Research Topics
Genomes and GenesSpecies | T F OberlanderSummaryAffiliation: University of British Columbia Country: Canada Publications
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Detail Information
Publications
Internalizing behaviors in 4-year-old children exposed in utero to psychotropic medicationsShaila Misri
Reproductive Mental Health Program, St Paul s Hospital, Rm 2B 185, 1081 Burrard St, Vancouver, BC V6Z 1Y6, Canada
Am J Psychiatry 163:1026-32. 2006..The authors had previously reported the effects of prenatal medication exposure in this same cohort when they were newborns and infants at 3 and 8 months of age...
Fetal serotonin signaling: setting pathways for early childhood development and behaviorTim F Oberlander
Department of Pediatrics, Child and Family Research Institute, Vancouver, British Columbia, Canada
J Adolesc Health 51:S9-16. 2012..Understanding the impact of early changes in serotonergic programming offers critical insights that might explain patterns of individual differences in developmental risk and resilience...- Sustained neurobehavioral effects of exposure to SSRI antidepressants during development: molecular to clinical evidenceT F Oberlander
Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada
Clin Pharmacol Ther 86:672-7. 2009..In humans, sustained developmental outcomes remain largely unstudied, and distinguishing between the effects of prenatal SSRI exposure and the impact of maternal mental illness remains a key challenge... - Pain reactivity in 2-month-old infants after prenatal and postnatal serotonin reuptake inhibitor medication exposureTim F Oberlander
Department of Pediatrics, Biobehavioral Research Unit, Centre for Community Child Health Research, Room L408, 4480 Oak St, Vancouver, BC, Canada
Pediatrics 115:411-25. 2005..Based on previous findings showing reduced pain responses in newborns after prenatal exposure, we hypothesized that altered pain reactivity would also be found at 2 months of age... - Infant serotonin transporter (SLC6A4) promoter genotype is associated with adverse neonatal outcomes after prenatal exposure to serotonin reuptake inhibitor medicationsT F Oberlander
Early Human Experience Unit, Department of Pediatrics, Centre for Community Child Health Research, University of British Columbia, Vancouver, BC, Canada
Mol Psychiatry 13:65-73. 2008.... - Neonatal outcomes after prenatal exposure to selective serotonin reuptake inhibitor antidepressants and maternal depression using population-based linked health dataTim F Oberlander
Department of Pediatrics, Human Early Learning Partnership, Faculty of Graduate Studies, University of British Columbia, Vancouver
Arch Gen Psychiatry 63:898-906. 2006..Prenatal exposure to selective serotonin reuptake inhibitor (SSRI) antidepressants and maternal depression both alter neonatal health, and distinguishing the effects of each influence remains challenging... - Externalizing and attentional behaviors in children of depressed mothers treated with a selective serotonin reuptake inhibitor antidepressant during pregnancyTim F Oberlander
Department of Pediatrics, Human Early Experience Unit, Centre for Community Child Health Research, Research Institute for Children s and Women s Health, University of British Columbia, 4480 Oak Street, Vancouver, BC, Canada V6 3V4
Arch Pediatr Adolesc Med 161:22-9. 2007..To evaluate attentional and activity behaviors in 4-year-olds following prenatal selective serotonin reuptake inhibitor (SSRI) exposure... - Major congenital malformations following prenatal exposure to serotonin reuptake inhibitors and benzodiazepines using population-based health dataTim F Oberlander
Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada
Birth Defects Res B Dev Reprod Toxicol 83:68-76. 2008..To determine a population-based incidence of congenital anomalies following prenatal exposure to serotonin reuptake inhibitor (SRI) antidepressants used alone and in combination with a benzodiazepines (BZ)... - Effects of timing and duration of gestational exposure to serotonin reuptake inhibitor antidepressants: population-based studyTim F Oberlander
Early Human Experience Unit, Centre for Community Child Health Research, Vancouver, BC, Canada
Br J Psychiatry 192:338-43. 2008..Late-gestational serotonin reuptake inhibitor (SRI) exposure has been linked to adverse neonatal outcomes; however, the impact of timing and duration of exposure is unknown... - Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant cortisol stress responsesTim F Oberlander
Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver, British Columbia, Canada
Epigenetics 3:97-106. 2008.... - Hypothalamic-pituitary-adrenal (HPA) axis function in 3-month old infants with prenatal selective serotonin reuptake inhibitor (SSRI) antidepressant exposureTim F Oberlander
Department of Pediatrics, UBC, Vancouver, BC, Canada V6H 3V4
Early Hum Dev 84:689-97. 2008.... - Pharmacologic factors associated with transient neonatal symptoms following prenatal psychotropic medication exposureTim F Oberlander
Department of Pediatrics, Centre for Community Child Health Research, University of British Columbia, L408 4480 Oak Street, Vancouver, BC, Canada V6H 3V4
J Clin Psychiatry 65:230-7. 2004..Also, this study explores relationships between neonatal outcomes and medication levels during pregnancy, at delivery, and in the newborn period... - Prenatal alcohol exposure alters biobehavioral reactivity to pain in newbornsTim F Oberlander
Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada
Alcohol Clin Exp Res 34:681-92. 2010..5 oz absolute alcohol/d) drinkers (controls)... - Prolonged prenatal psychotropic medication exposure alters neonatal acute pain responseTim F Oberlander
Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada
Pediatr Res 51:443-53. 2002..Possible 5HT-mediated pain inhibition, pharmacologic factors and the developmental course remain to be studied... - Does parenchymal brain injury affect biobehavioral pain responses in very low birth weight infants at 32 weeks' postconceptional age?Tim F Oberlander
Biobehavioral Research Unit, Centre for Community Child Health Research, B C Research Institute for Children s and Women s Health, Vancouver, British Columbia, Canada
Pediatrics 110:570-6. 2002..The purpose of this study was to determine whether infants with PBI display altered responses to acute procedural pain at 32 weeks' postconceptional age (PCA), compared with control subjects... - Methodological considerations for the use of heart rate variability as a measure of pain reactivity in vulnerable infantsTim Oberlander
Division of Developmental Pediatrics, University of British Columbia, Centre for Community Child Health Research, Children s and Women s Health Centre of B C, 4480 Oak Street, Vancouver, B C V6N 2H4, Canada
Clin Perinatol 29:427-43. 2002..Understanding cardiovascular reactivity as a measure of response to painful events in vulnerable infants requires ongoing work... - Biobehavioral pain responses in former extremely low birth weight infants at four months' corrected ageT F Oberlander
Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada
Pediatrics 105:e6. 2000..To compare biobehavioral responses to acute pain at 4 months' corrected age between former extremely low birth weight (ELBW) infants and term-born controls... - Neonatal S100B protein levels after prenatal exposure to selective serotonin reuptake inhibitorsJodi L Pawluski
Department of Pediatrics, University of British Columbia, Vancouver, Canada
Pediatrics 124:e662-70. 2009..This study investigated neonatal S100B levels as a biomarker of prenatal selective serotonin reuptake inhibitor (SSRI) exposure... - A register study of the impact of stopping third trimester selective serotonin reuptake inhibitor exposure on neonatal healthW Warburton
Human Early Learning Partnership, University of British Columbia, Vancouver, BC, Canada
Acta Psychiatr Scand 121:471-9. 2010..To determine whether risk for adverse neonatal outcomes are reduced by stopping SSRI use before the end of pregnancy... - Demographic and therapeutic determinants of pain reactivity in very low birth weight neonates at 32 Weeks' postconceptional AgeR E Grunau
Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada
Pediatrics 107:105-12. 2001..Management of pain in very low birth weight infants is limited by a lack of empiric knowledge about the multiple determinants of biobehavioral reactivity in infants receiving neonatal intensive care... - Prenatal effects of selective serotonin reuptake inhibitor antidepressants, serotonin transporter promoter genotype (SLC6A4), and maternal mood on child behavior at 3 years of ageTim F Oberlander
Early Human Experience Unit, Developmental Neurosciences and Child Health, and Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada
Arch Pediatr Adolesc Med 164:444-51. 2010.... - Biobehavioral responses to acute pain in adolescents with a significant neurologic impairmentT F Oberlander
Sunny Hill Heath Centre for Children, Department of Pediatrics, University of British Columbia, Vancouver, Canada
Clin J Pain 15:201-9. 1999..To further understand acute pain response in children with a significant neurologic impairment (SNI), we undertook a descriptive hypothesis-generating study of the response to a routine vaccine among adolescents with SNI... - Pain in children with significant neurological impairmentT F Oberlander
Division of Developmental Pediatrics, Sunny Hill Health Centre for Children, University of British Columbia, Vancouver, Canada
J Dev Behav Pediatr 20:235-43. 1999..With appropriate monitoring, demand and regional analgesic techniques can provide effective and safe postoperative pain control. The lack of basic and clinical knowledge in this field, however, adds another challenge to the clinician... 
Relations between behavioral and cardiac autonomic reactivity to acute pain in preterm neonatesS J Morison
Center for Community Health and Health Evaluation Research, British Columbia Research Institute for Children s and Women s Health, Vancouver, Canada
Clin J Pain 17:350-8. 2001..The purpose of this study was to assess relations and concordance between behavioral and physiologic reactivity to pain in preterm neonates at 32 weeks postconceptional age as a function of gestational age at birth...- Depression during pregnancy: the potential impact of increased risk for fetal aneuploidy on maternal moodC Hippman
Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada
Clin Genet 75:30-6. 2009..4% of women, respectively, scored above 12. Mean EPDS score was significantly higher in the MG group than in the control group (p < 0.0001). These results suggest a place for depression screening in prenatal genetic counseling... - Antenatal depression and anxiety affect postpartum parenting stress: a longitudinal, prospective studyShaila Misri
Department of Psychiatry and Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia
Can J Psychiatry 55:222-8. 2010..We studied the effect of antenatal depression and anxiety and treatment with selective serotonin reuptake inhibitors and selective norepinephrine reuptake inhibitors (antidepressants [ADs]) on postpartum parenting stress... - Cortisol, behavior, and heart rate reactivity to immunization pain at 4 months corrected age in infants born very pretermRuth E Grunau
Department of Pediatrics, University of British Columbia, Vancouver BC, Canada
Clin J Pain 26:698-704. 2010..To our knowledge, cortisol reactivity to pain has not been compared in preterm and full-term infants. We examined pain reactivity to immunization in preterm and full-term infants... - Is it painful or not? Discriminant validity of the Behavioral Indicators of Infant Pain (BIIP) scaleLiisa Holsti
Community Child Health Research, Child and Family Research Institute, Vancouver, Canada
Clin J Pain 24:83-8. 2008.... - Does prone or supine position influence pain responses in preterm infants at 32 weeks gestational age?Ruth Eckstein Grunau
Centre for Community Child Health Research, B C Research Institute for Children s and Women s Health, Vancouver, British Columbia, Canada
Clin J Pain 20:76-82. 2004..The purpose of this study was to examine the influence of prone and supine position in preterm infants during acute pain of blood collection... - Specific Newborn Individualized Developmental Care and Assessment Program movements are associated with acute pain in preterm infants in the neonatal intensive care unitLiisa Holsti
Centre for Community Child Health Research, British Columbia Research Institute for Children s and Women s Health, Vancouver, British Columbia, Canada
Pediatrics 114:65-72. 2004..The objective of this study was to identify developmentally relevant movements indicative of pain in preterm infants... - Relation between prenatal maternal mood and anxiety and neonatal healthShaila Misri
Department of Psychiatry, University of British Columbia, Vancouver
Can J Psychiatry 49:684-9. 2004..To examine the relation between the mood and anxiety of pregnant, psychiatrically treated women and neonatal health outcomes after birth... - Are there developmentally distinct motor indicators of pain in preterm infants?Sara J Morison
Centre for Community Child Health Research, British Columbia Research Institute for Children s and Women s Health, Room L 408, 4480 Oak Street, Vancouver, BC, Canada V6H 3V4
Early Hum Dev 72:131-46. 2003..Extension of extremities and finger splay, but not twitches and startles, from the NIDCAP, appear to be stress cues and show promise as clinical pain indicators to supplement facial and physiological pain measures in preterm infants... - Prior pain induces heightened motor responses during clustered care in preterm infants in the NICULiisa Holsti
Centre for Community Child Health Research, Room F6, 4480 Oak Street, Vancouver, British Columbia, Canada V6H 3V4
Early Hum Dev 81:293-302. 2005..Acute pain is a significant stressor for preterm infants in neonatal intensive care units (NICU); however, little is known about the effects of acute pain on subsequent motor responses during clusters of tactile handling... - Body movements: an important additional factor in discriminating pain from stress in preterm infantsLiisa Holsti
Centre for Community Child Health Research, British Columbia Research Institute for Children s and Women s Health, Vancouver, British Columbia, Canada
Clin J Pain 21:491-8. 2005.... - Behavioral responses to pain are heightened after clustered care in preterm infants born between 30 and 32 weeks gestational ageLiisa Holsti
Centre for Community Child Health Research, Child and Family Research Institute, Vancouver, Canada
Clin J Pain 22:757-64. 2006..To compare biobehavioral pain responses of preterm infants born at differing gestational ages (GAs) when pain was preceded by a rest period or by a series of routine nursing interventions... - Prenatal exposure to maternal depressed mood and the MTHFR C677T variant affect SLC6A4 methylation in infants at birthAngela M Devlin
Department of Pediatrics, Child and Family Research Institute, University of British Columbia, Vancouver, Canada
PLoS ONE 5:e12201. 2010..The methylation status of SLC6A4, which encodes the transmembrane serotonin transporter, and BDNF, which encodes brain derived neurotrophic factor, were assessed because of their potential role in behaviour... - Expression of pain in children with autismRami Nader
Department of Psychology, University of British Columbia, Vancouver, BC, Canada
Clin J Pain 20:88-97. 2004.... - Pain management of junctional epidermolysis bullosa in an 11-year-Old boyY K Chiu
Division of Dermatology, British Columbia's Children's Hospital and University of British Columbia, Vancouver, British Columbia, Canada
Pediatr Dermatol 16:465-8. 1999..Oral midazolam 0.33 mg/kg administered 20 minutes prior to baths and dressing changes substantially improved his tolerance of wound care... - A prospective controlled study of neurodevelopment in HIV-uninfected children exposed to combination antiretroviral drugs in pregnancyAriane Alimenti
Department of Pediatrics, University of British Columbia, Vancouver, British Columbia, Canada
Pediatrics 118:e1139-45. 2006..These results suggest that perinatal highly active antiretroviral therapy exposure is not associated with altered development and behavior at 18 to 36 months of age... - Stereoselective disposition of fluoxetine and norfluoxetine during pregnancy and breast-feedingJohn Kim
Department of Psychiatry, University of British Columbia
Br J Clin Pharmacol 61:155-63. 2006..Increased exposure may also result from decreased metabolism of the drug in the foetus and neonate... - Summary proceedings from the neonatal pain-control groupKanwaljeet J S Anand
Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
Pediatrics 117:S9-S22. 2006..Full-length articles on procedural pain, sedation and analgesia for ventilated infants, perioperative pain, and study designs for neonatal pain research were published in Clinical Therapeutics (June 2005)...