Allan B Okey

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi An aryl hydrocarbon receptor odyssey to the shores of toxicology: the Deichmann Lecture, International Congress of Toxicology-XI
    Allan B Okey
    Department of Pharmacology, Medical Sciences Building, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada M5S 1A8
    Toxicol Sci 98:5-38. 2007
  2. ncbi Toxicological implications of polymorphisms in receptors for xenobiotic chemicals: the case of the aryl hydrocarbon receptor
    Allan B Okey
    Department of Pharmacology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada
    Toxicol Appl Pharmacol 207:43-51. 2005
  3. ncbi Patterns of dioxin-altered mRNA expression in livers of dioxin-sensitive versus dioxin-resistant rats
    Monique A Franc
    Department of Pharmacology and Toxicology, Medical Sciences Building, University of Toronto, Toronto, ON, Canada
    Arch Toxicol 82:809-30. 2008
  4. doi Aryl hydrocarbon receptor-dependent induction of flavin-containing monooxygenase mRNAs in mouse liver
    Trine Celius
    Department of Pharmacology and Toxicology, Medical Sciences Building, 1 King s College Circle, University of Toronto, Toronto, ON, Canada M5S1A8
    Drug Metab Dispos 36:2499-505. 2008
  5. ncbi Aryl hydrocarbon receptor regulates distinct dioxin-dependent and dioxin-independent gene batteries
    Nathalie Tijet
    Department of Pharmacology, Medical Sciences Building, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Mol Pharmacol 69:140-53. 2006
  6. pmc mRNA levels in control rat liver display strain-specific, hereditary, and AHR-dependent components
    Paul C Boutros
    Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada
    PLoS ONE 6:e18337. 2011
  7. pmc Systematic evaluation of medium-throughput mRNA abundance platforms
    Stephenie D Prokopec
    Informatics and Biocomputing Platform, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada
    RNA 19:51-62. 2013
  8. pmc Flavin-containing monooxygenase-3: induction by 3-methylcholanthrene and complex regulation by xenobiotic chemicals in hepatoma cells and mouse liver
    Trine Celius
    Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada
    Toxicol Appl Pharmacol 247:60-9. 2010
  9. doi Hepatic transcriptomic responses to TCDD in dioxin-sensitive and dioxin-resistant rats during the onset of toxicity
    Paul C Boutros
    Informatics and Bio computing Platform, Ontario Institute for Cancer Research, Toronto, Canada
    Toxicol Appl Pharmacol 251:119-29. 2011
  10. ncbi microRNAs in adult rodent liver are refractory to dioxin treatment
    Ivy D Moffat
    Department of Pharmacology, University of Toronto, Toronto, Canada M5S 1A8
    Toxicol Sci 99:470-87. 2007

Collaborators

Detail Information

Publications29

  1. ncbi An aryl hydrocarbon receptor odyssey to the shores of toxicology: the Deichmann Lecture, International Congress of Toxicology-XI
    Allan B Okey
    Department of Pharmacology, Medical Sciences Building, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada M5S 1A8
    Toxicol Sci 98:5-38. 2007
    ....
  2. ncbi Toxicological implications of polymorphisms in receptors for xenobiotic chemicals: the case of the aryl hydrocarbon receptor
    Allan B Okey
    Department of Pharmacology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada
    Toxicol Appl Pharmacol 207:43-51. 2005
    ..dioxin-resistant rat strains and lines. Polymorphisms exist in the human AH receptor, but thus far they have not been shown to have any substantial effect on human responses to AHR-ligands...
  3. ncbi Patterns of dioxin-altered mRNA expression in livers of dioxin-sensitive versus dioxin-resistant rats
    Monique A Franc
    Department of Pharmacology and Toxicology, Medical Sciences Building, University of Toronto, Toronto, ON, Canada
    Arch Toxicol 82:809-30. 2008
    ..Type-II genes may lie in pathways that are central to the difference in susceptibility to TCDD lethality in this animal model...
  4. doi Aryl hydrocarbon receptor-dependent induction of flavin-containing monooxygenase mRNAs in mouse liver
    Trine Celius
    Department of Pharmacology and Toxicology, Medical Sciences Building, 1 King s College Circle, University of Toronto, Toronto, ON, Canada M5S1A8
    Drug Metab Dispos 36:2499-505. 2008
    ..However, FMO2 and FMO3 mRNAs were highly induced in transgenic mice that express wild-type rat AHR, indicating that lack of induction in rat is not due to an incompetent AHR in this species...
  5. ncbi Aryl hydrocarbon receptor regulates distinct dioxin-dependent and dioxin-independent gene batteries
    Nathalie Tijet
    Department of Pharmacology, Medical Sciences Building, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Mol Pharmacol 69:140-53. 2006
    ..Overall, our study identifies a wide range of genes that depend on the AHR, either for constitutive expression or for response to TCDD...
  6. pmc mRNA levels in control rat liver display strain-specific, hereditary, and AHR-dependent components
    Paul C Boutros
    Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada
    PLoS ONE 6:e18337. 2011
    ..This variability may be related to increased activity of specific transcription-factors and has clear functional consequences. Future studies may take advantage of this phenomenon by surveying panels of rat strains...
  7. pmc Systematic evaluation of medium-throughput mRNA abundance platforms
    Stephenie D Prokopec
    Informatics and Biocomputing Platform, Ontario Institute for Cancer Research, Toronto, Ontario M5G 0A3, Canada
    RNA 19:51-62. 2013
    ..This study provides the first detailed comparison of medium-throughput RNA quantification platforms and provides a template and a standard data set for the evaluation of additional technologies...
  8. pmc Flavin-containing monooxygenase-3: induction by 3-methylcholanthrene and complex regulation by xenobiotic chemicals in hepatoma cells and mouse liver
    Trine Celius
    Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada
    Toxicol Appl Pharmacol 247:60-9. 2010
    ..Although FMO3 mRNA is highly induced by 3MC or TCDD in mouse liver and in Hepa-1 cells, FMO protein levels and FMO catalytic function showed only modest elevation...
  9. doi Hepatic transcriptomic responses to TCDD in dioxin-sensitive and dioxin-resistant rats during the onset of toxicity
    Paul C Boutros
    Informatics and Bio computing Platform, Ontario Institute for Cancer Research, Toronto, Canada
    Toxicol Appl Pharmacol 251:119-29. 2011
    ..Far fewer genes were affected by feed-restriction, suggesting that only a minority of the TCDD-induced changes are secondary to the wasting syndrome...
  10. ncbi microRNAs in adult rodent liver are refractory to dioxin treatment
    Ivy D Moffat
    Department of Pharmacology, University of Toronto, Toronto, Canada M5S 1A8
    Toxicol Sci 99:470-87. 2007
    ..It is unlikely that mRNA downregulation by dioxins is mediated by miRNAs, nor are miRNAs likely to play a significant role in dioxin toxicity in adult rodent liver...
  11. pmc Aryl hydrocarbon receptor (AHR)-regulated transcriptomic changes in rats sensitive or resistant to major dioxin toxicities
    Ivy D Moffat
    Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada
    BMC Genomics 11:263. 2010
    ..We examined changes in hepatic mRNA abundances 19 hours after TCDD treatment in two dioxin-resistant rat strains/lines and two dioxin-sensitive rat strains/lines...
  12. doi Inter-strain heterogeneity in rat hepatic transcriptomic responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
    Cindy Q Yao
    Informatics and Biocomputing Platform, Ontario Institute for Cancer Research, Toronto, Canada
    Toxicol Appl Pharmacol 260:135-45. 2012
    ..This study reveals that different rat strains exhibit dramatic transcriptional heterogeneity in their hepatic responses to TCDD and that inter-strain comparisons can help identify candidate toxicity-related genes...
  13. pmc Transcriptomic responses to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in liver: comparison of rat and mouse
    Paul C Boutros
    Department of Pharmacology and Toxicology, University of Toronto, Toronto, Canada
    BMC Genomics 9:419. 2008
    ..Surprisingly, though, analysis of a limited portion of the transcriptome revealed that rat and mouse responses diverge greatly (Boverhof et al. Toxicol Sci 94:398-416, 2006)...
  14. ncbi Dioxin-responsive AHRE-II gene battery: identification by phylogenetic footprinting
    Paul C Boutros
    Department of Pharmacology, University of Toronto, Toronto, Ont, Canada M5S 1A8
    Biochem Biophys Res Commun 321:707-15. 2004
    ..Collectively, these results demonstrate that the AHRE-II induction mechanism is employed by multiple genes and provide the first categorization of the gene battery of a ligand-activated coactivator...
  15. ncbi Aryl hydrocarbon receptor splice variants in the dioxin-resistant rat: tissue expression and transactivational activity
    Ivy D Moffat
    Department of Pharmacology, Medical Sciences Building, University of Toronto, Toronto, Ontario, Canada
    Mol Pharmacol 72:956-66. 2007
    ....
  16. ncbi Regulating the regulator: factors that control levels and activity of the aryl hydrocarbon receptor
    Patricia A Harper
    Program in Developmental Biology, The Hospital for Sick Children, Toronto, Ont, Canada
    Biochem Pharmacol 72:267-79. 2006
    ..We have not yet entered an age of enlightenment sufficient to achieve true understanding of the interplay of mechanisms that regulate AHR expression in space and in time...
  17. ncbi PUNS: transcriptomic- and genomic-in silico PCR for enhanced primer design
    Paul C Boutros
    Department of Pharmacology, University of Toronto, Medical Sciences Building, 1 King s College Circle, Toronto, Ontario, M5S 1A8 Canada
    Bioinformatics 20:2399-400. 2004
    ..PUNS is particularly suited for the identification of highly selective primers for quantitative microarray validation...
  18. ncbi Microarray analysis of the developing cortex
    Mawahib O Semeralul
    Department of Pharmacology, Faculty of Medicine, University of Toronto, Ontario, Canada
    J Neurobiol 66:1646-58. 2006
    ....
  19. ncbi Unsupervised pattern recognition: an introduction to the whys and wherefores of clustering microarray data
    Paul C Boutros
    Department of Medical Biophysics, University of Toronto, Ontario, Canada M5S 1A8
    Brief Bioinform 6:331-43. 2005
    ..This review discusses the biological motivations for and applications of these techniques to integrating gene expression data with other biological information, such as functional annotation, promoter data and proteomic data...
  20. pmc Advances in analytical techniques for polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans and dioxin-like PCBs
    Eric J Reiner
    Ontario Ministry of the Environment, Toronto, ON, Canada
    Anal Bioanal Chem 386:791-806. 2006
    ..Sources, occurrence and temporal trends of PCDD/PCDF are summarized to provide examples of levels and concentration ranges for the methods and techniques reviewed...
  21. ncbi Polymorphisms of human nuclear receptors that control expression of drug-metabolizing enzymes
    Allan B Okey
    Department of Pharmacology, University of Toronto, Toronto, Ontario, Canada
    Pharmacogenet Genomics 15:371-9. 2005
    ..We suggest that the current scarcity of SNPs that are able to alter function in the DME-regulating NRs reflects considerable evolutionary selective pressures that conserve the key functional domains in these receptors...
  22. ncbi Gene expression profiling in a model of D-penicillamine-induced autoimmunity in the Brown Norway rat: predictive value of early signs of danger
    Beatrice Seguin
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, Ontario M5S 2S2, Canada
    Chem Res Toxicol 18:1193-202. 2005
    ..This "resistant" cluster of animals contains 87.5% (7/8) resistant animals but only 48% (12/25) "sensitive" animals. This separation is statistically significant at the p = 0.01 level...
  23. pmc Red meat intake, doneness, polymorphisms in genes that encode carcinogen-metabolizing enzymes, and colorectal cancer risk
    Michelle Cotterchio
    Population Studies and Surveillance, Cancer Care Ontario, 620 University Avenue, Toronto, Ontario, Canada, M5G 2L7
    Cancer Epidemiol Biomarkers Prev 17:3098-107. 2008
    ....
  24. ncbi AH receptor antagonist inhibits constitutive CYP1A1 and CYP1B1 expression in rat BP8 cells
    Steven Roblin
    Developmental Biology Program, The Hospital for Sick Children, Toronto, Ont, Canada
    Biochem Biophys Res Commun 317:142-8. 2004
    ..Inhibition by the AHR antagonist along with the diminished response to the mutated AHR indicates that BP8 cells contain some agent that acts as an agonist ligand for the AHR...
  25. ncbi Evaluation of various housekeeping genes for their applicability for normalization of mRNA expression in dioxin-treated rats
    Raimo Pohjanvirta
    Department of Food and Environmental Hygiene, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland
    Chem Biol Interact 160:134-49. 2006
    ..These findings show that normalization genes for qRT-PCR must be carefully validated in advance, especially if the study involves a potent modifier of gene expression...
  26. ncbi Differential expression profiling of the hepatic proteome in a rat model of dioxin resistance: correlation with genomic and transcriptomic analyses
    Roberta Pastorelli
    Department of Environmental Health Sciences, Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milan, Italy
    Mol Cell Proteomics 5:882-94. 2006
    ..As such, our work is expected to lead to new insights into the mechanism of TCDD toxicity and resistance...
  27. ncbi Polymorphisms in the human AH receptor
    Patricia A Harper
    Division of Clinical Pharmacology, Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada M5G 1X8
    Chem Biol Interact 141:161-87. 2002
    ..The search continues for polymorphisms that alter AHR function because this receptor is a central factor in determining responses to important environmental contaminants and also plays a physiologic role in early development in mammals...
  28. ncbi Genome-wide effects of acute progressive feed restriction in liver and white adipose tissue
    Raimo Pohjanvirta
    Department of Food and Environmental Hygiene, Faculty of Veterinary Medicine, P O Box 66, FI 00014, University of Helsinki, Finland
    Toxicol Appl Pharmacol 230:41-56. 2008
    ..This study demonstrates that body weight is a poor proxy of metabolic state and that the customary protocols of feed restriction can lead to rhythm entrainment...
  29. ncbi Role of aryl hydrocarbon receptor-mediated induction of the CYP1 enzymes in environmental toxicity and cancer
    Daniel W Nebert
    Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati Medical Center, Cincinnati, Ohio 45267 0056, USA
    J Biol Chem 279:23847-50. 2004
    ..In the future, use of "humanized" mouse lines, containing a human AHR or CYP1 allele in place of the orthologous mouse gene, is one likely approach to show that the AHR and the CYP1 enzymes in human behave similarly to that in mouse...