Catherine Adell O'Brien
Affiliation: University of Toronto
- ID1 and ID3 regulate the self-renewal capacity of human colon cancer-initiating cells through p21Catherine A O'Brien
Campbell Family Institute, Ontario Cancer Institute, Princess Margaret Hospital, University Health Network, Toronto, Ontario M5G 1L7, Canada
Cancer Cell 21:777-92. 2012..Additionally, silencing of ID1 and ID3 increases sensitivity of CC-ICs to the chemotherapeutic agent oxaliplatin, linking tumor initiation function with chemotherapy resistance...
- Cancer stem cells in solid tumors: an overviewCatherine Adell O'Brien
Department of General Surgery, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada
Semin Radiat Oncol 19:71-7. 2009..Emerging evidence indicates that these cells are also resistant to chemotherapy and radiation therapy, which has led to much speculation and interest surrounding the potential clinical applicability of CSCs...
- Colon cancer stem cellsAntonija Kreso
Department of Molecular and Medical Genetics, University of Toronto, Toronto, Ontario, Canada
Curr Protoc Stem Cell Biol . 2008..This unit will describe how to isolate and functionally test colon cancer stem cells, as well as provide advice on the potential challenges of the research...
- Cancer stem cells and self-renewalCatherine Adell O'Brien
Division of General Surgery, University Health Network, University of Toronto, Toronto, Ontario, Canada
Clin Cancer Res 16:3113-20. 2010..This review will address some of the main controversies in the CSC field and emphasize the importance of focusing first and foremost on the defining feature of CSCs: dysregulated self-renewal capacity...