    Biol Reprod 82:628-35. 2010
    ..This work provides the first evidence of increased S1P synthesis, degradation, and signaling in human decidua during gestation...
  21. ncbi request reprint Expression of growth hormone and its receptor in the lungs of embryonic chicks
    Jason A Beyea
    Department of Physiology and Perinatal Research Centre, University of Alberta, Edmonton, T6G 2H7, Canada
    Cell Tissue Res 322:379-92. 2005
    ..Lung GH may thus have autocrine or paracrine roles in lung development or in pulmonary function prior to the ontogeny of the pituitary gland and the appearance of GH in peripheral plasma...
  22. ncbi request reprint Hyperoxia increases protein mass of 5-lipoxygenase and its activating protein, flap, and leukotriene B(4) output in newborn rat lungs
    Gayle E Hosford
    Department of Physiology, The Perinatal Research Centre, The CIHR Group in Perinatal Health and Disease, University of Alberta, Edmonton, Canada
    Exp Lung Res 28:671-84. 2002
    ..These data show that hyperoxia increases LTB(4) output, as well as protein levels of 5-LO and FLAP, in newborn rat lungs during early postnatal life. Elevated LTB(4) may contribute to the etiology of newborn lung disease...
  23. ncbi request reprint Progesterone and prostaglandin H synthase-2 involvement in alcohol-induced preterm birth in mice
    J L Cook
    Perinatal Research Centre, Department of Obstetrics, University of Alberta, Edmonton, Canada
    Alcohol Clin Exp Res 23:1793-800. 1999
    ..It is possible that alcohol induces preterm birth by altering P4 or PGHS-2 levels. These studies were designed to determine the role of P4 and PGHS-2 in alcohol-induced preterm labor in mice...
  24. ncbi request reprint Regulation of prostaglandin H2 synthase-2 expression in primary human amnion cells by tyrosine kinase dependent mechanisms
    T Zakar
    Perinatal Research Centre, Department of Obstetrics and Gynaecology, University of Alberta, Edmonton, Alberta, Canada
    Biochim Biophys Acta 1391:37-51. 1998
    ..Tyrosine kinase inhibitors may constitute a new category of PGHS-2 inhibitors that act by blocking the expression of the enzyme...
  25. ncbi request reprint Maternal smoking and preeclampsia
    X Xiong
    Perinatal Research Centre, University of Alberta, and Health Surveillance, Alberta Health and Wellness, Edmonton, Canada
    J Reprod Med 45:727-32. 2000
    ..To study the relationship between maternal smoking and preeclampsia and whether this association differs between primiparous and multiparous women...
  26. ncbi request reprint Regulation of prostaglandin endoperoxide H2 synthase in term human gestational tissues
    T Zakar
    Department of Obstetrics and Gynaecology, University of Alberta Perinatal Research Centre, Edmonton, Canada
    Acta Physiol Hung 84:109-18. 1996
    ..However, the role of these effectors in the in vivo control of PGHS-2 expression remains to be determined...
  27. ncbi request reprint Mouse placental prostaglandins are associated with uterine activation and the timing of birth
    Jocelynn L Cook
    Department of Obstetrics and Gynaecology, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    Biol Reprod 68:579-87. 2003
    ....
  28. ncbi request reprint Maternal nutrient restriction alters renal development and blood pressure regulation of the offspring
    Kathryn A Brennan
    Perinatal Research Centre, Department of Obstetrics and Gynecology, University of Alberta, Edmonton, Canada
    Proc Nutr Soc 65:116-24. 2006
    ..In conclusion, NR does affect the GH-IGF and PG axes, and these changes may be important in the nutritional programming of renal functioning and adult blood pressure control...
  29. doi request reprint Specific inflammatory microenvironments in the zones of the fetal membranes at term delivery
    Nardhy Gomez-Lopez
    Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes, Mexico City, Mexico
    Am J Obstet Gynecol 205:235.e15-24. 2011
    ..The purpose of this study was to examine the histologic and immunologic differences between fetal membrane zones after membrane rupture at term delivery...
  30. ncbi request reprint Cloning and characterization of the promoter region of the human prostaglandin F2alpha receptor gene
    Dean B Zaragoza
    Perinatal Research Centre, CIHR Group in Perinatal Health and Disease, Department of Obstetrics and Gynecology, University of Alberta, Edmonton, AB T6G 2S2, Canada
    Biochim Biophys Acta 1676:193-202. 2004
    ..DNase I footprinting analysis of this region identifies a footprint over the GATA-like site at -2400. This suggests repression of basal FP transcription may be mediated by a GATA binding site...
  31. ncbi request reprint Proinflammatory cytokines inhibit human placental 11beta-hydroxysteroid dehydrogenase type 2 activity through Ca2+ and cAMP pathways
    Iren Kossintseva
    Department of Obstetrics and Gynecology, Univ of Alberta, Edmonton, Canada
    Am J Physiol Endocrinol Metab 290:E282-8. 2006
    ..This could result in excessive fetal exposure to maternal cortisol. This mechanism might mediate part of the increased risk of metabolic and cardiovascular disease in adult offspring...
  32. ncbi request reprint Growth hormone expression in the perinatal and postnatal rat lung
    Jason A Beyea
    Department of Physiology and Perinatal Research Centre, University of Alberta, Edmonton, Alberta T6G2H7, Canada
    Dev Dyn 232:1037-46. 2005
    ..Given that the GH receptor is present in the lung from early development, lung GH may have autocrine and/or paracrine roles in lung growth or differentiation or in pulmonary function...
  33. ncbi request reprint Effects of hyperoxia on VEGF, its receptors, and HIF-2alpha in the newborn rat lung
    Gayle E Hosford
    Department of Physiology, Canadian Institutes of Health Research Group in Perinatal Health and Disease, The Perinatal Research Centre, The University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    Am J Physiol Lung Cell Mol Physiol 285:L161-8. 2003
    ..Receptor protein levels did not increase with development; however, O2 did decrease protein to less than air values. Hyperoxic suppression of VEGF signaling from days 9-14 may be one mechanism by which alveolarization is arrested...
  34. ncbi request reprint Delay of preterm birth in sheep by THG113.31, a prostaglandin F2alpha receptor antagonist
    Jonathan J Hirst
    Department of Physiology, Monash University, Clayton, Victoria, Australia
    Am J Obstet Gynecol 193:256-66. 2005
    ..A novel prostaglandin F2alpha receptor antagonist, THG113.31, was tested for the suppression of uterine contractility and delay of preterm labor in sheep...
  35. ncbi request reprint Placental restriction increases the expression of prostaglandin endoperoxide G/H synthase-2 and EP2 mRNA in the fetal sheep kidney during late gestation
    Sarah J Williams
    Department of Physiology, Adelaide University, Adelaide, South Australia, Australia
    Pediatr Res 52:879-85. 2002
    ....
  36. ncbi request reprint Cortisol infusion decreases renin, but not PGHS-2, EP2, or EP4 mRNA expression in the kidney of the fetal sheep at days 109-116
    Sarah J Williams
    Department of Physiology, Adelaide University, Australia
    Pediatr Res 55:637-44. 2004
    ..During nephrogenesis, the insensitivity of PGHS-2, EP(2), and EP(4) expression to down-regulation by cortisol may permit continued PG regulation of renal development and urine formation...