Affiliation: University of Toronto
- Combining chemical genomics screens in yeast to reveal spectrum of effects of chemical inhibition of sphingolipid biosynthesisDanielle Kemmer
Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, Canada
BMC Microbiol 9:9. 2009..Single genome-wide screens for the effect of altered gene dosage on drug sensitivity in the model organism Saccharomyces cerevisiae provide only a partial picture of the mechanism of action of a drug...
- A comprehensive platform for highly multiplexed mammalian functional genetic screensTroy Ketela
Donnelly Centre and Banting and Best Department of Medical Research, University of Toronto, Toronto, Canada
BMC Genomics 12:213. 2011..The Gene Modulation Array Platform (GMAP) is a single microarray-based detection solution for deconvolution of loss and gain-of-function pooled screens...
- Novel insights into iron metabolism by integrating deletome and transcriptome analysis in an iron deficiency model of the yeast Saccharomyces cerevisiaeWilliam J Jo
Department of Nutritional Sciences and Toxicology, University of California, Berkeley, California 94720, USA
BMC Genomics 10:130. 2009..The resulting analysis provides a global perspective on the cellular processes involved in iron metabolism...
- Nucleosome-coupled expression differences in closely-related speciesYuanfang Guan
Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
BMC Genomics 12:466. 2011..The degree to which nucleosome-motif interactions relate to phenotypic changes across species is, however, unknown...