Georg Northoff

Summary

Affiliation: University of Ottawa
Country: Canada

Publications

  1. doi request reprint Rest-stimulus interaction in the brain: a review
    Georg Northoff
    Institute of Mental Health Research, University of Ottawa, Ottawa, ON K1Z 7K4, Canada
    Trends Neurosci 33:277-84. 2010
  2. doi request reprint Humans, brains, and their environment: marriage between neuroscience and anthropology?
    Georg Northoff
    Institute of Mental Health Research, University of Ottawa, Ottawa K1Z 7K4, Canada
    Neuron 65:748-51. 2010
  3. doi request reprint The brain and its resting state activity--experimental and methodological implications
    Georg Northoff
    Mind, Brain Imaging and Neuroethics Research Unit, Institute of Mental Health Research, University of Ottawa, Canada
    Prog Neurobiol 92:593-600. 2010
  4. doi request reprint Brain imaging of the self--conceptual, anatomical and methodological issues
    Georg Northoff
    Mind, Brain Imaging and Neuroethics, University of Ottawa Institute of Mental Health Research IMHR, 1145 Carling Avenue Ottawa, ON, Canada K1Z 7K4
    Conscious Cogn 20:52-63. 2011
  5. doi request reprint How can the brain's resting state activity generate hallucinations? A 'resting state hypothesis' of auditory verbal hallucinations
    Georg Northoff
    Mind, Brain Imaging and Neuroethics, Institute of Mental Health Research IMHR, 1145 Carling Avenue, Ottawa, ON K1Z 7K4, Canada
    Schizophr Res 127:202-14. 2011
  6. doi request reprint The 'resting-state hypothesis' of major depressive disorder-a translational subcortical-cortical framework for a system disorder
    Georg Northoff
    University of Ottawa Institue of Mental Health Research, University of Hangzhou, China
    Neurosci Biobehav Rev 35:1929-45. 2011
  7. doi request reprint Is our self nothing but reward?
    Georg Northoff
    Mind, Brain Imaging and Neuroethics Unit, Institute of Mental Health Research, Royal Ottawa Health Care Group, University of Ottawa, Ontario, Canada
    Biol Psychiatry 69:1019-25. 2011
  8. doi request reprint External awareness and GABA--a multimodal imaging study combining fMRI and [18F]flumazenil-PET
    Christine Wiebking
    Department of Biology, Freie Universitat Berlin, Berlin, Germany Institute of Mental Health Research, University of Ottawa, Ontario, Canada
    Hum Brain Mapp 35:173-84. 2014
  9. pmc Glutamate concentration in the medial prefrontal cortex predicts resting-state cortical-subcortical functional connectivity in humans
    Niall W Duncan
    Mind, Brain Imaging and Neuroethics Research Unit, University of Ottawa Institute of Mental Health Research, Ottawa, Canada
    PLoS ONE 8:e60312. 2013
  10. doi request reprint Involvement of glutamate in rest-stimulus interaction between perigenual and supragenual anterior cingulate cortex: a combined fMRI-MRS study
    Niall W Duncan
    Mind, Brain Imaging and Neuroethics, Institute of Mental Health Research, University of Ottawa, Ottawa, ON, Canada
    Hum Brain Mapp 32:2172-82. 2011

Collaborators

Detail Information

Publications25

  1. doi request reprint Rest-stimulus interaction in the brain: a review
    Georg Northoff
    Institute of Mental Health Research, University of Ottawa, Ottawa, ON K1Z 7K4, Canada
    Trends Neurosci 33:277-84. 2010
    ..We conclude that a better understanding of the rest-stimulus interaction is likely to be crucial to the elucidation of the brain's contribution to mental states...
  2. doi request reprint Humans, brains, and their environment: marriage between neuroscience and anthropology?
    Georg Northoff
    Institute of Mental Health Research, University of Ottawa, Ottawa K1Z 7K4, Canada
    Neuron 65:748-51. 2010
    ..However, rather than being incorporated into neuroscience, anthropology may be considered complementary, and a marriage of the two disciplines can provide deep insight into these fundamental questions...
  3. doi request reprint The brain and its resting state activity--experimental and methodological implications
    Georg Northoff
    Mind, Brain Imaging and Neuroethics Research Unit, Institute of Mental Health Research, University of Ottawa, Canada
    Prog Neurobiol 92:593-600. 2010
    ..This may also shed new light on some hitherto unresolved questions like the neuroscientific mechanisms underlying consciousness and psychiatric disorders...
  4. doi request reprint Brain imaging of the self--conceptual, anatomical and methodological issues
    Georg Northoff
    Mind, Brain Imaging and Neuroethics, University of Ottawa Institute of Mental Health Research IMHR, 1145 Carling Avenue Ottawa, ON, Canada K1Z 7K4
    Conscious Cogn 20:52-63. 2011
    ..Modifications of both conceptual and anatomical dimensions will allow an empirically more plausible account of the relationship between brain and self...
  5. doi request reprint How can the brain's resting state activity generate hallucinations? A 'resting state hypothesis' of auditory verbal hallucinations
    Georg Northoff
    Mind, Brain Imaging and Neuroethics, Institute of Mental Health Research IMHR, 1145 Carling Avenue, Ottawa, ON K1Z 7K4, Canada
    Schizophr Res 127:202-14. 2011
    ..We discuss evidence in favour of our 'resting state hypothesis' and show its correspondence with phenomenological accounts...
  6. doi request reprint The 'resting-state hypothesis' of major depressive disorder-a translational subcortical-cortical framework for a system disorder
    Georg Northoff
    University of Ottawa Institue of Mental Health Research, University of Hangzhou, China
    Neurosci Biobehav Rev 35:1929-45. 2011
    ....
  7. doi request reprint Is our self nothing but reward?
    Georg Northoff
    Mind, Brain Imaging and Neuroethics Unit, Institute of Mental Health Research, Royal Ottawa Health Care Group, University of Ottawa, Ontario, Canada
    Biol Psychiatry 69:1019-25. 2011
    ..This interaction may help to fill in some of the missing pieces regarding reward-related processing, as well as illuminate how brain function can bring forward the philosophical concept and psychological reality of self...
  8. doi request reprint External awareness and GABA--a multimodal imaging study combining fMRI and [18F]flumazenil-PET
    Christine Wiebking
    Department of Biology, Freie Universitat Berlin, Berlin, Germany Institute of Mental Health Research, University of Ottawa, Ontario, Canada
    Hum Brain Mapp 35:173-84. 2014
    ..This in turn has implications for our understanding of the biochemical mechanisms underlying awareness in general and its potential impact on psychiatric disorders...
  9. pmc Glutamate concentration in the medial prefrontal cortex predicts resting-state cortical-subcortical functional connectivity in humans
    Niall W Duncan
    Mind, Brain Imaging and Neuroethics Research Unit, University of Ottawa Institute of Mental Health Research, Ottawa, Canada
    PLoS ONE 8:e60312. 2013
    ..These results are in agreement with existing results from animal studies and may have relevance for MDD and schizophrenia...
  10. doi request reprint Involvement of glutamate in rest-stimulus interaction between perigenual and supragenual anterior cingulate cortex: a combined fMRI-MRS study
    Niall W Duncan
    Mind, Brain Imaging and Neuroethics, Institute of Mental Health Research, University of Ottawa, Ottawa, ON, Canada
    Hum Brain Mapp 32:2172-82. 2011
    ..This provides insight into the neuronal and biochemical mechanisms by means of which the resting state activity of the brain potentially impacts upon subsequent stimulus-induced activity...
  11. doi request reprint How is informed consent related to emotions and empathy? An exploratory neuroethical investigation
    Alexander Supady
    Department of Psychiatry, Otto von Guericke University, Magdeburg, Germany
    J Med Ethics 37:311-7. 2011
    ..While cognitive functions have been shown to play a central role, the impact of empathy and emotions on subjects' decisions in informed consent remains unclear...
  12. pmc Overview of potential procedural and participant-related confounds for neuroimaging of the resting state
    Niall W Duncan
    Mind, Brain Imaging and Neuroethics Research Unit, University of Ottawa Institute of Mental Health Research, Ottawa, Ont
    J Psychiatry Neurosci 38:84-96. 2013
    ..A particular theme that emerges from the overview is the range of systematic differences between types of study groups (e.g., between patients and controls) that may influence resting-state study results...
  13. pmc GABAA receptors predict aversion-related brain responses: an fMRI-PET investigation in healthy humans
    Dave J Hayes
    Mind, Brain Imaging and Neuroethics, Institute of Mental Health Research, Royal Ottawa Health Care Group, University of Ottawa, Ottawa, ON, Canada
    Neuropsychopharmacology 38:1438-50. 2013
    ..Together, these results demonstrate the central role of GABA in mediating context-dependent effects in aversion-related processing...
  14. pmc Self-specific stimuli interact differently than non-self-specific stimuli with eyes-open versus eyes-closed spontaneous activity in auditory cortex
    Pengmin Qin
    Mind, Brain Imaging and Neuroethics Unit, University of Ottawa Institute of Mental Health Research IMHR, Ottawa, ON, Canada
    Front Hum Neurosci 7:437. 2013
    ..These results support an impact of spontaneous activity on stimulus-induced activity, moreover an impact that depends on the high-level stimulus characteristic of self-specificity. ..
  15. pmc GABA(A) receptors in visual and auditory cortex and neural activity changes during basic visual stimulation
    Pengmin Qin
    Mind, Brain Imaging and Neuroethics, University of Ottawa Institute of Mental Health Research Ottawa, ON, Canada
    Front Hum Neurosci 6:337. 2012
    ..These findings contribute to our understanding of the role of GABA(A) receptors in stimulus-induced neural activity in local regions and in inter-regional functional connectivity...
  16. pmc Common brain activations for painful and non-painful aversive stimuli
    Dave J Hayes
    Mind, Brain Imaging and Neuroethics Research Unit, Institute of Mental Health Research, University of Ottawa, 1145 Carling Avenue, Ottawa, K1Z 7K4, Canada
    BMC Neurosci 13:60. 2012
    ..To help clarify this issue, this report used a cross-species translational approach in humans (i.e. meta-analysis) and rodents (i.e. systematic review of functional neuroanatomy)...
  17. doi request reprint Is there a core neural network in empathy? An fMRI based quantitative meta-analysis
    Yan Fan
    Institute of Mental Health Research, University of Ottawa, Ottawa, Canada
    Neurosci Biobehav Rev 35:903-11. 2011
    ..It was concluded that the dACC-aMCC-SMA and bilateral insula can be considered as forming a core network in empathy, and that cognitive-evaluative and affective-perceptual empathy can be distinguished at the level of regional activation...
  18. doi request reprint Impaired self-referential processing in mesial temporal lobe epilepsy: a functional MRI study
    Cuiping Yuan
    Department of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China Department of Medical Imaging, Jiangsu Province Traditional Chinese Medicine Hospital, Nanjing 210029, China Institute of Mental Health Research, University of Ottawa, 1145 Carling Avenue, Ottawa, ON K1Z 7K4, Canada
    Neurosci Lett 555:187-92. 2013
    ..The present findings implicate functional impairment of self-reference caused by epilepsy in mTLE. This study provided imaging evidence for functional impairments of self-referential processing and brain default-mode function in mTLE. ..
  19. doi request reprint How is our self related to midline regions and the default-mode network?
    Pengmin Qin
    Mind, Brain Imaging and Neuroethics, Institute of Mental Health Research, 1145 Carling Avenue Ottawa, ON, Canada K1Z 7K4
    Neuroimage 57:1221-33. 2011
    ..Taken together, our data suggest that our sense of self may result from a specific kind of interaction between resting state activity and stimulus-induced activity, i.e., rest-stimulus interaction, within the midline regions...
  20. doi request reprint What the brain's intrinsic activity can tell us about consciousness? A tri-dimensional view
    Georg Northoff
    University of Ottawa Institute of Mental Health Research, Ottawa, Canada
    Neurosci Biobehav Rev 37:726-38. 2013
    ..g., spatiotemporal structure, as provided by the intrinsic activity. In short, I here opt for tri-rather than bi-dimensional view of consciousness...
  21. doi request reprint Neuroimaging in pedophilia
    Christine Wiebking
    Mind, Brain Imaging and Neuroethics, Royal Ottawa Healthcare, Institute of Mental Health Research, Ottawa, Canada
    Curr Psychiatry Rep 15:351. 2013
    ....
  22. pmc Distinction between Externally vs. Internally Guided Decision-Making: Operational Differences, Meta-Analytical Comparisons and Their Theoretical Implications
    Takashi Nakao
    Mind, Brain Imaging and Neuroethics, Institute of Mental Health Research, Royal Ottawa Health Care Group, University of Ottawa Ottawa, ON, Canada
    Front Neurosci 6:31. 2012
    ..Finally, based on the review and results of the meta-analysis, we discuss the differences and relations between decision-making of these two types in terms of their operational, neuronal, and theoretical characteristics...
  23. pmc Identifying a network of brain regions involved in aversion-related processing: a cross-species translational investigation
    Dave J Hayes
    Mind, Brain Imaging and Neuroethics Research Unit, Institute of Mental Health Research, University of Ottawa Ottawa, ON, Canada
    Front Integr Neurosci 5:49. 2011
    ..This not only contributes to our understanding of the trans-species neural correlates of aversion but may also carry important implications for psychiatric disorders where abnormal aversive behavior can often be observed...
  24. doi request reprint Dissociation between anterior and posterior cortical regions during self-specificity and familiarity: a combined fMRI-meta-analytic study
    Pengmin Qin
    Laboratory for Higher Brain Function, Institute of Psychology, Chinese Academy of Sciences, Beijing, China
    Hum Brain Mapp 33:154-64. 2012
    ..Finally, the distinction between anterior and posterior regions for self and familiarity was confirmed by meta-analytic data. This study demonstrates a clear anterior-posterior cortical partition between self-specificity and familiarity...
  25. doi request reprint What is neuroethics? Empirical and theoretical neuroethics
    Georg Northoff
    Canada Research Chair for Mind, Brain and Neuroethics, Michael Smith Chair for Neuroscience and Mental Health, Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario, Canada
    Curr Opin Psychiatry 22:565-9. 2009
    ..In contrast, theoretical and methodological considerations have rather been neglected and thus what may be called theoretical neuroethics...