Catherine Adell O'Brien

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. ncbi ID1 and ID3 regulate the self-renewal capacity of human colon cancer-initiating cells through p21
    Catherine A O'Brien
    Campbell Family Institute, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, Ontario M5G 1L7, Canada
    Cancer Cell 21:777-92. 2012
  2. ncbi Cancer stem cells in solid tumors: an overview
    Catherine Adell O'Brien
    Department of General Surgery, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
    Semin Radiat Oncol 19:71-7. 2009
  3. ncbi Colon cancer stem cells
    Antonija Kreso
    Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario, Canada
    Curr Protoc Stem Cell Biol . 2008
  4. ncbi Cancer stem cells and self-renewal
    Catherine Adell O'Brien
    Division of General Surgery, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Clin Cancer Res 16:3113-20. 2010

Collaborators

Detail Information

Publications4

  1. ncbi ID1 and ID3 regulate the self-renewal capacity of human colon cancer-initiating cells through p21
    Catherine A O'Brien
    Campbell Family Institute, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, Ontario M5G 1L7, Canada
    Cancer Cell 21:777-92. 2012
    ..Additionally, silencing of ID1 and ID3 increases sensitivity of CC-ICs to the chemotherapeutic agent oxaliplatin, linking tumor initiation function with chemotherapy resistance...
  2. ncbi Cancer stem cells in solid tumors: an overview
    Catherine Adell O'Brien
    Department of General Surgery, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
    Semin Radiat Oncol 19:71-7. 2009
    ..Emerging evidence indicates that these cells are also resistant to chemotherapy and radiation therapy, which has led to much speculation and interest surrounding the potential clinical applicability of CSCs...
  3. ncbi Colon cancer stem cells
    Antonija Kreso
    Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario, Canada
    Curr Protoc Stem Cell Biol . 2008
    ..This unit will describe how to isolate and functionally test colon cancer stem cells, as well as provide advice on the potential challenges of the research...
  4. ncbi Cancer stem cells and self-renewal
    Catherine Adell O'Brien
    Division of General Surgery, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Clin Cancer Res 16:3113-20. 2010
    ..This review will address some of the main controversies in the CSC field and emphasize the importance of focusing first and foremost on the defining feature of CSCs: dysregulated self-renewal capacity...