Corey Nislow

Summary

Affiliation: University of Toronto
Country: Canada

Publications

  1. pmc Mitochondrial electron transport is the cellular target of the oncology drug elesclomol
    Ronald K Blackman
    Synta Pharmaceuticals Corp, Lexington, Massachusetts, United States of America
    PLoS ONE 7:e29798. 2012
  2. pmc A systems biology approach reveals the role of a novel methyltransferase in response to chemical stress and lipid homeostasis
    Elena Lissina
    Department of Molecular Genetics, University of Toronto, Toronto, Canada
    PLoS Genet 7:e1002332. 2011
  3. pmc Off-target effects of psychoactive drugs revealed by genome-wide assays in yeast
    Elke Ericson
    Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada
    PLoS Genet 4:e1000151. 2008
  4. pmc Genome-wide analysis of intracellular pH reveals quantitative control of cell division rate by pH(c) in Saccharomyces cerevisiae
    Rick Orij
    Molecular Biology and Microbial Food Safety, Swammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands
    Genome Biol 13:R80. 2012
  5. pmc Combining chemical genomics screens in yeast to reveal spectrum of effects of chemical inhibition of sphingolipid biosynthesis
    Danielle Kemmer
    Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, Canada
    BMC Microbiol 9:9. 2009
  6. pmc Novel insights into iron metabolism by integrating deletome and transcriptome analysis in an iron deficiency model of the yeast Saccharomyces cerevisiae
    William J Jo
    Department of Nutritional Sciences and Toxicology, University of California, Berkeley, California 94720, USA
    BMC Genomics 10:130. 2009
  7. pmc Nucleosome-coupled expression differences in closely-related species
    Yuanfang Guan
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    BMC Genomics 12:466. 2011
  8. pmc Quantitative phenotyping via deep barcode sequencing
    Andrew M Smith
    Department of Molecular Genetics, University of Toronto, Ontario, Canada
    Genome Res 19:1836-42. 2009
  9. doi request reprint Dosage suppression genetic interaction networks enhance functional wiring diagrams of the cell
    Leslie Magtanong
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    Nat Biotechnol 29:505-11. 2011
  10. pmc Functional analysis with a barcoder yeast gene overexpression system
    Alison C Douglas
    Department of Molecular Genetics, University of Toronto, Ontario M5S 1A8, Canada
    G3 (Bethesda) 2:1279-89. 2012

Collaborators

Detail Information

Publications64

  1. pmc Mitochondrial electron transport is the cellular target of the oncology drug elesclomol
    Ronald K Blackman
    Synta Pharmaceuticals Corp, Lexington, Massachusetts, United States of America
    PLoS ONE 7:e29798. 2012
    ....
  2. pmc A systems biology approach reveals the role of a novel methyltransferase in response to chemical stress and lipid homeostasis
    Elena Lissina
    Department of Molecular Genetics, University of Toronto, Toronto, Canada
    PLoS Genet 7:e1002332. 2011
    ..This approach demonstrates the value of combining chemical genomics with other systems-based methods for characterizing proteins and elucidating previously unknown mechanisms of action of small molecule inhibitors...
  3. pmc Off-target effects of psychoactive drugs revealed by genome-wide assays in yeast
    Elke Ericson
    Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada
    PLoS Genet 4:e1000151. 2008
    ....
  4. pmc Genome-wide analysis of intracellular pH reveals quantitative control of cell division rate by pH(c) in Saccharomyces cerevisiae
    Rick Orij
    Molecular Biology and Microbial Food Safety, Swammerdam Institute for Life Sciences, University of Amsterdam, Science Park 904, 1098 XH Amsterdam, The Netherlands
    Genome Biol 13:R80. 2012
    ..Since small changes in pH(c) can lead to major changes in metabolism, signal transduction, and phenotype, we decided to analyze pH(c) control...
  5. pmc Combining chemical genomics screens in yeast to reveal spectrum of effects of chemical inhibition of sphingolipid biosynthesis
    Danielle Kemmer
    Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, Canada
    BMC Microbiol 9:9. 2009
    ..Single genome-wide screens for the effect of altered gene dosage on drug sensitivity in the model organism Saccharomyces cerevisiae provide only a partial picture of the mechanism of action of a drug...
  6. pmc Novel insights into iron metabolism by integrating deletome and transcriptome analysis in an iron deficiency model of the yeast Saccharomyces cerevisiae
    William J Jo
    Department of Nutritional Sciences and Toxicology, University of California, Berkeley, California 94720, USA
    BMC Genomics 10:130. 2009
    ..The resulting analysis provides a global perspective on the cellular processes involved in iron metabolism...
  7. pmc Nucleosome-coupled expression differences in closely-related species
    Yuanfang Guan
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    BMC Genomics 12:466. 2011
    ..The degree to which nucleosome-motif interactions relate to phenotypic changes across species is, however, unknown...
  8. pmc Quantitative phenotyping via deep barcode sequencing
    Andrew M Smith
    Department of Molecular Genetics, University of Toronto, Ontario, Canada
    Genome Res 19:1836-42. 2009
    ..Together, this new assay and analysis routine provide a deep-sequencing-based toolkit for identifying gene-environment interactions on a genome-wide scale...
  9. doi request reprint Dosage suppression genetic interaction networks enhance functional wiring diagrams of the cell
    Leslie Magtanong
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    Nat Biotechnol 29:505-11. 2011
    ..This work suggests that integrating the results of dosage suppression studies with other interaction networks could generate insights into the functional wiring diagram of a cell...
  10. pmc Functional analysis with a barcoder yeast gene overexpression system
    Alison C Douglas
    Department of Molecular Genetics, University of Toronto, Ontario M5S 1A8, Canada
    G3 (Bethesda) 2:1279-89. 2012
    ..As a proof-of-principle, we describe the properties of the barFLEX overexpression collection and its application in synthetic dosage lethality studies under different environmental conditions...
  11. pmc Miniature short hairpin RNA screens to characterize antiproliferative drugs
    Saranya Kittanakom
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 3E1, Canada
    G3 (Bethesda) 3:1375-87. 2013
    ..This cost-effective approach to mammalian knockdown screens, combined with the increasing maturation of RNAi technology will expand the accessibility of similar approaches in academic settings. ..
  12. pmc Restriction of histone gene transcription to S phase by phosphorylation of a chromatin boundary protein
    Christoph F Kurat
    The Donnelly Center, University of Toronto, Toronto, Ontario M5S 3E1, Canada
    Genes Dev 25:2489-501. 2011
    ..Our study identified the chromatin boundary protein Yta7 as a key regulator that links S-phase kinases with RNAPII function at cell cycle-regulated histone gene promoters...
  13. pmc Genetic and genomic architecture of the evolution of resistance to antifungal drug combinations
    Jessica A Hill
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    PLoS Genet 9:e1003390. 2013
    ....
  14. pmc Identification of yeast genes that confer resistance to chitosan oligosaccharide (COS) using chemogenomics
    Maria D L A Jaime
    Department of Cell and Systems Biology, University of Toronto, Mississauga, Ontario, Canada
    BMC Genomics 13:267. 2012
    ..COS is relatively non-toxic to mammals. By identifying the molecular and genetic targets of COS, we hope to gain a better understanding of the antifungal mode of action of COS...
  15. pmc Target identification by chromatographic co-elution: monitoring of drug-protein interactions without immobilization or chemical derivatization
    Janet N Y Chan
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    Mol Cell Proteomics 11:M111.016642. 2012
    ..Furthermore, TICC identified Asc1 and Dak1, a core 40 S ribosomal protein that represses gene expression, and dihydroxyacetone kinase involved in stress adaptation, respectively, as novel yeast targets of a dopamine receptor agonist...
  16. pmc A survey of yeast genomic assays for drug and target discovery
    Andrew M Smith
    Department of Molecular Genetics, University of Toronto, 1 King s College Circle, Toronto, Ontario, Canada
    Pharmacol Ther 127:156-64. 2010
    ..In this review, we examine current yeast chemical genomic assays and summarize the potential applications of each approach...
  17. doi request reprint Dafadine inhibits DAF-9 to promote dauer formation and longevity of Caenorhabditis elegans
    Genna M Luciani
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    Nat Chem Biol 7:891-3. 2011
    ..This molecule (called dafadine) also inhibits the mammalian ortholog of DAF-9(CYP27A1), suggesting that dafadine can be used to interrogate developmental control and longevity in other animals...
  18. doi request reprint Yeast Barcoders: a chemogenomic application of a universal donor-strain collection carrying bar-code identifiers
    Zhun Yan
    Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada
    Nat Methods 5:719-25. 2008
    ..1% of all essential yeast genes. These experiments validate both the Barcoders and the DAmP strain collection as useful tools for genome-wide chemical-genetic assays...
  19. ncbi request reprint The genetic landscape of a cell
    Michael Costanzo
    Banting and Best Department of Medical Research, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada
    Science 327:425-31. 2010
    ..We also demonstrate that extensive and unbiased mapping of the genetic landscape provides a key for interpretation of chemical-genetic interactions and drug target identification...
  20. pmc Global analysis of SUMO chain function reveals multiple roles in chromatin regulation
    Tharan Srikumar
    Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada
    J Cell Biol 201:145-63. 2013
    ....
  21. doi request reprint Genomic approaches for determining nucleosome occupancy in yeast
    Kyle Tsui
    The Donnelly Centre for Biomolecular Research, University of Toronto, Toronto, ON, Canada
    Methods Mol Biol 833:389-411. 2012
    ..Here, we describe the use of genome-wide approaches to determining nucleosome occupancy in yeast...
  22. pmc Diversity of eukaryotic DNA replication origins revealed by genome-wide analysis of chromatin structure
    Nicolas M Berbenetz
    Department of Molecular Genetics, University of Toronto, Toronto, Canada
    PLoS Genet 6:e1001092. 2010
    ....
  23. pmc A comparative analysis of DNA barcode microarray feature size
    Ron Ammar
    Department of Molecular Genetics, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    BMC Genomics 10:471. 2009
    ..It is generally perceived that decreasing the size of microarray features leads to arrays with higher resolution (due to greater feature density), but this increase in resolution can compromise sensitivity...
  24. pmc Precise gene-dose alleles for chemical genetics
    Zhun Yan
    Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada
    Genetics 182:623-6. 2009
    ..The generated gene dosage allele set expands the genetic toolkit for uncovering novel phenotypes...
  25. doi request reprint Global gene deletion analysis exploring yeast filamentous growth
    Owen Ryan
    Banting and Best Department of Medical Research, University of Toronto, Toronto, ON M5S 3E1, Canada
    Science 337:1353-6. 2012
    ..cerevisiae and C. albicans...
  26. doi request reprint Exploring gene function and drug action using chemogenomic dosage assays
    Elke Ericson
    Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada
    Methods Enzymol 470:233-55. 2010
    ..Further, the compendium of results from these screens can inform large-scale network analysis of genetic function, gene-gene interactions, and mechanism of drug action...
  27. doi request reprint Chemogenomic approaches to elucidation of gene function and genetic pathways
    Sarah E Pierce
    Department of Pharmaceutical Sciences, University of Toronto, Toronto, ON, Canada M5S 3E1
    Methods Mol Biol 548:115-43. 2009
    ....
  28. pmc An algorithm for chemical genomic profiling that minimizes batch effects: bucket evaluations
    Daniel Shabtai
    Department of Cell and Systems Biology and the Donnelly Centre, University of Toronto, Toronto, ON, Canada
    BMC Bioinformatics 13:245. 2012
    ..We present a method, Bucket Evaluations (BE) that surmounts many of these problems and is extensible to other datasets such as those obtained via gene expression profiling and which is platform independent...
  29. pmc Chemical-genetic profiling of imidazo[1,2-a]pyridines and -pyrimidines reveals target pathways conserved between yeast and human cells
    Lisa Yu
    Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada
    PLoS Genet 4:e1000284. 2008
    ....
  30. pmc The extensive and condition-dependent nature of epistasis among whole-genome duplicates in yeast
    Gabriel Musso
    Banting and Best Department of Medical Research, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada
    Genome Res 18:1092-9. 2008
    ....
  31. doi request reprint Compound prioritization methods increase rates of chemical probe discovery in model organisms
    Iain M Wallace
    Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada
    Chem Biol 18:1273-83. 2011
    ..As community resources, the ~7500 growth-inhibitory molecules have been made commercially available and the computational model and filter used are provided...
  32. ncbi request reprint Mapping the cellular response to small molecules using chemogenomic fitness signatures
    Anna Y Lee
    The Donnelly Centre, University of Toronto, Toronto, Ontario M5S 3E1, Canada
    Science 344:208-11. 2014
    ..Our results provide a resource for the discovery of functional interactions among genes, chemicals, and biological processes. ..
  33. pmc Comparative chemogenomics to examine the mechanism of action of dna-targeted platinum-acridine anticancer agents
    Kahlin Cheung-Ong
    Department of Molecular Genetics and the Donnelly Centre, University of Toronto, Toronto, ON, M5S3E1 Canada
    ACS Chem Biol 7:1892-901. 2012
    ..Chemogenomic profiles from both S. cerevisiae and S. pombe demonstrate that several of the platinum-acridines damage DNA differently than cisplatin based on their requirement for distinct modules of DNA repair...
  34. pmc A comprehensive platform for highly multiplexed mammalian functional genetic screens
    Troy Ketela
    Donnelly Centre and Banting and Best Department of Medical Research, University of Toronto, Toronto, Canada
    BMC Genomics 12:213. 2011
    ..The Gene Modulation Array Platform (GMAP) is a single microarray-based detection solution for deconvolution of loss and gain-of-function pooled screens...
  35. pmc Systematic exploration of essential yeast gene function with temperature-sensitive mutants
    Zhijian Li
    Banting and Best Department of Medical Research, The Donnelly Centre, University of Toronto, Toronto, Ontario, Canada
    Nat Biotechnol 29:361-7. 2011
    ..This mutant collection should facilitate a wide range of systematic studies aimed at understanding the functions of essential genes...
  36. doi request reprint Barcode sequencing for understanding drug-gene interactions
    Andrew M Smith
    Donnelly Centre, University of Toronto, Toronto, ON, Canada
    Methods Mol Biol 910:55-69. 2012
    ..In addition, we provide guidelines for assessment of human knockdown cells using short-hairpin RNAs (shRNA) and an Illumina sequencing readout...
  37. pmc Timing of transcriptional quiescence during gametogenesis is controlled by global histone H3K4 demethylation
    Mengshu Xu
    Department of Molecular Genetics, University of Toronto, Toronto M5S 1A8, Canada
    Dev Cell 23:1059-71. 2012
    ....
  38. pmc Lysosomal disruption preferentially targets acute myeloid leukemia cells and progenitors
    Mahadeo A Sukhai
    Princess Margaret Hospital the Ontario Cancer Institute, University Health Network, Toronto, Ontario, Canada
    J Clin Invest 123:315-28. 2013
    ..These results demonstrate that lysosomal disruption preferentially targets AML cells and AML progenitor cells, providing a rationale for testing lysosomal disruption as a novel therapeutic strategy for AML...
  39. pmc Most "dark matter" transcripts are associated with known genes
    Harm van Bakel
    Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario, Canada
    PLoS Biol 8:e1000371. 2010
    ..We conclude that, while there are bona fide new intergenic transcripts, their number and abundance is generally low in comparison to known exons, and the genome is not as pervasively transcribed as previously reported...
  40. pmc Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress
    Johnny M Tkach
    Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    Nat Cell Biol 14:966-76. 2012
    ..This method identifies response pathways that were not detected in genetic and protein interaction screens, and can be readily applied to any form of chemical or genetic stress to reveal cellular response pathways...
  41. ncbi request reprint A novel calcineurin-independent activity of cyclosporin A in Saccharomyces cerevisiae
    Sheena D Singh-Babak
    Department of Molecular Genetics, University of Toronto, 1 King s College Circle, Medical Sciences Building, Room 4368, Toronto, Ontario M5S 1A8, Canada
    Mol Biosyst 8:2575-84. 2012
    ..Thus, systems level chemical genomic approaches implicate key cellular pathways in a novel mechanism of antifungal drug synergy...
  42. ncbi request reprint A predictive model for drug bioaccumulation and bioactivity in Caenorhabditis elegans
    Andrew R Burns
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    Nat Chem Biol 6:549-57. 2010
    ..Preselecting molecules that are more likely to reach a target by first applying our model to the tens of millions of commercially available compounds will undoubtedly increase the success of future small-molecule screens with C. elegans...
  43. pmc Chromatin is an ancient innovation conserved between Archaea and Eukarya
    Ron Ammar
    Department of Molecular Genetics, University of Toronto, Toronto, Canada Donnelly Centre, University of Toronto, Toronto, Canada
    elife 1:e00078. 2012
    ..DOI:http://dx.doi.org/10.7554/eLife.00078.001...
  44. doi request reprint Displaying chemical information on a biological network using Cytoscape
    Iain M Wallace
    Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada
    Methods Mol Biol 781:363-76. 2011
    ..ChEMBL is a very large, open-source repository of compound-target information available from the European Molecular Biology Laboratory...
  45. doi request reprint A high-throughput yeast assay identifies synergistic drug combinations
    Nikko P Torres
    Donnelly Centre, University of Toronto, Toronto, Canada
    Assay Drug Dev Technol 11:299-307. 2013
    ..Finally, we underscore the importance of testing the order of addition for assessing drug combinations...
  46. doi request reprint DNA-damaging agents in cancer chemotherapy: serendipity and chemical biology
    Kahlin Cheung-Ong
    Department of Molecular Genetics and the Donnelly Centre, University of Toronto, Toronto, ON M5S 3E1, Canada
    Chem Biol 20:648-59. 2013
    ....
  47. doi request reprint Recent advances and method development for drug target identification
    Janet N Y Chan
    Department of Molecular Genetics, Banting and Best Department of Medical Research, University of Toronto, Ontario, Canada M5S 3E1
    Trends Pharmacol Sci 31:82-8. 2010
    ..The continuous improvement and advancement of existing technologies is critically discussed and we offer a perspective on the future of innovative emerging new generation technologies...
  48. ncbi request reprint CHIP-MYTH: a novel interactive proteomics method for the assessment of agonist-dependent interactions of the human β₂-adrenergic receptor
    Saranya Kittanakom
    Donnelly Centre, University of Toronto, Ontario, Canada
    Biochem Biophys Res Commun 445:746-56. 2014
    ....
  49. pmc Highly-multiplexed barcode sequencing: an efficient method for parallel analysis of pooled samples
    Andrew M Smith
    Department of Molecular Genetics, University of Toronto, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Nucleic Acids Res 38:e142. 2010
    ....
  50. pmc A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters
    Gwenael Badis
    Banting and Best Department of Medical Research, University of Toronto, Toronto, ON M5S 3E1, Canada
    Mol Cell 32:878-87. 2008
    ....
  51. pmc Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia
    Marko Skrtic
    Campbell Family Cancer Research Institute, Princess Margaret Hospital, Ontario Cancer Institute, Toronto, Ontario M5G 2M9, Canada
    Cancer Cell 20:674-88. 2011
    ....
  52. pmc Integrating high-throughput genetic interaction mapping and high-content screening to explore yeast spindle morphogenesis
    Franco J Vizeacoumar
    Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario M5S 3E1, Canada
    J Cell Biol 188:69-81. 2010
    ..Although we focused on spindle disassembly in a proof-of-principle study, our integrated HCS-SGA method can be applied to virtually any pathway, making it a powerful means for identifying specific cellular functions...
  53. pmc Evolution of nucleosome occupancy: conservation of global properties and divergence of gene-specific patterns
    Kyle Tsui
    Donnelly Centre for Cellular and Biomolecular Research, 160 College Street, Toronto, Ontario M5S 3E1, Canada
    Mol Cell Biol 31:4348-55. 2011
    ..Thus, while some evolutionary changes in nucleosome occupancy contribute to gene expression divergence, nucleosome occupancy often diverges extensively with apparently little impact on gene expression...
  54. pmc A novel small molecule methyltransferase is important for virulence in Candida albicans
    Elena Lissina
    Department of Molecular Genetics, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College St, Toronto, M5S 3E1, Canada
    ACS Chem Biol 8:2785-93. 2013
    ..Finally we found that this novel lipid-related smMTase is required for virulence in the waxmoth Galleria mellonella, a model of infection. ..
  55. doi request reprint Two-color cell array screen reveals interdependent roles for histone chaperones and a chromatin boundary regulator in histone gene repression
    Jeffrey Fillingham
    Terrence Donnelly Center for Cellular and Biomolecular Research, University of Toronto, Canada
    Mol Cell 35:340-51. 2009
    ..Our data suggest that this pathway may represent a chromatin regulatory mechanism that is broadly used across the genome...
  56. ncbi request reprint Chemical-genetic approaches for exploring the mode of action of natural products
    Andres Lopez
    Banting and Best Department of Medical Research and Department of Medical Genetics and Microbiology, Terrence Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Canada
    Prog Drug Res 66:237, 239-71. 2008
    ..Extensive application of chemical genetics in yeast has the potential to develop a small molecule inhibitor for the majority of all approximately 6000 yeast genes...
  57. doi request reprint Self-reporting cells
    Corey Nislow
    Department of Molecular Genetics, University of Toronto, Donnelley CCBR, 160 College St, Rm 1210, Toronto, ON M5S 3E1, Canada
    Biotechniques 46:356-7. 2009
    ..Such cells can be engineered to report on diverse aspects of their physiology, potentially opening up new avenues of biological inquiry and enhancing our understanding of cell function...
  58. pmc Examining protein protein interactions using endogenously tagged yeast arrays: the cross-and-capture system
    Bernhard Suter
    Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 3E1, Canada
    Genome Res 17:1774-82. 2007
    ..Our studies establish the "Cross-and-Capture" assay as a novel, versatile tool that provides a valuable complement for the next generation of yeast proteomic studies...
  59. pmc Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system
    Leo C K Wan
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, ON M5G 1X5, Canada
    Nucleic Acids Res 41:6332-46. 2013
    ..The partial complementation of telomere maintenance by Qri7 hints that KEOPS has evolved novel functions in higher organisms. ..
  60. ncbi request reprint Experimental approaches to identify genetic networks
    Michael Costanzo
    Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, Ontario M5S 3E1, Canada
    Curr Opin Biotechnol 17:472-80. 2006
    ..Many of these experimental approaches have been adopted and adapted to study other systems, including worm, fly, fish and mammalian cultured cells, using an ingenious set of molecular tools...
  61. pmc A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds
    Cheuk Hei Ho
    Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada
    Nat Biotechnol 27:369-77. 2009
    ..We used the MoBY-ORF library to identify the genetic basis of several drug-resistant mutants and in this analysis discovered a new class of sterol-binding compounds...
  62. pmc Identification of small molecule inhibitors of Pseudomonas aeruginosa exoenzyme S using a yeast phenotypic screen
    Anthony Arnoldo
    Terrence Donnelly Centre for Cellular and Biomolecular Research, Department of Biochemistry, University of Toronto, Ontario, Canada
    PLoS Genet 4:e1000005. 2008
    ..Taken together, our integrated cell-based, chemical-genetic approach demonstrates that such screens can augment traditional drug screening approaches and facilitate the discovery of new compounds against a broad range of human pathogens...