Georg Northoff

Summary

Affiliation: University of Ottawa
Country: Canada

Publications

  1. doi Rest-stimulus interaction in the brain: a review
    Georg Northoff
    Institute of Mental Health Research, University of Ottawa, Ottawa, ON K1Z 7K4, Canada
    Trends Neurosci 33:277-84. 2010
  2. pmc Is our self nothing but reward? Neuronal overlap and distinction between reward and personal relevance and its relation to human personality
    Björn Enzi
    Department of Psychiatry, Otto von Guericke University Magdeburg, Magdeburg, Germany
    PLoS ONE 4:e8429. 2009
  3. pmc From emotions to consciousness - a neuro-phenomenal and neuro-relational approach
    Georg Northoff
    Mind, Brain Imaging and Neuroethics Research Unit, Institute of Mental Health Research, University of Ottawa Ottawa, ON, Canada
    Front Psychol 3:303. 2012
  4. doi The 'resting-state hypothesis' of major depressive disorder-a translational subcortical-cortical framework for a system disorder
    Georg Northoff
    University of Ottawa Institue of Mental Health Research, University of Hangzhou, China
    Neurosci Biobehav Rev 35:1929-45. 2011
  5. doi Is our self nothing but reward?
    Georg Northoff
    Mind, Brain Imaging and Neuroethics Unit, Institute of Mental Health Research, Royal Ottawa Health Care Group, University of Ottawa, Ontario, Canada
    Biol Psychiatry 69:1019-25. 2011
  6. doi Humans, brains, and their environment: marriage between neuroscience and anthropology?
    Georg Northoff
    Institute of Mental Health Research, University of Ottawa, Ottawa K1Z 7K4, Canada
    Neuron 65:748-51. 2010
  7. doi The brain and its resting state activity--experimental and methodological implications
    Georg Northoff
    Mind, Brain Imaging and Neuroethics Research Unit, Institute of Mental Health Research, University of Ottawa, Canada
    Prog Neurobiol 92:593-600. 2010
  8. doi Brain imaging of the self--conceptual, anatomical and methodological issues
    Georg Northoff
    Mind, Brain Imaging and Neuroethics, University of Ottawa Institute of Mental Health Research IMHR, 1145 Carling Avenue Ottawa, ON, Canada K1Z 7K4
    Conscious Cogn 20:52-63. 2011
  9. doi How can the brain's resting state activity generate hallucinations? A 'resting state hypothesis' of auditory verbal hallucinations
    Georg Northoff
    Mind, Brain Imaging and Neuroethics, Institute of Mental Health Research IMHR, 1145 Carling Avenue, Ottawa, ON K1Z 7K4, Canada
    Schizophr Res 127:202-14. 2011
  10. doi The relationship between aberrant neuronal activation in the pregenual anterior cingulate, altered glutamatergic metabolism, and anhedonia in major depression
    Martin Walter
    Department of Psychiatry, Ottovon Guericke University of Magdeburg, Magdeburg, Germany
    Arch Gen Psychiatry 66:478-86. 2009

Collaborators

Detail Information

Publications49

  1. doi Rest-stimulus interaction in the brain: a review
    Georg Northoff
    Institute of Mental Health Research, University of Ottawa, Ottawa, ON K1Z 7K4, Canada
    Trends Neurosci 33:277-84. 2010
    ..We conclude that a better understanding of the rest-stimulus interaction is likely to be crucial to the elucidation of the brain's contribution to mental states...
  2. pmc Is our self nothing but reward? Neuronal overlap and distinction between reward and personal relevance and its relation to human personality
    Björn Enzi
    Department of Psychiatry, Otto von Guericke University Magdeburg, Magdeburg, Germany
    PLoS ONE 4:e8429. 2009
    ..Although previous research demonstrated a relationship between reward and personal relevance, their exact neuronal relationship including the impact of personality traits remains unclear...
  3. pmc From emotions to consciousness - a neuro-phenomenal and neuro-relational approach
    Georg Northoff
    Mind, Brain Imaging and Neuroethics Research Unit, Institute of Mental Health Research, University of Ottawa Ottawa, ON, Canada
    Front Psychol 3:303. 2012
    ..Such neuro-phenomenal approach does not only inform emotions and emotional feeling but is also highly relevant to better understand the neuronal mechanisms underlying consciousness in general...
  4. doi The 'resting-state hypothesis' of major depressive disorder-a translational subcortical-cortical framework for a system disorder
    Georg Northoff
    University of Ottawa Institue of Mental Health Research, University of Hangzhou, China
    Neurosci Biobehav Rev 35:1929-45. 2011
    ....
  5. doi Is our self nothing but reward?
    Georg Northoff
    Mind, Brain Imaging and Neuroethics Unit, Institute of Mental Health Research, Royal Ottawa Health Care Group, University of Ottawa, Ontario, Canada
    Biol Psychiatry 69:1019-25. 2011
    ..This interaction may help to fill in some of the missing pieces regarding reward-related processing, as well as illuminate how brain function can bring forward the philosophical concept and psychological reality of self...
  6. doi Humans, brains, and their environment: marriage between neuroscience and anthropology?
    Georg Northoff
    Institute of Mental Health Research, University of Ottawa, Ottawa K1Z 7K4, Canada
    Neuron 65:748-51. 2010
    ..However, rather than being incorporated into neuroscience, anthropology may be considered complementary, and a marriage of the two disciplines can provide deep insight into these fundamental questions...
  7. doi The brain and its resting state activity--experimental and methodological implications
    Georg Northoff
    Mind, Brain Imaging and Neuroethics Research Unit, Institute of Mental Health Research, University of Ottawa, Canada
    Prog Neurobiol 92:593-600. 2010
    ..This may also shed new light on some hitherto unresolved questions like the neuroscientific mechanisms underlying consciousness and psychiatric disorders...
  8. doi Brain imaging of the self--conceptual, anatomical and methodological issues
    Georg Northoff
    Mind, Brain Imaging and Neuroethics, University of Ottawa Institute of Mental Health Research IMHR, 1145 Carling Avenue Ottawa, ON, Canada K1Z 7K4
    Conscious Cogn 20:52-63. 2011
    ..Modifications of both conceptual and anatomical dimensions will allow an empirically more plausible account of the relationship between brain and self...
  9. doi How can the brain's resting state activity generate hallucinations? A 'resting state hypothesis' of auditory verbal hallucinations
    Georg Northoff
    Mind, Brain Imaging and Neuroethics, Institute of Mental Health Research IMHR, 1145 Carling Avenue, Ottawa, ON K1Z 7K4, Canada
    Schizophr Res 127:202-14. 2011
    ..We discuss evidence in favour of our 'resting state hypothesis' and show its correspondence with phenomenological accounts...
  10. doi The relationship between aberrant neuronal activation in the pregenual anterior cingulate, altered glutamatergic metabolism, and anhedonia in major depression
    Martin Walter
    Department of Psychiatry, Ottovon Guericke University of Magdeburg, Magdeburg, Germany
    Arch Gen Psychiatry 66:478-86. 2009
    ..Major depressive disorder (MDD) is characterized by diverse metabolic and functional abnormalities that occur in, among other regions, the pregenual anterior cingulate cortex (pgACC), a cortical region linked to anhedonia...
  11. doi Distinguishing specific sexual and general emotional effects in fMRI-subcortical and cortical arousal during erotic picture viewing
    Martin Walter
    Department of Psychiatry, University Hospital, Magdeburg, Germany
    Neuroimage 40:1482-94. 2008
    ..No differences were found in these effects when comparing females and males. Our findings demonstrate for the first time neural differentiation between emotional and sexual components in the neural network underlying sexual arousal...
  12. ncbi Preceding attention and the dorsomedial prefrontal cortex: process specificity versus domain dependence
    Martin Walter
    Department of Psychiatry, Otto von Guericke University Magdeburg, Magdeburg, Germany
    Hum Brain Mapp 30:312-26. 2009
    ..This suggests that the anterior and posterior DMPFC is involved in the process of attending mental states while remaining more (posterior DMPFC) or less (anterior DMPFC) independent of the type or domain of the respective stimulus...
  13. doi Abnormal body perception and neural activity in the insula in depression: an fMRI study of the depressed "material me"
    Christine Wiebking
    Department of Psychiatry, Otto von Guericke University, Magdeburg, Germany
    World J Biol Psychiatry 11:538-49. 2010
    ..Since the "material me" has been especially associated with the anterior insula in healthy subjects, we hypothesized abnormalities in this region during interoceptive awareness in MDD...
  14. ncbi Differential parametric modulation of self-relatedness and emotions in different brain regions
    Georg Northoff
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    Hum Brain Mapp 30:369-82. 2009
    ..hum..
  15. doi Decreased neural activity in reward circuitry during personal reference in abstinent alcoholics--a fMRI study
    Moritz de Greck
    Department of Psychiatry, Otto von Guericke University Magdeburg, Leipziger Strasse 44, Magdeburg, Germany
    Hum Brain Mapp 30:1691-704. 2009
    ..Our results underline the important role of the reward circuitry during personal reference in the pathophysiology of alcohol addiction...
  16. doi Involvement of glutamate in rest-stimulus interaction between perigenual and supragenual anterior cingulate cortex: a combined fMRI-MRS study
    Niall W Duncan
    Mind, Brain Imaging and Neuroethics, Institute of Mental Health Research, University of Ottawa, Ottawa, ON, Canada
    Hum Brain Mapp 32:2172-82. 2011
    ..This provides insight into the neuronal and biochemical mechanisms by means of which the resting state activity of the brain potentially impacts upon subsequent stimulus-induced activity...
  17. doi High resolution fMRI of subcortical regions during visual erotic stimulation at 7 T
    Martin Walter
    Department of Psychiatry, University Hospital Otto v Guericke University, Leipziger Strasse 44, 39120 Magdeburg, Germany
    MAGMA 21:103-11. 2008
    ....
  18. ncbi Brain pathology in pedophilic offenders: evidence of volume reduction in the right amygdala and related diencephalic structures
    Kolja Schiltz
    Department of Psychiatry, Otto von Guericke University, Magdeburg, Saxony Anhalt 39120, Germany
    Arch Gen Psychiatry 64:737-46. 2007
    ..However, the role of alterations in brain structures that are crucial in the development of sexual behavior has not yet been systematically studied in pedophilic subjects...
  19. doi External awareness and GABA--a multimodal imaging study combining fMRI and [18F]flumazenil-PET
    Christine Wiebking
    Department of Biology, Freie Universitat Berlin, Berlin, Germany Institute of Mental Health Research, University of Ottawa, Ontario, Canada
    Hum Brain Mapp 35:173-84. 2014
    ..This in turn has implications for our understanding of the biochemical mechanisms underlying awareness in general and its potential impact on psychiatric disorders...
  20. doi How is informed consent related to emotions and empathy? An exploratory neuroethical investigation
    Alexander Supady
    Department of Psychiatry, Otto von Guericke University, Magdeburg, Germany
    J Med Ethics 37:311-7. 2011
    ..While cognitive functions have been shown to play a central role, the impact of empathy and emotions on subjects' decisions in informed consent remains unclear...
  21. doi Are emotions associated with activity during rest or interoception? An exploratory fMRI study in healthy subjects
    Christine Wiebking
    Clinic of Psychiatry, Otto von Guericke University, Magdeburg, Germany
    Neurosci Lett 491:87-92. 2011
    ..Our findings provide further insight into the psychological functions underlying rest activity. Our findings in healthy subjects may also have future implications for a better understanding of mood disorders...
  22. doi The role of hippocampus dysfunction in deficient memory encoding and positive symptoms in schizophrenia
    Kathrin Zierhut
    Department of Psychiatry, Otto von Guericke University of Magdeburg, Germany
    Psychiatry Res 183:187-94. 2010
    ..Declarative memory disturbances, known to substantially contribute to cognitive impairment in schizophrenia, have previously been attributed to prefrontal as well as hippocampal dysfunction...
  23. doi Is there a core neural network in empathy? An fMRI based quantitative meta-analysis
    Yan Fan
    Institute of Mental Health Research, University of Ottawa, Ottawa, Canada
    Neurosci Biobehav Rev 35:903-11. 2011
    ..It was concluded that the dACC-aMCC-SMA and bilateral insula can be considered as forming a core network in empathy, and that cognitive-evaluative and affective-perceptual empathy can be distinguished at the level of regional activation...
  24. pmc Glutamate concentration in the medial prefrontal cortex predicts resting-state cortical-subcortical functional connectivity in humans
    Niall W Duncan
    Mind, Brain Imaging and Neuroethics Research Unit, University of Ottawa Institute of Mental Health Research, Ottawa, Canada
    PLoS ONE 8:e60312. 2013
    ..These results are in agreement with existing results from animal studies and may have relevance for MDD and schizophrenia...
  25. ncbi GABA concentrations in the human anterior cingulate cortex predict negative BOLD responses in fMRI
    Georg Northoff
    Department of Psychiatry, Otto von Guericke University Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Nat Neurosci 10:1515-7. 2007
    ..Our findings show that default-mode network negative BOLD responses during emotions are mediated by GABA...
  26. ncbi How does our brain constitute defense mechanisms? First-person neuroscience and psychoanalysis
    Georg Northoff
    Department of Psychiatry, Psychotherapy and Psychosomatics, University of Magdeburg, Magdeburg, Germany
    Psychother Psychosom 76:141-53. 2007
    ....
  27. pmc GABAA receptors predict aversion-related brain responses: an fMRI-PET investigation in healthy humans
    Dave J Hayes
    Mind, Brain Imaging and Neuroethics, Institute of Mental Health Research, Royal Ottawa Health Care Group, University of Ottawa, Ottawa, ON, Canada
    Neuropsychopharmacology 38:1438-50. 2013
    ..Together, these results demonstrate the central role of GABA in mediating context-dependent effects in aversion-related processing...
  28. doi S-ketamine and GABA-A-receptor interaction in humans: an exploratory study with I-123-iomazenil SPECT
    Alexander Heinzel
    Department of Psychiatry, University of Magdeburg, Magdeburg, Germany
    Hum Psychopharmacol 23:549-54. 2008
    ..We aimed to probe for regional cerebral effects of S-ketamine on in vivo GABA-A-receptor binding in healthy human subjects...
  29. pmc Self-specific stimuli interact differently than non-self-specific stimuli with eyes-open versus eyes-closed spontaneous activity in auditory cortex
    Pengmin Qin
    Mind, Brain Imaging and Neuroethics Unit, University of Ottawa Institute of Mental Health Research IMHR, Ottawa, ON, Canada
    Front Hum Neurosci 7:437. 2013
    ..These results support an impact of spontaneous activity on stimulus-induced activity, moreover an impact that depends on the high-level stimulus characteristic of self-specificity. ..
  30. ncbi Psychopathology and pathophysiology of the self in depression - neuropsychiatric hypothesis
    Georg Northoff
    Laboratory of Neuroimaging and Neurophilosophy, Department of Psychiatry, Otto von Guericke University of Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    J Affect Disord 104:1-14. 2007
    ..The question of the self has intrigued philosophers and psychologists for a long time. More recently distinct concepts of self have also been suggested in neuroscience more specifically in neuroimaging...
  31. ncbi Pedophilia is linked to reduced activation in hypothalamus and lateral prefrontal cortex during visual erotic stimulation
    Martin Walter
    Department of Psychiatry, Otto von Guericke University of Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Biol Psychiatry 62:698-701. 2007
    ..Although pedophilic patients are sexually attracted to prepubescent children, they show no sexual interest toward adults. This study aimed to investigate the neural correlates of deficits of sexual and emotional arousal in pedophiles...
  32. ncbi What is neuroethics? Empirical and theoretical neuroethics
    Georg Northoff
    Canada Research Chair for Mind, Brain and Neuroethics, Michael Smith Chair for Neuroscience and Mental Health, Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario, Canada
    Curr Opin Psychiatry 22:565-9. 2009
    ..In contrast, theoretical and methodological considerations have rather been neglected and thus what may be called theoretical neuroethics...
  33. doi The trans-species concept of self and the subcortical-cortical midline system
    Georg Northoff
    Department of Psychiatry, University of Magdeburg, Leipziger Strasse 44, Magdeburg, Germany
    Trends Cogn Sci 12:259-64. 2008
    ..Recent data suggest that SRP is operating via a central integrative neural system made up of subcortical-cortical midline structures (SCMSs), that are homologous across mammalian species...
  34. pmc Overview of potential procedural and participant-related confounds for neuroimaging of the resting state
    Niall W Duncan
    Mind, Brain Imaging and Neuroethics Research Unit, University of Ottawa Institute of Mental Health Research, Ottawa, Ont
    J Psychiatry Neurosci 38:84-96. 2013
    ..A particular theme that emerges from the overview is the range of systematic differences between types of study groups (e.g., between patients and controls) that may influence resting-state study results...
  35. doi What the brain's intrinsic activity can tell us about consciousness? A tri-dimensional view
    Georg Northoff
    University of Ottawa Institute of Mental Health Research, Ottawa, Canada
    Neurosci Biobehav Rev 37:726-38. 2013
    ..g., spatiotemporal structure, as provided by the intrinsic activity. In short, I here opt for tri-rather than bi-dimensional view of consciousness...
  36. ncbi Neuroimaging in pedophilia
    Christine Wiebking
    Mind, Brain Imaging and Neuroethics, Royal Ottawa Healthcare, Institute of Mental Health Research, Ottawa, Canada
    Curr Psychiatry Rep 15:351. 2013
    ....
  37. doi Impaired self-referential processing in mesial temporal lobe epilepsy: a functional MRI study
    Cuiping Yuan
    Department of Medical Imaging, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China Department of Medical Imaging, Jiangsu Province Traditional Chinese Medicine Hospital, Nanjing 210029, China Institute of Mental Health Research, University of Ottawa, 1145 Carling Avenue, Ottawa, ON K1Z 7K4, Canada
    Neurosci Lett 555:187-92. 2013
    ..The present findings implicate functional impairment of self-reference caused by epilepsy in mTLE. This study provided imaging evidence for functional impairments of self-referential processing and brain default-mode function in mTLE. ..
  38. pmc Neuroscience of decision making and informed consent: an investigation in neuroethics
    Georg Northoff
    Department of Psychiatry, Section for Neurophilosophy, University of Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    J Med Ethics 32:70-3. 2006
    ..It is concluded that current progress in the neurosciences could complement and change the way in which we approach ethical problems in neuropsychiatry...
  39. pmc GABA(A) receptors in visual and auditory cortex and neural activity changes during basic visual stimulation
    Pengmin Qin
    Mind, Brain Imaging and Neuroethics, University of Ottawa Institute of Mental Health Research Ottawa, ON, Canada
    Front Hum Neurosci 6:337. 2012
    ..These findings contribute to our understanding of the role of GABA(A) receptors in stimulus-induced neural activity in local regions and in inter-regional functional connectivity...
  40. pmc Common brain activations for painful and non-painful aversive stimuli
    Dave J Hayes
    Mind, Brain Imaging and Neuroethics Research Unit, Institute of Mental Health Research, University of Ottawa, 1145 Carling Avenue, Ottawa, K1Z 7K4, Canada
    BMC Neurosci 13:60. 2012
    ..To help clarify this issue, this report used a cross-species translational approach in humans (i.e. meta-analysis) and rodents (i.e. systematic review of functional neuroanatomy)...
  41. doi How is our self related to midline regions and the default-mode network?
    Pengmin Qin
    Mind, Brain Imaging and Neuroethics, Institute of Mental Health Research, 1145 Carling Avenue Ottawa, ON, Canada K1Z 7K4
    Neuroimage 57:1221-33. 2011
    ..Taken together, our data suggest that our sense of self may result from a specific kind of interaction between resting state activity and stimulus-induced activity, i.e., rest-stimulus interaction, within the midline regions...
  42. pmc The association of interoceptive awareness and alexithymia with neurotransmitter concentrations in insula and anterior cingulate
    Jutta Ernst
    Clinic for Affective Disorders and General Psychiatry, Department of Psychiatry, Psychotherapy, and Psychosomatics, Psychiatric University Hospital, 8029 Zurich, Switzerland, Center for Anxiety and Depression, 8008 Zurich, Switzerland, University of Ottawa, Institute of Mental Health Research, Ottawa K1Z 7K4, Canada, Department of Psychiatry, Campus Benjamin Franklin, Charite, 14050 Berlin, and Languages of Emotion Cluster of Excellence, Freie Universitat Berlin, 14195 Berlin, Germany
    Soc Cogn Affect Neurosci 9:857-63. 2014
    ..Suppression of the unspecific emotional arousal evoked by increased awareness of bodily responses in alexithymics might thus be reflected in decreased neuronal activity mediated by increased GABA concentration in ACC. ..
  43. doi Immanuel Kant's mind and the brain's resting state
    Georg Northoff
    University of Ottawa Institute of Mental Health Research, Ottawa, ON K1Z 7K4, Canada
    Trends Cogn Sci 16:356-9. 2012
    ..Kant’s ideas may provide novel insights into how the brain’s intrinsic features must be so that they can be linked to the neural processing of extrinsic stimuli to enable the latter’s association with consciousness and self...
  44. ncbi Volume and neuron number of the mediodorsal thalamic nucleus in schizophrenia: a replication study
    Peter Danos
    Department of Psychiatry, University Hospital Giessen and Marburg, Location Giessen, Germany
    Psychiatry Res 140:281-9. 2005
    ..Taken together, the present results suggest that schizophrenia is associated with a moderate volume reduction in the left mediodorsal thalamic nucleus, while the neuron density and the total neuron number are unchanged...
  45. doi Neuropsychiatry. An old discipline in a new gestalt bridging biological psychiatry, neuropsychology, and cognitive neurology
    Georg Northoff
    Department of Psychiatry, Otto von Guericke University of Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany
    Eur Arch Psychiatry Clin Neurosci 258:226-38. 2008
    ....
  46. ncbi Resting-state functional magnetic resonance imaging: review of neurosurgical applications
    Stefan Lang
    Department of Neurosurgery, University of Calgary, Calgary, Alberta, Canada Mind, Brain Imaging, and Neuroethics Unit, Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario, Canada Center for Cognition and Brain Disorders, Hangzhou Normal University, Hangzhou, China
    Neurosurgery 74:453-64; discussion 464-5. 2014
    ....
  47. pmc Distinction between Externally vs. Internally Guided Decision-Making: Operational Differences, Meta-Analytical Comparisons and Their Theoretical Implications
    Takashi Nakao
    Mind, Brain Imaging and Neuroethics, Institute of Mental Health Research, Royal Ottawa Health Care Group, University of Ottawa Ottawa, ON, Canada
    Front Neurosci 6:31. 2012
    ..Finally, based on the review and results of the meta-analysis, we discuss the differences and relations between decision-making of these two types in terms of their operational, neuronal, and theoretical characteristics...
  48. doi Dissociation between anterior and posterior cortical regions during self-specificity and familiarity: a combined fMRI-meta-analytic study
    Pengmin Qin
    Laboratory for Higher Brain Function, Institute of Psychology, Chinese Academy of Sciences, Beijing, China
    Hum Brain Mapp 33:154-64. 2012
    ..Finally, the distinction between anterior and posterior regions for self and familiarity was confirmed by meta-analytic data. This study demonstrates a clear anterior-posterior cortical partition between self-specificity and familiarity...
  49. pmc Identifying a network of brain regions involved in aversion-related processing: a cross-species translational investigation
    Dave J Hayes
    Mind, Brain Imaging and Neuroethics Research Unit, Institute of Mental Health Research, University of Ottawa Ottawa, ON, Canada
    Front Integr Neurosci 5:49. 2011
    ..This not only contributes to our understanding of the trans-species neural correlates of aversion but may also carry important implications for psychiatric disorders where abnormal aversive behavior can often be observed...